CA2316976A1 - Osmotic delivery system with membrane plug retention mechanism - Google Patents

Osmotic delivery system with membrane plug retention mechanism Download PDF

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Publication number
CA2316976A1
CA2316976A1 CA002316976A CA2316976A CA2316976A1 CA 2316976 A1 CA2316976 A1 CA 2316976A1 CA 002316976 A CA002316976 A CA 002316976A CA 2316976 A CA2316976 A CA 2316976A CA 2316976 A1 CA2316976 A1 CA 2316976A1
Authority
CA
Canada
Prior art keywords
membrane plug
membrane
delivery system
capsule
osmotic delivery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002316976A
Other languages
French (fr)
Other versions
CA2316976C (en
Inventor
Rupal Ayer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Intarcia Therapeutics Inc
Original Assignee
Alza Corporation
Rupal Ayer
Intarcia Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corporation, Rupal Ayer, Intarcia Therapeutics, Inc. filed Critical Alza Corporation
Publication of CA2316976A1 publication Critical patent/CA2316976A1/en
Application granted granted Critical
Publication of CA2316976C publication Critical patent/CA2316976C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas

Abstract

An osmotic delivery system has a membrane plug retention mechanism which can also be used to control the delivery rate of a beneficial agent from the osmotic delivery system. The osmotic delivery device includes an implant capsule containing a beneficial agent and an osmotic agent. Holes are formed along a side wall of the implant capsule at an open end of the capsule. When the membrane plug is inserted into the open end of the capsule the membrane material swells into the holes in the capsule side wall creating a large frictional force which prevents expulsion of the membrane plug. A beneficial agent delivery rate of the osmotic delivery system is controllable by varying the size and number of the holes to change the amount of exposed surface area of the membrane plug. An increase in the surface area of the membrane plug exposed to the exterior environment causes a corresponding increase in the liquid permeation rate of the membrane and thus, increases the beneficial agent delivery rate.
CA002316976A 1997-12-29 1998-12-15 Osmotic delivery system with membrane plug retention mechanism Expired - Fee Related CA2316976C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6898797P 1997-12-29 1997-12-29
US60/068,987 1997-12-29
PCT/US1998/026654 WO1999033446A1 (en) 1997-12-29 1998-12-15 Osmotic delivery system with membrane plug retention mechanism

Publications (2)

Publication Number Publication Date
CA2316976A1 true CA2316976A1 (en) 1999-07-08
CA2316976C CA2316976C (en) 2009-02-17

Family

ID=22085978

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002316976A Expired - Fee Related CA2316976C (en) 1997-12-29 1998-12-15 Osmotic delivery system with membrane plug retention mechanism

Country Status (13)

Country Link
US (5) US6270787B1 (en)
EP (1) EP1041968B1 (en)
JP (1) JP4173635B2 (en)
AR (1) AR014194A1 (en)
AT (1) ATE260640T1 (en)
AU (1) AU1828599A (en)
CA (1) CA2316976C (en)
DE (1) DE69822208T2 (en)
ES (1) ES2217613T3 (en)
HK (1) HK1031332A1 (en)
TW (1) TW446552B (en)
WO (1) WO1999033446A1 (en)
ZA (1) ZA9811880B (en)

