CA2311301A1 - Method and apparatus for making quantitative measurements of localized aaccumulations of magnetic particles - Google Patents

Method and apparatus for making quantitative measurements of localized aaccumulations of magnetic particles Download PDF

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Publication number
CA2311301A1
CA2311301A1 CA002311301A CA2311301A CA2311301A1 CA 2311301 A1 CA2311301 A1 CA 2311301A1 CA 002311301 A CA002311301 A CA 002311301A CA 2311301 A CA2311301 A CA 2311301A CA 2311301 A1 CA2311301 A1 CA 2311301A1
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CA
Canada
Prior art keywords
magnetic particles
aaccumulations
localized
quantitative measurements
making quantitative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002311301A
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French (fr)
Other versions
CA2311301C (en
Inventor
Michael Bancroft Simmonds
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Quantum Design Inc
Original Assignee
Quantum Design, Inc.
Michael Bancroft Simmonds
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quantum Design, Inc., Michael Bancroft Simmonds filed Critical Quantum Design, Inc.
Publication of CA2311301A1 publication Critical patent/CA2311301A1/en
Application granted granted Critical
Publication of CA2311301C publication Critical patent/CA2311301C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y25/00—Nanomagnetism, e.g. magnetoimpedance, anisotropic magnetoresistance, giant magnetoresistance or tunneling magnetoresistance
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/72—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables
    • G01N27/74—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids
    • G01N27/745—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids for detecting magnetic beads used in biochemical assays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation

Abstract

Apparatus for quantitatively measuring groups of magnetic particles. The particles are complexed with substances to be determined and are excited in a magnetic field.
The magnetic particles (11) are thereby caused to oscillate at the excitation frequency in the manner of a dipole to create their own fields.
These fields are inductively coupled to sensing coils (43) fabricated in a gradiometer configuration. The output signals from the sensing coils are appropriately amplified and processed to provide useful output indications.
CA002311301A 1997-11-21 1998-08-27 Method and apparatus for making quantitative measurements of localized aaccumulations of magnetic particles Expired - Lifetime CA2311301C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/975,569 US6046585A (en) 1997-11-21 1997-11-21 Method and apparatus for making quantitative measurements of localized accumulations of target particles having magnetic particles bound thereto
US08/975,569 1997-11-21
PCT/US1998/017815 WO1999027369A1 (en) 1997-11-21 1998-08-27 Method and apparatus for making quantitave measurements of localized accumulations of magnetic particles

Publications (2)

Publication Number Publication Date
CA2311301A1 true CA2311301A1 (en) 1999-06-03
CA2311301C CA2311301C (en) 2005-01-18

Family

ID=25523154

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002311301A Expired - Lifetime CA2311301C (en) 1997-11-21 1998-08-27 Method and apparatus for making quantitative measurements of localized aaccumulations of magnetic particles

Country Status (15)

Country Link
US (2) US6046585A (en)
EP (1) EP1036328B1 (en)
JP (1) JP3760096B2 (en)
KR (1) KR100389778B1 (en)
CN (1) CN1128365C (en)
AT (1) ATE280390T1 (en)
AU (1) AU9207998A (en)
BR (1) BR9815566B1 (en)
CA (1) CA2311301C (en)
DE (1) DE69827158T2 (en)
DK (1) DK1036328T3 (en)
ES (1) ES2232020T3 (en)
HK (1) HK1033771A1 (en)
IL (1) IL136211A (en)
WO (1) WO1999027369A1 (en)

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Also Published As

Publication number Publication date
US6275031B1 (en) 2001-08-14
WO1999027369A1 (en) 1999-06-03
CA2311301C (en) 2005-01-18
JP2001524675A (en) 2001-12-04
IL136211A (en) 2003-04-10
ES2232020T3 (en) 2005-05-16
EP1036328B1 (en) 2004-10-20
JP3760096B2 (en) 2006-03-29
DE69827158T2 (en) 2005-10-13
EP1036328A1 (en) 2000-09-20
ATE280390T1 (en) 2004-11-15
IL136211A0 (en) 2001-05-20
KR100389778B1 (en) 2003-07-02
BR9815566A (en) 2000-10-31
US6046585A (en) 2000-04-04
BR9815566B1 (en) 2011-02-08
DE69827158D1 (en) 2004-11-25
HK1033771A1 (en) 2001-09-21
CN1279764A (en) 2001-01-10
KR20010032302A (en) 2001-04-16
DK1036328T3 (en) 2005-01-31
CN1128365C (en) 2003-11-19
AU9207998A (en) 1999-06-15

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