CA2318161A1 - Microfabricated aperture-based sensor - Google Patents

Microfabricated aperture-based sensor Download PDF

Info

Publication number
CA2318161A1
CA2318161A1 CA002318161A CA2318161A CA2318161A1 CA 2318161 A1 CA2318161 A1 CA 2318161A1 CA 002318161 A CA002318161 A CA 002318161A CA 2318161 A CA2318161 A CA 2318161A CA 2318161 A1 CA2318161 A1 CA 2318161A1
Authority
CA
Canada
Prior art keywords
based sensor
layer
analyte
diffusion layer
microfabricated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002318161A
Other languages
French (fr)
Other versions
CA2318161C (en
Inventor
Graham Davis
Chao Lin
Imants R. Lauks
Raymond J. Pierce
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Point of Care Inc
Original Assignee
I-Stat Corporation
Graham Davis
Chao Lin
Imants R. Lauks
Raymond J. Pierce
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by I-Stat Corporation, Graham Davis, Chao Lin, Imants R. Lauks, Raymond J. Pierce filed Critical I-Stat Corporation
Publication of CA2318161A1 publication Critical patent/CA2318161A1/en
Application granted granted Critical
Publication of CA2318161C publication Critical patent/CA2318161C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/004—Enzyme electrodes mediator-assisted
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/002—Electrode membranes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/817—Enzyme or microbe electrode

Abstract

A chemical sensor includes an enzyme layer (62), a diffusion layer (68) and an analyte barrier layer (60) positioned over the diffusion layer. Apertures (64) are formed by microfabrication in the analyte barrier layer to allow controlled analyte flux to the diffusion layer.
CA002318161A 1998-01-23 1999-01-21 Microfabricated aperture-based sensor Expired - Lifetime CA2318161C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US09/012,579 US6030827A (en) 1998-01-23 1998-01-23 Microfabricated aperture-based sensor
US09/012,579(CON) 1998-01-23
US09/012,579 1998-01-23
PCT/US1999/001375 WO1999038003A1 (en) 1998-01-23 1999-01-21 Microfabricated aperture-based sensor

Publications (2)

Publication Number Publication Date
CA2318161A1 true CA2318161A1 (en) 1999-07-29
CA2318161C CA2318161C (en) 2006-07-04

Family

ID=21755630

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002318161A Expired - Lifetime CA2318161C (en) 1998-01-23 1999-01-21 Microfabricated aperture-based sensor

Country Status (11)

Country Link
US (2) US6030827A (en)
EP (1) EP1057010B1 (en)
JP (1) JP3826189B2 (en)
KR (1) KR20010040357A (en)
CN (1) CN1292086A (en)
AT (1) ATE443859T1 (en)
AU (1) AU754095B2 (en)
CA (1) CA2318161C (en)
DE (1) DE69941449D1 (en)
ES (1) ES2333831T3 (en)
WO (1) WO1999038003A1 (en)

