CA2334773A1 - Benzothiepine-1,1-dioxide derivatives, method for producing them, medicaments containing these compounds and their use - Google Patents
Benzothiepine-1,1-dioxide derivatives, method for producing them, medicaments containing these compounds and their use Download PDFInfo
- Publication number
- CA2334773A1 CA2334773A1 CA002334773A CA2334773A CA2334773A1 CA 2334773 A1 CA2334773 A1 CA 2334773A1 CA 002334773 A CA002334773 A CA 002334773A CA 2334773 A CA2334773 A CA 2334773A CA 2334773 A1 CA2334773 A1 CA 2334773A1
- Authority
- CA
- Canada
- Prior art keywords
- compounds
- benzothiepine
- producing
- dioxide derivatives
- medicaments containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
- C07D337/02—Seven-membered rings
- C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D337/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/04—Drugs for disorders of the urinary system for urolithiasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
The invention relates to benzothiepine-1,1-dioxide derivatives and their acid addition salts, i.e. compounds of formula (I) wherein R1, R2, R3, R4, R5 and Z have the meanings given in the description and their physiologically compatible salts and physiologically functional derivatives. The invention also relates to a method for producing said compounds, which are suitable for use as e.g. hypolipidaemics.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19825804.6 | 1998-06-10 | ||
| DE19825804A DE19825804C2 (en) | 1998-06-10 | 1998-06-10 | 1,4-Benzothiepin-1,1-dioxide derivatives, processes for their preparation and medicaments containing these compounds |
| PCT/EP1999/003743 WO1999064409A2 (en) | 1998-06-10 | 1999-05-29 | Benzothiepine-1,1-dioxide derivatives, method for producing them, medicaments containing these compounds and their use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2334773A1 true CA2334773A1 (en) | 1999-12-16 |
| CA2334773C CA2334773C (en) | 2009-05-26 |
Family
ID=7870440
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002334775A Expired - Fee Related CA2334775C (en) | 1998-06-10 | 1999-05-28 | Benzo(b)thiepine-1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use |
| CA002334773A Expired - Lifetime CA2334773C (en) | 1998-06-10 | 1999-05-29 | Benzothiepine-1,1-dioxide derivatives, method for producing them, medicaments containing these compounds and their use |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002334775A Expired - Fee Related CA2334775C (en) | 1998-06-10 | 1999-05-28 | Benzo(b)thiepine-1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6387944B1 (en) |
| EP (2) | EP1086092B1 (en) |
| JP (2) | JP4374426B2 (en) |
| KR (2) | KR100681721B1 (en) |
| CN (2) | CN1127497C (en) |
| AR (2) | AR018633A1 (en) |
| AT (2) | ATE227715T1 (en) |
| AU (2) | AU753275B2 (en) |
| BR (2) | BR9912188B1 (en) |
| CA (2) | CA2334775C (en) |
| CZ (2) | CZ297989B6 (en) |
| DE (3) | DE19825804C2 (en) |
| DK (2) | DK1086092T3 (en) |
| ES (2) | ES2182535T3 (en) |
| HK (2) | HK1039490A1 (en) |
| HU (2) | HU229761B1 (en) |
| ID (2) | ID28695A (en) |
| IL (1) | IL140078A (en) |
| NO (1) | NO327075B1 (en) |
| NZ (1) | NZ508681A (en) |
| PL (2) | PL196074B1 (en) |
| PT (2) | PT1086092E (en) |
| RU (2) | RU2215001C2 (en) |
| TR (2) | TR200003634T2 (en) |
| WO (2) | WO1999064410A1 (en) |
| ZA (2) | ZA200007060B (en) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6221897B1 (en) * | 1998-06-10 | 2001-04-24 | Aventis Pharma Deutschland Gmbh | Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use |
| SE0000772D0 (en) | 2000-03-08 | 2000-03-08 | Astrazeneca Ab | Chemical compounds |
| EG26979A (en) | 2000-12-21 | 2015-03-01 | Astrazeneca Ab | Chemical compounds |
| MXPA03005155A (en) * | 2000-12-21 | 2003-09-10 | Aventis Pharma Gmbh | Novel 1,2-diphenzylazetidinones, method for producing the same, medicaments containing said compounds, and the use thereof for treating disorders of the lipid metabolism. |
