CA2339821A1 - Enzymatic measurement of mycophenolic acid - Google Patents

Enzymatic measurement of mycophenolic acid Download PDF

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Publication number
CA2339821A1
CA2339821A1 CA002339821A CA2339821A CA2339821A1 CA 2339821 A1 CA2339821 A1 CA 2339821A1 CA 002339821 A CA002339821 A CA 002339821A CA 2339821 A CA2339821 A CA 2339821A CA 2339821 A1 CA2339821 A1 CA 2339821A1
Authority
CA
Canada
Prior art keywords
mycophenolic acid
enzymatic measurement
measurement
present
biological samples
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002339821A
Other languages
French (fr)
Other versions
CA2339821C (en
Inventor
Allan R. Dorn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics Operations Inc
Original Assignee
Roche Diagnostics Corporation
Allan R. Dorn
Roche Diagnostics Operations, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics Corporation, Allan R. Dorn, Roche Diagnostics Operations, Inc. filed Critical Roche Diagnostics Corporation
Publication of CA2339821A1 publication Critical patent/CA2339821A1/en
Application granted granted Critical
Publication of CA2339821C publication Critical patent/CA2339821C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9493—Immunosupressants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit

Abstract

The present invention provides a method for the enzymatic measurement of mycophenolic acid and other IMPDH
inhibitors in biological samples. The present invention also provides assay reagents and packaged kits useful for performing enzymatic measurement of mycophenolic acid and other IMPDH inhibitors in biological samples.
CA002339821A 1999-06-09 2000-05-11 Enzymatic measurement of mycophenolic acid Expired - Lifetime CA2339821C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/328,741 1999-06-09
US09/328,741 US6107052A (en) 1999-06-09 1999-06-09 Enzymatic measurement of mycophenolic acid
PCT/US2000/012872 WO2000075363A2 (en) 1999-06-09 2000-05-11 Enzymatic measurement of mycophenolic acid

Publications (2)

Publication Number Publication Date
CA2339821A1 true CA2339821A1 (en) 2000-12-14
CA2339821C CA2339821C (en) 2009-01-27

Family

ID=23282234

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002339821A Expired - Lifetime CA2339821C (en) 1999-06-09 2000-05-11 Enzymatic measurement of mycophenolic acid

Country Status (8)

Country Link
US (1) US6107052A (en)
EP (1) EP1112373B1 (en)
JP (1) JP3854864B2 (en)
AT (1) ATE333510T1 (en)
CA (1) CA2339821C (en)
DE (1) DE60029413T2 (en)
ES (1) ES2267541T3 (en)
WO (1) WO2000075363A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6811998B2 (en) * 1999-06-25 2004-11-02 Roche Diagnostics Operations, Inc. Conjugates of uncompetitive inhibitors of inosine monophosphate dehydrogenase
US6524808B1 (en) * 1999-06-25 2003-02-25 Roche Diagnostics Corporation Enzyme inhibition immunoassay
EP1207394B1 (en) * 2000-11-14 2009-12-30 Roche Diagnostics GmbH Immunoassay for HIV protease inhibitors
US6471980B2 (en) 2000-12-22 2002-10-29 Avantec Vascular Corporation Intravascular delivery of mycophenolic acid
US20030050692A1 (en) * 2000-12-22 2003-03-13 Avantec Vascular Corporation Delivery of therapeutic capable agents
US7077859B2 (en) * 2000-12-22 2006-07-18 Avantec Vascular Corporation Apparatus and methods for variably controlled substance delivery from implanted prostheses
US20050203612A1 (en) * 2000-12-22 2005-09-15 Avantec Vascular Corporation Devices delivering therapeutic agents and methods regarding the same
US7083642B2 (en) * 2000-12-22 2006-08-01 Avantec Vascular Corporation Delivery of therapeutic capable agents
US20050125054A1 (en) * 2000-12-22 2005-06-09 Avantec Vascular Corporation Devices delivering therapeutic agents and methods regarding the same
WO2003009779A2 (en) * 2001-07-26 2003-02-06 Avantec Vascular Corporation Delivery of therapeutic capable agents
US7276362B2 (en) * 2004-01-30 2007-10-02 Roche Diagnostics Operations, Inc. Recombinant histidine-tagged inosine monophosphate dehydrogenase polypeptides
JP2007532585A (en) * 2004-04-26 2007-11-15 テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ Method for preparing mycophenolic acid and its ester derivatives
DE602007004728D1 (en) * 2006-06-29 2010-03-25 Ivax Pharmaceuticals Sro REGULATION OF ACID METABOLITE PRODUCTION
TW200904982A (en) * 2007-04-11 2009-02-01 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Method for reducing impurity level in mycophenolic acid fermentation
JP2022518594A (en) * 2019-01-31 2022-03-15 エフ．ホフマン－ラ ロシュ アーゲー Stabilization of NADPH or NADH in ammonia detection assay

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4753935A (en) * 1987-01-30 1988-06-28 Syntex (U.S.A.) Inc. Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions
US5665583A (en) * 1988-08-12 1997-09-09 Arch Dev Corp Methods and materials relating to IMPDH and GMP production
US5283257A (en) * 1992-07-10 1994-02-01 The Board Of Trustees Of The Leland Stanford Junior University Method of treating hyperproliferative vascular disease
WO1994012184A1 (en) * 1992-11-24 1994-06-09 Syntex (U.S.A.) Inc. Use of mycophenolic acid, mycophenolate mofetil or derivate thereof to inhibit stenosis
US5444072A (en) * 1994-02-18 1995-08-22 Syntex (U.S.A.) Inc. 6-substituted mycophenolic acid and derivatives
US5380879A (en) * 1994-02-18 1995-01-10 Syntex (U.S.A.) Inc. Derivatives of mycophenolic acid
US6225073B1 (en) * 1994-07-07 2001-05-01 Dade Behring Marburg Gmbh Immunoassay for mycophenolic acid
US5807876A (en) * 1996-04-23 1998-09-15 Vertex Pharmaceuticals Incorporated Inhibitors of IMPDH enzyme
CN1515248A (en) * 1996-04-23 2004-07-28 ��̩��˹ҩ��ɷ����޹�˾ Urea derivative used as inosine-5'-dehydrogenase monophosphate inhibitor
US6153398A (en) * 1997-12-24 2000-11-28 The University Of Chicago Method to identify specific inhibitors of IMP dehydrogenase

Also Published As

Publication number Publication date
JP3854864B2 (en) 2006-12-06
JP2003523730A (en) 2003-08-12
ATE333510T1 (en) 2006-08-15
WO2000075363A2 (en) 2000-12-14
EP1112373B1 (en) 2006-07-19
ES2267541T3 (en) 2007-03-16
EP1112373A2 (en) 2001-07-04
DE60029413D1 (en) 2006-08-31
DE60029413T2 (en) 2007-02-22
CA2339821C (en) 2009-01-27
US6107052A (en) 2000-08-22
WO2000075363A3 (en) 2001-04-12

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