CA2323551A1 - Method for preferential outer retinal stimulation - Google Patents

Method for preferential outer retinal stimulation Download PDF

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Publication number
CA2323551A1
CA2323551A1 CA002323551A CA2323551A CA2323551A1 CA 2323551 A1 CA2323551 A1 CA 2323551A1 CA 002323551 A CA002323551 A CA 002323551A CA 2323551 A CA2323551 A CA 2323551A CA 2323551 A1 CA2323551 A1 CA 2323551A1
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CA
Canada
Prior art keywords
pulse
signal
retinal
tion
duration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002323551A
Other languages
French (fr)
Other versions
CA2323551C (en
Inventor
Robert J. Greenberg
Mark S. Humayun
Eugene De Juan Jr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
Original Assignee
Johns Hopkins University
Robert J. Greenberg
Mark S. Humayun
Eugene De Juan Jr.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21919111&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2323551(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Johns Hopkins University, Robert J. Greenberg, Mark S. Humayun, Eugene De Juan Jr. filed Critical Johns Hopkins University
Publication of CA2323551A1 publication Critical patent/CA2323551A1/en
Application granted granted Critical
Publication of CA2323551C publication Critical patent/CA2323551C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36046—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of the eye

Abstract

A method of focused phosphene gener-ation through deeper intermediate retinal cel-lular electrical stimulation to the exclusion of direct ganglion cellular electrical stimulation comprises the steps of: a) positioning a stim-ulating electrode in the vicinity of retinal tis-sue; and b) applying a long duration stimula-tion signal to the electrode such that deeper in-termediate retinal cells are preferentially stim-ulated over the retinal ganglion cells and proximal overlying surface axons. The long dura-tion stimulation signal is preferably a biphasic signal having a negative and a positive phase pulse which is applied in cathodic fashion. To preferentially stimulate the deeper intermediate retinal elements the duration of the long dura-tion stimulation signal is greater than 0.5 mil-lisecond per phase pulse, and preferably equal to or longer than 2 millisecond per phase pulse.
The biphasic signal is preferably adjusted to simulate a monophasic signal by adjusting the magnitude of the negative pulse in relation to positive pulse, and by adjusting the duration of the positive pulse in relation to the nega-tive pulse to maintain approximately net zero charge introduction. Preferably, the ratio of the negative pulse to the positive pulse is ap-proximately 10:1 or greater.
CA002323551A 1998-03-13 1999-03-11 Method for preferential outer retinal stimulation Expired - Lifetime CA2323551C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/041,932 1998-03-13
US09/041,932 US5944747A (en) 1998-03-13 1998-03-13 Method for preferential outer retinal stimulation
PCT/US1999/005259 WO1999046001A1 (en) 1998-03-13 1999-03-11 Method for preferential outer retinal stimulation

Publications (2)

Publication Number Publication Date
CA2323551A1 true CA2323551A1 (en) 1999-09-16
CA2323551C CA2323551C (en) 2008-07-29

Family

ID=21919111

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002323551A Expired - Lifetime CA2323551C (en) 1998-03-13 1999-03-11 Method for preferential outer retinal stimulation

Country Status (9)

Country Link
US (1) US5944747A (en)
EP (1) EP1061996B1 (en)
JP (1) JP3929701B2 (en)
AT (1) ATE287277T1 (en)
AU (1) AU739523B2 (en)
CA (1) CA2323551C (en)
DE (1) DE69923296T2 (en)
ES (1) ES2235468T3 (en)
WO (1) WO1999046001A1 (en)

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Also Published As

Publication number Publication date
ES2235468T3 (en) 2005-07-01
DE69923296T2 (en) 2005-06-09
US5944747A (en) 1999-08-31
ATE287277T1 (en) 2005-02-15
JP3929701B2 (en) 2007-06-13
WO1999046001A1 (en) 1999-09-16
EP1061996B1 (en) 2005-01-19
DE69923296D1 (en) 2005-02-24
AU2997699A (en) 1999-09-27
JP2002505929A (en) 2002-02-26
AU739523B2 (en) 2001-10-18
CA2323551C (en) 2008-07-29
EP1061996A1 (en) 2000-12-27

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