CA2318161A1 - Microfabricated aperture-based sensor - Google Patents

Microfabricated aperture-based sensor Download PDF

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Publication number
CA2318161A1
CA2318161A1 CA002318161A CA2318161A CA2318161A1 CA 2318161 A1 CA2318161 A1 CA 2318161A1 CA 002318161 A CA002318161 A CA 002318161A CA 2318161 A CA2318161 A CA 2318161A CA 2318161 A1 CA2318161 A1 CA 2318161A1
Authority
CA
Canada
Prior art keywords
based sensor
layer
analyte
diffusion layer
microfabricated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002318161A
Other languages
French (fr)
Other versions
CA2318161C (en
Inventor
Graham Davis
Chao Lin
Imants R. Lauks
Raymond J. Pierce
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Point of Care Inc
Original Assignee
I-Stat Corporation
Graham Davis
Chao Lin
Imants R. Lauks
Raymond J. Pierce
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by I-Stat Corporation, Graham Davis, Chao Lin, Imants R. Lauks, Raymond J. Pierce filed Critical I-Stat Corporation
Publication of CA2318161A1 publication Critical patent/CA2318161A1/en
Application granted granted Critical
Publication of CA2318161C publication Critical patent/CA2318161C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/004—Enzyme electrodes mediator-assisted
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/002—Electrode membranes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/817—Enzyme or microbe electrode

Abstract

A chemical sensor includes an enzyme layer (62), a diffusion layer (68) and an analyte barrier layer (60) positioned over the diffusion layer. Apertures (64) are formed by microfabrication in the analyte barrier layer to allow controlled analyte flux to the diffusion layer.
CA002318161A 1998-01-23 1999-01-21 Microfabricated aperture-based sensor Expired - Lifetime CA2318161C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US09/012,579 US6030827A (en) 1998-01-23 1998-01-23 Microfabricated aperture-based sensor
US09/012,579 1998-01-23
US09/012,579(CON) 1998-01-23
PCT/US1999/001375 WO1999038003A1 (en) 1998-01-23 1999-01-21 Microfabricated aperture-based sensor

Publications (2)

Publication Number Publication Date
CA2318161A1 true CA2318161A1 (en) 1999-07-29
CA2318161C CA2318161C (en) 2006-07-04

Family

ID=21755630

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002318161A Expired - Lifetime CA2318161C (en) 1998-01-23 1999-01-21 Microfabricated aperture-based sensor

Country Status (11)

Country Link
US (2) US6030827A (en)
EP (1) EP1057010B1 (en)
JP (1) JP3826189B2 (en)
KR (1) KR20010040357A (en)
CN (1) CN1292086A (en)
AT (1) ATE443859T1 (en)
AU (1) AU754095B2 (en)
CA (1) CA2318161C (en)
DE (1) DE69941449D1 (en)
ES (1) ES2333831T3 (en)
WO (1) WO1999038003A1 (en)

