CA2322745A1 - Method of treating neuroma pain - Google Patents

Method of treating neuroma pain Download PDF

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Publication number
CA2322745A1
CA2322745A1 CA002322745A CA2322745A CA2322745A1 CA 2322745 A1 CA2322745 A1 CA 2322745A1 CA 002322745 A CA002322745 A CA 002322745A CA 2322745 A CA2322745 A CA 2322745A CA 2322745 A1 CA2322745 A1 CA 2322745A1
Authority
CA
Canada
Prior art keywords
neuroma
treating
pain
local anesthetic
neuroma pain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002322745A
Other languages
French (fr)
Other versions
CA2322745C (en
Inventor
Bradley S. Galer
Larry J. Caldwell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Caldwell Galer Inc
Original Assignee
Caldwell Galer, Incorporated
Bradley S. Galer
Larry J. Caldwell
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Caldwell Galer, Incorporated, Bradley S. Galer, Larry J. Caldwell filed Critical Caldwell Galer, Incorporated
Publication of CA2322745A1 publication Critical patent/CA2322745A1/en
Application granted granted Critical
Publication of CA2322745C publication Critical patent/CA2322745C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies

Abstract

Methods of treating a host suffering from neuroma pain are provided. In the subject methods, a topical local anesthetic composition is applied to a keratinized skin site of the host proximal to the neuroma responsible for the neuroma pain. Preferably, the topical local anesthetic composition comprises eucalyptol in addition to an effective amount of a local anesthetic. The subject methods find particular use in the treatment of pain associated with Morton's neuroma.
CA002322745A 1998-03-20 1999-03-15 Method of treating neuroma pain Expired - Fee Related CA2322745C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/045,285 US6103771A (en) 1998-03-20 1998-03-20 Method of treating neuroma pain
US09/045,285 1998-03-20
PCT/US1999/005553 WO1999048485A1 (en) 1998-03-20 1999-03-15 Method of treating neuroma pain

Publications (2)

Publication Number Publication Date
CA2322745A1 true CA2322745A1 (en) 1999-09-30
CA2322745C CA2322745C (en) 2009-08-04

Family

ID=21937019

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002322745A Expired - Fee Related CA2322745C (en) 1998-03-20 1999-03-15 Method of treating neuroma pain

Country Status (10)

Country Link
US (1) US6103771A (en)
EP (1) EP1063978B1 (en)
JP (1) JP2002507563A (en)
AT (1) ATE268173T1 (en)
CA (1) CA2322745C (en)
DE (1) DE69917756T2 (en)
DK (1) DK1063978T3 (en)
ES (1) ES2221373T3 (en)
PT (1) PT1063978E (en)
WO (1) WO1999048485A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030124174A1 (en) * 2001-10-25 2003-07-03 Endo Pharmaceuticals, Inc Method for treating non-neuropathic pain
WO2003097010A1 (en) * 2002-05-15 2003-11-27 Johannes Wohlrab Medicinal preparation in a colloid for topical application in the therapy and prophylaxis of states of pain and itching
US20060079558A1 (en) * 2004-09-27 2006-04-13 Bridge Pharma. Inc. R-isomer of 2-{2[N-(2-indanyl)-N-phenylamino]ethyl}piperidine and other dermal anesthetics
US7718674B2 (en) * 2004-09-27 2010-05-18 Bridge Pharma, Inc. Methods of relieving neuropathic pain with the S-isomer of 2-{2[N-(2-indanyl)-N-phenylamino]ethyl}piperidine
WO2008011161A2 (en) * 2006-07-21 2008-01-24 Bridge Pharma, Inc. Dermal anesthetic compounds
US8337883B2 (en) 2006-11-03 2012-12-25 Durect Corporation Transdermal delivery systems
WO2013052770A1 (en) * 2011-10-05 2013-04-11 Sanders Jennifer L Methods and compositions for treating foot or hand pain

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4440777A (en) * 1981-07-07 1984-04-03 Merck & Co., Inc. Use of eucalyptol for enhancing skin permeation of bio-affecting agents
US4560553A (en) * 1981-07-07 1985-12-24 Merck & Co., Inc. Use of eucalyptol for enhancing skin permeation of bio-affecting agents
US4588580B2 (en) * 1984-07-23 1999-02-16 Alaz Corp Transdermal administration of fentanyl and device therefor
US4963591A (en) * 1985-12-16 1990-10-16 Carter-Wallace Inc. Cosmetic compositions
US4911707A (en) * 1987-02-13 1990-03-27 Ciba-Geigy Corporation Monolithic user-activated transdermal therapeutic system
AU622162B2 (en) * 1988-04-22 1992-04-02 Ciba-Geigy Ag Transdermal monolith systems
US5411738A (en) * 1989-03-17 1995-05-02 Hind Health Care, Inc. Method for treating nerve injury pain associated with shingles (herpes-zoster and post-herpetic neuralgia) by topical application of lidocaine
EP0399432B1 (en) * 1989-05-25 1994-06-22 Takeda Chemical Industries, Ltd. Transdermal therapeutic composition
US5070084A (en) * 1990-02-26 1991-12-03 Campbell James N Treatment of sympathetically maintained pain
US5069909A (en) * 1990-06-20 1991-12-03 Cygnus Therapeutic Systems Transdermal administration of buprenorphine
JP2849950B2 (en) * 1990-11-30 1999-01-27 日東電工株式会社 Transdermal formulation
US5401728A (en) * 1992-04-02 1995-03-28 Simon; John A. Lecithin based topical liniment
US5613958A (en) * 1993-05-12 1997-03-25 Pp Holdings Inc. Transdermal delivery systems for the modulated administration of drugs
US5330452A (en) * 1993-06-01 1994-07-19 Zook Gerald P Topical medicating device
US5543148A (en) * 1994-07-12 1996-08-06 Combe, Incorporated Stick delivery system for topical application of a treatment agent
US5665378A (en) * 1994-09-30 1997-09-09 Davis; Roosevelt Transdermal therapeutic formulation
US5667719A (en) * 1995-06-02 1997-09-16 Hoechst Celanese Corp. High extinction polarizer films comprising liquid crystal polymeric moieties
US5667799A (en) * 1995-10-30 1997-09-16 Caldwell; Larry J. Method for treating headache pain with topical local anesthetic compositions

Also Published As

Publication number Publication date
ES2221373T3 (en) 2004-12-16
WO1999048485A1 (en) 1999-09-30
DE69917756D1 (en) 2004-07-08
DK1063978T3 (en) 2004-09-27
EP1063978B1 (en) 2004-06-02
EP1063978A1 (en) 2001-01-03
ATE268173T1 (en) 2004-06-15
JP2002507563A (en) 2002-03-12
PT1063978E (en) 2004-10-29
DE69917756T2 (en) 2005-06-16
CA2322745C (en) 2009-08-04
EP1063978A4 (en) 2002-07-03
US6103771A (en) 2000-08-15

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