CA2313483A1 - Assessment of human papilloma virus-related disease - Google Patents

Assessment of human papilloma virus-related disease Download PDF

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Publication number
CA2313483A1
CA2313483A1 CA002313483A CA2313483A CA2313483A1 CA 2313483 A1 CA2313483 A1 CA 2313483A1 CA 002313483 A CA002313483 A CA 002313483A CA 2313483 A CA2313483 A CA 2313483A CA 2313483 A1 CA2313483 A1 CA 2313483A1
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Canada
Prior art keywords
hpv
group
mrna
ratio
patient
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Granted
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CA002313483A
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French (fr)
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CA2313483C (en
Inventor
Attila T. Lorincz
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Qiagen Gaithersburg LLC
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/708—Specific hybridization probes for papilloma
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development

Abstract

This invention provides novel methods for assessing the stage and prognosis of an HPV infection and/or related disease. In one embodiment, gene expression levels are used assess the stage of the HPV infection and to make a prognosis concerning the progression of the HPV infection from benign to malignant growth by determining the ratio between mRNA levels of E6 and/or E7 and E2 and/or L1. Also provided are kits for carrying out the methods of this invention.

Description

ASSESSMENT O

Claims (8)

1. A method of detecting HPV-induced cell transformation in a patient infected with HPV comprising the steps of:
- measuring at least two HPV-expressed mRNA levels from a sample collected from said patient, wherein said mRNAs comprise a first RNA selected from the group consisting of E6 mRNA and E7 mRNA and a second RNA selected from the group consisting of E2 mRNA and L1 mRNA;
- determining expression level of E6 and/or E7 and expression level of E2 and/or L1 such that a ratio of E6 and/or E7 to L1 and/or E2 is determined, wherein a ratio of greater than 2 is indicative of HPV-induced cell transformation and risk of neoplasia.
2. A method of predicting the onset of HPV-induced cancer in a patient infected with HPV comprising the steps of:
- measuring a group 1 and a group 2 and/or a group 3 HPV
mRNA from a sample collected from said patient;
- determining ratio of group 1 mRNA level to group 2 and/or group 3 mRNA level wherein a ratio of greater than a value of 2 is indicative of neoplastic onset.
3. A method of monitoring stage of HPV-induced disease in a patient infected with HPV comprising the steps of:
- measuring HPV-expressed mRNA levels from a sample collected from said patient;
- determining expression level of E6 and/or E7 and expression level of E2 and/or L1; and - determining a ratio of E6 and/or E7 expression level to L1 and/or E2 expression level wherein a ratio of greater than 2 is indicative or neoplastic change.
4. A method of detecting HPV-induced cancer in a patient infected with HPV
comprising the steps of:
- measuring at least two HPV-expressed mRNA levels from a sample collected from said patient, wherein said mRNAs comprise a first RNA selected from the group consisting of E6 mRNA and E7 mRNA and a second RNA selected from the group consisting of E2 mRNA and L1 mRNA;
- determining expression level of E6 and/or E7 and expression level of E2 and/or L1 such that a ratio of E6 and/or E7 to L1 and/or E2 is determined, wherein a ratio of greater than 4 is indicative of HPV-induced cancer.
5. A method of predicting the risk or onset of HPV-induced cancer in a patient infected with HPV comprising the steps of:
- measuring a group 1 and a group 2 and/or a group 3 HPV
mRNA from a sample collected from said patient;
- determining ratio of group 1 mRNA level to group 2 and/or group 3 mRNA level wherein a ratio of greater than a value of 4 is indicative of HPV-induced cancer onset.
6. A kit comprising at least two different probes capable of detecting HPV
nucleic acid, wherein a first probe is selected from the group consisting of a nucleic acid encoding E2, E4, E6 and E7, and a second probe is selected from the group consisting of a nucleic acid encoding L1, L2, E1, E2, E4, and E5.
7. The kit according to claim 6, wherein at least one probe is a DNA probe.
8. A kit comprising at least two different probes capable of detecting HPV
nucleic acid, wherein a first probe contains a sequence selected from the group consisting of a nucleic acid encoding E2, E4, E7 and E7 and a second probe is selected from the group consisting of a nucleic acid encoding L1, L2, E 1 and E5.
CA2313483A 1997-12-12 1998-12-11 Assessment of human papilloma virus-related disease Expired - Lifetime CA2313483C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US6942697P 1997-12-12 1997-12-12
US7048698P 1998-01-05 1998-01-05
US8216798P 1998-04-17 1998-04-17
US60/070,486 1998-04-17
US60/069,426 1998-04-17
US60/082,167 1998-04-17
PCT/US1998/026447 WO1999029890A2 (en) 1997-12-12 1998-12-11 Assessment of human papilloma virus-related disease