Families Citing this family (207)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6811037B2 (en) 1996-07-11 2004-11-02 Fraunhofer-Fesellschaft Zur Forderung Derangewandten Forschung E.V. Sensor and/or separating element and process for the production and use thereof
US8527026B2 (en) 1997-03-04 2013-09-03 Dexcom, Inc. Device and method for determining analyte levels
US9155496B2 (en) 1997-03-04 2015-10-13 Dexcom, Inc. Low oxygen in vivo analyte sensor
US7899511B2 (en) 2004-07-13 2011-03-01 Dexcom, Inc. Low oxygen in vivo analyte sensor
US6001067A (en) 1997-03-04 1999-12-14 Shults; Mark C. Device and method for determining analyte levels
AU9599498A (en) 1997-09-30 1999-04-23 M-Biotech, Inc. Biosensor
US6036924A (en) 1997-12-04 2000-03-14 Hewlett-Packard Company Cassette of lancet cartridges for sampling blood
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
EP0995803A3 (en) * 1998-10-20 2001-11-07 Matsushita Electric Industrial Co., Ltd. Sample treating kit and sample treating method using the same for analysis with a biosensor
JP4246396B2 (en) * 1998-10-31 2009-04-02 イエロー・スプリングス・オプティカル・センサー・カンパニー・ピーエルエル Sensor capsule for CO2 sensor
US6283938B1 (en) * 1999-05-04 2001-09-04 Mcconnell Daniel E. Medicating bandage and controllable permeable membrane
US6475750B1 (en) 1999-05-11 2002-11-05 M-Biotech, Inc. Glucose biosensor
JP4801301B2 (en) * 1999-06-18 2011-10-26 アボット ダイアベティス ケア インコーポレイテッド In vivo analyte sensor with limited mass transfer
JP2003517588A (en) * 1999-08-27 2003-05-27 エム−バイオテック インコーポレイテッド Glucose biosensor
US6343225B1 (en) * 1999-09-14 2002-01-29 Implanted Biosystems, Inc. Implantable glucose sensor
US6540675B2 (en) * 2000-06-27 2003-04-01 Rosedale Medical, Inc. Analyte monitor
US6602401B1 (en) * 2000-11-01 2003-08-05 Rosemount Analytical Inc. Amperometric sensor for low level dissolved oxygen with self-depleting sensor design
US8372139B2 (en) 2001-02-14 2013-02-12 Advanced Bio Prosthetic Surfaces, Ltd. In vivo sensor and method of making same
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
JP4517498B2 (en) * 2000-11-24 2010-08-04 パナソニック株式会社 Biosensor
US6896793B2 (en) * 2001-03-07 2005-05-24 Instrumentation Laboratory Company Liquid junction reference electrode and methods of use thereof
JP4517527B2 (en) * 2001-03-29 2010-08-04 パナソニック株式会社 Biosensor
DE10119036C1 (en) * 2001-04-18 2002-12-12 Disetronic Licensing Ag Immersion sensor for measuring the concentration of an analyte using an oxidase
US6613379B2 (en) 2001-05-08 2003-09-02 Isense Corp. Implantable analyte sensor
US6872297B2 (en) * 2001-05-31 2005-03-29 Instrumentation Laboratory Company Analytical instruments, biosensors and methods thereof
US6960466B2 (en) * 2001-05-31 2005-11-01 Instrumentation Laboratory Company Composite membrane containing a cross-linked enzyme matrix for a biosensor
US6652720B1 (en) 2001-05-31 2003-11-25 Instrumentation Laboratory Company Analytical instruments, biosensors and methods thereof
US6896778B2 (en) * 2001-06-04 2005-05-24 Epocal Inc. Electrode module
US7214300B2 (en) * 2001-06-04 2007-05-08 Epocal Inc. Integrated electrokinetic devices and methods of manufacture
US7025774B2 (en) 2001-06-12 2006-04-11 Pelikan Technologies, Inc. Tissue penetration device
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7682318B2 (en) 2001-06-12 2010-03-23 Pelikan Technologies, Inc. Blood sampling apparatus and method
EP1404234B1 (en) 2001-06-12 2011-02-09 Pelikan Technologies Inc. Apparatus for improving success rate of blood yield from a fingerstick
DE60234598D1 (en) 2001-06-12 2010-01-14 Pelikan Technologies Inc SELF-OPTIMIZING LANZET DEVICE WITH ADAPTANT FOR TEMPORAL FLUCTUATIONS OF SKIN PROPERTIES
US7749174B2 (en) * 2001-06-12 2010-07-06 Pelikan Technologies, Inc. Method and apparatus for lancet launching device intergrated onto a blood-sampling cartridge
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
ATE485766T1 (en) 2001-06-12 2010-11-15 Pelikan Technologies Inc ELECTRICAL ACTUATING ELEMENT FOR A LANCET
US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US20030032874A1 (en) 2001-07-27 2003-02-13 Dexcom, Inc. Sensor head for use with implantable devices
US7244393B2 (en) 2001-12-21 2007-07-17 Kimberly-Clark Worldwide, Inc. Diagnostic device and system
