CA2294981A1 - Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof - Google Patents

Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof Download PDF

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Publication number
CA2294981A1
CA2294981A1 CA002294981A CA2294981A CA2294981A1 CA 2294981 A1 CA2294981 A1 CA 2294981A1 CA 002294981 A CA002294981 A CA 002294981A CA 2294981 A CA2294981 A CA 2294981A CA 2294981 A1 CA2294981 A1 CA 2294981A1
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CA
Canada
Prior art keywords
paclitaxel
formulation
administration
subject
dose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002294981A
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French (fr)
Other versions
CA2294981C (en
Inventor
Neil P. Desai
Patrick Soon-Shiong
Shlomo Magdassi
David C. Sahadevan
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Abraxis Bioscience LLC
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Individual
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Priority claimed from US08/926,155 external-priority patent/US6096331A/en
Application filed by Individual filed Critical Individual
Priority to CA2765222A priority Critical patent/CA2765222C/en
Publication of CA2294981A1 publication Critical patent/CA2294981A1/en
Application granted granted Critical
Publication of CA2294981C publication Critical patent/CA2294981C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5169—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

In accordance with the present invention, there are provided compositions and methods useful for the in vivo delivery of substantially water insoluble pharmacologically active agents (such as the anticancer drug paclitaxel) in which the pharmacologically active agent is delivered in the form of suspended particles coated with protein (which acts as a stabilizing agent). In particular, protein and pharmacologically active agent in a biocompatible dispersing medium are subjected to high shear, in the absence of any conventional surfactants, and also in the absence of any polymeric core material for the particles. The procedure yields particles with a diameter of less than about 1 micron. The use of specific composition and preparation conditions (e.g., addition of a polar solvent to the organic phase), and careful selection of the proper organic phase and phase fraction, enables the reproducible production of unusually small nanoparticles of less than 200 nm diameter, which can be sterile-filtered. The particulate system produced according to the invention can be converted into a redispersible dry powder comprising nanoparticles of water-insoluble drug coated with a protein, and free protein to which molecules of the pharmacological agent are bound. This results in a unique delivery system, in which part of the pharmacologically active agent is readily bioavailable (in the form of molecules bound to the protein), and part of the agent is present within particles without any polymeric matrix therein.

Claims (65)

1. A method for reducing the toxicity of paclitaxel in a subject undergoing treatment with paclitaxel, said method comprising systemically administering said paclitaxel to said subject in a pharmaceutically acceptable formulation at a dose of at least 175 mg/m2 over an administration period of no greater than 2 hours.
2. A method according to claim 1, wherein said dose is at least 250 mg/m2.
3. A method according to claim 1, wherein said dose is at least 325 mg/m2.