Publications (2)

Publication Number Publication Date
CA2313483A1 true CA2313483A1 (en) 1999-06-17
CA2313483C CA2313483C (en) 2017-12-05

Family

ID=27371534

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002313641A Abandoned CA2313641A1 (en) 1997-12-12 1998-12-11 Universal collection medium
CA2313483A Expired - Lifetime CA2313483C (en) 1997-12-12 1998-12-11 Assessment of human papilloma virus-related disease

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA002313641A Abandoned CA2313641A1 (en) 1997-12-12 1998-12-11 Universal collection medium

Country Status (13)

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US (5) US6969585B2 (en)
EP (2) EP1038022B1 (en)
JP (3) JP2001526045A (en)
AT (1) ATE299946T1 (en)
AU (2) AU746061B2 (en)
BR (2) BR9814272A (en)
CA (2) CA2313641A1 (en)
DE (1) DE69830927T2 (en)
DK (1) DK1038022T3 (en)
ES (1) ES2246546T3 (en)
NO (2) NO20002980L (en)
PT (1) PT1038022E (en)
WO (2) WO1999031273A2 (en)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1038022B1 (en) * 1997-12-12 2005-07-20 Digene Corporation Assessment of human papilloma virus-related disease
KR20020064298A (en) 1999-10-13 2002-08-07 시쿼넘, 인코포레이티드 Methods for generating databases and databases for identifying polymorphic genetic markers
KR100382703B1 (en) * 2000-03-15 2003-05-09 주식회사 바이오메드랩 diagnosis kit for genotyping of Human Papillomavirus and manufacturing method for thereof
AU2001249526A1 (en) * 2000-03-28 2001-10-08 Biosearch International Pty Ltd Approaches for hpv detection and staging by targeting the e6 gene region of the viral genome
EP1294939B1 (en) * 2000-04-03 2010-01-27 Cytyc Corporation Detection and typing of human papillomavirus using pna probes
US20040115692A1 (en) * 2000-04-03 2004-06-17 Cytyc Corporation Methods, compositions and apparatuses for detecting a target in a preservative solution
IT1316070B1 (en) * 2000-05-05 2003-03-28 Bioanalisi Ct Sud Snc Di Perse METHOD AND MEANS FOR IDENTIFICATION OF VIRUS HPV
US7601497B2 (en) 2000-06-15 2009-10-13 Qiagen Gaithersburg, Inc. Detection of nucleic acids by target-specific hybrid capture method
US7439016B1 (en) * 2000-06-15 2008-10-21 Digene Corporation Detection of nucleic acids by type-specific hybrid capture method
WO2001098542A2 (en) 2000-06-21 2001-12-27 Digene Corporation Universal collection medium
GB0018140D0 (en) * 2000-07-24 2000-09-13 Medical Res Council Screening for abnormalities
US20040229298A1 (en) * 2000-11-11 2004-11-18 Lu Peter S. Methods and compositions for treating cervical cancer
US20040121310A1 (en) * 2002-12-18 2004-06-24 Ecker David J. Methods for rapid detection and identification of bioagents in forensic studies
KR100437626B1 (en) * 2001-06-21 2004-06-26 주식회사 마이진 Methods for Dectecting Human Papillomavirus and Detection Kit Thereof
AU2003201639C1 (en) 2002-01-07 2009-02-26 Norchip A/S Method for detecting human papillomavirus mRNA
AU2003284239B2 (en) 2002-10-21 2008-08-21 Eisai Inc. Compositions and methods for treating human papillomavirus-mediated disease
ATE382099T1 (en) * 2003-03-31 2008-01-15 Stichting Res Fonds Pathologie DETECTION OF INVASIVE CANCER INDUCED BY HPV AND ITS PRECURSOR LESIONS WITH INVASION POTENTIAL
US20040203004A1 (en) * 2003-04-10 2004-10-14 Bernard Hans Ulrich Diagnostic apparatus and method
US7361460B2 (en) 2003-04-11 2008-04-22 Digene Corporation Approach to molecular diagnosis of human papillomavirus-related diseases
WO2005008248A2 (en) * 2003-07-18 2005-01-27 Georgetown University Diagnosis and treatment of cervical cancer
ATE289685T1 (en) * 2003-08-25 2005-03-15 Mtm Lab Ag METHOD FOR DETECTING CARCINOMAS IN SOLUBILIZED CERVICAL BODY SAMPLES
EP1510820B1 (en) * 2003-08-25 2010-03-17 MTM Laboratories AG Method for detecting medically relevant conditions in a solubilized LBC sample