Families Citing this family (207)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6811037B2 (en) 1996-07-11 2004-11-02 Fraunhofer-Fesellschaft Zur Forderung Derangewandten Forschung E.V. Sensor and/or separating element and process for the production and use thereof
US6001067A (en) 1997-03-04 1999-12-14 Shults; Mark C. Device and method for determining analyte levels
US8527026B2 (en) 1997-03-04 2013-09-03 Dexcom, Inc. Device and method for determining analyte levels
US9155496B2 (en) 1997-03-04 2015-10-13 Dexcom, Inc. Low oxygen in vivo analyte sensor
US7899511B2 (en) 2004-07-13 2011-03-01 Dexcom, Inc. Low oxygen in vivo analyte sensor
EP1029229A1 (en) 1997-09-30 2000-08-23 M- Biotech, Inc. Biosensor
US6036924A (en) 1997-12-04 2000-03-14 Hewlett-Packard Company Cassette of lancet cartridges for sampling blood
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
EP0995803A3 (en) * 1998-10-20 2001-11-07 Matsushita Electric Industrial Co., Ltd. Sample treating kit and sample treating method using the same for analysis with a biosensor
DE69924516D1 (en) * 1998-10-31 2005-05-04 Yellow Springs Optical Sensor CAPSULE FOR CO2 SENSOR
US6283938B1 (en) * 1999-05-04 2001-09-04 Mcconnell Daniel E. Medicating bandage and controllable permeable membrane
US6475750B1 (en) 1999-05-11 2002-11-05 M-Biotech, Inc. Glucose biosensor
EP2322645A1 (en) * 1999-06-18 2011-05-18 Abbott Diabetes Care Inc. Mass transport limited in vivo analyte sensor
EP1212601A4 (en) * 1999-08-27 2006-03-29 Biotech Inc M Glucose biosensor
US6343225B1 (en) * 1999-09-14 2002-01-29 Implanted Biosystems, Inc. Implantable glucose sensor
US6540675B2 (en) 2000-06-27 2003-04-01 Rosedale Medical, Inc. Analyte monitor
US6602401B1 (en) 2000-11-01 2003-08-05 Rosemount Analytical Inc. Amperometric sensor for low level dissolved oxygen with self-depleting sensor design
US8372139B2 (en) * 2001-02-14 2013-02-12 Advanced Bio Prosthetic Surfaces, Ltd. In vivo sensor and method of making same
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
JP4517498B2 (en) * 2000-11-24 2010-08-04 パナソニック株式会社 Biosensor
JP2004525369A (en) * 2001-03-07 2004-08-19 インスツルメンテーション ラボラトリー カンパニー Reference electrode
JP4517527B2 (en) * 2001-03-29 2010-08-04 パナソニック株式会社 Biosensor
DE10119036C1 (en) * 2001-04-18 2002-12-12 Disetronic Licensing Ag Immersion sensor for measuring the concentration of an analyte using an oxidase
US6613379B2 (en) 2001-05-08 2003-09-02 Isense Corp. Implantable analyte sensor
US6960466B2 (en) * 2001-05-31 2005-11-01 Instrumentation Laboratory Company Composite membrane containing a cross-linked enzyme matrix for a biosensor
US6872297B2 (en) * 2001-05-31 2005-03-29 Instrumentation Laboratory Company Analytical instruments, biosensors and methods thereof
US6652720B1 (en) 2001-05-31 2003-11-25 Instrumentation Laboratory Company Analytical instruments, biosensors and methods thereof
US6896778B2 (en) * 2001-06-04 2005-05-24 Epocal Inc. Electrode module
US7214300B2 (en) * 2001-06-04 2007-05-08 Epocal Inc. Integrated electrokinetic devices and methods of manufacture
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
DE60238119D1 (en) 2001-06-12 2010-12-09 Pelikan Technologies Inc ELECTRIC ACTUATOR ELEMENT FOR A LANZETTE
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
EP1404232B1 (en) 2001-06-12 2009-12-02 Pelikan Technologies Inc. Blood sampling apparatus and method
US7699791B2 (en) 2001-06-12 2010-04-20 Pelikan Technologies, Inc. Method and apparatus for improving success rate of blood yield from a fingerstick
US7025774B2 (en) 2001-06-12 2006-04-11 Pelikan Technologies, Inc. Tissue penetration device
US7749174B2 (en) 2001-06-12 2010-07-06 Pelikan Technologies, Inc. Method and apparatus for lancet launching device intergrated onto a blood-sampling cartridge
US7316700B2 (en) 2001-06-12 2008-01-08 Pelikan Technologies, Inc. Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US20030032874A1 (en) * 2001-07-27 2003-02-13 Dexcom, Inc. Sensor head for use with implantable devices
US7244393B2 (en) 2001-12-21 2007-07-17 Kimberly-Clark Worldwide, Inc. Diagnostic device and system
US7004928B2 (en) 2002-02-08 2006-02-28 Rosedale Medical, Inc. Autonomous, ambulatory analyte monitor or drug delivery device
US8364229B2 (en) * 2003-07-25 2013-01-29 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