SUBSTI
4. A method according to claim 1, wherein said administration period is no greater than 1 hour.
5. A method according to claim 1, wherein said administration period is no greater than 30 minutes.
6. A method according to claim 1, wherein said paclitaxel is administered orally, intramuscularly, intravenously, intraperitoneally, or by inhalation.
7. A method according to claim 1, wherein said treatment is for prostate cancer, orchidectomy, pancreatic cancer, or brain tumor.
8. A method according to claim 1, wherein the hematologic or neurological toxicity of said paclitaxel is reduced.
9. A method for the administration of paclitaxel to a subject in need thereof, without the need for pre-medication prior to administration of said paclitaxel, said method comprising systemically administering said paclitaxel to said subject in a pharmaceutically acceptable formulation at a dose of at least 135 mg/m2 over an administration period of no greater than 2 hours.
10. A method according to claim 9, wherein said dose is at least 250 mg/m2.
11. A method according to claim 9, wherein said dose is at least 325 mg/m2.
12. A method according to claim 9, wherein said administration period is no greater than 1 hour.
13. A method according to claim 9, wherein said administration period is no greater than 5 minutes.
14. A method according to claim 9, wherein said paclitaxel is administered orally, intramuscularly, intravenously, or intraperitoneally, intraarterial, intraurethral, intrathecal.
15. A method according to claim 9, wherein said treatment is for prostate cancer, orchidectomy, pancreatic cancer, or brain tumor.
16. A method for the administration of paclitaxel to a subject in need thereof, said method comprising systemically administering said paclitaxel to said subject in a pharmaceutically acceptable formulation at a dose of at least 135 mg/m2 over an administration period of no greater than 2 hours, with a treatment cycle of less than 3 weeks.
17. A method according to claim 16, wherein said dose is at least 250 mg/m2.
18. A method according to claim 16, wherein said dose is at least 325 mg/m2.
19. A method according to claim 16, wherein said treatment cycle is less than 2 weeks.
20. A method according to claim 16, wherein said treatment cycle is less than 1 week.
21. A method according to claim 16, wherein said paclitaxel is administered orally, intramuscularly, intravenously, or intraperitoneally.
22. A method according to claim 16, wherein said treatment is for prostate cancer, orchidectomy, pancreatic cancer, or brain tumor.
23. A method for the administration of paclitaxel to a subject in need thereof, said method comprising systemically administering said paclitaxel to said subject in a pharmaceutically acceptable formulation at a dose of at least 250 mg/m2.
24. A method according to claim 23, wherein said dose is at least 325 mg/m2.
25. A method according to claim 23, wherein said treatment cycle is less than 2 weeks.
26. A method according to claim 23, wherein said treatment cycle is less than 1 week.
27. A method according to claim 23, wherein said paclitaxel is administered orally, intramuscularly, intravenously, or intraperitoneally.
28. A method according to claim 23, wherein said treatment is for prostate cancer, orchidectomy, pancreatic cancer, or brain tumor.
29. A method for the administration of paclitaxel to a subject in need thereof, said method comprising systemically administering said paclitaxel to said subject in a formulation that may be safely administered using medical hardware made from materials containing extractable components.
30. A method according to claim 29, wherein said medical hardware is selected from the group consisting of tubing, catheters, infusion bags, bottles, and syringes.
31. A method for the administration of paclitaxel to a subject in need thereof, said method comprising systemically administering said paclitaxel to said subject in a formulation that may be safely administered without the use of an in-line filter.
32. A method for the administration of paclitaxel to a subject in need thereof, said method comprising systemically administering a complete dose of said paclitaxel to said subject in a volume of less than 250 ml.
33. A method according to claim 32, wherein said volume is less than 150 ml.
34. A method according to claim 32, wherein said volume is less than 60 ml.
35. A method for the administration of paclitaxel to a subject in need thereof, said method comprising systemically administering said paclitaxel to said subject at a rate of at least 50 mg/m2/hour.
36. A formulation of paclitaxel having reduced hematologic toxicity to a subject undergoing treatment with paclitaxel, said formulation comprising paclitaxel in a pharmaceutically acceptable formulation suitable for systemic administration at a dose of at least 175 mg/m2 over an administration period of no greater than 2 hours.
37. A formulation according to claim 36 wherein said dose is at least 250 mg/m2.
38. A formulation according to claim 36 wherein said dose is at least 325 mg/m2.
39. A formulation of paclitaxel suitable for administration of paclitaxel to a subject in need thereof, without the need for pre-medication prior to administration of said paclitaxel, said formulation comprising paclitaxel in a pharmaceutically acceptable formulation suitable for systemic administration at a dose of at least 135 mg/m2 over an administration period of no greater than 2 hours.
40. A formulation according to claim 39 wherein said dose is at least 250 mg/m2.
41. A formulation according to claim 39 wherein said dose is at least 325 mg/m2.