US7004928B2 (en) * 2002-02-08 2006-02-28 Rosedale Medical, Inc. Autonomous, ambulatory analyte monitor or drug delivery device
US7613491B2 (en) 2002-05-22 2009-11-03 Dexcom, Inc. Silicone based membranes for use in implantable glucose sensors
US8364229B2 (en) * 2003-07-25 2013-01-29 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
US7828728B2 (en) * 2003-07-25 2010-11-09 Dexcom, Inc. Analyte sensor
US7101472B2 (en) * 2002-03-13 2006-09-05 The Charles Stark Draper Laboratory, Inc. Microfluidic ion-selective electrode sensor system
US7407570B2 (en) * 2002-03-13 2008-08-05 The Charles Stark Draper Laboratory, Inc. Disposable, self-administered electrolyte test
US7909778B2 (en) 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7717863B2 (en) 2002-04-19 2010-05-18 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8360992B2 (en) 2002-04-19 2013-01-29 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US7371247B2 (en) 2002-04-19 2008-05-13 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US7648468B2 (en) * 2002-04-19 2010-01-19 Pelikon Technologies, Inc. Method and apparatus for penetrating tissue
US7291117B2 (en) 2002-04-19 2007-11-06 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7892185B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US7175642B2 (en) 2002-04-19 2007-02-13 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7232451B2 (en) 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7226461B2 (en) 2002-04-19 2007-06-05 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with sterility barrier release
US7491178B2 (en) 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7331931B2 (en) 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7226978B2 (en) * 2002-05-22 2007-06-05 Dexcom, Inc. Techniques to improve polyurethane membranes for implantable glucose sensors
US20040018577A1 (en) * 2002-07-29 2004-01-29 Emerson Campbell John Lewis Multiple hybrid immunoassay
US9237865B2 (en) * 2002-10-18 2016-01-19 Medtronic Minimed, Inc. Analyte sensors and methods for making and using them
KR100508114B1 (en) * 2002-10-22 2005-08-19 한국전자통신연구원 Formation method of outermost layer of enzymatic electrode sensor
US7638228B2 (en) 2002-11-27 2009-12-29 Saint Louis University Enzyme immobilization for use in biofuel cells and sensors
US7842234B2 (en) * 2002-12-02 2010-11-30 Epocal Inc. Diagnostic devices incorporating fluidics and methods of manufacture
US7767068B2 (en) 2002-12-02 2010-08-03 Epocal Inc. Heterogeneous membrane electrodes
US7422903B2 (en) * 2002-12-11 2008-09-09 Instrumentation Laboratory Company Multi-analyte reference solutions
US7265881B2 (en) * 2002-12-20 2007-09-04 Hewlett-Packard Development Company, L.P. Method and apparatus for measuring assembly and alignment errors in sensor assemblies
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
US20040154933A1 (en) * 2003-02-11 2004-08-12 Instrumentation Laboratory Company Polymeric membranes for use in electrochemical sensors
US20040256227A1 (en) * 2003-02-11 2004-12-23 Jungwon Shin Electrochemical urea sensors and methods of making the same
US7263501B2 (en) 2003-03-11 2007-08-28 I-Stat Corporation Point-of-care inventory management system and method
US7052652B2 (en) * 2003-03-24 2006-05-30 Rosedale Medical, Inc. Analyte concentration detection devices and methods
JP2004343275A (en) * 2003-05-14 2004-12-02 Murata Mach Ltd Image processing system and scanner
EP1628567B1 (en) 2003-05-30 2010-08-04 Pelikan Technologies Inc. Method and apparatus for fluid injection
DK1633235T3 (en) 2003-06-06 2014-08-18 Sanofi Aventis Deutschland Apparatus for sampling body fluid and detecting analyte
WO2006001797A1 (en) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Low pain penetrating
US20070173709A1 (en) * 2005-04-08 2007-07-26 Petisce James R Membranes for an analyte sensor
US9763609B2 (en) 2003-07-25 2017-09-19 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
JP2007500336A (en) 2003-07-25 2007-01-11 デックスコム・インコーポレーテッド Electrode system for electrochemical sensors
US7651596B2 (en) 2005-04-08 2010-01-26 Dexcom, Inc. Cellulosic-based interference domain for an analyte sensor
US7761130B2 (en) 2003-07-25 2010-07-20 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
JP4708342B2 (en) 2003-07-25 2011-06-22 デックスコム・インコーポレーテッド Oxygen augmentation membrane system for use in implantable devices