Families Citing this family (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY125870A (en) * 1997-07-25 2006-08-30 Alza Corp Osmotic delivery system flow modulator apparatus and method
EP1041968B1 (en) * 1997-12-29 2004-03-03 Alza Corporation Osmotic delivery system with membrane plug retention mechanism
ATE234603T1 (en) 1998-12-31 2003-04-15 Alza Corp OSMOTIC ADMINISTRATION SYSTEM WITH SPACE-SAVING PISTONS
US7258869B1 (en) * 1999-02-08 2007-08-21 Alza Corporation Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle
US7919109B2 (en) 1999-02-08 2011-04-05 Intarcia Therapeutics, Inc. Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles
WO2001045675A2 (en) * 1999-12-21 2001-06-28 Alza Corporation Valve for osmotic devices
US7163688B2 (en) * 2001-06-22 2007-01-16 Alza Corporation Osmotic implant with membrane and membrane retention means
US20100311701A1 (en) * 2002-02-15 2010-12-09 Transform Pharmaceuticals, Inc Pharmaceutical Co-Crystal Compositions
US7927613B2 (en) * 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
US7790905B2 (en) * 2002-02-15 2010-09-07 Mcneil-Ppc, Inc. Pharmaceutical propylene glycol solvate compositions
CA2477923C (en) * 2002-03-01 2021-02-23 University Of South Florida Multiple-component solid phases containing at least one active pharmaceutical ingredient
JP2005533782A (en) * 2002-06-17 2005-11-10 アルザ コーポレイション An osmotic delivery system having an engine with fast extruding force and zero order including an osmotic agent dispersed in a fluid vehicle
MXPA05000232A (en) * 2002-06-21 2005-06-17 Transform Pharmaceuticals Inc Pharmaceutical compositions with improved dissolution.
ES2295642T3 (en) 2002-06-26 2008-04-16 Intarcia Therapeutics, Inc. EFFICIENT VOLUME PISTON OF MINIMUM OCCUPATION FOR MEDICINAL ADMINISTRATION SYSTEMS.
US7014636B2 (en) * 2002-11-21 2006-03-21 Alza Corporation Osmotic delivery device having a two-way valve and a dynamically self-adjusting flow channel
KR20050088196A (en) * 2002-12-19 2005-09-02 알자 코포레이션 Stable, non-aqueous, single-phase gels and formulations thereof for delivery from an implantable device
US7731947B2 (en) * 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
EP2339328A3 (en) 2002-12-30 2011-07-13 Transform Pharmaceuticals, Inc. Pharmaceutical co-crystal compositions of celecoxib
US8183290B2 (en) * 2002-12-30 2012-05-22 Mcneil-Ppc, Inc. Pharmaceutically acceptable propylene glycol solvate of naproxen
AU2003272270A1 (en) 2003-02-28 2004-09-28 The Regents Of The University Of Michigan Pharmaceutical co-crystal compositions of drugs such as carbamazeptine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
CN1767815A (en) 2003-03-31 2006-05-03 阿尔萨公司 Non-aqueous single phase vehicles and formulations utilizing such vehicles
KR20060017749A (en) 2003-03-31 2006-02-27 알자 코포레이션 Osmotic pump with means for dissipating internal pressure
CA2520766A1 (en) * 2003-03-31 2004-10-21 Alza Corporation Osmotic delivery system and method for decreasing start-up times for osmotic delivery systems
US20040214893A1 (en) * 2003-04-11 2004-10-28 Matthew Peterson Gabapentin compositions
JP2007502329A (en) 2003-05-23 2007-02-08 トランスフォーム・ファーマシューティカルズ・インコーポレイテッド Sertraline composition
CA2540059C (en) 2003-09-26 2013-08-06 Alza Corporation Controlled release formulations exhibiting an ascending rate of release
AU2004314693B2 (en) 2003-09-26 2011-04-07 Alza Corporation Drug coating providing high drug loading and methods for providing the same
JP5670609B2 (en) * 2003-09-26 2015-02-18 アルザ・コーポレーシヨン OROS push-stick for controlled delivery of active ingredients
CA2540056C (en) * 2003-09-26 2015-03-24 Alza Corporation Controlled release formulations of opioid and nonopioid analgesics
EP1682099A2 (en) 2003-09-30 2006-07-26 ALZA Corporation Osmotically driven active agent delivery device providing an ascending release profile
JP2007509703A (en) 2003-10-31 2007-04-19 アルザ・コーポレーシヨン Osmotic pump with self-holding, quick start membrane plug
US20050113410A1 (en) * 2003-11-03 2005-05-26 Mark Tawa Pharmaceutical salts of zafirlukast