42. A formulation of paclitaxel suitable for administration of paclitaxel to a subject in need thereof with a treatment cycle of less than 3 weeks, said formulation comprising paclitaxel in a pharmaceutically acceptable formulation suitable for systemic administration at a dose of at least 135 mg/m2 over an administration period of no greater than 2 hours.
43. A formulation according to claim 42 wherein said dose is at least 250 mg/m2.
44. A formulation according to claim 42 wherein said dose is at least 325 mg/m2.
45. A formulation of paclitaxel suitable for administration of paclitaxel to a subject in need thereof, said formulation comprising paclitaxel in a pharmaceutically acceptable formulation free of cremaphor.
46. A lyophilized formulation of paclitaxel suitable for administration of paclitaxel to a subject in need thereof upon reconstitution.
47. A reconstituted formulation of paclitaxel suitable for administration of paclitaxel to a subject in need thereof, said formulation comprising the lyophilized formulation of claim 41 and water or an aqueous solution.
48. A frozen formulation of paclitaxel suitable for administration of paclitaxel to a subject in need thereof upon thawing.
49. A liquid formulation of paclitaxel comprising water and paclitaxel at a concentration of at least 2.0 mg/ml.
50. A liquid formulation of paclitaxel according to claim 49, wherein said paclitaxel concentration is at least 5.0 mg/ml.
51. A liquid formulation of paclitaxel according to claim 49, wherein said paclitaxel concentration is at least 10.0 mg/ml.
52. A drug formulation suitable for administration of drug to a subject in need thereof by inhalation, said formulation comprising protein microparticles having a size of about 1-10 µm, wherein said protein microparticles comprise drug nanoparticles having a size of about 50-1,000 nm, plus optionally an excipient.
53. A method of making nanoparticles containing an active agent, said method comprising:
a) combining a non-volatile phase, a volatile phase, and a surfactant that spontaneously form a microemulsion, wherein said volatile phase contains said active agent; and b) removing said volatile phase and thereby obtaining a suspension of solid nanoparticles in said non-volatile phase, wherein said nanoparticles contain said active agent and have an average diameter of less than 100 nm.
54. A method according to claim 53, wherein said nanoparticles have an average diameter of less than 50 nm.
55. A method according to claim 53, wherein said microemulsion further comprises a cosurfactant.
56. A method according to claim 53, further comprising:
c) removing said surfactant and/or cosurfactant by dialysis, ultrafiltration, or adsorption.
57. A method according to claim 53, further comprising:
c) removing essentially all of the remaining non-volatile phase by freeze-drying, spray-drying, or lyophilization, so as to obtain a dry powder of nanoparticles.
58. A method according to claim 57, further comprising:
d) resuspending said dry powder of nanoparticles in a pharmaceutically acceptable carrier.
59. A method according to claim 58, further comprising:
e) administering said resuspended nanoparticles to a patient.
60. A method according to claim 53, further comprising:
c) filtering said suspension of solid nanoparticles through a filter of sufficiently small pore size so as to sterilize said suspension.
61. A method of making nanoparticles containing an active agent, said method comprising:
a) combining a non-volatile phase and a volatile phase that spontaneously form a microemulsion, wherein said non-volatile phase contains said active agent; and b) removing said non-volatile phase and thereby obtaining solid nanoparticles in said volatile phase, wherein said nanoparticles contain said active agent and have an average diameter of less than 100 nm.
62. A suspension of nanoparticles made by the method of claim 53.
63. Dry nanoparticles made by the method of claim 57.
64. A suspension of nanoparticles made by the method of claim 58.
65.A suspension of nanoparticles made by the method of claim 61.
CA2294981A 1997-06-27 1998-06-26 Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof Expired - Lifetime CA2294981C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2765222A CA2765222C (en) 1997-06-27 1998-06-26 Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US5102197P 1997-06-27 1997-06-27
US60/051,021 1997-06-27
US08/926,155 US6096331A (en) 1993-02-22 1997-09-09 Methods and compositions useful for administration of chemotherapeutic agents
US08/926,155 1997-09-09
PCT/US1998/013272 WO1999000113A1 (en) 1997-06-27 1998-06-26 Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof

Related Child Applications (1)

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CA2765222A Division CA2765222C (en) 1997-06-27 1998-06-26 Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof

Publications (2)

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CA2294981A1 true CA2294981A1 (en) 1999-01-07
CA2294981C CA2294981C (en) 2012-04-03

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US (2) US20080161382A1 (en)
EP (1) EP1023050B1 (en)
JP (2) JP4865937B2 (en)
KR (3) KR100789008B1 (en)
CN (2) CN100525748C (en)
AU (1) AU8266298A (en)
BR (1) BRPI9810945B8 (en)
CA (1) CA2294981C (en)
DK (1) DK1023050T3 (en)
ES (1) ES2435944T3 (en)
HK (1) HK1030543A1 (en)
HU (1) HU230338B1 (en)
IL (2) IL133672A0 (en)
MX (1) MX337149B (en)
NO (2) NO332166B1 (en)
NZ (2) NZ502500A (en)
PT (1) PT1023050E (en)
SG (1) SG113402A1 (en)
WO (1) WO1999000113A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7314637B1 (en) 1999-06-29 2008-01-01 Neopharm, Inc. Method of administering liposomal encapsulated taxane
US8298573B2 (en) 2003-02-03 2012-10-30 Jia-Ai Zhang Stable sterile filterable liposomal encapsulated taxane and other antineoplastic drugs