US7482142B1 (en) 2004-05-07 2009-01-27 Roche Molecular Systems, Inc. High-risk human papillomavirus detection
US7316904B1 (en) 2004-06-30 2008-01-08 Chromodynamics, Inc. Automated pap screening using optical detection of HPV with or without multispectral imaging
KR100572721B1 (en) * 2004-07-26 2006-04-24 이미영 RNA preservation medium comprising cathodic electrolyzed water and method of preserving RNA using the same
WO2006063065A2 (en) 2004-12-08 2006-06-15 Gen-Probe Incorporated Detection of nucleic acids from multiple types of human papillomaviruses
US20060189893A1 (en) * 2005-01-06 2006-08-24 Diamics, Inc. Systems and methods for detecting abnormal cells
US20060161076A1 (en) * 2005-01-06 2006-07-20 Diamics, Inc. Systems and methods for collection of cell clusters
GB0500996D0 (en) * 2005-01-18 2005-02-23 Delfts Diagnostic Labaratory B Detection method and materials therefor
US7524631B2 (en) * 2005-02-02 2009-04-28 Patterson Bruce K HPV E6, E7 mRNA assay and methods of use thereof
US20070111960A1 (en) * 2005-03-04 2007-05-17 Advandx, Inc. High affinity probes for analysis of human papillomavirus expression
DE102005015005A1 (en) * 2005-04-01 2006-10-05 Qiagen Gmbh Process for treating a sample containing biomolecules
US7972776B2 (en) * 2005-11-15 2011-07-05 Oncohealth Corporation Protein chips for HPV detection
US7732166B2 (en) * 2005-11-15 2010-06-08 Oncohealth Corporation Detection method for human pappilomavirus (HPV) and its application in cervical cancer
EP2041315B1 (en) * 2006-06-19 2010-08-25 Becton, Dickinson and Company Methods and compositions for obtaining amplifiable nucleic acids from tissues, cells, or viruses exposed to transport media
EP2484781B1 (en) * 2006-08-01 2017-08-23 Applied Biosystems, LLC Detection of analytes and nucleic acids
US8968995B2 (en) * 2008-11-12 2015-03-03 Oncohealth Corp. Detection, screening, and diagnosis of HPV-associated cancers
US8916342B2 (en) 2006-11-13 2014-12-23 Oncohealth Corp. Identification of high grade or ≧ CIN2 for early stages and late stages detection, screening, and diagnosis of human papillomavirus (HPV) and HPV-associated cancers
US20100003704A1 (en) * 2008-06-13 2010-01-07 Shuling Cheng IN SITU detection of early stages and late stages HPV infection
WO2008071998A2 (en) * 2006-12-15 2008-06-19 Oncomethylome Sciences Sa Diagnostic methods for diseases caused by a hpv infection comprising determining the methylation status of the hpv genome
JP5241100B2 (en) * 2006-12-28 2013-07-17 シスメックス株式会社 Antigen activation liquid, antigen activation method, and cell detection method
US20090311392A1 (en) * 2007-09-20 2009-12-17 Paul Bernard Newman Novel approach to the controlled decontamination and or detoxification of nuts, grains, fruits and vegetables
WO2009092017A1 (en) * 2008-01-16 2009-07-23 Medical College Of Georgia Research Institute, Inc. Biomarkers for hpv-induced cancer
JP2011518333A (en) * 2008-04-17 2011-06-23 キアジェン ゲイサーズバーグ インコーポレイテッド Composition, method, and kit using synthetic probe for determining presence of target nucleic acid
US8968210B2 (en) 2008-10-01 2015-03-03 Covidien LLP Device for needle biopsy with integrated needle protection
US9782565B2 (en) 2008-10-01 2017-10-10 Covidien Lp Endoscopic ultrasound-guided biliary access system
US11298113B2 (en) 2008-10-01 2022-04-12 Covidien Lp Device for needle biopsy with integrated needle protection
US9186128B2 (en) 2008-10-01 2015-11-17 Covidien Lp Needle biopsy device
US9332973B2 (en) 2008-10-01 2016-05-10 Covidien Lp Needle biopsy device with exchangeable needle and integrated needle protection
WO2010062556A1 (en) 2008-10-27 2010-06-03 Qiagen Gaithersburg Inc. Fast results hybrid capture assay and system
EP2184368A1 (en) 2008-11-07 2010-05-12 DKFZ Deutsches Krebsforschungszentrum Diagnostic transcript and splice patterns of HPV16 in different cervical lesions
