CA2334773A1 - Benzothiepine-1,1-dioxide derivatives, method for producing them, medicaments containing these compounds and their use - Google Patents

Benzothiepine-1,1-dioxide derivatives, method for producing them, medicaments containing these compounds and their use Download PDF

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Publication number
CA2334773A1
CA2334773A1 CA002334773A CA2334773A CA2334773A1 CA 2334773 A1 CA2334773 A1 CA 2334773A1 CA 002334773 A CA002334773 A CA 002334773A CA 2334773 A CA2334773 A CA 2334773A CA 2334773 A1 CA2334773 A1 CA 2334773A1
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CA
Canada
Prior art keywords
compounds
benzothiepine
producing
dioxide derivatives
medicaments containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002334773A
Other languages
French (fr)
Other versions
CA2334773C (en
Inventor
Wendelin Frick
Alfons Enhsen
Heiner Glombik
Hubert Heuer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Aventis Pharma Deutschland Gmbh
Wendelin Frick
Alfons Enhsen
Heiner Glombik
Hubert Heuer
Sanofi-Aventis Deutschland Gmbh
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Filing date
Publication date
Application filed by Aventis Pharma Deutschland Gmbh, Wendelin Frick, Alfons Enhsen, Heiner Glombik, Hubert Heuer, Sanofi-Aventis Deutschland Gmbh filed Critical Aventis Pharma Deutschland Gmbh
Publication of CA2334773A1 publication Critical patent/CA2334773A1/en
Application granted granted Critical
Publication of CA2334773C publication Critical patent/CA2334773C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D337/00Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02Seven-membered rings
    • C07D337/06Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/08Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/38Heterocyclic compounds having sulfur as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/04Drugs for disorders of the urinary system for urolithiasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06086Dipeptides with the first amino acid being basic
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32Polymers modified by chemical after-treatment
    • C08G65/329Polymers modified by chemical after-treatment with organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention relates to benzothiepine-1,1-dioxide derivatives and their acid addition salts, i.e. compounds of formula (I) wherein R1, R2, R3, R4, R5 and Z have the meanings given in the description and their physiologically compatible salts and physiologically functional derivatives. The invention also relates to a method for producing said compounds, which are suitable for use as e.g. hypolipidaemics.
CA002334773A 1998-06-10 1999-05-29 Benzothiepine-1,1-dioxide derivatives, method for producing them, medicaments containing these compounds and their use Expired - Lifetime CA2334773C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19825804A DE19825804C2 (en) 1998-06-10 1998-06-10 1,4-Benzothiepin-1,1-dioxide derivatives, processes for their preparation and medicaments containing these compounds
DE19825804.6 1998-06-10
PCT/EP1999/003743 WO1999064409A2 (en) 1998-06-10 1999-05-29 Benzothiepine-1,1-dioxide derivatives, method for producing them, medicaments containing these compounds and their use

Publications (2)

Publication Number Publication Date
CA2334773A1 true CA2334773A1 (en) 1999-12-16
CA2334773C CA2334773C (en) 2009-05-26

Family

ID=7870440

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002334775A Expired - Fee Related CA2334775C (en) 1998-06-10 1999-05-28 Benzo(b)thiepine-1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use
CA002334773A Expired - Lifetime CA2334773C (en) 1998-06-10 1999-05-29 Benzothiepine-1,1-dioxide derivatives, method for producing them, medicaments containing these compounds and their use

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA002334775A Expired - Fee Related CA2334775C (en) 1998-06-10 1999-05-28 Benzo(b)thiepine-1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use

Country Status (26)