Families Citing this family (140)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070116761A1 (en) * 1993-02-22 2007-05-24 Desai Neil P Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
US6537579B1 (en) * 1993-02-22 2003-03-25 American Bioscience, Inc. Compositions and methods for administration of pharmacologically active compounds
US5439686A (en) * 1993-02-22 1995-08-08 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor
US20070092563A1 (en) * 1996-10-01 2007-04-26 Abraxis Bioscience, Inc. Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
US20030199425A1 (en) * 1997-06-27 2003-10-23 Desai Neil P. Compositions and methods for treatment of hyperplasia
US8853260B2 (en) 1997-06-27 2014-10-07 Abraxis Bioscience, Llc Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
KR100789008B1 (en) * 1997-06-27 2007-12-26 아브락시스 바이오사이언스 인크. Novel Formulations of Pharmacological Agents
US6040330A (en) * 1999-01-08 2000-03-21 Bionumerik Pharmaceuticals, Inc. Pharmaceutical formulations of taxanes
EP1178786A4 (en) * 1999-05-21 2006-03-01 American Bioscience Inc Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
GB9920548D0 (en) * 1999-08-31 1999-11-03 Rhone Poulenc Rorer Sa Treatment of hepatocellular carcinoma
MXPA02008361A (en) 2000-02-28 2004-05-17 Genesegues Inc Nanocapsule encapsulation system and method.
ITMI20001107A1 (en) * 2000-05-18 2001-11-18 Acs Dobfar Spa METHOD FOR TREATMENT OF SOLIC TUMORS BY INCORPORATING PACLITAXEL MICROPARTICLES OF ALBUMIN
JP2004517127A (en) 2000-12-21 2004-06-10 ネクター セラピューティックス Pulmonary delivery of polyene antifungals
US20050048126A1 (en) 2000-12-22 2005-03-03 Barrett Rabinow Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
KR100426636B1 (en) * 2001-05-18 2004-04-08 한국과학기술연구원 Injectable Gel Type Lipid Composition And Preparation Method Thereof
US20060003012A9 (en) 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
EP1429749A2 (en) 2001-09-26 2004-06-23 Baxter International Inc. Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal
EP1478343B1 (en) 2001-10-15 2017-03-22 Crititech, Inc. Compositions and methods for delivery of poorly water soluble drugs and methods of treatment
ITMI20020680A1 (en) * 2002-03-29 2003-09-29 Acs Dobfar Spa IMPROVED ANTI-TUMOR COMPOSITION BASED ON PACLITAXEL AND METHOD FOR ITS OBTAINING
ITMI20020681A1 (en) * 2002-03-29 2003-09-29 Acs Dobfar Spa PROCEDURE FOR THE PRODUCTION OF PACLITAXEL AND ALBUMINA NANOPARTICLES
US20030207907A1 (en) 2002-05-03 2003-11-06 Iversen Patrick L. Delivery of microparticle-conjugated drugs for inhibition of stenosis
ITMI20021392A1 (en) * 2002-06-25 2003-12-29 Nicox Sa PHARMACEUTICAL FORMS FOR THE ORAL ADMINISTRATION OF LIQUID DRUGS AT AMBIENT TEMPERATURE EQUIPPED WITH BETTER BIOAVAILABILITY
ATE424187T1 (en) 2002-07-15 2009-03-15 Alcon Inc BIOERODIBLE FILM FOR DELIVERING AN OPHTHALMIC MEDICINAL PRODUCT
GB0216700D0 (en) 2002-07-18 2002-08-28 Astrazeneca Ab Process
IL150906A0 (en) * 2002-07-25 2003-02-12 Yissum Res Dev Co Diagnostic microspheres
DE10234784A1 (en) * 2002-07-30 2004-02-19 Günenthal GmbH Pharmaceutical dosage form that can be administered intravenously
US7838034B2 (en) 2002-07-30 2010-11-23 Grunenthal Gmbh Intravenous pharmaceutical form of administration
US20050004002A1 (en) 2002-12-09 2005-01-06 American Bioscience, Inc. Compositions and methods of delivery of pharmacological agents
KR100871529B1 (en) * 2002-12-09 2008-12-05 치아-시앙 수 Method of making fibrinogen particles suited for intravenous injections
GB0302673D0 (en) 2003-02-06 2003-03-12 Astrazeneca Ab Pharmaceutical formulations
CN1303994C (en) * 2003-03-03 2007-03-14 浙江海正药业股份有限公司 Taxol vesicle injection and its prepn
US8476010B2 (en) 2003-07-10 2013-07-02 App Pharmaceuticals Llc Propofol formulations with non-reactive container closures
ATE493116T1 (en) 2004-01-21 2011-01-15 Univ London Pharmacy METHOD FOR PRODUCING MICROPARTICLES
KR100578382B1 (en) 2004-07-16 2006-05-11 나재운 Water soluble chitosan nanoparticle for delivering a anticance agent and preparing method thereof
US8735394B2 (en) 2005-02-18 2014-05-27 Abraxis Bioscience, Llc Combinations and modes of administration of therapeutic agents and combination therapy
DK2301531T3 (en) 2005-02-18 2018-07-30 Abraxis Bioscience Llc COMBINATIONS AND WAYS FOR ADMINISTRATING THERAPEUTIC SUBSTANCES AND COMBINATION THERAPY
EP1908511A1 (en) * 2005-06-29 2008-04-09 Mitsubishi Chemical Corporation Granule dispersion composition, process for producing the same, and granular material and medicine
ES2718323T3 (en) 2005-08-31 2019-07-01 Abraxis Bioscience Llc Compositions comprising low water soluble pharmaceutical agents
KR101457834B1 (en) * 2005-08-31 2014-11-05 아브락시스 바이오사이언스, 엘엘씨 Compositions and methods for preparation of poorly water soluble drugs with increased stability
EP1931417A2 (en) * 2005-09-30 2008-06-18 Transcutaneous Technologies Inc. Transdermal drug delivery systems, devices, and methods employing novel pharmaceutical vehicles
EA015781B1 (en) * 2005-10-21 2011-12-30 Панацея Биотек Лимитед Compositions for cancer therapy
EP2029640A4 (en) * 2006-06-08 2010-04-28 3M Innovative Properties Co Polymeric beads and methods of making polymeric beads
WO2008041553A1 (en) 2006-09-26 2008-04-10 Astellas Pharma Inc. Tacrolimus sustained-release preparation
ES2700074T3 (en) 2006-12-14 2019-02-13 Abraxis Bioscience Llc Therapy for breast cancer based on the status of the hormone receptors with nanoparticles that comprise taxane
CA2674039A1 (en) 2006-12-28 2008-07-17 Astellas Pharma Inc. Sustained release formulation for tacrolimus
CA3201293A1 (en) 2007-03-07 2008-09-12 Abraxis Bioscience, Llc Nanoparticle comprising rapamycin and albumin as anticancer agent
CA2686736A1 (en) 2007-05-03 2008-11-13 Abraxis Bioscience, Llc Nanoparticle compositions comprising rapamycin for treating pulmonary hypertension
US8927019B2 (en) 2007-06-01 2015-01-06 Abraxis Bioscience, Llc Methods and compositions for treating recurrent cancer