| HUP0401318A3 (en) * | 2001-08-22 | 2008-03-28 | Sanofi Aventis Deutschland | Combined preparations containing 2,3,4,5-tetrahydro-benzo[b]thiepine-1,1-dioxide derivatives and other active substances, and the use thereof |
| GB0121337D0 (en) | 2001-09-04 | 2001-10-24 | Astrazeneca Ab | Chemical compounds |
| GB0121621D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
| GB0121622D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
| DE60217136T2 (en) | 2001-09-08 | 2007-09-27 | Astrazeneca Ab | BENZOTHIAZEPINE AND BENZOTHIADIAZEPINE DERIVATIVE WITH HEMMETIC EFFECT ON THE ACID TRANSPORT IN THE GALLENGES FOR THE TREATMENT OF HYPERLIPIDAEMIA |
| GB0209467D0 (en) | 2002-04-25 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
| GB0213669D0 (en) | 2002-06-14 | 2002-07-24 | Astrazeneca Ab | Chemical compounds |
| SE0201937D0 (en) | 2002-06-20 | 2002-06-20 | Astrazeneca Ab | Therapeutic agents |
| FR2848452B1 (en) * | 2002-12-12 | 2007-04-06 | Aventis Pharma Sa | APPLICATION OF INTESTINAL BILIARY ACID RECAPTURE INHIBITORS FOR THE PREVENTION AND TREATMENT OF ALZHEIMER'S DISEASE |
| US20040138145A1 (en) * | 2002-12-12 | 2004-07-15 | Aventis Pharma S.A. | Application of intestinal biliary acid reuptake inhibitors for the prevention and treatment of alzheimer's disease |
| GB0304194D0 (en) | 2003-02-25 | 2003-03-26 | Astrazeneca Ab | Chemical compounds |
| GB0307918D0 (en) | 2003-04-05 | 2003-05-14 | Astrazeneca Ab | Therapeutic use |
| DE102006053635B4 (en) * | 2006-11-14 | 2011-06-30 | Sanofi-Aventis Deutschland GmbH, 65929 | Novel benzyl-substituted 1,4-benzothiepine-1,1-dioxide derivatives, drugs containing these compounds and their use |
| DE102006053636B4 (en) * | 2006-11-14 | 2008-09-18 | Sanofi-Aventis Deutschland Gmbh | New cyclohexyl substituted 1,4-benzothiepine 1,1-dioxide derivatives and their use |
| US20100221513A1 (en) * | 2008-09-05 | 2010-09-02 | Wisconsin Alumni Research Foundation | Self sintering transparent nanoporous thin-films for use in self-cleaning, anti-fogging, anti-corrosion, anti-erosion electronic and optical applications |
| EP3593802A3 (en) | 2010-05-26 | 2020-03-25 | Satiogen Pharmaceuticals, Inc. | Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions |
| CA2815749C (en) | 2010-11-08 | 2019-12-03 | Albireo Ab | Ibat inhibitors for the treatment of liver diseases |
| RU2619215C2 (en) | 2010-11-08 | 2017-05-12 | Альбирео Аб | Pharmaceutical combination comprising ibat-inhibitor and bile acid binder |
| CA2852957C (en) | 2011-10-28 | 2020-08-04 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease |
| WO2013063512A1 (en) * | 2011-10-28 | 2013-05-02 | Lumena Pharmaceuticals, Inc | Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases |
| US20140271734A1 (en) | 2013-03-15 | 2014-09-18 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of barrett's esophagus and gastroesophageal reflux disease |
| CA2907230A1 (en) | 2013-03-15 | 2014-09-18 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of primary sclerosing cholangitis and inflammatory bowel disease |
| JO3301B1 (en) | 2013-04-26 | 2018-09-16 | Albireo Ab | Crystal modifications of elobixibat |
| KR102560954B1 (en) | 2014-06-25 | 2023-07-31 | 이에이 파마 가부시키가이샤 | Solid preparation, and method for preventing or reducing discoloration thereof |
| EP3012252A1 (en) | 2014-10-24 | 2016-04-27 | Ferring BV | Crystal modifications of elobixibat |
| JP6954927B2 (en) | 2016-02-09 | 2021-10-27 | アルビレオ・アクチボラグ | Oral cholestyramine preparation and its use |
| US10441604B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Cholestyramine pellets and methods for preparation thereof |
| US10441605B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US10786529B2 (en) | 2016-02-09 | 2020-09-29 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| CN108601744B (en) | 2016-02-09 | 2022-01-04 | 阿尔比里奥公司 | Oral cholestyramine formulations and uses thereof |
| JP7328207B2 (en) | 2017-08-09 | 2023-08-16 | アルビレオ・アクチボラグ | Cholestyramine pellets, oral cholestyramine preparations, and their uses |