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US7722817B2 (en) * 2003-08-28 2010-05-25 Epocal Inc. Lateral flow diagnostic devices with instrument controlled fluidics
US7723099B2 (en) * 2003-09-10 2010-05-25 Abbott Point Of Care Inc. Immunoassay device with immuno-reference electrode
US7682833B2 (en) * 2003-09-10 2010-03-23 Abbott Point Of Care Inc. Immunoassay device with improved sample closure
US8282576B2 (en) 2003-09-29 2012-10-09 Sanofi-Aventis Deutschland Gmbh Method and apparatus for an improved sample capture device
DE602004026763D1 (en) * 2003-09-30 2010-06-02 Roche Diagnostics Gmbh SENSOR WITH IMPROVED BIOKOMPATIBILITY
EP1680014A4 (en) 2003-10-14 2009-01-21 Pelikan Technologies Inc Method and apparatus for a variable user interface
US20050090607A1 (en) * 2003-10-28 2005-04-28 Dexcom, Inc. Silicone composition for biocompatible membrane
US8859151B2 (en) * 2003-11-05 2014-10-14 St. Louis University Immobilized enzymes in biocathodes
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
DE602004029092D1 (en) 2003-12-05 2010-10-21 Dexcom Inc CALIBRATION METHODS FOR A CONTINUOUSLY WORKING ANALYTIC SENSOR
US8423114B2 (en) 2006-10-04 2013-04-16 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US11633133B2 (en) 2003-12-05 2023-04-25 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
EP1706026B1 (en) 2003-12-31 2017-03-01 Sanofi-Aventis Deutschland GmbH Method and apparatus for improving fluidic flow and sample capture
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
US7709134B2 (en) 2004-03-15 2010-05-04 St. Louis University Microfluidic biofuel cell
US8277713B2 (en) 2004-05-03 2012-10-02 Dexcom, Inc. Implantable analyte sensor
US8828203B2 (en) 2004-05-20 2014-09-09 Sanofi-Aventis Deutschland Gmbh Printable hydrogels for biosensors
EP1765194A4 (en) 2004-06-03 2010-09-29 Pelikan Technologies Inc Method and apparatus for a fluid sampling device
US9775553B2 (en) * 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
US8565848B2 (en) 2004-07-13 2013-10-22 Dexcom, Inc. Transcutaneous analyte sensor
US20060016700A1 (en) 2004-07-13 2006-01-26 Dexcom, Inc. Transcutaneous analyte sensor
US7946984B2 (en) 2004-07-13 2011-05-24 Dexcom, Inc. Transcutaneous analyte sensor
EP2653923A1 (en) 2004-08-11 2013-10-23 Dow Corning Corporation Method for forming semipermeable membranes for sensor applications using photopolymerizable silicone materials
EP1789796B1 (en) * 2004-09-02 2011-05-11 Abbott Point Of Care, Inc. Blood urea nitrogen (bun) sensor
CA2583396C (en) 2004-10-12 2015-06-23 Bayer Healthcare Llc Concentration determination in a diffusion barrier layer
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
US20060249381A1 (en) * 2005-05-05 2006-11-09 Petisce James R Cellulosic-based resistance domain for an analyte sensor
US8744546B2 (en) * 2005-05-05 2014-06-03 Dexcom, Inc. Cellulosic-based resistance domain for an analyte sensor
US20060281187A1 (en) 2005-06-13 2006-12-14 Rosedale Medical, Inc. Analyte detection devices and methods with hematocrit/volume correction and feedback control
CA2612635C (en) 2005-07-14 2013-03-12 I-Stat Corporation Photoformed silicone sensor membrane
KR101321296B1 (en) 2005-07-20 2013-10-28 바이엘 헬스케어 엘엘씨 Gated amperometry temperature determination
US8801631B2 (en) * 2005-09-30 2014-08-12 Intuity Medical, Inc. Devices and methods for facilitating fluid transport
EP1928304B1 (en) 2005-09-30 2012-10-24 Intuity Medical, Inc. Catalysts for body fluid sample extraction
US9668683B2 (en) 2005-12-27 2017-06-06 Ascensia Diabetes Care Holdings Ag Electrochemical sensor system using a substrate with at least one aperture and method of making the same
US9757061B2 (en) 2006-01-17 2017-09-12 Dexcom, Inc. Low oxygen in vivo analyte sensor
US8052855B2 (en) * 2006-05-11 2011-11-08 Samsung Electronics Co., Ltd. Carbon nanotube gas sensor and method of manufacturing the same
GB0609493D0 (en) * 2006-05-12 2006-06-21 Oxford Biosensors Ltd Cholesterol sensor
GB0609494D0 (en) * 2006-05-12 2006-06-21 Oxford Biosensors Ltd HDL cholesterol sensor using specific surfactant
JP2009544083A (en) 2006-07-13 2009-12-10 アイ−スタット コーポレイション System and method for medical data acquisition and patient management
EP1892877B1 (en) * 2006-08-25 2008-12-03 Alcatel Lucent Digital signal receiver with Q-monitor
