CA2318191A1 - Method and apparatus for detecting molecular binding events - Google Patents

Method and apparatus for detecting molecular binding events Download PDF

Info

Publication number
CA2318191A1
CA2318191A1 CA002318191A CA2318191A CA2318191A1 CA 2318191 A1 CA2318191 A1 CA 2318191A1 CA 002318191 A CA002318191 A CA 002318191A CA 2318191 A CA2318191 A CA 2318191A CA 2318191 A1 CA2318191 A1 CA 2318191A1
Authority
CA
Canada
Prior art keywords
molecular binding
binding events
detecting molecular
signal
response
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002318191A
Other languages
French (fr)
Other versions
CA2318191C (en
Inventor
John Hefti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DH Technologies Development Pte Ltd
Original Assignee
Signature Bioscience, Inc.
John Hefti
Mds Inc.
Dh Technologies Development Pte. Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Signature Bioscience, Inc., John Hefti, Mds Inc., Dh Technologies Development Pte. Ltd. filed Critical Signature Bioscience, Inc.
Publication of CA2318191A1 publication Critical patent/CA2318191A1/en
Application granted granted Critical
Publication of CA2318191C publication Critical patent/CA2318191C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • G—PHYSICS
    • G11—INFORMATION STORAGE
    • G11C—STATIC STORES
    • G11C13/00—Digital stores characterised by the use of storage elements not covered by groups G11C11/00, G11C23/00, or G11C25/00
    • G11C13/0002—Digital stores characterised by the use of storage elements not covered by groups G11C11/00, G11C23/00, or G11C25/00 using resistive RAM [RRAM] elements
    • G11C13/0009—RRAM elements whose operation depends upon chemical change
    • G11C13/0014—RRAM elements whose operation depends upon chemical change comprising cells based on organic memory material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/806—Electrical property or magnetic property

Abstract

Systems and methods for detecting molecular binding events and other environmental effects using the unique dielectric properties of the bound molecular structure or structures are presented. A molecular binding layer is coupled along the surface of a signal path. A
test signal is propagated along the signal path, whereby the test signal couples to the molecular binding layer, and in response, exhibits a signal response.
CA002318191A 1998-02-02 1999-02-01 Method and apparatus for detecting molecular binding events Expired - Fee Related CA2318191C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7344598P 1998-02-02 1998-02-02
US60/073,445 1998-02-02
PCT/US1999/002147 WO1999039190A1 (en) 1998-02-02 1999-02-01 Method and apparatus for detecting molecular binding events

Publications (2)

Publication Number Publication Date
CA2318191A1 true CA2318191A1 (en) 1999-08-05
CA2318191C CA2318191C (en) 2009-05-05

Family

ID=22113726

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002318191A Expired - Fee Related CA2318191C (en) 1998-02-02 1999-02-01 Method and apparatus for detecting molecular binding events

Country Status (13)