| CN111032019B (en) | 2017-08-09 | 2022-07-05 | 阿尔比里奥公司 | Cholestyramine granules, oral cholestyramine preparation and application thereof |
| US10793534B2 (en) | 2018-06-05 | 2020-10-06 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| CN112449637B (en) | 2018-06-05 | 2024-03-19 | 阿尔比里奥公司 | Benzothiazepine compounds and their use as bile acid modulators |
| BR112020024461A2 (en) | 2018-06-20 | 2021-03-23 | Albireo Ab | pharmaceutical formulation of odevixibat, process for the preparation of the pharmaceutical formulation, and, formulation. |
| US11801226B2 (en) | 2018-06-20 | 2023-10-31 | Albireo Ab | Pharmaceutical formulation of odevixibat |
| US11007142B2 (en) | 2018-08-09 | 2021-05-18 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US10722457B2 (en) | 2018-08-09 | 2020-07-28 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US11549878B2 (en) | 2018-08-09 | 2023-01-10 | Albireo Ab | In vitro method for determining the adsorbing capacity of an insoluble adsorbant |
| CA3127408A1 (en) | 2019-02-06 | 2020-08-13 | Albireo Ab | Benzothiazepine compounds and their use as bile acid modulators |
| US10941127B2 (en) | 2019-02-06 | 2021-03-09 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
| PT3921028T (en) | 2019-02-06 | 2023-02-15 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
| US10975045B2 (en) | 2019-02-06 | 2021-04-13 | Aibireo AB | Benzothiazepine compounds and their use as bile acid modulators |
| CN114072152A (en) | 2019-02-12 | 2022-02-18 | 米鲁姆制药公司 | Genotype and dose-dependent response to ASBTI in patients with bile salt efflux pump deficiency |
| FI4069360T3 (en) | 2019-12-04 | 2024-02-20 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| EP4069361B1 (en) | 2019-12-04 | 2024-01-03 | Albireo AB | Benzothia(di)azepine compounds and their use as bile acid modulators |
| CA3158276A1 (en) | 2019-12-04 | 2021-06-10 | Per-Goran Gillberg | Benzothia(di)azepine compounds and their use as bile acid modulators |
| JP2023504644A (en) | 2019-12-04 | 2023-02-06 | アルビレオ・アクチボラグ | Benzothiadiazepine compounds and their use as bile acid modulators |
| TW202134220A (en) | 2019-12-04 | 2021-09-16 | 瑞典商艾爾比瑞歐公司 | Benzothia(di)azepine compounds and their use as bile acid modulators |
| WO2021110885A1 (en) | 2019-12-04 | 2021-06-10 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
| WO2021110884A1 (en) | 2019-12-04 | 2021-06-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| WO2021110883A1 (en) | 2019-12-04 | 2021-06-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| WO2021110887A1 (en) | 2019-12-04 | 2021-06-10 | Albireo Ab | Benzothiazepine compounds and their use as bile acid modulators |
| US11014898B1 (en) | 2020-12-04 | 2021-05-25 | Albireo Ab | Benzothiazepine compounds and their use as bile acid modulators |
| WO2022029101A1 (en) | 2020-08-03 | 2022-02-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| CA3186857A1 (en) | 2020-08-03 | 2022-02-10 | Per-Goran Gillberg | Benzothia(di)azepine compounds and their use as bile acid modulators |
| EP4243831A1 (en) | 2020-11-12 | 2023-09-20 | Albireo AB | Odevixibat for treating progressive familial intrahepatic cholestasis (pfic) |
| JP2024500309A (en) | 2020-12-04 | 2024-01-09 | アルビレオ エービー | Benzothia(di)azepine compounds and their use as bile acid modulators |
| TW202313579A (en) | 2021-06-03 | 2023-04-01 | 瑞典商艾爾比瑞歐公司 | Benzothia(di)azepine compounds and their use as bile acid modulators |
| US20230398125A1 (en) | 2022-06-09 | 2023-12-14 | Albireo Ab | Treating hepatitis |
| WO2024008766A1 (en) | 2022-07-05 | 2024-01-11 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0781278B1 (en) * | 1994-09-13 | 2001-03-14 | Monsanto Company | Novel benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| US5994391A (en) * | 1994-09-13 | 1999-11-30 | G.D. Searle And Company | Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| RU2202549C2 (en) * | 1996-03-11 | 2003-04-20 | Джи. Ди. Сирл Энд Ко. | Benzothiepines, pharmaceutical composition based on thereof, method of prophylaxis and treatment of hyperlipidemic state |