GB0820822D0 (en) * 2008-11-13 2008-12-24 Inst Catala D Oncologia Novel product and processes
WO2010064628A1 (en) * 2008-12-05 2010-06-10 オリンパス株式会社 Method for preparing sample containing nucleic acid, solution for preparing sample, and method for analyzing nucleic acid
SG173140A1 (en) 2009-01-27 2011-08-29 Genetic Technologies Ltd Biological sampling device
ES2644516T3 (en) * 2009-01-28 2017-11-29 Qiagen Gaithersburg, Inc. Method and test for sample preparation of large sequence specific volume
CN102414327B (en) 2009-05-01 2015-04-08 奇亚根盖瑟斯堡股份有限公司 A non-target amplification method for detection of RNA splice-forms in a sample
BR112012004699B1 (en) 2009-09-03 2019-10-15 Becton, Dickinson And Company METHODS, COMPOSITIONS AND KITS FOR DIRECT CHEMICAL LYSIS
WO2011032124A1 (en) 2009-09-14 2011-03-17 Qiagen Gaithersburg, Inc. Compositions and methods for recovery of nucleic acids or proteins from tissue samples fixed in cytology media
EP2521778B1 (en) * 2010-01-04 2014-03-19 QIAGEN Gaithersburg, Inc. Methods, compositions, and kits for recovery of nucleic acids or proteins from fixed tissue samples
US9128094B2 (en) 2010-01-08 2015-09-08 Oncohealth Corp. High throughput cell-based HPV immunoassays for diagnosis and screening of HPV-associated cancers
WO2011094528A2 (en) 2010-01-29 2011-08-04 Qiagen Gaithersburg, Inc. Method of determining and confirming the presence of an hpv in a sample
JP6103941B2 (en) * 2010-01-29 2017-03-29 キアジェン ゲイサーズバーグ インコーポレイテッド Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids
WO2011146629A2 (en) 2010-05-19 2011-11-24 Qiagen Gaithersburg Inc. Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids
US9376727B2 (en) 2010-05-25 2016-06-28 Qiagen Gaithersburg, Inc. Fast results hybrid capture assay and associated strategically truncated probes
US9885092B2 (en) 2011-02-24 2018-02-06 Qiagen Gaithersburg Inc. Materials and methods for detection of HPV nucleic acids
US20140127745A1 (en) * 2011-06-24 2014-05-08 Biotechnology Developers, S.A. Method, compositions and device for preparing cytological specimens
JP6103778B2 (en) 2011-11-03 2017-03-29 キアジェン ゲイサーズバーグ インコーポレイテッド Materials and methods for fixing, isolating and concentrating cells using carboxylated surfaces
JP5960421B2 (en) * 2011-12-05 2016-08-02 株式会社日立ハイテクノロジーズ Cell measuring method and cell measuring reagent
DE112013002256T5 (en) 2012-04-28 2015-03-12 CYTOCORE, Inc Method, packaging and device for taking biological samples
US8734364B1 (en) 2013-11-07 2014-05-27 Genetic Technologies Limited Device and method for obtaining a biological sample
WO2016005789A1 (en) * 2014-07-07 2016-01-14 Institut Pasteur Broad range gene and genotype papillomavirus transcriptome as a biomarker of papillomavirus- associated cancer stages
RU2663122C1 (en) 2015-06-30 2018-08-01 Сисмекс Корпорейшн Solution for cell preservation, its application and method for producing a solution for preservation of cells
MX2019003768A (en) 2016-10-03 2019-06-24 Juno Therapeutics Inc Hpv-specific binding molecules.
AU2018345539A1 (en) 2017-10-03 2020-04-16 Editas Medicine, Inc. HPV-specific binding molecules
SG11202009284TA (en) 2018-04-05 2020-10-29 Juno Therapeutics Inc T cell receptors and engineered cells expressing same
PL240016B1 (en) * 2019-09-09 2022-02-07 Genomtec Spolka Akcyjna Set of primers for the detection of human papillomavirus type 16 (HPV16 Human papillomavirus type 16) and human papillomavirus type 18 (HPV18 Human papillomavirus type 18), method of detecting HPV16 and HPV18 infections, the application of a set of primers for the detection of HPV16 and HPV18 infections
US20230087422A1 (en) * 2020-02-07 2023-03-23 Isa Pharmaceuticals B.V. Treatment of hpv-related diseases
WO2023081900A1 (en) 2021-11-08 2023-05-11 Juno Therapeutics, Inc. Engineered t cells expressing a recombinant t cell receptor (tcr) and related systems and methods