Country Link
US (1) US6368795B1 (en)
EP (1) EP0991938B1 (en)
JP (2) JP2002502028A (en)
KR (1) KR20010040559A (en)
CN (1) CN1292087A (en)
AT (1) ATE270429T1 (en)
AU (1) AU745416B2 (en)
CA (1) CA2318191C (en)
DE (1) DE69918389T2 (en)
GB (1) GB2342176B (en)
IL (1) IL137260A0 (en)
NO (1) NO20003911L (en)
WO (1) WO1999039190A1 (en)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6368795B1 (en) 1998-02-02 2002-04-09 Signature Bioscience, Inc. Bio-assay device and test system for detecting molecular binding events
US20020177175A1 (en) * 1998-02-02 2002-11-28 Hefti John J. Coplanar waveguide biosensor for detecting molecular or cellular events
US6287776B1 (en) 1998-02-02 2001-09-11 Signature Bioscience, Inc. Method for detecting and classifying nucleic acid hybridization
US6485905B2 (en) * 1998-02-02 2002-11-26 Signature Bioscience, Inc. Bio-assay device
US6287874B1 (en) * 1998-02-02 2001-09-11 Signature Bioscience, Inc. Methods for analyzing protein binding events
AU769226B2 (en) * 1998-02-02 2004-01-22 Signature Bioscience Inc. Test systems and sensors for detecting molecular binding events
US6395480B1 (en) 1999-02-01 2002-05-28 Signature Bioscience, Inc. Computer program and database structure for detecting molecular binding events
DE69905464T2 (en) * 1998-05-22 2004-01-15 Inspire Pharmaceuticals Inc THERAPEUTIC DINUCLEOTIDES AND THEIR DERIVATIVES
WO2000045160A1 (en) * 1999-02-01 2000-08-03 Signature Bioscience Inc. Method and apparatus for detecting molecular binding events
EP1224453A2 (en) * 1999-10-13 2002-07-24 Signature Bioscience, Inc. System and method for detecting and identifying molecular events in a test sample
DE10002597A1 (en) * 2000-01-21 2001-08-02 Infineon Technologies Ag Method and device for identifying molecules present in a carrier liquid
AU8095101A (en) 2000-08-02 2002-02-13 Caliper Techn Corp High throughput separations based analysis systems
JP4860841B2 (en) * 2000-08-25 2012-01-25 シスメックス株式会社 Analysis data providing method, analysis data providing apparatus, and analysis data providing program
US6586946B2 (en) 2000-11-13 2003-07-01 Signature Bioscience, Inc. System and method for detecting and identifying molecular events in a test sample using a resonant test structure
US8900811B2 (en) 2000-11-16 2014-12-02 Caliper Life Sciences, Inc. Method and apparatus for generating thermal melting curves in a microfluidic device
US6778724B2 (en) 2000-11-28 2004-08-17 The Regents Of The University Of California Optical switching and sorting of biological samples and microparticles transported in a micro-fluidic device, including integrated bio-chip devices
AU2002238100A1 (en) * 2001-02-12 2002-08-28 Signature Bioscience, Inc. A system and method for characterizing the permittivity of molecular events
WO2002077605A2 (en) * 2001-03-21 2002-10-03 Signature Bioscience, Inc. Reentrant cavity bioassay for detecting molecular or cellular events
US6627461B2 (en) * 2001-04-18 2003-09-30 Signature Bioscience, Inc. Method and apparatus for detection of molecular events using temperature control of detection environment
WO2002099386A2 (en) * 2001-06-07 2002-12-12 Proligo Llc Microcalorimetric detection of analytes and binding events
US20040166593A1 (en) * 2001-06-22 2004-08-26 Nolte David D. Adaptive interferometric multi-analyte high-speed biosensor
US20030032000A1 (en) * 2001-08-13 2003-02-13 Signature Bioscience Inc. Method for analyzing cellular events
US6801029B2 (en) * 2001-10-12 2004-10-05 Wisconsin Alumni Research Foundation Microwave dielectric spectroscopy method and apparatus
WO2003076052A1 (en) 2002-03-05 2003-09-18 Caliper Life Sciences, Inc. Mixed mode microfluidic systems
CA2480200A1 (en) 2002-04-02 2003-10-16 Caliper Life Sciences, Inc. Methods and apparatus for separation and isolation of components from a biological sample