US20200037874A1 (en) 2007-05-18 2020-02-06 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
US20090014340A1 (en) * 2007-06-15 2009-01-15 Williams John R Devices, systems, and methods for measuring glucose
US8268604B2 (en) * 2007-12-20 2012-09-18 Abbott Point Of Care Inc. Compositions for forming immobilized biological layers for sensing
US8241697B2 (en) * 2007-12-20 2012-08-14 Abbott Point Of Care Inc. Formation of immobilized biological layers for sensing
US8682408B2 (en) 2008-03-28 2014-03-25 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US11730407B2 (en) 2008-03-28 2023-08-22 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US8583204B2 (en) 2008-03-28 2013-11-12 Dexcom, Inc. Polymer membranes for continuous analyte sensors
WO2009126900A1 (en) 2008-04-11 2009-10-15 Pelikan Technologies, Inc. Method and apparatus for analyte detecting device
WO2009145920A1 (en) * 2008-05-30 2009-12-03 Intuity Medical, Inc. Body fluid sampling device -- sampling site interface
US9636051B2 (en) 2008-06-06 2017-05-02 Intuity Medical, Inc. Detection meter and mode of operation
EP2299904B1 (en) 2008-06-06 2019-09-11 Intuity Medical, Inc. Medical measurement method
US8181531B2 (en) * 2008-06-27 2012-05-22 Edwin Carlen Accessible stress-based electrostatic monitoring of chemical reactions and binding
US20100025238A1 (en) * 2008-07-31 2010-02-04 Medtronic Minimed, Inc. Analyte sensor apparatuses having improved electrode configurations and methods for making and using them
US8700114B2 (en) 2008-07-31 2014-04-15 Medtronic Minmed, Inc. Analyte sensor apparatuses comprising multiple implantable sensor elements and methods for making and using them
US9011670B2 (en) * 2008-08-14 2015-04-21 The Charles Stark Draper Laboratory, Inc. Three-dimensional metal ion sensor arrays on printed circuit boards
US8216529B2 (en) * 2008-09-15 2012-07-10 Abbott Point Of Care Inc. Fluid-containing pouches with reduced gas exchange and methods for making same
EP2326944B1 (en) 2008-09-19 2020-08-19 Dexcom, Inc. Particle-containing membrane and particulate electrode for analyte sensors
US20100187132A1 (en) * 2008-12-29 2010-07-29 Don Alden Determination of the real electrochemical surface areas of screen printed electrodes
CA2749041C (en) 2008-12-31 2019-09-03 Abbott Point Of Care Inc. Method and device for immunoassay using obligonucleotide conjugates
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
US8084272B2 (en) 2009-03-25 2011-12-27 Abbott Point Of Care Inc. Amelioration of heterophile antibody immunosensor interference
US8389293B2 (en) * 2009-11-17 2013-03-05 Abbott Point Of Care Inc. Reducing leukocyte interference in competitive immunoassays
US8377669B2 (en) 2009-11-17 2013-02-19 Abbott Point Of Care Inc. Reducing leukocyte interference in non-competitive immunoassays
EP3106871B1 (en) 2009-11-30 2021-10-27 Intuity Medical, Inc. A method of verifying the accuracy of the operation of an analyte monitoring device
EP2512677B1 (en) * 2009-12-18 2018-08-15 Abbott Point Of Care, Inc. Integrated hinged cartridge housings for sample analysis
US8660628B2 (en) * 2009-12-21 2014-02-25 Medtronic Minimed, Inc. Analyte sensors comprising blended membrane compositions and methods for making and using them
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
EP2559380B1 (en) * 2010-04-16 2019-06-05 ARKRAY, Inc. Sensor and method for removal of interfering substance
US8476079B2 (en) 2010-04-30 2013-07-02 Abbott Point Of Care Inc. Reagents for reducing leukocyte interference in immunoassays
US8394325B2 (en) 2010-06-14 2013-03-12 Abbott Point Of Care Inc. Magnetic beads for reducing leukocyte interference in immunoassays
CA2803797A1 (en) 2010-06-25 2011-12-29 Intuity Medical, Inc. Analyte monitoring methods and systems
US8808532B2 (en) * 2011-01-20 2014-08-19 Medtronic Minimed, Inc Electrode compositions for use with analyte sensors
US8776246B2 (en) 2011-03-11 2014-07-08 Abbott Point Of Care, Inc. Systems, methods and analyzers for establishing a secure wireless network in point of care testing
US8549600B2 (en) 2011-03-11 2013-10-01 Abbott Point Of Care Inc. Systems, methods and analyzers for establishing a secure wireless network in point of care testing
EP3407064B1 (en) 2011-08-03 2020-04-22 Intuity Medical, Inc. Body fluid sampling arrangement
