CA2302601A1 - Transdermal therapeutic system comprising a reservoir-type pressure-sensitive adhesive layer and a back layer with uni-directional resilience - Google Patents

Transdermal therapeutic system comprising a reservoir-type pressure-sensitive adhesive layer and a back layer with uni-directional resilience Download PDF

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Publication number
CA2302601A1
CA2302601A1 CA002302601A CA2302601A CA2302601A1 CA 2302601 A1 CA2302601 A1 CA 2302601A1 CA 002302601 A CA002302601 A CA 002302601A CA 2302601 A CA2302601 A CA 2302601A CA 2302601 A1 CA2302601 A1 CA 2302601A1
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CA
Canada
Prior art keywords
sensitive adhesive
therapeutic system
transdermal therapeutic
uni
reservoir
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002302601A
Other languages
French (fr)
Other versions
CA2302601C (en
Inventor
Thomas Hille
Lothar Deurer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LTS Lohmann Therapie Systeme AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2302601A1 publication Critical patent/CA2302601A1/en
Application granted granted Critical
Publication of CA2302601C publication Critical patent/CA2302601C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Abstract

A transdermal therapeutic system (TTS), in particular a patch, is described, comprising - a redetachable protective layer, - a pressure-sensitive adhesive reservoir layer and - a backing layer with or without a coating of pressure-sensitive adhesive and featuring a unidirectionally, preferably longitudinally, elastic material having an elasticity of at least 20%. The TTS is particularly suitable for use as a multi-day plaster, for the treatment, for instance, of pain or of drug dependency.
CA002302601A 1997-09-05 1998-08-21 Transdermal therapeutic system comprising a reservoir-type pressure-sensitive adhesive layer and a back layer with uni-directional resilience Expired - Lifetime CA2302601C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19738855.8 1997-09-05
DE19738855A DE19738855C2 (en) 1997-09-05 1997-09-05 Transdermal therapeutic system with adhesive reservoir layer and unidirectional elastic back layer
PCT/EP1998/005321 WO1999012529A2 (en) 1997-09-05 1998-08-21 Transdermal therapeutic system comprising a reservoir-type pressure-sensitive adhesive layer and a back layer with uni-directional resilience

Publications (2)

Publication Number Publication Date
CA2302601A1 true CA2302601A1 (en) 1999-03-18
CA2302601C CA2302601C (en) 2006-06-13

Family

ID=7841309

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002302601A Expired - Lifetime CA2302601C (en) 1997-09-05 1998-08-21 Transdermal therapeutic system comprising a reservoir-type pressure-sensitive adhesive layer and a back layer with uni-directional resilience

Country Status (14)

Country Link
US (2) US6814976B1 (en)
EP (1) EP1009393B1 (en)
JP (1) JP3847088B2 (en)
KR (1) KR100515007B1 (en)
AT (1) ATE215364T1 (en)
AU (1) AU738033B2 (en)
CA (1) CA2302601C (en)
DE (2) DE19738855C2 (en)
DK (1) DK1009393T3 (en)
ES (1) ES2175792T3 (en)
NO (1) NO327605B1 (en)
PT (1) PT1009393E (en)
SI (1) SI1009393T1 (en)
WO (1) WO1999012529A2 (en)

Cited By (1)

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US6756052B1 (en) 1999-05-21 2004-06-29 Lts Lohmann Therapie-Systeme Ag Device and method for increasing the transdermal permeation of medicaments