Family Cites Families (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4732847A (en) 1981-06-09 1988-03-22 University Of Hawaii Monoclonal antibodies for DNA-RNA hybrid complexes and their uses
FI63596C (en) 1981-10-16 1983-07-11 Orion Yhtymae Oy MICROBIA DIAGNOSIS FOERFARANDE SOM GRUNDAR SIG PAO SKIKTSHYBRIDISERING AV NUCLEINSYROR OCH VID FOERFARANDET ANVAENDA KOMBINATIONER AV REAGENSER
US4578282A (en) * 1982-02-04 1986-03-25 Harrison James S Composition for diagnostic reagents
US4465078A (en) * 1982-09-30 1984-08-14 Medtest Corporation Method for cell sampling in a body cavity
US4865980A (en) 1982-12-29 1989-09-12 University Of Hawaii Monoclonal antibodies for DNA-RNA hybrid complexes and their uses
US5288611A (en) 1983-01-10 1994-02-22 Gen-Probe Incorporated Method for detecting, identifying, and quantitating organisms and viruses
WO1984002721A1 (en) 1983-01-10 1984-07-19 Gen Probe Inc Method for detecting, identifying, and quantitating organisms and viruses
US5200313A (en) 1983-08-05 1993-04-06 Miles Inc. Nucleic acid hybridization assay employing detectable anti-hybrid antibodies
US4743535A (en) 1984-11-07 1988-05-10 Miles Inc. Hybridization assay employing labeled probe and anti-hybrid
EP0144914A3 (en) 1983-12-12 1986-08-13 Miles Inc. Hybridization assay employing labeled pairs of hybrid binding reagents
AU3844485A (en) 1984-02-09 1985-08-15 Enzo Biochem Inc. Heterologous detection of cabeled dna
FI71768C (en) 1984-02-17 1987-02-09 Orion Yhtymae Oy Enhanced nucleic acid reagents and process for their preparation.
CA1260372A (en) * 1984-04-27 1989-09-26 Elazar Rabbani Hybridization method for the detection of genetic materials
US6221581B1 (en) 1984-04-27 2001-04-24 Enzo Diagnostics, Inc. Processes for detecting polynucleotides, determining genetic mutations or defects in genetic material, separating or isolating nucleic acid of interest from samples, and useful compositions of matter and multihybrid complex compositions
CA1253777A (en) 1984-06-01 1989-05-09 Robert J. Carrico Nucleic acid hybridization assay employing immobilized rna probes
ZA853756B (en) 1984-06-01 1986-01-29 Miles Lab Nucleic acid hybridization assay employing immobilized rna probes
US4563417A (en) 1984-08-31 1986-01-07 Miles Laboratories, Inc. Nucleic acid hybridization assay employing antibodies to intercalation complexes
US4775619A (en) 1984-10-16 1988-10-04 Chiron Corporation Polynucleotide determination with selectable cleavage sites
US4751177A (en) 1985-06-13 1988-06-14 Amgen Methods and kits for performing nucleic acid hybridization assays
US5641630A (en) 1985-06-13 1997-06-24 Amgen Inc. Method and kit for performing nucleic acid hybridization assays
US4888278A (en) * 1985-10-22 1989-12-19 University Of Massachusetts Medical Center In-situ hybridization to detect nucleic acid sequences in morphologically intact cells
US4868105A (en) 1985-12-11 1989-09-19 Chiron Corporation Solution phase nucleic acid sandwich assay
US5750338A (en) 1986-10-23 1998-05-12 Amoco Corporation Target and background capture methods with amplification for affinity assays
IL85551A0 (en) 1987-04-01 1988-08-31 Miles Inc Rapid hybridization assay and reagent system used therein