US7828728B2 (en) * 2003-07-25 2010-11-09 Dexcom, Inc. Analyte sensor
US7613491B2 (en) 2002-05-22 2009-11-03 Dexcom, Inc. Silicone based membranes for use in implantable glucose sensors
US7101472B2 (en) * 2002-03-13 2006-09-05 The Charles Stark Draper Laboratory, Inc. Microfluidic ion-selective electrode sensor system
US7407570B2 (en) * 2002-03-13 2008-08-05 The Charles Stark Draper Laboratory, Inc. Disposable, self-administered electrolyte test
US7717863B2 (en) 2002-04-19 2010-05-18 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7909778B2 (en) 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7648468B2 (en) * 2002-04-19 2010-01-19 Pelikon Technologies, Inc. Method and apparatus for penetrating tissue
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7713214B2 (en) 2002-04-19 2010-05-11 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with optical analyte sensing
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7491178B2 (en) 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7331931B2 (en) 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US7232451B2 (en) 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US7291117B2 (en) 2002-04-19 2007-11-06 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US8360992B2 (en) 2002-04-19 2013-01-29 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8372016B2 (en) 2002-04-19 2013-02-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling and analyte sensing
US7175642B2 (en) 2002-04-19 2007-02-13 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7371247B2 (en) 2002-04-19 2008-05-13 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US7226978B2 (en) 2002-05-22 2007-06-05 Dexcom, Inc. Techniques to improve polyurethane membranes for implantable glucose sensors
US20040018577A1 (en) * 2002-07-29 2004-01-29 Emerson Campbell John Lewis Multiple hybrid immunoassay
US9237865B2 (en) * 2002-10-18 2016-01-19 Medtronic Minimed, Inc. Analyte sensors and methods for making and using them
KR100508114B1 (en) * 2002-10-22 2005-08-19 한국전자통신연구원 Formation method of outermost layer of enzymatic electrode sensor
US7638228B2 (en) 2002-11-27 2009-12-29 Saint Louis University Enzyme immobilization for use in biofuel cells and sensors
US7767068B2 (en) * 2002-12-02 2010-08-03 Epocal Inc. Heterogeneous membrane electrodes
US7842234B2 (en) * 2002-12-02 2010-11-30 Epocal Inc. Diagnostic devices incorporating fluidics and methods of manufacture
US7422903B2 (en) * 2002-12-11 2008-09-09 Instrumentation Laboratory Company Multi-analyte reference solutions
US7265881B2 (en) * 2002-12-20 2007-09-04 Hewlett-Packard Development Company, L.P. Method and apparatus for measuring assembly and alignment errors in sensor assemblies
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
US20040154933A1 (en) * 2003-02-11 2004-08-12 Instrumentation Laboratory Company Polymeric membranes for use in electrochemical sensors
US20040256227A1 (en) * 2003-02-11 2004-12-23 Jungwon Shin Electrochemical urea sensors and methods of making the same
US7263501B2 (en) 2003-03-11 2007-08-28 I-Stat Corporation Point-of-care inventory management system and method
US7052652B2 (en) 2003-03-24 2006-05-30 Rosedale Medical, Inc. Analyte concentration detection devices and methods
JP2004343275A (en) * 2003-05-14 2004-12-02 Murata Mach Ltd Image processing system and scanner
US8262614B2 (en) 2003-05-30 2012-09-11 Pelikan Technologies, Inc. Method and apparatus for fluid injection
US7850621B2 (en) 2003-06-06 2010-12-14 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
WO2006001797A1 (en) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Low pain penetrating
US7074307B2 (en) 2003-07-25 2006-07-11 Dexcom, Inc. Electrode systems for electrochemical sensors
EP1648298A4 (en) * 2003-07-25 2010-01-13 Dexcom Inc Oxygen enhancing membrane systems for implantable devices
US7761130B2 (en) 2003-07-25 2010-07-20 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US9763609B2 (en) 2003-07-25 2017-09-19 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
US7494465B2 (en) 2004-07-13 2009-02-24 Dexcom, Inc. Transcutaneous analyte sensor
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US7722817B2 (en) * 2003-08-28 2010-05-25 Epocal Inc. Lateral flow diagnostic devices with instrument controlled fluidics