WO2013022778A1 (en) 2011-08-05 2013-02-14 Ibis Biosciences, Inc. Nucleic acid sequencing by electrochemical detection
US9873119B2 (en) 2011-12-28 2018-01-23 Ibis Biosciences, Inc. Multiple- analyte assay device and system
US9592507B2 (en) 2012-06-22 2017-03-14 Abbott Point Of Care Inc. Integrated cartridge housings for sample analysis
EP2939023B1 (en) 2012-12-28 2019-04-17 Abbott Point of Care Inc. System and method for identifying a hook effect and expanding the dynamic range in point of care immunoassays
KR101490584B1 (en) * 2013-03-08 2015-02-05 (주) 더바이오 Current law-based chip sensor to detect perchlorate ion by interface liquid/gel and detecting apparatus including ir
US9651547B2 (en) 2013-03-14 2017-05-16 Abbott Point Of Care Inc. Electrochemical methods and devices for amending urine samples for immunosensor detection
US9488663B2 (en) 2013-03-14 2016-11-08 Abbott Point Of Care Inc. Electrochemical methods and devices for amending urine samples for immunosensor detection
WO2014159615A2 (en) 2013-03-14 2014-10-02 Abbott Point Of Care Inc Thermal control system for controlling the temperature of a fluid
US9562874B2 (en) 2013-03-15 2017-02-07 Abbott Point Of Care Inc. Biosensor with improved interference characteristics
US9249450B2 (en) 2013-03-15 2016-02-02 Abbott Point Of Care Inc. Glutamate oxidase mutagenesis for diagnostic testing
WO2014150876A2 (en) 2013-03-15 2014-09-25 Abbott Point Of Care Inc Biosensor structures for improved point of care testing and methods of manufacture thereof
US10729386B2 (en) 2013-06-21 2020-08-04 Intuity Medical, Inc. Analyte monitoring system with audible feedback
US20150122647A1 (en) 2013-11-07 2015-05-07 Medtronic Minimed, Inc. Enzyme matrices for use with ethylene oxide sterilization
US10254237B2 (en) * 2014-06-07 2019-04-09 Ascilion Ab Microfabricated sensor and a method of detecting a component in bodily fluid
EP4043879A1 (en) 2014-09-26 2022-08-17 Abbott Point Of Care Inc Single channel cartridge device for coagulation assays in fluid samples
EP3198280B1 (en) 2014-09-26 2021-05-26 Abbott Point Of Care, Inc. Sensors for assaying coagulation in fluid samples
ES2898200T3 (en) 2014-09-26 2022-03-04 Abbott Point Of Care Inc Microfabricated device with microenvironment sensors to assess coagulation in fluid samples
US9921232B2 (en) 2014-09-26 2018-03-20 Abbott Point Of Care Inc. Ellagic acid formulations for use in coagulation assays
WO2016049552A1 (en) 2014-09-26 2016-03-31 Abbott Point Of Care Inc. Cartridge device identification for coagulation assays in fluid samples
WO2016049533A1 (en) 2014-09-26 2016-03-31 Abbott Point Of Care Inc. Cartridge device with fluidic junctions for coagulation assays in fluid samples
US10048281B2 (en) 2014-09-26 2018-08-14 Abbott Point Of Care Inc. Cartridge device with segmented fluidics for assaying coagulation in fluid samples
US10987039B2 (en) 2014-12-03 2021-04-27 Stmicroelectronics S.R.L. Microneedle array device and method of making
CN104792832A (en) * 2015-04-16 2015-07-22 三诺生物传感股份有限公司 Bilirubin electrochemical transducer and preparation method thereof
ITUB20154036A1 (en) 2015-09-30 2017-03-30 St Microelectronics Srl BIOSENSOR FOR DETECTION OF ANALYTES IN SWEAT, AND METHOD OF MANUFACTURE OF THE BIOSENSOR
US11298059B2 (en) * 2016-05-13 2022-04-12 PercuSense, Inc. Analyte sensor
CN111278356B (en) * 2017-06-23 2023-12-05 博卡赛恩斯公司 analyte sensor
US11752098B2 (en) * 2017-10-10 2023-09-12 North Carolina State University Core-shell microneedle patch for H2O2 and pH cascade-triggered insulin delivery
EP3814009A1 (en) 2018-06-29 2021-05-05 Abbott Point Of Care, Inc. Cartridge device with bypass channel for mitigating drift of fluid samples
US20200241015A1 (en) * 2019-01-28 2020-07-30 Abbott Diabetes Care Inc. Analyte Sensors and Sensing Methods for Detecting Creatinine
CN110028670A (en) * 2019-04-11 2019-07-19 明士新材料有限公司 Low-dielectric loss negative light-sensitive poly amic acid ester resin, resin combination, preparation method and application
US20230123613A1 (en) 2021-10-14 2023-04-20 Medtronic Minimed, Inc. Sensors for 3-hydroxybutyrate detection
US20230172497A1 (en) 2021-12-02 2023-06-08 Medtronic Minimed, Inc. Ketone limiting membrane and dual layer membrane approach for ketone sensing

