CA2334269A1 - Diagnostic assay requiring a small sample of biological fluid - Google Patents

Diagnostic assay requiring a small sample of biological fluid Download PDF

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Publication number
CA2334269A1
CA2334269A1 CA002334269A CA2334269A CA2334269A1 CA 2334269 A1 CA2334269 A1 CA 2334269A1 CA 002334269 A CA002334269 A CA 002334269A CA 2334269 A CA2334269 A CA 2334269A CA 2334269 A1 CA2334269 A1 CA 2334269A1
Authority
CA
Canada
Prior art keywords
sample
optical reading
opening
reading chamber
layer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002334269A
Other languages
French (fr)
Other versions
CA2334269C (en
Inventor
Sie Ting Wong
Robert G. Hiltibran
Tung-Ming Huang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Sie Ting Wong
Robert G. Hiltibran
Tung-Ming Huang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22253133&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2334269(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Laboratories, Sie Ting Wong, Robert G. Hiltibran, Tung-Ming Huang filed Critical Abbott Laboratories
Publication of CA2334269A1 publication Critical patent/CA2334269A1/en
Application granted granted Critical
Publication of CA2334269C publication Critical patent/CA2334269C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5302—Apparatus specially adapted for immunological test procedures
    • G01N33/5304—Reaction vessels, e.g. agglutination plates

Abstract

An article and a method for monitoring the concentration of glucose in blood. In one aspect, the invention involves an article comprising a multiple-layer element utilizing reagents capable of reacting with an analyte of interest. In a prefered embodiment, the element comprises: (a) a core layer having two major surfaces, an optical reading chamber extending from a first opening in one of said two major surfaces to a second opening in the other of said two major surfaces, said core layer further having a third opening therein and a flow channel, one end of which flow channel communicates with the third opening and the other end of which flow channel communicates with the optical reading chamber; and (b) a base layer in face-to-face contact with one major surface of said core layer; and (c) a cover layer in face-to-face contact with the other major surface of said core layer, said cover layer having an opening therein to vent the element. In this embodiment, the optical reading chamber extends completely through the core layer. The sample is introduced into the third opening and then flows through the flow channel into the optical reading chamber. The reagents with which the analyte in the sample reacts to form an optically detectable reaction product can be disposed in the optical reading chamber or can be added to the sample before the sample enters the optical reading chamber. In another aspect, the invention involves a method comprising the steps of:
(a) obtaining a sample of biological fluid, e.g., interstitial fluid, from the body of a patient; (b) introducing the sample to article comprising a multiple-layer element having an optical reading chamber, (c) allowing reagents to react with an analyte of interest in the sample; and (d) measuring the concentration of analyte in the sample by means of an optical instrument.
CA002334269A 1998-06-10 1999-06-03 Diagnostic assay requiring a small sample of biological fluid Expired - Lifetime CA2334269C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/095,683 US6077660A (en) 1998-06-10 1998-06-10 Diagnostic assay requiring a small sample of biological fluid
US09/095,683 1998-06-10
PCT/US1999/012294 WO1999064620A2 (en) 1998-06-10 1999-06-03 Diagnostic assay requiring a small sample of biological fluid

Publications (2)

Publication Number Publication Date
CA2334269A1 true CA2334269A1 (en) 1999-12-16
CA2334269C CA2334269C (en) 2008-08-19

Family

ID=22253133

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002334269A Expired - Lifetime CA2334269C (en) 1998-06-10 1999-06-03 Diagnostic assay requiring a small sample of biological fluid

Country Status (10)

Country Link
US (1) US6077660A (en)
EP (1) EP1102991B1 (en)
JP (1) JP2003534526A (en)
AT (1) ATE227848T1 (en)
AU (1) AU766762B2 (en)
CA (1) CA2334269C (en)
DE (2) DE69903954T2 (en)
ES (1) ES2187165T3 (en)
IT (1) ITMI20070307U1 (en)
WO (1) WO1999064620A2 (en)

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Also Published As

Publication number Publication date
ATE227848T1 (en) 2002-11-15
CA2334269C (en) 2008-08-19
ES2187165T3 (en) 2003-05-16
AU766762B2 (en) 2003-10-23
DE29924971U1 (en) 2007-07-19
WO1999064620A3 (en) 2001-01-18
AU4414599A (en) 1999-12-30
WO1999064620A2 (en) 1999-12-16
US6077660A (en) 2000-06-20
EP1102991B1 (en) 2002-11-13
JP2003534526A (en) 2003-11-18
DE69903954T2 (en) 2003-09-04
ITMI20070307U1 (en) 2008-12-11
EP1102991A2 (en) 2001-05-30
DE69903954D1 (en) 2002-12-19

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Effective date: 20190603