US7732127B2 (en) * 2002-12-20 2010-06-08 Acea Biosciences, Inc. Dynamic monitoring of cell adhesion and spreading using the RT-CES system
US8206903B2 (en) 2002-12-20 2012-06-26 Acea Biosciences Device and method for electroporation-based delivery of molecules into cells and dynamic monitoring of cell responses
US7468255B2 (en) * 2002-12-20 2008-12-23 Acea Biosciences Method for assaying for natural killer, cytotoxic T-lymphocyte and neutrophil-mediated killing of target cells using real-time microelectronic cell sensing technology
US7470533B2 (en) * 2002-12-20 2008-12-30 Acea Biosciences Impedance based devices and methods for use in assays
US7560269B2 (en) 2002-12-20 2009-07-14 Acea Biosciences, Inc. Real time electronic cell sensing system and applications for cytotoxicity profiling and compound assays
CA2493108C (en) * 2002-07-20 2011-08-30 Xiaobo Wang Impedance based devices and methods for use in assays
US7192752B2 (en) * 2002-12-20 2007-03-20 Acea Biosciences Real time electronic cell sensing systems and applications for cell-based assays
US8263375B2 (en) 2002-12-20 2012-09-11 Acea Biosciences Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology
US11346797B2 (en) 2002-12-20 2022-05-31 Agilent Technologies, Inc. System and method for monitoring cardiomyocyte beating, viability, morphology and electrophysiological properties
US10539523B2 (en) 2002-12-20 2020-01-21 Acea Biosciences, Inc. System and method for monitoring cardiomyocyte beating, viability, morphology, and electrophysiological properties
US10215748B2 (en) 2002-12-20 2019-02-26 Acea Biosciences, Inc. Using impedance-based cell response profiling to identify putative inhibitors for oncogene addicted targets or pathways
US10551371B2 (en) 2003-11-10 2020-02-04 Acea Biosciences, Inc. System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function
AU2004269406B2 (en) 2003-08-28 2010-12-16 Progenity, Inc. Methods and apparatus for sorting cells using an optical switch in a microfluidic channel network
US20070072286A1 (en) * 2003-09-29 2007-03-29 Koninkljke Philips Electronics N.V. Label-free detection of biomolecules
US7514938B2 (en) * 2004-05-11 2009-04-07 Board Of Regents Of The University And College System Of Nevada, On Behalf Of The University Of Nevada, Reno Dielectric relaxation spectroscopy apparatus and methods of use
JP4546326B2 (en) * 2004-07-30 2010-09-15 キヤノン株式会社 Sensing device
KR100667305B1 (en) * 2005-01-03 2007-01-12 삼성전자주식회사 Apparatus for detecting biomolecular bondig and Method thereof
US7910356B2 (en) * 2005-02-01 2011-03-22 Purdue Research Foundation Multiplexed biological analyzer planar array apparatus and methods
US20070023643A1 (en) * 2005-02-01 2007-02-01 Nolte David D Differentially encoded biological analyzer planar array apparatus and methods
US7663092B2 (en) * 2005-02-01 2010-02-16 Purdue Research Foundation Method and apparatus for phase contrast quadrature interferometric detection of an immunoassay
WO2007131103A2 (en) * 2006-05-03 2007-11-15 Quadraspec, Inc. Direct printing of patterned hydrophobic wells
US8041515B2 (en) * 2006-09-20 2011-10-18 Acea Biosciences, Inc. Use of impedance-based cytological profiling to classify cellular response profiles upon exposure to biologically active agents
US20080144899A1 (en) * 2006-11-30 2008-06-19 Manoj Varma Process for extracting periodic features from images by template matching
US7522282B2 (en) * 2006-11-30 2009-04-21 Purdue Research Foundation Molecular interferometric imaging process and apparatus
US20080230605A1 (en) * 2006-11-30 2008-09-25 Brian Weichel Process and apparatus for maintaining data integrity
JP4928249B2 (en) * 2006-12-20 2012-05-09 キヤノン株式会社 Detection device