US7682833B2 (en) 2003-09-10 2010-03-23 Abbott Point Of Care Inc. Immunoassay device with improved sample closure
US7723099B2 (en) * 2003-09-10 2010-05-25 Abbott Point Of Care Inc. Immunoassay device with immuno-reference electrode
WO2005033659A2 (en) 2003-09-29 2005-04-14 Pelikan Technologies, Inc. Method and apparatus for an improved sample capture device
ATE464834T1 (en) * 2003-09-30 2010-05-15 Hoffmann La Roche SENSOR WITH IMPROVED BIOCOMPATIBILITY
EP1680014A4 (en) 2003-10-14 2009-01-21 Pelikan Technologies Inc Method and apparatus for a variable user interface
US20050090607A1 (en) * 2003-10-28 2005-04-28 Dexcom, Inc. Silicone composition for biocompatible membrane
US8859151B2 (en) * 2003-11-05 2014-10-14 St. Louis University Immobilized enzymes in biocathodes
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
US8423114B2 (en) 2006-10-04 2013-04-16 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
WO2005057168A2 (en) 2003-12-05 2005-06-23 Dexcom, Inc. Calibration techniques for a continuous analyte sensor
US11633133B2 (en) 2003-12-05 2023-04-25 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
US8668656B2 (en) 2003-12-31 2014-03-11 Sanofi-Aventis Deutschland Gmbh Method and apparatus for improving fluidic flow and sample capture
EP1726059A4 (en) 2004-03-15 2008-10-22 Univ St Louis Microfluidic biofuel cell
US8277713B2 (en) 2004-05-03 2012-10-02 Dexcom, Inc. Implantable analyte sensor
WO2006011062A2 (en) 2004-05-20 2006-02-02 Albatros Technologies Gmbh & Co. Kg Printable hydrogel for biosensors
EP1765194A4 (en) 2004-06-03 2010-09-29 Pelikan Technologies Inc Method and apparatus for a fluid sampling device
US9775553B2 (en) * 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
US8565848B2 (en) 2004-07-13 2013-10-22 Dexcom, Inc. Transcutaneous analyte sensor
US20060020192A1 (en) 2004-07-13 2006-01-26 Dexcom, Inc. Transcutaneous analyte sensor
WO2006023037A2 (en) 2004-08-11 2006-03-02 Dow Corning Corporation Photopolymerizable silicone materials forming semipermeable membranes for sensor applications
JP4659041B2 (en) * 2004-09-02 2011-03-30 アボット ポイント オブ ケア インコーポレイテッド Blood urea nitrogen (BUN) sensor
KR101365933B1 (en) 2004-10-12 2014-02-24 바이엘 헬스케어 엘엘씨 An electrochemical system for determining the concentration of an anylyte in a sample
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
WO2006110193A2 (en) 2005-04-08 2006-10-19 Dexcom, Inc. Cellulosic-based interference domain for an analyte sensor
US8744546B2 (en) 2005-05-05 2014-06-03 Dexcom, Inc. Cellulosic-based resistance domain for an analyte sensor
WO2006121661A2 (en) * 2005-05-05 2006-11-16 Dexcom, Inc. Cellulosic-based resistance domain for an analyte sensor
US20060281187A1 (en) 2005-06-13 2006-12-14 Rosedale Medical, Inc. Analyte detection devices and methods with hematocrit/volume correction and feedback control
CA2612635C (en) * 2005-07-14 2013-03-12 I-Stat Corporation Photoformed silicone sensor membrane
BRPI0613592A2 (en) 2005-07-20 2011-01-18 Bayer Healthcare Llc port-connected amperometry
US8801631B2 (en) 2005-09-30 2014-08-12 Intuity Medical, Inc. Devices and methods for facilitating fluid transport
EP3461406A1 (en) 2005-09-30 2019-04-03 Intuity Medical, Inc. Multi-site body fluid sampling and analysis cartridge
BRPI0620735A2 (en) 2005-12-27 2011-11-22 Bayer Healthcare Llc electrochemical sensor system using a substrate with at least one aperture and method of fabrication thereof
US9757061B2 (en) 2006-01-17 2017-09-12 Dexcom, Inc. Low oxygen in vivo analyte sensor
EP2004796B1 (en) * 2006-01-18 2015-04-08 DexCom, Inc. Membranes for an analyte sensor
US8052855B2 (en) * 2006-05-11 2011-11-08 Samsung Electronics Co., Ltd. Carbon nanotube gas sensor and method of manufacturing the same
GB0609494D0 (en) * 2006-05-12 2006-06-21 Oxford Biosensors Ltd HDL cholesterol sensor using specific surfactant
GB0609493D0 (en) * 2006-05-12 2006-06-21 Oxford Biosensors Ltd Cholesterol sensor
JP2009544083A (en) 2006-07-13 2009-12-10 アイ−スタット コーポレイション System and method for medical data acquisition and patient management
EP1892877B1 (en) * 2006-08-25 2008-12-03 Alcatel Lucent Digital signal receiver with Q-monitor
US20200037874A1 (en) 2007-05-18 2020-02-06 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