GB8717169D0 (en) * 1987-07-21 1987-08-26 Ti Interlock Ltd Pneumatic control system
US5656731A (en) 1987-10-15 1997-08-12 Chiron Corporation Nucleic acid-amplified immunoassay probes
US5359100A (en) 1987-10-15 1994-10-25 Chiron Corporation Bifunctional blocked phosphoramidites useful in making nucleic acid mutimers
US5082830A (en) 1988-02-26 1992-01-21 Enzo Biochem, Inc. End labeled nucleotide probe
US6326136B1 (en) 1988-04-01 2001-12-04 Digene Corporation Macromolecular conjugate made using unsaturated aldehydes
US5374524A (en) 1988-05-10 1994-12-20 E. I. Du Pont De Nemours And Company Solution sandwich hybridization, capture and detection of amplified nucleic acids
US5639871A (en) * 1988-09-09 1997-06-17 Roche Molecular Systems, Inc. Detection of human papillomavirus by the polymerase chain reaction
DE69017204T2 (en) 1989-03-10 1995-08-03 Amoco Corp IMMOBILIZED OLIGONUCLEOTIDE PROBE AND THEIR USE.
US5106727A (en) 1989-04-27 1992-04-21 Life Technologies, Inc. Amplification of nucleic acid sequences using oligonucleotides of random sequences as primers
ATE174926T1 (en) 1989-06-30 1999-01-15 Chiron Corp HYDROPHOBIC NUCLEIC ACID PROBE
US5116734A (en) 1989-09-01 1992-05-26 Digene Diagnostics, Inc. Highly sensitive method for detecting peroxidase
JPH05501650A (en) * 1989-12-01 1993-04-02 バイシス・インコーポレーテツド Detection of HPV transcripts
US5580970A (en) 1989-12-01 1996-12-03 Amoco Corporation Detection of HPV transcripts
US5629153A (en) 1990-01-10 1997-05-13 Chiron Corporation Use of DNA-dependent RNA polymerase transcripts as reporter molecules for signal amplification in nucleic acid hybridization assays
US5792606A (en) 1990-02-26 1998-08-11 Boehringer Mannheim Gmbh Nucleic acid hybridization based assay for determining a substance of interest
CA2039517C (en) 1990-04-03 2006-11-07 David Segev Dna probe signal amplification
US5695926A (en) 1990-06-11 1997-12-09 Bio Merieux Sandwich hybridization assays using very short capture probes noncovalently bound to a hydrophobic support
US5484699A (en) 1990-09-28 1996-01-16 Abbott Laboratories Nucleotide sequences useful as type specific probes, PCR primers and LCR probes for the amplification and detection of human papilloma virus, and related kits and methods
CA2095611A1 (en) 1990-11-14 1992-05-15 Jennifer Kyoko Ishii Non-isotopic detection of nucleic acids using a polystyrene support-based sandwich hybridization assay and compositions useful therefor
US5256571A (en) * 1991-05-01 1993-10-26 Cytyc Corporation Cell preservative solution
US5543294A (en) * 1991-07-19 1996-08-06 The Trustees Of Columbia University In The City Of New York Polymerase chain reaction/restriction fragment length polymorphism method for the detection and typing of myobacteria
US5556748A (en) 1991-07-30 1996-09-17 Xenopore Corporation Methods of sandwich hybridization for the quantitative analysis of oligonucleotides
US5981179A (en) 1991-11-14 1999-11-09 Digene Diagnostics, Inc. Continuous amplification reaction
ES2145750T3 (en) 1991-11-14 2000-07-16 Dgi Inc KIT AND DOSAGE USING NON-RADIOACTIVE HYBRIDIZATION.
DE69231693T2 (en) 1991-12-23 2001-05-31 Bayer Ag HBV AMPLIFICATION PROBE FOR USE IN HYBRIDIZATION SANDWICH ASSAY IN THE SOLUTION PHASE