US7659968B2 (en) * 2007-01-19 2010-02-09 Purdue Research Foundation System with extended range of molecular sensing through integrated multi-modal data acquisition
WO2008118934A1 (en) * 2007-03-26 2008-10-02 Purdue Research Foundation Method and apparatus for conjugate quadrature interferometric detection of an immunoassay
WO2009039298A2 (en) * 2007-09-18 2009-03-26 University Of Florida Research Foundation, Inc. Sensors using aigan/gan high electron mobility transistors
EP2291645B1 (en) 2008-05-05 2015-09-09 Acea Biosciences, Inc. Label-free monitoring of excitation-contraction coupling and excitable cells using impedance based systems with millisecond time resolution
US8836351B2 (en) * 2008-06-10 2014-09-16 University Of Florida Research Foundation, Inc. Chloride detection
US8968210B2 (en) 2008-10-01 2015-03-03 Covidien LLP Device for needle biopsy with integrated needle protection
US9186128B2 (en) 2008-10-01 2015-11-17 Covidien Lp Needle biopsy device
US9782565B2 (en) 2008-10-01 2017-10-10 Covidien Lp Endoscopic ultrasound-guided biliary access system
US11298113B2 (en) 2008-10-01 2022-04-12 Covidien Lp Device for needle biopsy with integrated needle protection
US9332973B2 (en) 2008-10-01 2016-05-10 Covidien Lp Needle biopsy device with exchangeable needle and integrated needle protection
US8741591B2 (en) 2009-10-09 2014-06-03 The Research Foundation For The State University Of New York pH-insensitive glucose indicator protein
WO2011146531A1 (en) 2010-05-18 2011-11-24 Acea Biosciences, Inc Data analysis of impedance-based cardiomyocyte-beating signals as detected on real-time cell analysis (rtca) cardio instruments
EP2929333B1 (en) * 2012-12-07 2018-07-04 Ascilion AB A microfabricated sensor and a method of sensing the level of a component in bodily fluid
EP3071965A1 (en) 2013-11-21 2016-09-28 Avails Medical, Inc. Electrical biosensor for detecting a substance in a bodily fluid, and method and system for same
US9702847B2 (en) * 2014-12-30 2017-07-11 Avails Medical, Inc. Systems and methods for detecting a substance in bodily fluid
WO2017035393A1 (en) 2015-08-25 2017-03-02 eSense, LLC Devices, systems and methods for detecting viable microorganisms in a fluid sample
AT517604B1 (en) * 2015-10-06 2017-03-15 Siemens Ag Oesterreich PROBE
US10254245B2 (en) 2016-01-25 2019-04-09 Avails Medical, Inc. Devices, systems and methods for detecting viable infectious agents in a fluid sample using an electrolyte-insulator-semiconductor sensor
US10174356B2 (en) 2016-05-31 2019-01-08 Avails Medical, Inc. Devices, systems and methods to detect viable infectious agents in a fluid sample and susceptibility of infectious agents to anti-infectives
CN108241056A (en) * 2016-12-23 2018-07-03 财团法人金属工业研究发展中心 Biological monitor
CN110582569B (en) 2017-03-03 2024-04-02 安捷伦科技有限公司 Methods and systems for functional maturation of iPSC and ESC-derived cardiomyocytes
WO2019005296A1 (en) 2017-06-27 2019-01-03 Avails Medical, Inc. Apparatus, systems, and methods for determining susceptibility of microorganisms to anti-infectives
GB201711543D0 (en) 2017-07-18 2017-08-30 Univ Oxford Innovation Ltd Sensor, sensing system and sensing method
US10775422B2 (en) * 2017-09-05 2020-09-15 Texas Instruments Incorporated Molecular spectroscopy cell with resonant cavity
WO2019070739A1 (en) 2017-10-03 2019-04-11 Avails Medical, Inc. Apparatus, systems, and methods for determining the concentration of microorganisms and the susceptibility of microorganisms to anti-infectives based on redox reactions
USD941488S1 (en) 2020-02-07 2022-01-18 Agilent Technologies, Inc. Instrument for analyzing biological cells
CN113218968B (en) * 2021-05-26 2022-07-15 江南大学 High-sensitivity microwave biosensor for yeast test and application thereof