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT369254B (en) * 1981-05-07 1982-12-27 Otto Dipl Ing Dr Tech Prohaska MEDICAL PROBE
US4484987A (en) * 1983-05-19 1984-11-27 The Regents Of The University Of California Method and membrane applicable to implantable sensor
US4650547A (en) * 1983-05-19 1987-03-17 The Regents Of The University Of California Method and membrane applicable to implantable sensor
SE8305704D0 (en) * 1983-10-18 1983-10-18 Leo Ab Cuvette
GB8514176D0 (en) * 1985-06-05 1985-07-10 Ici Plc Membrane
US5185256A (en) * 1985-06-21 1993-02-09 Matsushita Electric Industrial Co., Ltd. Method for making a biosensor
EP0230472B2 (en) * 1985-06-21 2000-12-13 Matsushita Electric Industrial Co., Ltd. Biosensor and method of manufacturing same
GB8522834D0 (en) * 1985-09-16 1985-10-23 Ici Plc Sensor
US4890620A (en) * 1985-09-20 1990-01-02 The Regents Of The University Of California Two-dimensional diffusion glucose substrate sensing electrode
GB8529300D0 (en) * 1985-11-28 1986-01-02 Ici Plc Membrane
US5352348A (en) * 1987-04-09 1994-10-04 Nova Biomedical Corporation Method of using enzyme electrode
US4759828A (en) * 1987-04-09 1988-07-26 Nova Biomedical Corporation Glucose electrode and method of determining glucose
US4933048A (en) * 1988-02-16 1990-06-12 I-Stat Corporation Reference electrode, method of making and method of using same
US5063081A (en) * 1988-11-14 1991-11-05 I-Stat Corporation Method of manufacturing a plurality of uniform microfabricated sensing devices having an immobilized ligand receptor
US5200051A (en) * 1988-11-14 1993-04-06 I-Stat Corporation Wholly microfabricated biosensors and process for the manufacture and use thereof
US5112455A (en) * 1990-07-20 1992-05-12 I Stat Corporation Method for analytically utilizing microfabricated sensors during wet-up
JPH04278450A (en) * 1991-03-04 1992-10-05 Adam Heller Biosensor and method for analyzing subject
US5262305A (en) * 1991-03-04 1993-11-16 E. Heller & Company Interferant eliminating biosensors
EP0529125B1 (en) * 1991-08-27 1996-07-31 International Business Machines Corporation Method and apparatus for generating high resolution optical images
AU3274693A (en) * 1991-12-31 1993-07-28 Abbott Laboratories Composite membrane
US5514253A (en) * 1994-07-13 1996-05-07 I-Stat Corporation Method of measuring gas concentrations and microfabricated sensing device for practicing same
US5719033A (en) * 1995-06-28 1998-02-17 Motorola, Inc. Thin film transistor bio/chemical sensor
US5696314A (en) * 1996-07-12 1997-12-09 Chiron Diagnostics Corporation Multilayer enzyme electrode membranes and methods of making same
US5804048A (en) * 1996-08-15 1998-09-08 Via Medical Corporation Electrode assembly for assaying glucose