US5747244A (en) 1991-12-23 1998-05-05 Chiron Corporation Nucleic acid probes immobilized on polystyrene surfaces
US5424413A (en) 1992-01-22 1995-06-13 Gen-Probe Incorporated Branched nucleic acid probes
IL106273A0 (en) 1992-07-17 1993-11-15 Res Dev Foundation Rapid detection of biopolymers in stained specimens
DE69327454T2 (en) 1992-10-09 2000-05-11 Vysis Inc ANALYTICAL PROCEDURE
WO1994016108A1 (en) 1993-01-15 1994-07-21 The Public Health Research Institute Of The City Of New York, Inc. Sensitive nucleic acid sandwich hybridization assays and kits
US5357977A (en) * 1993-04-23 1994-10-25 St. Mary's Hospital And Medical Center, Inc. Cytological sampling method and device
WO1994028156A1 (en) 1993-05-20 1994-12-08 Dana-Farber Cancer Institute Compositions and methods for treatment of herpesvirus infections
WO1995003430A1 (en) 1993-07-23 1995-02-02 Gen-Probe Incorporated Methods for enhancing nucleic acid amplification
DE4331012A1 (en) 1993-09-13 1995-03-16 Bayer Ag Nucleic acid-binding oligomers with N-branching for therapy and diagnostics
US5370128A (en) * 1993-12-02 1994-12-06 Wainwright; Sharon R. Pap brush and pap unit container systems
US5681697A (en) 1993-12-08 1997-10-28 Chiron Corporation Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor
EP0754241B1 (en) 1994-04-04 1998-12-02 Ciba Corning Diagnostics Corp. Hibridization-ligation assays for the detection of specific nucleic acid sequences
CA2126952C (en) 1994-06-28 2010-12-14 Sithian Pandian Probe, kit, and method of amplification for increasing the sensitivity of nucleic acid hybridization assays
US5681702A (en) 1994-08-30 1997-10-28 Chiron Corporation Reduction of nonspecific hybridization by using novel base-pairing schemes
JP3093116B2 (en) 1994-09-30 2000-10-03 株式会社豊田中央研究所 Nucleic acid detection method
US6057099A (en) 1994-12-02 2000-05-02 Intelligene Ltd. Detection of nucleic acid sequences
US5747248A (en) 1994-12-05 1998-05-05 Chiron Corporation Discontinuous probe design using hybritope mapping
DE4445769C1 (en) * 1994-12-21 1995-11-09 Biochrom Kg Protective media for storing vital tissues
CA2139070C (en) 1994-12-23 2010-03-30 Burton W. Blais Method for enhancing detection ability of nucleic acid assays employing polymerase chain reaction
US5731153A (en) 1996-08-26 1998-03-24 The Regents Of The University Of California Identification of random nucleic acid sequence aberrations using dual capture probes which hybridize to different chromosome regions
US5888724A (en) 1995-02-17 1999-03-30 The Trustees Of Columbia University In The City Of New York Detection of high oncogenic-risk papilloma virus in high grade cervical lesions and cancers by a PCR/ELISA assay
US6083925A (en) 1995-06-07 2000-07-04 Connaught Laboratories Limited Nucleic acid respiratory syncytial virus vaccines
WO1997018334A2 (en) 1995-11-15 1997-05-22 Gen-Probe Incorporated Nucleic acid probes complementary to human papillomavirus nucleic acid and related methods and kits
US5853993A (en) 1996-10-21 1998-12-29 Hewlett-Packard Company Signal enhancement method and kit
US5679333A (en) * 1996-10-25 1997-10-21 Dunphy; Brian William Formaldehyde-free tissue preservative compositions
US6110676A (en) 1996-12-04 2000-08-29 Boston Probes, Inc. Methods for suppressing the binding of detectable probes to non-target sequences in hybridization assays