Family Cites Families (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4288229A (en) 1980-03-07 1981-09-08 Envirotech Corporation Determination of total organic carbon in a plurality of aqueous samples containing halide ion
US4407290A (en) 1981-04-01 1983-10-04 Biox Technology, Inc. Blood constituent measuring device and method
US4767717A (en) 1985-05-02 1988-08-30 Baisden C Robert Method of detecting and quantitating cell malignancy in biological tissue
EP0213825A3 (en) 1985-08-22 1989-04-26 Molecular Devices Corporation Multiple chemically modulated capacitance
US4765179A (en) 1985-09-09 1988-08-23 Solid State Farms, Inc. Radio frequency spectroscopy apparatus and method using multiple frequency waveforms
US4679426A (en) 1985-09-09 1987-07-14 Fuller Milton E Wave shape chemical analysis apparatus and method
US4822566A (en) * 1985-11-19 1989-04-18 The Johns Hopkins University Optimized capacitive sensor for chemical analysis and measurement
GB8612221D0 (en) 1986-05-20 1986-06-25 Amersham Int Plc Assaying species in sample
GB8801807D0 (en) 1988-01-27 1988-02-24 Amersham Int Plc Biological sensors
EP0341927B1 (en) 1988-05-10 1993-07-14 AMERSHAM INTERNATIONAL plc Biological sensors
GB8811919D0 (en) 1988-05-20 1988-06-22 Amersham Int Plc Biological sensors
US5120648A (en) 1988-05-26 1992-06-09 Lim Technology Laboratories, Inc. Chemical analyzer using rf radiation attenuation measurements
GB8813307D0 (en) 1988-06-06 1988-07-13 Amersham Int Plc Biological sensors
US5478755A (en) * 1988-07-25 1995-12-26 Ares Serono Research & Development Ltd. Long range surface plasma resonance immunoassay
WO1990002327A1 (en) * 1988-08-18 1990-03-08 AUSTRALIAN MEMBRANE AND BIOTECHNOLOGY RESEARCH INSTITUTE LTD., Commonwealth Scientific and Industrial Research Organization Improvements in sensitivity and selectivity of ion channel membrane biosensors
US5156810A (en) * 1989-06-15 1992-10-20 Biocircuits Corporation Biosensors employing electrical, optical and mechanical signals
US5025222A (en) 1989-07-07 1991-06-18 Phase Dynamics, Inc. System and method for monitoring substances and reactions
US5434084A (en) 1989-09-06 1995-07-18 The Washington Research Foundation Flow optrode having separate reaction and detection chambers
US5082629A (en) 1989-12-29 1992-01-21 The Board Of The University Of Washington Thin-film spectroscopic sensor
US5082630A (en) * 1990-04-30 1992-01-21 The United States Of America As Represented By The United States Department Of Energy Fiber optic detector for immuno-testing
JPH087147B2 (en) 1990-06-04 1996-01-29 ベーリング ダイアグノスティクス インコーポレイテッド Analytical assay
GB9019123D0 (en) 1990-09-01 1990-10-17 Fisons Plc Analytical device
US5212099A (en) 1991-01-18 1993-05-18 Eastman Kodak Company Method and apparatus for optically measuring concentration of an analyte
US5233306A (en) 1991-02-13 1993-08-03 The Board Of Regents Of The University Of Wisconsin System Method and apparatus for measuring the permittivity of materials
GB9111912D0 (en) 1991-06-04 1991-07-24 Fisons Plc Analytical methods
US5340715A (en) * 1991-06-07 1994-08-23 Ciba Corning Diagnostics Corp. Multiple surface evanescent wave sensor with a reference
CA2069537A1 (en) * 1991-06-07 1992-12-08 Thomas A. Cook Multiple output referencing system for evanescent wave sensor
DE69110032T2 (en) * 1991-06-08 1995-12-21 Hewlett Packard Gmbh Method and device for determining and / or determining the concentration of biomolecules.
US5218814A (en) * 1991-06-14 1993-06-15 Deere & Company Engine and transaxle module
AU2907092A (en) 1991-10-21 1993-05-21 James W. Holm-Kennedy Method and device for biochemical sensing
IL103674A0 (en) 1991-11-19 1993-04-04 Houston Advanced Res Center Method and apparatus for molecule detection
US5846708A (en) * 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
US5403747A (en) 1992-04-01 1995-04-04 Thomas Jefferson University Protein assay using microwave energy
US5478748A (en) 1992-04-01 1995-12-26 Thomas Jefferson University Protein assay using microwave energy
GB9212416D0 (en) * 1992-06-11 1992-07-22 Medical Res Council Reversible binding substances
US5504366A (en) 1992-07-17 1996-04-02 Biotechnology Research And Development Corp. System for analyzing surfaces of samples
US5397896A (en) 1992-07-17 1995-03-14 Penn State Research Foundation And Biotechnology Research And Development Corporation Multiple source and detection frequencies in detecting threshold phenomena associated with and/or atomic or molecular spectra
US5268573A (en) 1992-07-17 1993-12-07 The Penn State Research Foundation System for detecting threshold phenomena associated with and/or atomic or molecular spectra of a substance
US5348003A (en) 1992-09-03 1994-09-20 Sirraya, Inc. Method and apparatus for chemical analysis