CN1874763A (en) * 2003-11-06 2006-12-06 阿尔扎公司 Modular imbibition rate reducer for use with implantable osmotic pump
EP2428516A1 (en) 2003-11-19 2012-03-14 Metabasis Therapeutics, Inc. Novel phosphorus-containing thyromimetics
WO2005092065A2 (en) * 2004-03-25 2005-10-06 Transform Pharmaceuticals, Inc. Novel tricyclic compounds and related methods of treatment
JP2007531145A (en) * 2004-03-31 2007-11-01 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ Method and system for transferring a budget in a limited budget usage approach
US20050266087A1 (en) * 2004-05-25 2005-12-01 Gunjan Junnarkar Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium
JP5017103B2 (en) * 2004-06-17 2012-09-05 トランスフオーム・フアーマシユーチカルズ・インコーポレーテツド Pharmaceutical co-crystal composition and related methods of use
CN101010114B (en) 2004-08-27 2010-05-26 皇家飞利浦电子股份有限公司 Electronically and remotely controlled pill and system for delivering at least one medicament
US8541026B2 (en) * 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
US8779175B2 (en) 2004-10-25 2014-07-15 Synthonics, Inc. Coordination complexes, pharmaceutical solutions comprising coordination complexes, and methods of treating patients
US20060160783A1 (en) * 2004-12-30 2006-07-20 Transform Pharmaceuticals, Inc. Novel omeprazole forms and related methods
WO2006083761A2 (en) 2005-02-03 2006-08-10 Alza Corporation Solvent/polymer solutions as suspension vehicles
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
EP2361630A1 (en) * 2005-02-03 2011-08-31 Intarcia Therapeutics, Inc Implantable drug delivery device comprising particles and an osmotic pump
US7959938B2 (en) 2005-03-15 2011-06-14 Intarcia Therapeutics, Inc. Polyoxaester suspending vehicles for use with implantable delivery systems
WO2007005680A1 (en) * 2005-06-30 2007-01-11 Alza Corporation Osmotic intraosseous drug delivery system
US20070027105A1 (en) * 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
US7931620B2 (en) * 2006-02-01 2011-04-26 Roche Diagnostics International Ag Self-sealing connection for housing shells of an administering device
CN101432032A (en) * 2006-04-28 2009-05-13 皇家飞利浦电子股份有限公司 Osmotic pump with at least one chargeable material
JP5143131B2 (en) 2006-05-30 2013-02-13 インターシア セラピューティクス，インコーポレイティド Two-piece internal channel flow modulator for osmotic delivery system
PL2359808T3 (en) * 2006-08-09 2013-10-31 Intarcia Therapeutics Inc Osmotic delivery systems and piston assemblies
US9114133B2 (en) 2006-08-25 2015-08-25 U.S. Dept. Of Veterans Affairs Method of improving diastolic dysfunction
US8617143B2 (en) * 2006-12-07 2013-12-31 The Regents Of The University Of California Therapeutic agent delivery systems and devices
KR20180099916A (en) 2007-02-09 2018-09-05 메타베이시스 테라퓨틱스, 인크. Novel antagonists of the glucagon receptor
MX2009011123A (en) * 2007-04-23 2009-11-02 Intarcia Therapeutics Inc Suspension formulations of insulinotropic peptides and uses thereof.
US20090028941A1 (en) * 2007-07-27 2009-01-29 Depomed, Inc. Pulsatile gastric retentive dosage forms
CA2695583A1 (en) 2007-08-13 2009-02-19 Metabasis Therapeutics, Inc. Novel activators of glucokinase
US9226907B2 (en) 2008-02-01 2016-01-05 Abbvie Inc. Extended release hydrocodone acetaminophen and related methods and uses thereof
EP2240155B1 (en) 2008-02-13 2012-06-06 Intarcia Therapeutics, Inc Devices, formulations, and methods for delivery of multiple beneficial agents
EP3153501B1 (en) 2008-08-13 2018-11-28 Metabasis Therapeutics, Inc. Glucagon antagonists
CN106880596A (en) * 2008-10-15 2017-06-23 精达制药公司 Highly enriched drug particles, preparation, supensoid agent and its application
BRPI1006765A2 (en) 2009-04-07 2019-03-26 Koninl Philips Electronics Nv ingestible capsule for drug release
US10046109B2 (en) 2009-08-12 2018-08-14 Progenity, Inc. Drug delivery device with compressible drug reservoir
NZ598686A (en) 2009-09-28 2014-05-30 Intarcia Therapeutics Inc Rapid establishment and/or termination of substantial steady-state drug delivery
AU2011237592B2 (en) 2010-04-08 2016-10-27 Emory University Substituted androst-4-ene diones