WO2008157325A2 (en) * 2007-06-15 2008-12-24 Charles Stark Draper Laboratory, Inc. Devices, systems, and methods for measuring glucose
US8268604B2 (en) * 2007-12-20 2012-09-18 Abbott Point Of Care Inc. Compositions for forming immobilized biological layers for sensing
US8241697B2 (en) 2007-12-20 2012-08-14 Abbott Point Of Care Inc. Formation of immobilized biological layers for sensing
US8682408B2 (en) * 2008-03-28 2014-03-25 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US11730407B2 (en) 2008-03-28 2023-08-22 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US8583204B2 (en) 2008-03-28 2013-11-12 Dexcom, Inc. Polymer membranes for continuous analyte sensors
EP2265324B1 (en) 2008-04-11 2015-01-28 Sanofi-Aventis Deutschland GmbH Integrated analyte measurement system
JP5816080B2 (en) * 2008-05-30 2015-11-17 インテュイティ メディカル インコーポレイテッド Body fluid collection device and collection site interface
ES2907152T3 (en) 2008-06-06 2022-04-22 Intuity Medical Inc Blood glucose meter and method of operation
US9636051B2 (en) 2008-06-06 2017-05-02 Intuity Medical, Inc. Detection meter and mode of operation
US8181531B2 (en) * 2008-06-27 2012-05-22 Edwin Carlen Accessible stress-based electrostatic monitoring of chemical reactions and binding
US8700114B2 (en) * 2008-07-31 2014-04-15 Medtronic Minmed, Inc. Analyte sensor apparatuses comprising multiple implantable sensor elements and methods for making and using them
US20100025238A1 (en) * 2008-07-31 2010-02-04 Medtronic Minimed, Inc. Analyte sensor apparatuses having improved electrode configurations and methods for making and using them
US9011670B2 (en) * 2008-08-14 2015-04-21 The Charles Stark Draper Laboratory, Inc. Three-dimensional metal ion sensor arrays on printed circuit boards
US8216529B2 (en) * 2008-09-15 2012-07-10 Abbott Point Of Care Inc. Fluid-containing pouches with reduced gas exchange and methods for making same
US8560039B2 (en) 2008-09-19 2013-10-15 Dexcom, Inc. Particle-containing membrane and particulate electrode for analyte sensors
US20100187132A1 (en) * 2008-12-29 2010-07-29 Don Alden Determination of the real electrochemical surface areas of screen printed electrodes
US8445199B2 (en) * 2008-12-31 2013-05-21 Abbott Point Of Care Inc. Method and device for immunoassay using nucleotide conjugates
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
US8084272B2 (en) 2009-03-25 2011-12-27 Abbott Point Of Care Inc. Amelioration of heterophile antibody immunosensor interference
US8377669B2 (en) * 2009-11-17 2013-02-19 Abbott Point Of Care Inc. Reducing leukocyte interference in non-competitive immunoassays
US8389293B2 (en) * 2009-11-17 2013-03-05 Abbott Point Of Care Inc. Reducing leukocyte interference in competitive immunoassays
EP3106871B1 (en) 2009-11-30 2021-10-27 Intuity Medical, Inc. A method of verifying the accuracy of the operation of an analyte monitoring device
WO2011075663A1 (en) 2009-12-18 2011-06-23 Abbott Point Of Care Inc. Integrated hinged cartridge housings for sample analysis
US8660628B2 (en) * 2009-12-21 2014-02-25 Medtronic Minimed, Inc. Analyte sensors comprising blended membrane compositions and methods for making and using them
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9271671B2 (en) 2010-04-16 2016-03-01 Arkray, Inc. Sensor and method for removing interfering substance
US8476079B2 (en) 2010-04-30 2013-07-02 Abbott Point Of Care Inc. Reagents for reducing leukocyte interference in immunoassays
US8394325B2 (en) 2010-06-14 2013-03-12 Abbott Point Of Care Inc. Magnetic beads for reducing leukocyte interference in immunoassays
EP2584964B1 (en) 2010-06-25 2021-08-04 Intuity Medical, Inc. Analyte monitoring devices
US8808532B2 (en) * 2011-01-20 2014-08-19 Medtronic Minimed, Inc Electrode compositions for use with analyte sensors
US8776246B2 (en) 2011-03-11 2014-07-08 Abbott Point Of Care, Inc. Systems, methods and analyzers for establishing a secure wireless network in point of care testing
US8549600B2 (en) 2011-03-11 2013-10-01 Abbott Point Of Care Inc. Systems, methods and analyzers for establishing a secure wireless network in point of care testing
US9782114B2 (en) 2011-08-03 2017-10-10 Intuity Medical, Inc. Devices and methods for body fluid sampling and analysis