US20020034737A1 (en) 1997-03-04 2002-03-21 Hyseq, Inc. Methods and compositions for detection or quantification of nucleic acid species
US6043038A (en) 1998-03-31 2000-03-28 Tularik, Inc. High-throughput screening assays for modulators of primase activity
WO1999023250A2 (en) 1997-11-04 1999-05-14 Roche Diagnostics Gmbh Specific and sensitive method for detecting nucleic acids
EP1038022B1 (en) 1997-12-12 2005-07-20 Digene Corporation Assessment of human papilloma virus-related disease
US20030096232A1 (en) 1997-12-19 2003-05-22 Kris Richard M. High throughput assay system
US5994079A (en) 1998-02-06 1999-11-30 Digene Corporation Direct detection of RNA mediated by reverse transcriptase lacking RNAse H function
US6686151B1 (en) 1998-02-06 2004-02-03 Digene Corporation Immunological detection of RNA:DNA hybrids on microarrays
US7399589B2 (en) 1998-02-06 2008-07-15 Digene Corporation Immunological detection of RNA:DNA hybrids on microarrays
US20010055766A1 (en) 1999-04-02 2001-12-27 Alexander Aristarkhov Immunosorbant assay using branched bis-biotin/avidin/multiple label complex as a detection reagent
US7019822B1 (en) 1999-04-29 2006-03-28 Mss, Inc. Multi-grade object sorting system and method
US6544732B1 (en) 1999-05-20 2003-04-08 Illumina, Inc. Encoding and decoding of array sensors utilizing nanocrystals
US6893819B1 (en) 2000-11-21 2005-05-17 Stratagene California Methods for detection of a nucleic acid by sequential amplification
US6436662B1 (en) 2000-04-04 2002-08-20 Digene Corporation Device and method for cytology slide preparation
US6521190B1 (en) 2000-05-19 2003-02-18 Digene Corporation Cell collection apparatus
EP1290225A4 (en) 2000-05-20 2004-09-15 Univ Michigan Method of producing a dna library using positional amplification
US7601497B2 (en) 2000-06-15 2009-10-13 Qiagen Gaithersburg, Inc. Detection of nucleic acids by target-specific hybrid capture method
US7439016B1 (en) 2000-06-15 2008-10-21 Digene Corporation Detection of nucleic acids by type-specific hybrid capture method
WO2001098542A2 (en) 2000-06-21 2001-12-27 Digene Corporation Universal collection medium
US6977148B2 (en) 2001-10-15 2005-12-20 Qiagen Gmbh Multiple displacement amplification
CA2594771A1 (en) 2005-01-14 2006-07-20 The Regents Of The University Of Michigan Systems, methods, and compositions for detection of human papilloma virus in biological samples
US7972776B2 (en) 2005-11-15 2011-07-05 Oncohealth Corporation Protein chips for HPV detection
EP2413142B1 (en) 2007-02-27 2013-06-05 Nuclea Biomarkers LLC Method for predicting the response of NSCLC-patients to treatment by an EGFR-TK inhibitor
US7985375B2 (en) 2007-04-06 2011-07-26 Qiagen Gaithersburg, Inc. Sample preparation system and method for processing clinical specimens
JP2011518333A (en) 2008-04-17 2011-06-23 キアジェン ゲイサーズバーグ インコーポレイテッド Composition, method, and kit using synthetic probe for determining presence of target nucleic acid
US9090948B2 (en) 2008-09-30 2015-07-28 Abbott Molecular Inc. Primers and probes for detecting human papillomavirus and human beta globin sequences in test samples

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