Also Published As

Publication number Publication date
AU2465399A (en) 1999-08-09
WO1999038003A1 (en) 1999-07-29
JP2002501195A (en) 2002-01-15
ATE443859T1 (en) 2009-10-15
KR20010040357A (en) 2001-05-15
AU754095B2 (en) 2002-11-07
US6379883B2 (en) 2002-04-30
CN1292086A (en) 2001-04-18
US20010003045A1 (en) 2001-06-07
EP1057010A4 (en) 2003-03-05
US6030827A (en) 2000-02-29
ES2333831T3 (en) 2010-03-01
JP3826189B2 (en) 2006-09-27
CA2318161C (en) 2006-07-04
DE69941449D1 (en) 2009-11-05
EP1057010B1 (en) 2009-09-23
EP1057010A1 (en) 2000-12-06
WO1999038003A9 (en) 1999-10-21

Similar Documents

Publication Publication Date Title
CA2318161A1 (en) Microfabricated aperture-based sensor
CA2309280A1 (en) Improved electrochemical biosensor test strip
AU2465999A (en) Electrochemical analyte sensor
WO2001068901A3 (en) Implantable analyte sensor
AU8747698A (en) Positioning device, driving unit, and aligner equipped with the device
AU3227400A (en) Flow cell, analyte measurement apparatus and methods related thereto
HK1030834A1 (en) Electrode means, with or without functional elements and an electrode device formed of said means.
CA2285441A1 (en) Microplate with transparent base
AU2508499A (en) Ligands of the cd47 antigen, agents binding the ligands of the cd47 antigen and uses thereof
CA2328535A1 (en) Biosensor apparatus
ZA200110099B (en) Amphiphilic drug-oligomer conjugates with hydrolyzable lipophile components and methods for making and using the same.
ZA982187B (en) Adsorbent construction; and, method.
AU6855398A (en) Biopsy needle, method for fabricating, and apparatus for operating the same
CA2328751A1 (en) Microsphere containing sensor
AUPP312998A0 (en) Diagnostic assay
AU1285000A (en) Electrochemical sensor
GB2338244B (en) A microbe composition, a method to prepare the same and uses thereof
AU6115199A (en) Device comprising a microfabricated diffusion chamber
AU2884499A (en) Selective cell analysis
AU1975099A (en) Reagents specific for st2l and uses therefor
CA2428043A1 (en) Gas diffusion electrode
CA2372990A1 (en) Means for detecting and treating pathologies linked to fgfr3
HK1047503A1 (en) Sealing plate, cell using the sealing plate, and method of manufacturing the cell.
ZA988B (en) 3-aminocarbonyl-/3-aminothiocarbonyl-substituted 2-benzoylcyclohexane-1,3-diones.
EP0666323A4 (en) Reagent for assaying glucose.

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20190121