US8088412B2 (en) 2008-01-30 2012-01-03 University Of Kansas Intralymphatic chemotherapy drug carriers
ES2447465T3 (en) 2008-03-05 2014-03-12 Baxter International Inc. Modified surface particles and methods for targeted drug administration
JP2011517683A (en) * 2008-04-10 2011-06-16 アブラクシス バイオサイエンス， エルエルシー Composition of hydrophobic taxane derivative and use thereof
MX2010011165A (en) * 2008-04-10 2011-02-22 Abraxis Bioscience Llc Compositions of hydrophobic taxane derivatives and uses thereof.
EP2310006A4 (en) 2008-07-03 2012-04-25 Mayo Foundation Treating cancer
KR101043407B1 (en) * 2009-02-19 2011-06-22 한국과학기술연구원 A tumor targeting protein conjugate and a method for preparing the same
KR101066197B1 (en) 2009-04-06 2011-09-20 한국생명공학연구원 Coenzyme Q10 nanoparticles, method for preparing the same, and composition comprising the same
KR20120005505A (en) * 2009-04-10 2012-01-16 아브락시스 바이오사이언스, 엘엘씨 Nanoparticle formulations and uses therof
WO2010121000A1 (en) * 2009-04-15 2010-10-21 Abraxis Bioscience, Llc Prion-free nanoparticle compositions and methods
WO2011025838A1 (en) * 2009-08-25 2011-03-03 Abraxis Bioscience, Llc Combination therapy with nanoparticle compositions of taxane and hedgehog inhibitors
JP4856752B2 (en) * 2009-11-30 2012-01-18 ホソカワミクロン株式会社 Method for producing drug-containing nanoparticles
RU2589697C2 (en) 2009-12-18 2016-07-10 Экзодос Лайф Сайенсиз Лимитед Партнершип Methods of producing a stable liquid drugs and compositions thereof
EP2531173B1 (en) * 2010-02-03 2018-09-26 Oncbiomune, L.L.C. Taxane- and taxoid-protein compositions
KR101786142B1 (en) 2010-03-26 2017-10-17 아브락시스 바이오사이언스, 엘엘씨 Methods of treatment of hepatocellular carcinoma
CN107158389A (en) 2010-03-29 2017-09-15 阿布拉科斯生物科学有限公司 Strengthen the method for medicine delivery and therapeutic agent validity
WO2011123395A1 (en) 2010-03-29 2011-10-06 Abraxis Bioscience, Llc Methods of treating cancer
EA027666B1 (en) 2010-05-03 2017-08-31 ТЕИКОКУ ФАРМА ЮСЭй, ИНК. Non-aqueous taxane pro-emulsion formulations and methods of making and using the same
EP2575804A4 (en) 2010-06-04 2013-10-23 Abraxis Bioscience Llc Methods of treatment of pancreatic cancer
CA2801891C (en) * 2010-06-07 2020-10-27 Abraxis Bioscience, Llc Combination therapy methods for treating proliferative diseases
KR101007948B1 (en) 2010-08-13 2011-01-14 김지훈 A forming method of rubber block using steam
US9782342B2 (en) 2010-10-11 2017-10-10 Wichita State University Composite magnetic nanoparticle drug delivery system
CN102670518B (en) * 2011-03-14 2014-08-20 齐鲁制药有限公司 Preparation method for insoluble spherical medical granules
SG193505A1 (en) 2011-04-01 2013-10-30 Astrazeneca Ab Therapeutic treatment
PT2707030T (en) 2011-05-09 2020-05-22 Mayo Found Medical Education & Res Cancer treatments
RU2640485C2 (en) 2011-11-30 2018-01-09 Астразенека Аб Combination treatment of cancer
DK2790675T3 (en) 2011-12-14 2019-09-09 Abraxis Bioscience Llc APPLICATION OF POLYMER EXCIPIENTS FOR FREEZING DRY OR FREEZING OF PARTICLES
WO2013115559A1 (en) * 2012-01-30 2013-08-08 성균관대학교 산학협력단 Method for preparing albumin nanoparticles containing poorly water soluble drug therein
KR101809858B1 (en) 2012-04-04 2017-12-15 할로자임, 아이엔씨 Combination therapy with an anti-hyaluronan agent and a tumor-targeted taxane
AU2013204533B2 (en) 2012-04-17 2017-02-02 Astrazeneca Ab Crystalline forms
JO3685B1 (en) 2012-10-01 2020-08-27 Teikoku Pharma Usa Inc Non-aqueous taxane nanodispersion formulations and methods of using the same
US10413606B2 (en) 2012-10-01 2019-09-17 Mayo Foundation For Medical Education And Research Methods for treating cancer with nanoparticle complexes of albumin-bound paclitaxel and anti-VEGF antibodies
US9149455B2 (en) 2012-11-09 2015-10-06 Abraxis Bioscience, Llc Methods of treating melanoma
JP6145513B2 (en) * 2012-11-15 2017-06-14 ユタ−イナ ディーディーエス アンド アドバンスト セラピューティクス リサーチ センター Biodegradable microbeads with improved ability to adsorb anticancer agents containing albumin and dextran sulfate and method for producing the same
KR101569482B1 (en) 2012-11-27 2015-11-17 재단법인 유타 인하 디디에스 및 신의료기술개발 공동연구소 Biodegradable microbeads with an improved ability to absorb antitumor agent, comprising anionic polymer and Methods for preparing thereof
CN103908432B (en) * 2013-01-02 2018-09-21 博瑞生物医药（苏州）股份有限公司 A kind of freeze-dried composition and preparation method thereof of Ipsapirone albumin
US9511046B2 (en) 2013-01-11 2016-12-06 Abraxis Bioscience, Llc Methods of treating pancreatic cancer
JP6546098B2 (en) 2013-03-04 2019-07-17 アストラゼネカ アクチボラグ Combination treatment
EP3698784A1 (en) 2013-03-12 2020-08-26 Abraxis BioScience, LLC Methods of treating lung cancer
KR20150127187A (en) 2013-03-14 2015-11-16 아브락시스 바이오사이언스, 엘엘씨 Methods of treating bladder cancer
KR101329646B1 (en) 2013-05-02 2013-11-14 주식회사 지니스 Targeting-enhancing anticancer nanoparticles and preparation method the same
IL228528A (en) 2013-09-17 2015-01-29 Technion Res & Dev Foundation Potato protein nanoparticles
WO2015051349A1 (en) * 2013-10-04 2015-04-09 Sorrento Therapeutics, Inc. Treating metastatic cancer with micellular paclitaxel
CN104758942A (en) * 2014-01-02 2015-07-08 国家纳米科学中心 Protein-based pharmacological active substance composition, and preparation method and applications thereof
WO2015152433A1 (en) * 2014-03-31 2015-10-08 Hanmi Pharm. Co., Ltd. Amorphous solid dispersion comprising paclitaxel, tablet comprising the same, and method for preparing the same
US20150342872A1 (en) * 2014-06-01 2015-12-03 Crititech, Inc. Use of Paclitaxel Particles
US20150352176A1 (en) * 2014-06-06 2015-12-10 Newport Research, Inc. Oil-free and fat-free aqueous suspensions of cyclosporin
MX2016016617A (en) 2014-06-16 2017-03-23 Mayo Foundation Treating myelomas.
SG10201902499VA (en) 2014-09-03 2019-04-29 Genesegues Inc Therapeutic nanoparticles and related compositions, methods and systems
US9446148B2 (en) 2014-10-06 2016-09-20 Mayo Foundation For Medical Education And Research Carrier-antibody compositions and methods of making and using the same