| US6221897B1 (en) * | 1998-06-10 | 2001-04-24 | Aventis Pharma Deutschland Gmbh | Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use |
| CA2337307A1 (en) * | 1998-08-20 | 2000-03-02 | Osamu Nishimura | Quaternary ammonium salts and their use |
-
1998
- 1998-06-10 DE DE19825804A patent/DE19825804C2/en not_active Expired - Lifetime
-
1999
- 1999-05-28 JP JP2000553419A patent/JP4374426B2/en not_active Expired - Fee Related
- 1999-05-28 KR KR1020007013964A patent/KR100681721B1/en not_active IP Right Cessation
- 1999-05-28 BR BRPI9912188-3A patent/BR9912188B1/en not_active IP Right Cessation
- 1999-05-28 US US09/719,047 patent/US6387944B1/en not_active Expired - Lifetime
- 1999-05-28 TR TR2000/03634T patent/TR200003634T2/en unknown
- 1999-05-28 RU RU2001101491/04A patent/RU2215001C2/en not_active IP Right Cessation
- 1999-05-28 AU AU45019/99A patent/AU753275B2/en not_active Ceased
- 1999-05-28 CA CA002334775A patent/CA2334775C/en not_active Expired - Fee Related
- 1999-05-28 WO PCT/EP1999/003701 patent/WO1999064410A1/en active IP Right Grant
- 1999-05-28 HU HU0102256 patent/HU229761B1/en not_active IP Right Cessation
- 1999-05-28 CZ CZ20004592A patent/CZ297989B6/en not_active IP Right Cessation
- 1999-05-28 PT PT99927784T patent/PT1086092E/en unknown
- 1999-05-28 EP EP99927784A patent/EP1086092B1/en not_active Expired - Lifetime
- 1999-05-28 CN CN99807171A patent/CN1127497C/en not_active Expired - Fee Related
- 1999-05-28 DE DE59903411T patent/DE59903411D1/en not_active Expired - Lifetime
- 1999-05-28 ES ES99927784T patent/ES2182535T3/en not_active Expired - Lifetime
- 1999-05-28 ID IDW20002562A patent/ID28695A/en unknown
- 1999-05-28 AT AT99927784T patent/ATE227715T1/en active
- 1999-05-28 PL PL344827A patent/PL196074B1/en unknown
- 1999-05-28 DK DK99927784T patent/DK1086092T3/en active
- 1999-05-29 TR TR2000/03632T patent/TR200003632T2/en unknown
- 1999-05-29 PL PL99345901A patent/PL196057B1/en unknown
- 1999-05-29 WO PCT/EP1999/003743 patent/WO1999064409A2/en active Search and Examination
- 1999-05-29 EP EP99927802A patent/EP1086113B1/en not_active Expired - Lifetime
- 1999-05-29 CN CNB998071722A patent/CN1152039C/en not_active Expired - Lifetime
- 1999-05-29 NZ NZ508681A patent/NZ508681A/en not_active IP Right Cessation
- 1999-05-29 IL IL14007899A patent/IL140078A/en not_active IP Right Cessation
- 1999-05-29 HU HU0102554A patent/HU228570B1/en unknown
- 1999-05-29 CA CA002334773A patent/CA2334773C/en not_active Expired - Lifetime
- 1999-05-29 DK DK99927802T patent/DK1086113T3/en active
- 1999-05-29 AU AU45031/99A patent/AU752633B2/en not_active Expired
- 1999-05-29 DE DE59908522T patent/DE59908522D1/en not_active Expired - Lifetime
- 1999-05-29 ID IDW20002564A patent/ID26876A/en unknown
- 1999-05-29 JP JP2000553418A patent/JP3374129B2/en not_active Expired - Lifetime
- 1999-05-29 BR BRPI9911123-3A patent/BR9911123B1/en not_active IP Right Cessation
- 1999-05-29 KR KR1020007013931A patent/KR100562184B1/en active IP Right Grant
- 1999-05-29 AT AT99927802T patent/ATE259372T1/en active
- 1999-05-29 RU RU2001101499/04A patent/RU2220141C2/en active
- 1999-05-29 CZ CZ20004591A patent/CZ297925B6/en not_active IP Right Cessation
- 1999-05-29 PT PT99927802T patent/PT1086113E/en unknown
- 1999-05-29 ES ES99927802T patent/ES2215387T3/en not_active Expired - Lifetime
- 1999-06-08 AR ARP990102715A patent/AR018633A1/en active IP Right Grant
- 1999-06-08 AR ARP990102716A patent/AR018634A1/en active IP Right Grant
-
2000
- 2000-11-30 ZA ZA200007060A patent/ZA200007060B/en unknown
- 2000-11-30 ZA ZA200007061A patent/ZA200007061B/en unknown
- 2000-12-08 NO NO20006251A patent/NO327075B1/en not_active IP Right Cessation
-
2001
- 2001-11-06 HK HK01107746A patent/HK1039490A1/en not_active IP Right Cessation
- 2001-11-06 HK HK01107735A patent/HK1036799A1/en not_active IP Right Cessation
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| Date | Code | Title | Description |
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| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20190529 |