CA2329167A1 - Method and apparatus for enhancing flux rates of a fluid in a microporated biological tissue - Google Patents

Method and apparatus for enhancing flux rates of a fluid in a microporated biological tissue Download PDF

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Publication number
CA2329167A1
CA2329167A1 CA002329167A CA2329167A CA2329167A1 CA 2329167 A1 CA2329167 A1 CA 2329167A1 CA 002329167 A CA002329167 A CA 002329167A CA 2329167 A CA2329167 A CA 2329167A CA 2329167 A1 CA2329167 A1 CA 2329167A1
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CA
Canada
Prior art keywords
fluid
microporated
tissue
biological tissue
flux rates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002329167A
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French (fr)
Other versions
CA2329167C (en
Inventor
Jonathan A. Eppstein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nitto Denko Corp
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Individual
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Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CA2637760A priority Critical patent/CA2637760C/en
Publication of CA2329167A1 publication Critical patent/CA2329167A1/en
Application granted granted Critical
Publication of CA2329167C publication Critical patent/CA2329167C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0047—Sonopheresis, i.e. ultrasonically-enhanced transdermal delivery, electroporation of a pharmacologically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A61B2010/008—Interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A61B2017/00765—Decreasing the barrier function of skin tissue by radiated energy, e.g. using ultrasound, using laser for skin perforation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis

Abstract

A method and apparatus for enhancing the flux rate of a fluid through a biological membrane. The method includes the steps of porating a section of the tissue to form one or more micropores in the tissue, and applying a flux enhancer to the tissue through the one or more micropores. The resulting enhancement of fluid flux in the tissue enables more effective harvesting from the body of fluids, as well as more effective delivery of a drug.
CA002329167A 1998-03-06 1999-03-05 Method and apparatus for enhancing flux rates of a fluid in a microporated biological tissue Expired - Lifetime CA2329167C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2637760A CA2637760C (en) 1998-03-06 1999-03-05 Method and apparatus for enhancing flux rates of a fluid in a microporated biological tissue

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/036,053 US6173202B1 (en) 1998-03-06 1998-03-06 Method and apparatus for enhancing flux rates of a fluid in a microporated biological tissue
US09/036,053 1998-03-06
PCT/US1999/004798 WO1999044637A1 (en) 1998-03-06 1999-03-05 Method and apparatus for enhancing flux rates of a fluid in a microporated biological tissue

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2637760A Division CA2637760C (en) 1998-03-06 1999-03-05 Method and apparatus for enhancing flux rates of a fluid in a microporated biological tissue

Publications (2)

Publication Number Publication Date
CA2329167A1 true CA2329167A1 (en) 1999-09-10
CA2329167C CA2329167C (en) 2008-11-18

Family

ID=21886346

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002329167A Expired - Lifetime CA2329167C (en) 1998-03-06 1999-03-05 Method and apparatus for enhancing flux rates of a fluid in a microporated biological tissue
CA2637760A Expired - Lifetime CA2637760C (en) 1998-03-06 1999-03-05 Method and apparatus for enhancing flux rates of a fluid in a microporated biological tissue

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2637760A Expired - Lifetime CA2637760C (en) 1998-03-06 1999-03-05 Method and apparatus for enhancing flux rates of a fluid in a microporated biological tissue

Country Status (10)

Country Link
US (2) US6173202B1 (en)
EP (1) EP1059939B1 (en)
JP (3) JP2002505304A (en)
AT (1) ATE273024T1 (en)
AU (1) AU747794B2 (en)
CA (2) CA2329167C (en)
DE (1) DE69919335T2 (en)
DK (1) DK1059939T3 (en)
ES (1) ES2226353T3 (en)
WO (1) WO1999044637A1 (en)

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US6508785B1 (en) 2003-01-21

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