US20200237859A1 (en) 2019-01-25 2020-07-30 Newport Research, Inc. Aqueous suspensions of cyclosporin
US11324800B2 (en) 2015-01-15 2022-05-10 Wellspring Ophthalmics, Inc. Aqueous suspensions of cyclosporin
US10705070B1 (en) 2015-03-05 2020-07-07 Abraxis Bioscience, Llc Methods of assessing suitability of use of pharmaceutical compositions of albumin and poorly water soluble drug
US10527604B1 (en) 2015-03-05 2020-01-07 Abraxis Bioscience, Llc Methods of assessing suitability of use of pharmaceutical compositions of albumin and paclitaxel
US11291646B2 (en) 2015-06-04 2022-04-05 Crititech, Inc. Nozzle assembly and methods for use
EA036790B1 (en) 2015-06-29 2020-12-22 АБРАКСИС БАЙОСАЙЕНС, ЭлЭлСи Method of treating malignant pecoma
TW201707725A (en) 2015-08-18 2017-03-01 美國馬友醫藥教育研究基金會 Carrier-antibody compositions and methods of making and using the same
BR112018005200A2 (en) 2015-09-16 2018-10-09 Dfb Soria Llc release of drug nanoparticles and methods of using them
TW201713360A (en) 2015-10-06 2017-04-16 Mayo Foundation Methods of treating cancer using compositions of antibodies and carrier proteins
CN105412024B (en) * 2015-12-14 2018-03-30 广州帝奇医药技术有限公司 Target hydrophobic anticancer drug nanometer formulation and preparation method thereof
US11571469B2 (en) 2016-01-07 2023-02-07 Mayo Foundation For Medical Education And Research Methods of treating cancer with interferon wherein the cancer cells are HLA negative or have reduced HLA expression
US11833118B2 (en) 2016-01-20 2023-12-05 Flurry Powders, Llc Encapsulation of lipophilic ingredients in dispersible spray dried powders suitable for inhalation
WO2017127641A1 (en) * 2016-01-20 2017-07-27 Flurry Powders Encapsulation of lipophilic ingredients in dispersible spray dried powders suitable for inhalation
AU2017217881B2 (en) 2016-02-12 2022-11-17 Mayo Foundation For Medical Education And Research Hematologic cancer treatments
EP3432928A4 (en) 2016-03-21 2019-11-20 Mayo Foundation for Medical Education and Research Methods for improving the therapeutic index for a chemotherapeutic drug
EP3432926A4 (en) 2016-03-21 2019-11-20 Mayo Foundation for Medical Education and Research Methods for reducing toxicity of a chemotherapeutic drug
EP3439635B1 (en) 2016-04-04 2020-12-09 Crititech, Inc. Formulations for solid tumor treatment
US10618969B2 (en) 2016-04-06 2020-04-14 Mayo Foundation For Medical Education And Research Carrier-binding agent compositions and methods of making and using the same
CN105944109B (en) * 2016-05-03 2019-06-11 四川大学 A kind of protein nano particle medicinal composition and application thereof of glomerulus targeting
EP3505165A4 (en) * 2016-08-26 2020-05-20 Tetsuji Okuno Fine nano-sized medicinal agent and use thereof
AU2017321798B2 (en) 2016-09-01 2023-06-15 Mayo Foundation For Medical Education And Research Methods and compositions for targeting T-cell cancers
CA3035378A1 (en) 2016-09-01 2018-03-08 Mayo Foundation For Medical Education And Research Carrier-pd-l1 binding agent compositions for treating cancers
US11590098B2 (en) 2016-09-06 2023-02-28 Mayo Foundation For Medical Education And Research Methods of treating triple-negative breast cancer using compositions of antibodies and carrier proteins
JP2019526587A (en) 2016-09-06 2019-09-19 マヨ ファウンデーション フォー メディカル エデュケーション アンド リサーチＭａｙｏ Ｆｏｕｎｄａｔｉｏｎ Ｆｏｒ Ｍｅｄｉｃａｌ Ｅｄｕｃａｔｉｏｎ Ａｎｄ Ｒｅｓｅａｒｃｈ Methods for treating cancers expressing PD-L1
KR102486055B1 (en) 2016-09-06 2023-01-09 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 Paclitaxel-albumin-binder compositions and methods of use and preparation thereof
AR109685A1 (en) * 2016-10-10 2019-01-09 Abraxis Bioscience Llc COMPOSITIONS OF NANOPARTICLES AND METHODS TO MANUFACTURE AND USE THEM
ES2955884T3 (en) 2017-03-15 2023-12-07 Dfb Soria Llc Topical therapy for the treatment of skin malignancies with taxane nanoparticles
SG11201909840TA (en) 2017-06-09 2019-11-28 Crititech Inc Treatment of epithelial cysts by intracystic injection of antineoplastic particles
BR112019022720A2 (en) 2017-06-14 2020-05-12 Crititech, Inc. METHODS FOR TREATING PULMONARY DISORDERS
EP3648741A4 (en) * 2017-07-07 2021-05-05 DFB Pharmaceuticals, LLC Treatment of hyperplastic tissue growths including benign prostatic hyperplasia (bph) by direct injection of an antineoplastic agent
CN107510600A (en) * 2017-08-07 2017-12-26 苏州大学 A kind of device and method for preparing medicinal solid particulate
EP3691631A1 (en) 2017-10-03 2020-08-12 Crititech, Inc. Local delivery of antineoplastic particles in combination with systemic delivery of immunotherapeutic agents for the treatment of cancer
EP3755148A4 (en) 2018-02-23 2021-12-15 RHNanoPharma Nanosuspensions of salsalate and methods of using the same
WO2019178024A1 (en) 2018-03-16 2019-09-19 Dfb Soria, Llc Topical therapy for the treatment of cervical intraepithelial neoplasia (cin) and cervical cancer using nanoparticles of taxanes
JP2021528362A (en) 2018-03-20 2021-10-21 アブラクシス バイオサイエンス， エルエルシー Methods of treating central nervous system disorders through administration of mTOR inhibitors and nanoparticles of albumin
AU2019258679A1 (en) * 2018-04-25 2020-10-15 Ethris Gmbh Cryoprotective agents for particulate formulations
WO2019222435A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20
CA3174213A1 (en) * 2019-06-14 2020-12-17 Daniela Oana Trambitas Method for micro-encapsulation of natural ingredients by means of contacting with supercritical gas
US11497737B2 (en) 2019-10-28 2022-11-15 Abraxis Bioscience, Llc Pharmaceutical compositions of albumin and rapamycin
WO2023063796A1 (en) * 2021-10-14 2023-04-20 주식회사 스카이테라퓨틱스 Nano-molecule aggregate consisting of organic material, inorganic material or salt thereof and preparation method therefor
WO2023194441A1 (en) 2022-04-05 2023-10-12 Istituto Nazionale Tumori Irccs - Fondazione G. Pascale Combination of hdac inhibitors and statins for use in the treatment of pancreatic cancer