US9670538B2 (en) 2011-08-05 2017-06-06 Ibis Biosciences, Inc. Nucleic acid sequencing by electrochemical detection
US9873119B2 (en) 2011-12-28 2018-01-23 Ibis Biosciences, Inc. Multiple- analyte assay device and system
US9592507B2 (en) 2012-06-22 2017-03-14 Abbott Point Of Care Inc. Integrated cartridge housings for sample analysis
US9671398B2 (en) 2012-12-28 2017-06-06 Abbott Point Of Care Inc. Apparatus and method for identifying a hook effect and expanding the dynamic range in point of care immunoassays
KR101490584B1 (en) * 2013-03-08 2015-02-05 (주) 더바이오 Current law-based chip sensor to detect perchlorate ion by interface liquid/gel and detecting apparatus including ir
US9488663B2 (en) 2013-03-14 2016-11-08 Abbott Point Of Care Inc. Electrochemical methods and devices for amending urine samples for immunosensor detection
WO2014159615A2 (en) 2013-03-14 2014-10-02 Abbott Point Of Care Inc Thermal control system for controlling the temperature of a fluid
US9651547B2 (en) 2013-03-14 2017-05-16 Abbott Point Of Care Inc. Electrochemical methods and devices for amending urine samples for immunosensor detection
US9249450B2 (en) 2013-03-15 2016-02-02 Abbott Point Of Care Inc. Glutamate oxidase mutagenesis for diagnostic testing
US9562874B2 (en) 2013-03-15 2017-02-07 Abbott Point Of Care Inc. Biosensor with improved interference characteristics
WO2014150876A2 (en) 2013-03-15 2014-09-25 Abbott Point Of Care Inc Biosensor structures for improved point of care testing and methods of manufacture thereof
WO2014205412A1 (en) 2013-06-21 2014-12-24 Intuity Medical, Inc. Analyte monitoring system with audible feedback
US20150122647A1 (en) 2013-11-07 2015-05-07 Medtronic Minimed, Inc. Enzyme matrices for use with ethylene oxide sterilization
US10254237B2 (en) * 2014-06-07 2019-04-09 Ascilion Ab Microfabricated sensor and a method of detecting a component in bodily fluid
EP3198271B1 (en) 2014-09-26 2022-03-02 Abbott Point Of Care, Inc. Single channel cartridge device for blood coagulation assays in fluid samples
EP3198270A1 (en) 2014-09-26 2017-08-02 Abbott Point Of Care, Inc. Cartridge device with fluidic junctions for coagulation assays in fluid samples
WO2016049552A1 (en) 2014-09-26 2016-03-31 Abbott Point Of Care Inc. Cartridge device identification for coagulation assays in fluid samples
US9921232B2 (en) 2014-09-26 2018-03-20 Abbott Point Of Care Inc. Ellagic acid formulations for use in coagulation assays
EP3955003B1 (en) 2014-09-26 2023-06-21 Abbott Point Of Care Inc Sensors for assaying coagulation in fluid samples
EP3197603A1 (en) 2014-09-26 2017-08-02 Abbott Point of Care Inc. Cartridge device with segmented fluidics for assaying coagulation in fluid samples
CN106999931B (en) 2014-09-26 2020-08-18 雅培医护站股份有限公司 Microfabricated device with micro-environment sensor for determining coagulation in fluid sample
US10987039B2 (en) 2014-12-03 2021-04-27 Stmicroelectronics S.R.L. Microneedle array device and method of making
CN104792832A (en) * 2015-04-16 2015-07-22 三诺生物传感股份有限公司 Bilirubin electrochemical transducer and preparation method thereof
ITUB20154036A1 (en) * 2015-09-30 2017-03-30 St Microelectronics Srl BIOSENSOR FOR DETECTION OF ANALYTES IN SWEAT, AND METHOD OF MANUFACTURE OF THE BIOSENSOR
US11298059B2 (en) * 2016-05-13 2022-04-12 PercuSense, Inc. Analyte sensor
WO2018237259A1 (en) * 2017-06-23 2018-12-27 Percusense Analyte sensor
WO2019075029A2 (en) * 2017-10-10 2019-04-18 North Carolina State University Core-shell microneedle patch for h2o2 and ph cascade-triggered insulin delivery
WO2020005455A1 (en) 2018-06-29 2020-01-02 Abbott Point Of Care Inc. Cartridge device with bypass channel for mitigating drift of fluid samples
WO2020159584A1 (en) * 2019-01-28 2020-08-06 Abbott Diabetes Care Inc. Analyte sensors and sensing methods for detecting creatinine
CN110028670A (en) * 2019-04-11 2019-07-19 明士新材料有限公司 Low-dielectric loss negative light-sensitive poly amic acid ester resin, resin combination, preparation method and application
US20230123613A1 (en) 2021-10-14 2023-04-20 Medtronic Minimed, Inc. Sensors for 3-hydroxybutyrate detection
US20230172497A1 (en) 2021-12-02 2023-06-08 Medtronic Minimed, Inc. Ketone limiting membrane and dual layer membrane approach for ketone sensing