US5543329A (en) 1992-11-03 1996-08-06 Intelligent Monitoring Systems And Advanced Global Technologies Sensor for antigen-antibody reactions
US5359681A (en) * 1993-01-11 1994-10-25 University Of Washington Fiber optic sensor and methods and apparatus relating thereto
US5327225A (en) * 1993-01-28 1994-07-05 The Center For Innovative Technology Surface plasmon resonance sensor
US5363052A (en) 1993-02-16 1994-11-08 Solid State Farms, Inc. Permittivity spectroscopy apparatus and method
US5512492A (en) * 1993-05-18 1996-04-30 University Of Utah Research Foundation Waveguide immunosensor with coating chemistry providing enhanced sensitivity
US5919712A (en) * 1993-05-18 1999-07-06 University Of Utah Research Foundation Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
DE69406920T2 (en) 1993-06-01 1998-04-09 Du Pont ANALYT REACTIVE KTP COMPOSITION AND METHOD
GB2296571B (en) 1993-07-26 1998-02-11 Phase Dynamics Inc System and method for monitoring substances and reactions
US5508203A (en) 1993-08-06 1996-04-16 Fuller; Milton E. Apparatus and method for radio frequency spectroscopy using spectral analysis
US5792668A (en) 1993-08-06 1998-08-11 Solid State Farms, Inc. Radio frequency spectral analysis for in-vitro or in-vivo environments
JPH0763760A (en) * 1993-08-31 1995-03-10 Daikin Ind Ltd Optical method and device for measuring immunity
US5432096A (en) 1993-12-20 1995-07-11 Cetac Technologies Inc. Simultaneous multiple, single wavelength electromagnetic wave energy absorbtion detection and quantifying spectrophotometric system, and method of use
GB9401170D0 (en) * 1994-01-21 1994-03-16 Lynxvale Limited . Optical sensor
EP0690306A1 (en) * 1994-06-28 1996-01-03 Mochida Pharmaceutical Co., Ltd. Method and device for specific binding assay
US5485277A (en) * 1994-07-26 1996-01-16 Physical Optics Corporation Surface plasmon resonance sensor and methods for the utilization thereof
US5656428A (en) 1994-09-08 1997-08-12 Biode, Inc. Homogeneous bioassay using acoustic emission spectroscopy
GB9418981D0 (en) 1994-09-21 1994-11-09 Univ Glasgow Apparatus and method for carrying out analysis of samples
US5599668A (en) * 1994-09-22 1997-02-04 Abbott Laboratories Light scattering optical waveguide method for detecting specific binding events
US5620850A (en) * 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
US6035246A (en) 1994-11-04 2000-03-07 Sandia Corporation Method for identifying known materials within a mixture of unknowns
US5814565A (en) * 1995-02-23 1998-09-29 University Of Utah Research Foundation Integrated optic waveguide immunosensor
US5629213A (en) * 1995-03-03 1997-05-13 Kornguth; Steven E. Analytical biosensor
CA2221307A1 (en) * 1995-05-17 1996-11-21 Australian Membrane And Biotechnology Research Institute Improvement in ionic reservoir through application of an electrical potential
GB9518429D0 (en) * 1995-09-08 1995-11-08 Pharmacia Biosensor A rapid method for providing kinetic and structural data in molecular interaction analysis
WO1997015819A1 (en) * 1995-10-25 1997-05-01 University Of Washington Surface plasmon resonance light pipe sensor
WO1997015820A1 (en) * 1995-10-25 1997-05-01 University Of Washington Surface plasmon resonance electrode as chemical sensor
US5661301A (en) 1996-02-07 1997-08-26 The Penn State Research Foundation Spectroscopy and mapping of atoms, molecules and surface features via difference frequency generation with a scanning tunneling microscope or related instruments
US5671303A (en) 1996-04-17 1997-09-23 Motorola, Inc. Molecular detection apparatus and method using optical waveguide detection
AU711861B2 (en) * 1996-04-25 1999-10-21 Mcgill University Biosensor device and method
US5827482A (en) 1996-08-20 1998-10-27 Motorola Corporation Transistor-based apparatus and method for molecular detection and field enhancement
US5832165A (en) * 1996-08-28 1998-11-03 University Of Utah Research Foundation Composite waveguide for solid phase binding assays
US5858666A (en) 1996-08-29 1999-01-12 Biotechnology Research And Development Corporation Apparatus and method of detection employing an AC frequency sensor array
US5846843A (en) 1996-11-18 1998-12-08 The University Of Toledo Sensor using long range surface plasmon resonance with diffraction double-grating
US6306584B1 (en) 1997-01-21 2001-10-23 President And Fellows Of Harvard College Electronic-property probing of biological molecules at surfaces
US6048692A (en) 1997-10-07 2000-04-11 Motorola, Inc. Sensors for electrically sensing binding events for supported molecular receptors
US6368795B1 (en) 1998-02-02 2002-04-09 Signature Bioscience, Inc. Bio-assay device and test system for detecting molecular binding events
US6395480B1 (en) 1999-02-01 2002-05-28 Signature Bioscience, Inc. Computer program and database structure for detecting molecular binding events