Family Cites Families (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2660556A (en) * 1952-09-08 1953-11-24 Donald G Butler Electric arc production of combustible gases
US3536074A (en) * 1968-03-29 1970-10-27 Alfred Aufhauser Oral administration of a pill,tablet or capsule
US3959457A (en) * 1970-06-05 1976-05-25 Temple University Microparticulate material and method of making such material
US4073943A (en) * 1974-09-11 1978-02-14 Apoteksvarucentralen Vitrum Ab Method of enhancing the administration of pharmalogically active agents
US4107288A (en) * 1974-09-18 1978-08-15 Pharmaceutical Society Of Victoria Injectable compositions, nanoparticles useful therein, and process of manufacturing same
DK143689C (en) * 1975-03-20 1982-03-15 J Kreuter PROCEDURE FOR THE PREPARATION OF AN ADVERTISED VACCINE
CA1077842A (en) * 1975-10-09 1980-05-20 Minnesota Mining And Manufacturing Company Albumin medicament carrier system
US4357259A (en) * 1977-08-01 1982-11-02 Northwestern University Method of incorporating water-soluble heat-sensitive therapeutic agents in albumin microspheres
EP0007895B1 (en) * 1978-07-19 1983-06-22 Patrick Couvreur Biodegradable nanoparticles, pharmaceutical compositions containing them and process for their preparation
US4344934A (en) * 1978-11-20 1982-08-17 American Home Products Corporation Therapeutic compositions with enhanced bioavailability
DE3013839A1 (en) * 1979-04-13 1980-10-30 Freunt Ind Co Ltd METHOD FOR PRODUCING AN ACTIVATED PHARMACEUTICAL COMPOSITION
US4247406A (en) * 1979-04-23 1981-01-27 Widder Kenneth J Intravascularly-administrable, magnetically-localizable biodegradable carrier
DE3119383A1 (en) * 1981-05-15 1982-12-02 Basf Ag, 6700 Ludwigshafen METHOD FOR PRODUCING FINE DISTRIBUTED, POWDERED CAROTINO PREPARATIONS
US4572203A (en) * 1983-01-27 1986-02-25 Feinstein Steven B Contact agents for ultrasonic imaging
US4622219A (en) * 1983-06-17 1986-11-11 Haynes Duncan H Method of inducing local anesthesia using microdroplets of a general anesthetic
US4818542A (en) * 1983-11-14 1989-04-04 The University Of Kentucky Research Foundation Porous microspheres for drug delivery and methods for making same
US4671954A (en) * 1983-12-13 1987-06-09 University Of Florida Microspheres for incorporation of therapeutic substances and methods of preparation thereof
US4914084A (en) * 1984-05-09 1990-04-03 Synthetic Blood Corporation Composition and method for introducing heme, hemoproteins, and/or heme-hemoprotein complexes into the body
US4963367A (en) * 1984-04-27 1990-10-16 Medaphore, Inc. Drug delivery compositions and methods
US4826689A (en) * 1984-05-21 1989-05-02 University Of Rochester Method for making uniformly sized particles from water-insoluble organic compounds
US4752567A (en) * 1984-06-21 1988-06-21 Janssen Pharmaceutica N.V. Method of visualizing individual submicroscopic metal particles
EP0241469B1 (en) * 1984-12-14 1991-10-23 Gergely, Gerhard, Dr. Particles from a hydrophobic or poorly soluble substance and process for rendering them hydrophilic
GB8601100D0 (en) * 1986-01-17 1986-02-19 Cosmas Damian Ltd Drug delivery system
WO1987004592A1 (en) * 1986-02-10 1987-08-13 Liposome Technology, Inc. Controlled-release liposome delivery system
US4966773A (en) * 1986-11-25 1990-10-30 Alcon Laboratories, Inc. Topical ophthalmic compositions containing microfine retinoid particles
CA1338736C (en) * 1986-12-05 1996-11-26 Roger Baurain Microcrystals containing an active ingredient with affinity for phospholipids and at least one phospholipid; process for preparing the same
FR2634397B2 (en) * 1986-12-31 1991-04-19 Centre Nat Rech Scient PROCESS FOR THE PREPARATION OF DISPERSIBLE COLLOIDAL SYSTEMS OF A PROTEIN IN THE FORM OF NANOPARTICLES
FR2608988B1 (en) * 1986-12-31 1991-01-11 Centre Nat Rech Scient PROCESS FOR THE PREPARATION OF COLLOIDAL DISPERSIBLE SYSTEMS OF A SUBSTANCE, IN THE FORM OF NANOPARTICLES
FR2608942B1 (en) * 1986-12-31 1991-01-11 Centre Nat Rech Scient PROCESS FOR THE PREPARATION OF COLLOIDAL DISPERSIBLE SYSTEMS OF A SUBSTANCE, IN THE FORM OF NANOCAPSULES
US4861579A (en) * 1988-03-17 1989-08-29 American Cyanamid Company Suppression of B-lymphocytes in mammals by administration of anti-B-lymphocyte antibodies
US4929446A (en) * 1988-04-19 1990-05-29 American Cyanamid Company Unit dosage form
US5041292A (en) * 1988-08-31 1991-08-20 Theratech, Inc. Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents
US4957656A (en) * 1988-09-14 1990-09-18 Molecular Biosystems, Inc. Continuous sonication method for preparing protein encapsulated microbubbles
US5114703A (en) * 1989-05-30 1992-05-19 Alliance Pharmaceutical Corp. Percutaneous lymphography using particulate fluorocarbon emulsions
JP2642486B2 (en) * 1989-08-04 1997-08-20 田辺製薬株式会社 Ultrafine particle method for poorly soluble drugs
US5079018A (en) * 1989-08-14 1992-01-07 Neophore Technologies, Inc. Freeze dry composition and method for oral administration of drugs, biologicals, nutrients and foodstuffs
US5188837A (en) * 1989-11-13 1993-02-23 Nova Pharmaceutical Corporation Lipsopheres for controlled delivery of substances
CA2013485C (en) * 1990-03-06 1997-04-22 John Michael Gardlik Solid consumer product compositions containing small particle cyclodextrin complexes
US5091187A (en) * 1990-04-26 1992-02-25 Haynes Duncan H Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs
US5091188A (en) * 1990-04-26 1992-02-25 Haynes Duncan H Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs
US5441739A (en) * 1990-06-22 1995-08-15 The Regents Of The University Of California Reduced and controlled surface binding of biologically active molecules
US5059699A (en) * 1990-08-28 1991-10-22 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol
US5310540A (en) * 1990-10-05 1994-05-10 Sintetica Sa Method for the preparation of stable suspensions of hollow gas-filled microspheres suitable for ultrasonic echography
US20030087985A1 (en) * 1990-10-15 2003-05-08 Hubbell Jeffrey A. Gels for encapsulation of biological materials
ATE147976T1 (en) * 1991-01-15 1997-02-15 Hemosphere Inc PROTEIN NANOMATRICES AND PROCESS FOR PRODUCTION
US5145684A (en) * 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
US5399363A (en) * 1991-01-25 1995-03-21 Eastman Kodak Company Surface modified anticancer nanoparticles
AU642066B2 (en) * 1991-01-25 1993-10-07 Nanosystems L.L.C. X-ray contrast compositions useful in medical imaging
US5143716A (en) * 1991-02-01 1992-09-01 Unger Evan C Phosphorylated sugar alcohols, Mono- and Di-Saccharides as contrast agents for use in magnetic resonance imaging of the gastrointestinal region
JPH06511481A (en) * 1991-07-05 1994-12-22 ユニバーシティ オブ ロチェスター Ultra-fine non-agglomerated porous particles that incorporate air bubbles
