CA2316976A1 - Osmotic delivery system with membrane plug retention mechanism - Google Patents

Osmotic delivery system with membrane plug retention mechanism Download PDF

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Publication number
CA2316976A1
CA2316976A1 CA002316976A CA2316976A CA2316976A1 CA 2316976 A1 CA2316976 A1 CA 2316976A1 CA 002316976 A CA002316976 A CA 002316976A CA 2316976 A CA2316976 A CA 2316976A CA 2316976 A1 CA2316976 A1 CA 2316976A1
Authority
CA
Canada
Prior art keywords
membrane plug
membrane
delivery system
capsule
osmotic delivery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002316976A
Other languages
French (fr)
Other versions
CA2316976C (en
Inventor
Rupal Ayer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Intarcia Therapeutics Inc
Original Assignee
Alza Corporation
Rupal Ayer
Intarcia Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corporation, Rupal Ayer, Intarcia Therapeutics, Inc. filed Critical Alza Corporation
Publication of CA2316976A1 publication Critical patent/CA2316976A1/en
Application granted granted Critical
Publication of CA2316976C publication Critical patent/CA2316976C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas

Abstract

An osmotic delivery system has a membrane plug retention mechanism which can also be used to control the delivery rate of a beneficial agent from the osmotic delivery system. The osmotic delivery device includes an implant capsule containing a beneficial agent and an osmotic agent. Holes are formed along a side wall of the implant capsule at an open end of the capsule. When the membrane plug is inserted into the open end of the capsule the membrane material swells into the holes in the capsule side wall creating a large frictional force which prevents expulsion of the membrane plug. A beneficial agent delivery rate of the osmotic delivery system is controllable by varying the size and number of the holes to change the amount of exposed surface area of the membrane plug. An increase in the surface area of the membrane plug exposed to the exterior environment causes a corresponding increase in the liquid permeation rate of the membrane and thus, increases the beneficial agent delivery rate.
CA002316976A 1997-12-29 1998-12-15 Osmotic delivery system with membrane plug retention mechanism Expired - Fee Related CA2316976C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6898797P 1997-12-29 1997-12-29
US60/068,987 1997-12-29
PCT/US1998/026654 WO1999033446A1 (en) 1997-12-29 1998-12-15 Osmotic delivery system with membrane plug retention mechanism

Publications (2)

Publication Number Publication Date
CA2316976A1 true CA2316976A1 (en) 1999-07-08
CA2316976C CA2316976C (en) 2009-02-17

Family

ID=22085978

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002316976A Expired - Fee Related CA2316976C (en) 1997-12-29 1998-12-15 Osmotic delivery system with membrane plug retention mechanism

Country Status (13)

Country Link
US (5) US6270787B1 (en)
EP (1) EP1041968B1 (en)
JP (1) JP4173635B2 (en)
AR (1) AR014194A1 (en)
AT (1) ATE260640T1 (en)
AU (1) AU1828599A (en)
CA (1) CA2316976C (en)
DE (1) DE69822208T2 (en)
ES (1) ES2217613T3 (en)
HK (1) HK1031332A1 (en)
TW (1) TW446552B (en)
WO (1) WO1999033446A1 (en)
ZA (1) ZA9811880B (en)

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Also Published As

Publication number Publication date
US6270787B1 (en) 2001-08-07
JP2001526939A (en) 2001-12-25
AR014194A1 (en) 2001-02-07
EP1041968A1 (en) 2000-10-11
DE69822208D1 (en) 2004-04-08
AU1828599A (en) 1999-07-19
US20040243106A1 (en) 2004-12-02
ZA9811880B (en) 1999-06-29
ATE260640T1 (en) 2004-03-15
US6976981B2 (en) 2005-12-20
HK1031332A1 (en) 2001-06-15
TW446552B (en) 2001-07-21
CA2316976C (en) 2009-02-17
US20050048097A1 (en) 2005-03-03
WO1999033446A1 (en) 1999-07-08
ES2217613T3 (en) 2004-11-01
US20010022974A1 (en) 2001-09-20
US20010021822A1 (en) 2001-09-13
JP4173635B2 (en) 2008-10-29
US6899887B2 (en) 2005-05-31
EP1041968B1 (en) 2004-03-03
DE69822208T2 (en) 2005-04-28

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