Also Published As

Publication number Publication date
WO1999039190A1 (en) 1999-08-05
EP0991938B1 (en) 2004-06-30
GB9923039D0 (en) 1999-12-01
ATE270429T1 (en) 2004-07-15
NO20003911D0 (en) 2000-08-01
DE69918389T2 (en) 2005-10-06
GB2342176B (en) 2001-05-02
KR20010040559A (en) 2001-05-15
CA2318191C (en) 2009-05-05
JP2002502028A (en) 2002-01-22
CN1292087A (en) 2001-04-18
AU2490699A (en) 1999-08-16
NO20003911L (en) 2000-09-29
US6368795B1 (en) 2002-04-09
EP0991938A1 (en) 2000-04-12
DE69918389D1 (en) 2004-08-05
JP2005308761A (en) 2005-11-04
AU745416B2 (en) 2002-03-21
GB2342176A (en) 2000-04-05
IL137260A0 (en) 2001-07-24

Similar Documents

Publication Publication Date Title
CA2318191A1 (en) Method and apparatus for detecting molecular binding events
NO976127D0 (en) Method for Determining Equivalent Fracture Permeability for a Fracture Network in a Multilayer Substrate Medium
DE69626303T2 (en) VERY THIN MICROFIBRE FLEECE
AU7163696A (en) Enhanced wet signal response in absorbent articles
AU7982198A (en) High resolution determination of seismic polar anisotropy
AU2922497A (en) Detection probes, kits and assays
AU4430899A (en) An apparatus and method for measuring a property of a layer in a multilayered structure
DE69610211D1 (en) FIBROUS INSULATION OBJECT WITH INORGANIC BINDING AGENT
AU2001272326A1 (en) Method and device for the detection and evaluation of surface damage to laid tracks and points components
AU3265597A (en) Method for measuring a sound signal propagation delay in a fluid by zero-crossing of the said sound signal
AU5748598A (en) Method and devices for measuring distances between object structures
AU3892297A (en) Sensor for detecting heparin and other analytes
AU7616196A (en) Non-destructive surface sampler
DE69023087T2 (en) TV receiver with circuits for extracting two sound signals.
EP0785433A3 (en) Test sample card
AU1595592A (en) Test strip for immunoassay, assay method using the same and immunoassay device
NO960357D0 (en) Logging tools and method for optimizing the signal-to-noise ratio in acoustic signals
AU1336697A (en) Fecal test method and device
AU4371899A (en) Feeling method and a device for determining the surface characteristics of a test piece according to the feeling method
BR9504806A (en) Test connector
AU2780497A (en) Method and devices for detecting flexure, and structure such as a geotechnical or building structure equipped with such device
AU9571798A (en) Apparatus and methods for stacking forms and moving the stacked forms selectively in one of two directions
AU3451899A (en) Apparatus and method for accurately determining the location of events such as peaks in seismic data
AU2002221761A1 (en) Method for evaluating the signals of an optoelectronic displacement or angle measuring device and implementation of said method
AU6156396A (en) Card with electronic sound recording

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20150202