CA2807656A1 (en) 2010-08-30 2012-03-08 SinuSys Corporation Devices and methods for dilating a paranasal sinus opening and for treating sinusitis
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
WO2012129237A2 (en) 2011-03-20 2012-09-27 Trustees Of Boston University Therapeutic agent for emphysema and copd
JP5992991B2 (en) * 2011-03-24 2016-09-14 メディメトリクス ペルソナリズド ドルグ デリヴェリー ベー ヴェ Swallowable medical capsule
ITFI20110114A1 (en) 2011-05-31 2012-12-01 Scuola Superiore Di Studi Universit Arie Di Perfe ROBOTIC PLATFORM FOR MINING-INVASIVE SURGERY
US20140227293A1 (en) 2011-06-30 2014-08-14 Trustees Of Boston University Method for controlling tumor growth, angiogenesis and metastasis using immunoglobulin containing and proline rich receptor-1 (igpr-1)
US20130090633A1 (en) * 2011-10-07 2013-04-11 University Of Southern California Osmotic patch pump
TWI615155B (en) * 2011-11-01 2018-02-21 拜耳股份有限公司 Osmotically active vaginal delivery system
US9138569B2 (en) 2012-02-29 2015-09-22 SinuSys Corporation Devices and methods for dilating a paranasal sinus opening and for treating sinusitis
US9737364B2 (en) 2012-05-14 2017-08-22 Vanderbilt University Local magnetic actuation of surgical devices
CA2873967A1 (en) 2012-05-21 2013-11-28 Bayer Pharma Aktiengesellschaft Substituted benzothienopyrimidines
US9826904B2 (en) 2012-09-14 2017-11-28 Vanderbilt University System and method for detecting tissue surface properties
US20140081169A1 (en) * 2012-09-17 2014-03-20 Vanderbilt University System and method of tetherless insufflation in colon capsule endoscopy
TW201412740A (en) 2012-09-20 2014-04-01 Bayer Pharma AG Substituted pyrrolopyrimidinylamino-benzothiazolones
CN102871982B (en) 2012-10-16 2014-09-10 中国科学院上海药物研究所 Medicine osmotic pump preparation
US10485409B2 (en) 2013-01-17 2019-11-26 Vanderbilt University Real-time pose and magnetic force detection for wireless magnetic capsule
US9687263B2 (en) 2013-05-30 2017-06-27 SinuSys Corporation Devices and methods for inserting a sinus dilator
WO2015027146A1 (en) 2013-08-22 2015-02-26 The General Hospital Corporation Inhibitors of human 12/15-lipoxygenase
WO2015191900A1 (en) 2014-06-12 2015-12-17 Ligand Pharmaceuticals, Inc. Glucagon antagonists
EP3190945A4 (en) 2014-09-09 2018-06-27 Vanderbilt University Hydro-jet endoscopic capsule and methods for gastric cancer screening in low resource settings
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
AU2016270984B2 (en) 2015-06-03 2021-02-25 Intarcia Therapeutics, Inc. Implant placement and removal systems
PL3370705T3 (en) 2015-11-05 2022-08-01 The General Hospital Corporation Intrathecal delivery of nucleic acid sequences encoding abcd1 for treatment of adrenomyeloneuropathy
CN109310743A (en) 2016-05-16 2019-02-05 因塔西亚制药公司 Glucagon receptor selectivity polypeptide and its application method
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
CA3040906A1 (en) 2016-10-20 2018-04-26 Peptron, Inc. Methods of delivering a neuroprotective polypeptide to the central nervous system
EP3565580B1 (en) 2017-01-03 2024-03-06 i2o Therapeutics, Inc. Continuous administration of exenatide and co-adminstration of acetaminophen, ethinylestradiol or levonorgestrel
US20200188479A1 (en) 2017-03-08 2020-06-18 Intarcia Therapeutics, Inc. Apparatus and methods for administration of a nauseogenic compound from a drug delivery device
US11122965B2 (en) 2017-10-09 2021-09-21 Vanderbilt University Robotic capsule system with magnetic actuation and localization
USD933219S1 (en) 2018-07-13 2021-10-12 Intarcia Therapeutics, Inc. Implant removal tool and assembly
AU2019357621A1 (en) 2018-10-11 2021-05-27 Intarcia Therapeutics, Inc. Human amylin analog polypeptides and methods of use
US20200155466A1 (en) * 2018-11-21 2020-05-21 II Don S. Houtz Oral Medicine Delivery Capsule
CN109589491B (en) * 2019-01-29 2024-01-09 上海安翰医疗技术有限公司 Automatic drug delivery device
KR20220140711A (en) 2020-01-13 2022-10-18 듀렉트 코퍼레이션 Reduced Impurity Sustained Release Drug Delivery Systems and Related Methods