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US5968547A (en) 1997-02-24 1999-10-19 Euro-Celtique, S.A. Method of providing sustained analgesia with buprenorphine
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GB0117583D0 (en) * 2001-07-19 2001-09-12 Astrazeneca Ab Novel compounds
DE10159745A1 (en) * 2001-12-05 2003-07-03 Lohmann Therapie Syst Lts Transdermal therapeutic system with improved long-term comfort
EP1795189A3 (en) * 2002-03-20 2007-08-15 Euro-Celtique S.A. Method of administering buprenorphine to treat depression
AU2003224742A1 (en) * 2002-03-20 2003-10-08 Euro-Celtique S.A. Method of administering buprenorphine to treat depression
DE10305137A1 (en) * 2003-02-07 2004-08-26 Novosis Ag Transdermal therapeutic delivery systems with a butenolide
CA2516618A1 (en) * 2003-02-27 2004-09-10 Shirankai Kyoto University Faculty Of Medicine Alumni Association Inc. Pharmaceutical composition for treatment of drug dependence
US7052052B2 (en) * 2003-03-13 2006-05-30 Donaldson Company, Inc. Sealing gasket for a clamp
RU2356580C2 (en) * 2003-10-28 2009-05-27 Новен Фармасьютикалз, Инк Compositions and methods providing controlled drug loss and delivery within transdermal drug delivery systems
DE102004012442C5 (en) * 2004-03-13 2012-01-26 Paul Hartmann Ag Elastic bandage segment
EP1802258A4 (en) 2004-09-13 2015-09-23 Chrono Therapeutics Inc Biosynchronous transdermal drug delivery
US8252321B2 (en) 2004-09-13 2012-08-28 Chrono Therapeutics, Inc. Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like
DE502006002907D1 (en) * 2005-09-13 2009-04-02 Sabine Hohmann COMPOSITE MATERIAL WITH ACTIVE SUBSTANCES
US7955677B2 (en) * 2005-12-07 2011-06-07 Mylan Technologies, Inc. Two-sided non-stick release film
BRPI0620216A2 (en) * 2005-12-20 2011-11-01 Teikoku Pharma Usa Inc methods for transdermally administering an indole serotonin receptor agonist and transdermal compositions for use therein
BRPI0809430A2 (en) * 2007-07-23 2014-09-09 Teikoku Pharma Usa Inc ORGANOLEPTICALLY ACCEPTABLE ORAL FORMULATIONS OF AN INDOL CEROTONIN RECEIVER AGONIST AND METHODS OF USE
EP2178480B1 (en) * 2007-08-21 2010-10-27 LTS LOHMANN Therapie-Systeme AG Method for the multi-track tailoring of transdermal therapeutic patches
DE102008059054A1 (en) 2008-11-26 2010-05-27 Otto Bock Pur Life Science Gmbh Polyurethane patch for the transdermal application of active substances and process for its preparation
US8299079B2 (en) 2009-05-22 2012-10-30 Kaufman Herbert E Preparations and methods for ameliorating or reducing presbyopia
DE102009056746A1 (en) * 2009-12-04 2011-06-09 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system for the administration of peptides
EP2366388A1 (en) * 2010-03-17 2011-09-21 Ratiopharm GmbH Non-occlusive transdermal therapeutic system for administering buprenorphine
US20130017259A1 (en) 2011-07-06 2013-01-17 The Parkinson's Institute Compositions and Methods for Treatment of Symptoms in Parkinson's Disease Patients
DE102014007650A1 (en) 2013-05-24 2014-11-27 Amw Gmbh Plaster with bielastic backing layer
AP2015008920A0 (en) 2013-06-04 2015-12-31 Lohmann Therapie Syst Lts Transdermal delivery system
EP2921184A1 (en) * 2014-03-19 2015-09-23 LTS LOHMANN Therapie-Systeme AG Finishing plaster having improved tolerability and a long adhesive period and method for producing the same
DE102014013448A1 (en) 2014-09-16 2016-03-17 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Transdermal therapeutic system comprising buprenorphine
US9656441B2 (en) 2015-01-08 2017-05-23 Alfred E. Tiefenbacher ( Gmbh & Co. Kg) Transdermal patch
US10213586B2 (en) 2015-01-28 2019-02-26 Chrono Therapeutics Inc. Drug delivery methods and systems
CA2977814A1 (en) 2015-03-12 2016-09-15 Chrono Therapeutics Inc. Craving input and support system
EP3067050A1 (en) 2015-03-13 2016-09-14 Acino AG Transdermal therapeutic system with an overtape comprising two adhesive layers
DE102015006599A1 (en) 2015-05-21 2016-11-24 Amw Gmbh Plaster with bielastic backing layer
PL3297591T3 (en) 2015-05-21 2023-05-15 Adhexpharma Sas Plaster with bi-elastic backing layer
DE102016105889A1 (en) * 2016-03-31 2017-10-05 Amw Gmbh Transdermal application system with information layer
CA3049529A1 (en) 2017-01-06 2018-07-12 Chrono Therapeutics Inc. Transdermal drug delivery devices and methods
DE102017112543A1 (en) * 2017-06-07 2018-12-13 Amw Gmbh Overtape for a transdermal delivery system
GB2571696B (en) 2017-10-09 2020-05-27 Compass Pathways Ltd Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
CN107753181A (en) * 2017-10-19 2018-03-06 中国计量大学 The topical application of drug device of disease of skin
CA3101966A1 (en) 2018-05-29 2019-12-05 Morningside Venture Investments Limited Drug delivery methods and systems
CN113993523A (en) 2019-04-17 2022-01-28 指南针探路者有限公司 Treatment of depression and other various disorders with siloxibin

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6756052B1 (en) 1999-05-21 2004-06-29 Lts Lohmann Therapie-Systeme Ag Device and method for increasing the transdermal permeation of medicaments

Also Published As

Publication number Publication date
NO20001003D0 (en) 2000-02-28
US6814976B1 (en) 2004-11-09
US20040253301A1 (en) 2004-12-16
JP2001515856A (en) 2001-09-25
JP3847088B2 (en) 2006-11-15
SI1009393T1 (en) 2002-10-31
PT1009393E (en) 2002-09-30
KR100515007B1 (en) 2005-09-14
ES2175792T3 (en) 2002-11-16
US7384651B2 (en) 2008-06-10
DK1009393T3 (en) 2002-07-22
EP1009393B1 (en) 2002-04-03
WO1999012529A3 (en) 1999-05-27
ATE215364T1 (en) 2002-04-15
NO20001003L (en) 2000-02-28
DE19738855C2 (en) 2001-01-04
AU738033B2 (en) 2001-09-06
CA2302601C (en) 2006-06-13
EP1009393A2 (en) 2000-06-21
DE19738855A1 (en) 1999-03-11
DE59803647D1 (en) 2002-05-08
AU9532998A (en) 1999-03-29
WO1999012529A2 (en) 1999-03-18
KR20010023691A (en) 2001-03-26
NO327605B1 (en) 2009-08-31

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EEER Examination request
MKEX Expiry

Effective date: 20180821