Country Link
US (1) US6387944B1 (en)
EP (2) EP1086092B1 (en)
JP (2) JP4374426B2 (en)
KR (2) KR100681721B1 (en)
CN (2) CN1127497C (en)
AR (2) AR018633A1 (en)
AT (2) ATE227715T1 (en)
AU (2) AU753275B2 (en)
BR (2) BR9912188B1 (en)
CA (2) CA2334775C (en)
CZ (2) CZ297989B6 (en)
DE (3) DE19825804C2 (en)
DK (2) DK1086092T3 (en)
ES (2) ES2182535T3 (en)
HK (2) HK1039490A1 (en)
HU (2) HU229761B1 (en)
ID (2) ID28695A (en)
IL (1) IL140078A (en)
NO (1) NO327075B1 (en)
NZ (1) NZ508681A (en)
PL (2) PL196074B1 (en)
PT (2) PT1086092E (en)
RU (2) RU2215001C2 (en)
TR (2) TR200003634T2 (en)
WO (2) WO1999064410A1 (en)
ZA (2) ZA200007061B (en)

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AU4503199A (en) 1999-12-30
JP4374426B2 (en) 2009-12-02
NO327075B1 (en) 2009-04-20
KR20010052682A (en) 2001-06-25
TR200003632T2 (en) 2001-04-20
AU753275B2 (en) 2002-10-10
ES2215387T3 (en) 2004-10-01
HUP0102256A3 (en) 2002-04-29
CZ20004591A3 (en) 2001-04-11
PL344827A1 (en) 2001-11-19
ZA200007061B (en) 2001-07-18
BR9912188B1 (en) 2010-12-14
PT1086113E (en) 2004-06-30
CN1305469A (en) 2001-07-25
ATE227715T1 (en) 2002-11-15
RU2215001C2 (en) 2003-10-27
CZ20004592A3 (en) 2001-04-11
ATE259372T1 (en) 2004-02-15
DK1086092T3 (en) 2003-03-10
HU228570B1 (en) 2013-04-29
NO20006251D0 (en) 2000-12-08
HUP0102554A1 (en) 2001-10-28
AU752633B2 (en) 2002-09-26
AR018634A1 (en) 2001-11-28
CA2334773C (en) 2009-05-26
NZ508681A (en) 2002-06-28
BR9911123B1 (en) 2010-12-14
CZ297925B6 (en) 2007-05-02
CN1127497C (en) 2003-11-12
DE59903411D1 (en) 2002-12-19
EP1086113A2 (en) 2001-03-28
ID28695A (en) 2001-06-28
CA2334775A1 (en) 1999-12-16
HK1039490A1 (en) 2002-04-26
JP3374129B2 (en) 2003-02-04
CN1152039C (en) 2004-06-02
CN1305487A (en) 2001-07-25
PL196057B1 (en) 2007-11-30
KR100681721B1 (en) 2007-02-15
JP2002517490A (en) 2002-06-18
HU229761B1 (en) 2014-06-30
RU2220141C2 (en) 2003-12-27
BR9911123A (en) 2006-01-03
AU4501999A (en) 1999-12-30
KR20010052701A (en) 2001-06-25
EP1086092B1 (en) 2002-11-13
KR100562184B1 (en) 2006-03-20
PL345901A1 (en) 2002-01-14
CZ297989B6 (en) 2007-05-16
CA2334775C (en) 2009-10-13
AR018633A1 (en) 2001-11-28
PL196074B1 (en) 2007-12-31
DE19825804A1 (en) 1999-12-16
WO1999064409A3 (en) 2000-03-02
NO20006251L (en) 2001-02-07
DE59908522D1 (en) 2004-03-18
WO1999064409A2 (en) 1999-12-16
WO1999064410A1 (en) 1999-12-16
ES2182535T3 (en) 2003-03-01
IL140078A (en) 2004-08-31
HK1036799A1 (en) 2002-01-18
HUP0102256A1 (en) 2001-12-28
HUP0102554A3 (en) 2002-12-28
DK1086113T3 (en) 2004-05-24
EP1086092A1 (en) 2001-03-28
ZA200007060B (en) 2001-07-18
ID26876A (en) 2001-02-15
TR200003634T2 (en) 2001-06-21
PT1086092E (en) 2003-03-31
EP1086113B1 (en) 2004-02-11
BR9912188A (en) 2001-04-10
US6387944B1 (en) 2002-05-14
DE19825804C2 (en) 2000-08-24
IL140078A0 (en) 2002-02-10
JP2002517491A (en) 2002-06-18

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