CA2314326A1 - Transdermal therapeutic device and method with capsaicin and capsaicin analogs - Google Patents

Transdermal therapeutic device and method with capsaicin and capsaicin analogs Download PDF

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Publication number
CA2314326A1
CA2314326A1 CA002314326A CA2314326A CA2314326A1 CA 2314326 A1 CA2314326 A1 CA 2314326A1 CA 002314326 A CA002314326 A CA 002314326A CA 2314326 A CA2314326 A CA 2314326A CA 2314326 A1 CA2314326 A1 CA 2314326A1
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CA
Canada
Prior art keywords
capsaicin
therapeutic device
transdermal therapeutic
analogs
application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002314326A
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French (fr)
Other versions
CA2314326C (en
Inventor
Wendye R. Robbins
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
The Regents Of The University Of California
Wendye R. Robbins
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Regents Of The University Of California, Wendye R. Robbins filed Critical The Regents Of The University Of California
Publication of CA2314326A1 publication Critical patent/CA2314326A1/en
Application granted granted Critical
Publication of CA2314326C publication Critical patent/CA2314326C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

Transdermal application of capsaicin (or a capsaicin analog) in a concentration from greater than about 5 % to about 10 % by weight has been discovered to be an extremely effective therapy for treating neuropathic pain, so long as an anesthetic, preferably by means of a transdermal patch, is administered initially to the affected area to minimize the expected side effects from subsequent capsaicin application.
CA002314326A 1997-12-15 1998-12-08 Transdermal therapeutic device and method with capsaicin and capsaicin analogs Expired - Lifetime CA2314326C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/990,633 US6239180B1 (en) 1995-11-08 1997-12-15 Transdermal therapeutic device and method with capsaicin and capsaicin analogs
US08/990,633 1997-12-15
PCT/US1998/025794 WO1999030560A1 (en) 1997-12-15 1998-12-08 Transdermal therapeutic device and method with capsaicin and capsaicin analogs

Publications (2)

Publication Number Publication Date
CA2314326A1 true CA2314326A1 (en) 1999-06-24
CA2314326C CA2314326C (en) 2008-11-18

Family

ID=25536360

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002314326A Expired - Lifetime CA2314326C (en) 1997-12-15 1998-12-08 Transdermal therapeutic device and method with capsaicin and capsaicin analogs

Country Status (11)

Country Link
US (2) US6239180B1 (en)
EP (2) EP1039802B1 (en)
AT (2) ATE344023T1 (en)
CA (1) CA2314326C (en)
CY (1) CY1107582T1 (en)
DE (2) DE69814917T2 (en)
DK (2) DK1316308T3 (en)
ES (2) ES2272827T3 (en)
HK (1) HK1030853A1 (en)
PT (1) PT1039802E (en)
WO (1) WO1999030560A1 (en)

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Also Published As

Publication number Publication date
PT1039802E (en) 2003-10-31
US6239180B1 (en) 2001-05-29
DE69814917D1 (en) 2003-06-26
DK1316308T3 (en) 2007-03-05
DK1039802T3 (en) 2003-09-22
HK1030853A1 (en) 2001-05-25
ES2196640T3 (en) 2003-12-16
ATE240723T1 (en) 2003-06-15
CY1107582T1 (en) 2013-03-13
EP1316308B1 (en) 2006-11-02
EP1039802A4 (en) 2002-01-23
EP1039802A1 (en) 2000-10-04
ES2272827T3 (en) 2007-05-01
DE69814917T2 (en) 2004-02-12
WO1999030560A1 (en) 1999-06-24
EP1039802B1 (en) 2003-05-21
EP1316308A1 (en) 2003-06-04
US20010002406A1 (en) 2001-05-31
DE69836352T2 (en) 2007-05-24
CA2314326C (en) 2008-11-18
ATE344023T1 (en) 2006-11-15
DE69836352D1 (en) 2006-12-14

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