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3732865A (en) 1971-01-13 1973-05-15 Alza Corp Osmotic dispenser
US3995631A (en) 1971-01-13 1976-12-07 Alza Corporation Osmotic dispenser with means for dispensing active agent responsive to osmotic gradient
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3929132A (en) * 1973-04-10 1975-12-30 Alza Corp Osmotic dispenser
US3995632A (en) 1973-05-04 1976-12-07 Alza Corporation Osmotic dispenser
US3916889A (en) 1973-09-28 1975-11-04 Sandoz Ag Patient ventilator apparatus
US3888249A (en) * 1973-11-02 1975-06-10 David L Spencer Arterial infusion catheter
US4203439A (en) 1976-11-22 1980-05-20 Alza Corporation Osmotic system with volume amplifier for increasing amount of agent delivered therefrom
US4111203A (en) 1976-11-22 1978-09-05 Alza Corporation Osmotic system with means for improving delivery kinetics of system
US4111202A (en) 1976-11-22 1978-09-05 Alza Corporation Osmotic system for the controlled and delivery of agent over time
US4243030A (en) 1978-08-18 1981-01-06 Massachusetts Institute Of Technology Implantable programmed microinfusion apparatus
US4373527B1 (en) 1979-04-27 1995-06-27 Univ Johns Hopkins Implantable programmable medication infusion system
US4340054A (en) 1980-12-29 1982-07-20 Alza Corporation Dispenser for delivering fluids and solids
US4439196A (en) 1982-03-18 1984-03-27 Merck & Co., Inc. Osmotic drug delivery system
US4552561A (en) 1982-12-23 1985-11-12 Alza Corporation Body mounted pump housing and pump assembly employing the same
US4639244A (en) 1983-05-03 1987-01-27 Nabil I. Rizk Implantable electrophoretic pump for ionic drugs and associated methods
US4865845A (en) 1986-03-21 1989-09-12 Alza Corporation Release rate adjustment of osmotic or diffusional delivery devices
US4874388A (en) 1987-06-25 1989-10-17 Alza Corporation Multi-layer delivery system
US5151093A (en) 1990-10-29 1992-09-29 Alza Corporation Osmotically driven syringe with programmable agent delivery
GB9027422D0 (en) 1990-12-18 1991-02-06 Scras Osmotically driven infusion device
US5137727A (en) 1991-06-12 1992-08-11 Alza Corporation Delivery device providing beneficial agent stability
US5223265A (en) 1992-01-10 1993-06-29 Alza Corporation Osmotic device with delayed activation of drug delivery
US5456679A (en) 1992-02-18 1995-10-10 Alza Corporation Delivery devices with pulsatile effect
US5308348A (en) 1992-02-18 1994-05-03 Alza Corporation Delivery devices with pulsatile effect
WO1995035131A1 (en) * 1994-06-22 1995-12-28 Unasco Pty. Ltd. Controlled release device and method
US5731001A (en) * 1995-06-07 1998-03-24 Magruder; Judy A. Locking couplings for osmotic delivery devices
CZ293808B6 (en) * 1996-02-02 2004-08-18 Alzaácorporation Implantable device for delivering leuprolide to a fluid environment of use
EP1041968B1 (en) * 1997-12-29 2004-03-03 Alza Corporation Osmotic delivery system with membrane plug retention mechanism
ES2378675T3 (en) * 1997-12-30 2012-04-16 Intarcia Therapeutics, Inc Delivery system of a beneficial agent with a sealing membrane

Also Published As

Publication number Publication date
DE69822208D1 (en) 2004-04-08
WO1999033446A1 (en) 1999-07-08
CA2316976C (en) 2009-02-17
JP2001526939A (en) 2001-12-25
US6270787B1 (en) 2001-08-07
ATE260640T1 (en) 2004-03-15
US20040243106A1 (en) 2004-12-02
US20050048097A1 (en) 2005-03-03
EP1041968A1 (en) 2000-10-11
DE69822208T2 (en) 2005-04-28
ZA9811880B (en) 1999-06-29
AU1828599A (en) 1999-07-19
ES2217613T3 (en) 2004-11-01
TW446552B (en) 2001-07-21
JP4173635B2 (en) 2008-10-29
HK1031332A1 (en) 2001-06-15
US20010021822A1 (en) 2001-09-13
US20010022974A1 (en) 2001-09-20
US6899887B2 (en) 2005-05-31
US6976981B2 (en) 2005-12-20
EP1041968B1 (en) 2004-03-03
AR014194A1 (en) 2001-02-07

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