US5250236A (en) * 1991-08-05 1993-10-05 Gasco Maria R Method for producing solid lipid microspheres having a narrow size distribution
US5233995A (en) * 1991-11-21 1993-08-10 Sterling Winthrop Inc. Encapsulated particles useful as contrast agents in ultrasound and x-ray imaging compositions and methods
WO1993018751A1 (en) * 1992-03-23 1993-09-30 Georgetown University Liposome encapsulated taxol and a method of using the same
US5334640A (en) * 1992-04-08 1994-08-02 Clover Consolidated, Ltd. Ionically covalently crosslinked and crosslinkable biocompatible encapsulation compositions and methods
WO1993024476A1 (en) * 1992-06-04 1993-12-09 Clover Consolidated, Limited Water-soluble polymeric carriers for drug delivery
FR2692168B1 (en) * 1992-06-16 1995-03-24 Centre Nat Rech Scient Preparation and use of new dispersible colloidal systems based on cyclodextrin, in the form of nanospheres.
DE4220624A1 (en) * 1992-06-24 1994-01-05 Zahnradfabrik Friedrichshafen Rotary slide valve, especially for power steering
ZA935111B (en) * 1992-07-17 1994-02-04 Smithkline Beecham Corp Rapamycin derivatives
CA2086874E (en) * 1992-08-03 2000-01-04 Renzo Mauro Canetta Methods for administration of taxol
BR9405798A (en) * 1993-02-22 1995-12-12 Vivorx Pharmaceuticals Inc Methods for in vivo release of biological material and useful compositions thereof
US5362478A (en) * 1993-03-26 1994-11-08 Vivorx Pharmaceuticals, Inc. Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell
US5650156A (en) * 1993-02-22 1997-07-22 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of nutriceuticals and compositions useful therefor
US20070116761A1 (en) * 1993-02-22 2007-05-24 Desai Neil P Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
US5665382A (en) * 1993-02-22 1997-09-09 Vivorx Pharmaceuticals, Inc. Methods for the preparation of pharmaceutically active agents for in vivo delivery
US5439686A (en) * 1993-02-22 1995-08-08 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor
US5916596A (en) * 1993-02-22 1999-06-29 Vivorx Pharmaceuticals, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
US5665383A (en) * 1993-02-22 1997-09-09 Vivorx Pharmaceuticals, Inc. Methods for the preparation of immunostimulating agents for in vivo delivery
US5554730A (en) * 1993-03-09 1996-09-10 Middlesex Sciences, Inc. Method and kit for making a polysaccharide-protein conjugate
WO1994026291A1 (en) * 1993-05-13 1994-11-24 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5886026A (en) * 1993-07-19 1999-03-23 Angiotech Pharmaceuticals Inc. Anti-angiogenic compositions and methods of use
US5543158A (en) * 1993-07-23 1996-08-06 Massachusetts Institute Of Technology Biodegradable injectable nanoparticles
PT711158E (en) * 1993-07-29 2004-04-30 Us Gov Health & Human Serv METHOD FOR TREATING ATHEROSCLEROSIS OR RESTENING USING A MICROTUBLE STABILIZING AGENT
US5415869A (en) * 1993-11-12 1995-05-16 The Research Foundation Of State University Of New York Taxol formulation
ES2104518T1 (en) * 1994-03-07 1997-10-16 Dow Chemical Co CONJUGATES BIOACTIVE DENDRIMEROS AND / OR DIRECTORS TO DIANA.
US5565478A (en) * 1994-03-14 1996-10-15 The United States Of America As Represented By The Department Of Health & Human Services Combination therapy using signal transduction inhibitors with paclitaxel and other taxane analogs
FR2718963B1 (en) * 1994-04-25 1996-05-24 Rhone Poulenc Rorer Sa New pharmaceutical composition based on taxoids.
ES2078190B1 (en) * 1994-05-20 1996-08-01 Cusi Lab PROCEDURE FOR THE COATING OF GOTICLES OR PARTICLES OF NANOMETRIC SIZE.
US5616330A (en) * 1994-07-19 1997-04-01 Hemagen/Pfc Stable oil-in-water emulsions incorporating a taxine (taxol) and method of making same
US5626862A (en) * 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
US5534270A (en) * 1995-02-09 1996-07-09 Nanosystems Llc Method of preparing stable drug nanoparticles
US5510118A (en) * 1995-02-14 1996-04-23 Nanosystems Llc Process for preparing therapeutic compositions containing nanoparticles
US5565188A (en) * 1995-02-24 1996-10-15 Nanosystems L.L.C. Polyalkylene block copolymers as surface modifiers for nanoparticles
CA2222595A1 (en) * 1995-06-07 1996-12-19 The Regents Of The University Of California Therapeutic microdevices and methods of making and using same
US5609629A (en) * 1995-06-07 1997-03-11 Med Institute, Inc. Coated implantable medical device
KR0180334B1 (en) * 1995-09-21 1999-03-20 김윤 Drug messenger using el-2l-2 micelle and method for sealing drug to it
US5637625A (en) * 1996-03-19 1997-06-10 Research Triangle Pharmaceuticals Ltd. Propofol microdroplet formulations
CN1148957A (en) * 1996-09-02 1997-05-07 张海茹 Aqueously soluble powder preparation of taxinol and its preparing method
US20070092563A1 (en) * 1996-10-01 2007-04-26 Abraxis Bioscience, Inc. Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
US20030199425A1 (en) * 1997-06-27 2003-10-23 Desai Neil P. Compositions and methods for treatment of hyperplasia
KR100789008B1 (en) * 1997-06-27 2007-12-26 아브락시스 바이오사이언스 인크. Novel Formulations of Pharmacological Agents
US8853260B2 (en) * 1997-06-27 2014-10-07 Abraxis Bioscience, Llc Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
WO2000064437A1 (en) * 1999-04-22 2000-11-02 American Biosciences, Inc. Long term administration of pharmacologically active agents
ITMI20020680A1 (en) * 2002-03-29 2003-09-29 Acs Dobfar Spa IMPROVED ANTI-TUMOR COMPOSITION BASED ON PACLITAXEL AND METHOD FOR ITS OBTAINING
ITMI20020681A1 (en) * 2002-03-29 2003-09-29 Acs Dobfar Spa PROCEDURE FOR THE PRODUCTION OF PACLITAXEL AND ALBUMINA NANOPARTICLES
US20050004002A1 (en) * 2002-12-09 2005-01-06 American Bioscience, Inc. Compositions and methods of delivery of pharmacological agents
US8420603B2 (en) * 2004-05-14 2013-04-16 Abraxis Bioscience, Llc SPARC and methods of use thereof
US20070166388A1 (en) * 2005-02-18 2007-07-19 Desai Neil P Combinations and modes of administration of therapeutic agents and combination therapy
DK2301531T3 (en) * 2005-02-18 2018-07-30 Abraxis Bioscience Llc COMBINATIONS AND WAYS FOR ADMINISTRATING THERAPEUTIC SUBSTANCES AND COMBINATION THERAPY
KR101457834B1 (en) * 2005-08-31 2014-11-05 아브락시스 바이오사이언스, 엘엘씨 Compositions and methods for preparation of poorly water soluble drugs with increased stability
ES2718323T3 (en) * 2005-08-31 2019-07-01 Abraxis Bioscience Llc Compositions comprising low water soluble pharmaceutical agents

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7314637B1 (en) 1999-06-29 2008-01-01 Neopharm, Inc. Method of administering liposomal encapsulated taxane
US8298573B2 (en) 2003-02-03 2012-10-30 Jia-Ai Zhang Stable sterile filterable liposomal encapsulated taxane and other antineoplastic drugs

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