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT369254B (en) * 1981-05-07 1982-12-27 Otto Dipl Ing Dr Tech Prohaska MEDICAL PROBE
US4650547A (en) * 1983-05-19 1987-03-17 The Regents Of The University Of California Method and membrane applicable to implantable sensor
US4484987A (en) * 1983-05-19 1984-11-27 The Regents Of The University Of California Method and membrane applicable to implantable sensor
SE8305704D0 (en) * 1983-10-18 1983-10-18 Leo Ab Cuvette
GB8514176D0 (en) * 1985-06-05 1985-07-10 Ici Plc Membrane
US5185256A (en) * 1985-06-21 1993-02-09 Matsushita Electric Industrial Co., Ltd. Method for making a biosensor
WO1986007632A1 (en) * 1985-06-21 1986-12-31 Matsushita Electric Industrial Co., Ltd. Biosensor and method of manufacturing same
GB8522834D0 (en) * 1985-09-16 1985-10-23 Ici Plc Sensor
US4890620A (en) * 1985-09-20 1990-01-02 The Regents Of The University Of California Two-dimensional diffusion glucose substrate sensing electrode
GB8529300D0 (en) * 1985-11-28 1986-01-02 Ici Plc Membrane
US4759828A (en) * 1987-04-09 1988-07-26 Nova Biomedical Corporation Glucose electrode and method of determining glucose
US5352348A (en) * 1987-04-09 1994-10-04 Nova Biomedical Corporation Method of using enzyme electrode
US4933048A (en) * 1988-02-16 1990-06-12 I-Stat Corporation Reference electrode, method of making and method of using same
US5200051A (en) * 1988-11-14 1993-04-06 I-Stat Corporation Wholly microfabricated biosensors and process for the manufacture and use thereof
US5063081A (en) * 1988-11-14 1991-11-05 I-Stat Corporation Method of manufacturing a plurality of uniform microfabricated sensing devices having an immobilized ligand receptor
US5112455A (en) * 1990-07-20 1992-05-12 I Stat Corporation Method for analytically utilizing microfabricated sensors during wet-up
CA2050057A1 (en) * 1991-03-04 1992-09-05 Adam Heller Interferant eliminating biosensors
US5262305A (en) * 1991-03-04 1993-11-16 E. Heller & Company Interferant eliminating biosensors
DE69121201D1 (en) * 1991-08-27 1996-09-05 Ibm Method and device for generating high-resolution optical images
AU3274693A (en) * 1991-12-31 1993-07-28 Abbott Laboratories Composite membrane
US5514253A (en) * 1994-07-13 1996-05-07 I-Stat Corporation Method of measuring gas concentrations and microfabricated sensing device for practicing same
US5719033A (en) * 1995-06-28 1998-02-17 Motorola, Inc. Thin film transistor bio/chemical sensor
US5696314A (en) * 1996-07-12 1997-12-09 Chiron Diagnostics Corporation Multilayer enzyme electrode membranes and methods of making same
US5804048A (en) * 1996-08-15 1998-09-08 Via Medical Corporation Electrode assembly for assaying glucose

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