CA2294756A1 - Cross-linked polysaccharide drug carrier - Google Patents
Cross-linked polysaccharide drug carrier Download PDFInfo
- Publication number
- CA2294756A1 CA2294756A1 CA002294756A CA2294756A CA2294756A1 CA 2294756 A1 CA2294756 A1 CA 2294756A1 CA 002294756 A CA002294756 A CA 002294756A CA 2294756 A CA2294756 A CA 2294756A CA 2294756 A1 CA2294756 A1 CA 2294756A1
- Authority
- CA
- Canada
- Prior art keywords
- sulfate
- polysaccharide
- cross
- drug carrier
- linked polysaccharide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
Abstract
A carrier and a method for preparing it are provided for use in the delivery of therapeutic agents. A polysaccharide is reacted with an oxidizing agent to open sugar rings on the polysaccharide to form aldehyde groups. The aldehyde groups are reacted to form covalent oxime linkages with a second polysaccharide and each of the first and second polysaccharide is selected from the group consisting of hyaluronic acid, dextran, dextran sulfate, chondroitin sulfate, dermatan sulfate, keratan sulfate, heparan, heparan sulfate and alginate.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88799497A | 1997-07-03 | 1997-07-03 | |
US08/887,994 | 1997-07-03 | ||
PCT/US1998/013997 WO1999001143A1 (en) | 1997-07-03 | 1998-07-01 | Cross-linked polysaccharide drug carrier |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2294756A1 true CA2294756A1 (en) | 1999-01-14 |
CA2294756C CA2294756C (en) | 2008-04-29 |
Family
ID=25392304
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002294756A Expired - Fee Related CA2294756C (en) | 1997-07-03 | 1998-07-01 | Cross-linked polysaccharide drug carrier |
Country Status (8)
Country | Link |
---|---|
US (3) | US6303585B1 (en) |
EP (1) | EP1011690A4 (en) |
JP (1) | JP4247846B2 (en) |
CN (1) | CN1161127C (en) |
AU (1) | AU752800B2 (en) |
CA (1) | CA2294756C (en) |
NZ (1) | NZ502134A (en) |
WO (1) | WO1999001143A1 (en) |
Families Citing this family (90)
Publication number | Priority date | Publication date | Assignee | Title |
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US6221854B1 (en) * | 1996-03-05 | 2001-04-24 | Orquest, Inc. | Method of promoting bone growth with hyaluronic acid and growth factors |
EP1011690A4 (en) * | 1997-07-03 | 2006-08-23 | Depuy Spine Inc | Cross-linked polysaccharide drug carrier |
DE69939025D1 (en) | 1998-10-14 | 2008-08-14 | Depuy Spine Inc | EXTRACELLULAR GDF-5 CONTAINING MATRIX FOR THE INDUCTION OR REINFORCEMENT OF CHONDROGENESIS |
IT1302534B1 (en) | 1998-12-21 | 2000-09-05 | Fidia Advanced Biopolymers Srl | INJECTABLE, BIOCOMPATIBLE AND BIODEGRADABLE COMPOSITIONS INCLUDING AT LEAST A DERIVATIVE OF HYALURONIC ACID, CHONDROGENIC CELLS, FOR |
GB9902652D0 (en) * | 1999-02-05 | 1999-03-31 | Fermentech Med Ltd | Process |
FR2794649B1 (en) * | 1999-06-11 | 2003-04-11 | Solutions | BIOMATERIAL BASED ON AN INSOLUBILIZED DEXTRAN DERIVATIVE AND A GROWTH FACTOR, METHOD FOR PREPARING SAME AND ITS APPLICATIONS |
US6288043B1 (en) * | 1999-06-18 | 2001-09-11 | Orquest, Inc. | Injectable hyaluronate-sulfated polysaccharide conjugates |
US6790840B1 (en) * | 1999-11-26 | 2004-09-14 | The Regents Of The University Of Michigan | Reversibly cross-linked hydrogels |
US6773723B1 (en) * | 2000-08-30 | 2004-08-10 | Depuy Acromed, Inc. | Collagen/polysaccharide bilayer matrix |
FR2823117A1 (en) * | 2000-11-14 | 2002-10-11 | Pharmascience Lab | PHARMACEUTICAL OR COSMETIC COMPOSITION AND USE OF AT LEAST ONE ACTIVE COMPOUND FOR INHIBITING MIGRATION OF LANGERHANS CELLS |
US6846923B2 (en) * | 2001-09-18 | 2005-01-25 | Hercules, Inc. | Oxime-linked polysaccharides and methods of preparing the same |
DE10152407A1 (en) * | 2001-10-24 | 2003-05-08 | Aesculap Ag & Co Kg | Composition of at least two biocompatible chemically crosslinkable components |
MXPA04006438A (en) * | 2001-12-31 | 2005-06-08 | Ares Lab Llc | Hemostatic compositions and methods for controlling bleeding. |
EP1476471A4 (en) * | 2002-01-23 | 2005-03-16 | Inst Of Nutraceutical Res Pty | Nutraceuticals for the treatment, protection and restoration of connective tissues |
JP4624678B2 (en) | 2002-02-21 | 2011-02-02 | パイオニア・サージカル・オーソバイオロジックス,インコーポレイテッド | Cross-linked bioactive hydrogel matrix |
US20080086792A1 (en) | 2006-10-13 | 2008-04-17 | Thomas Charles Kuracina | Method and apparatus for diverting sweat, liquid, moisture or the like from an eye |
IL149562A0 (en) | 2002-05-09 | 2002-11-10 | Prochon Ltd | Fgf variants and methods for use thereof |
WO2004029137A2 (en) * | 2002-09-25 | 2004-04-08 | Johns Hopkins University School Of Medicine | Cross-linked polymer matrices, and methods of making and using same |
US8673333B2 (en) | 2002-09-25 | 2014-03-18 | The Johns Hopkins University | Cross-linked polymer matrices, and methods of making and using same |
US7862831B2 (en) * | 2002-10-09 | 2011-01-04 | Synthasome, Inc. | Method and material for enhanced tissue-biomaterial integration |
WO2004083256A1 (en) * | 2003-03-21 | 2004-09-30 | Unilever N.V. | Polymer composition of proteins, polysaccharides and / or glycerides |
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DE10318802A1 (en) * | 2003-04-17 | 2004-11-04 | Aesculap Ag & Co. Kg | Self-adhesive, resorbable hemostatic |
US7067123B2 (en) | 2003-04-29 | 2006-06-27 | Musculoskeletal Transplant Foundation | Glue for cartilage repair |
US7901457B2 (en) | 2003-05-16 | 2011-03-08 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
US20070116768A1 (en) * | 2003-12-09 | 2007-05-24 | Michael Chorny | Sustained release preparations composed of biocompatible complex microparticles |
WO2005067942A1 (en) * | 2004-01-16 | 2005-07-28 | Institute Of Nutraceutical Research Pty Ltd | Glycosaminoglycan peptides derived from connective tissues and use thereof in the prevention of arthritis and other degenerative medical conditions |
US8293890B2 (en) | 2004-04-30 | 2012-10-23 | Advanced Cardiovascular Systems, Inc. | Hyaluronic acid based copolymers |
US7563780B1 (en) * | 2004-06-18 | 2009-07-21 | Advanced Cardiovascular Systems, Inc. | Heparin prodrugs and drug delivery stents formed therefrom |
US8512730B2 (en) * | 2004-07-12 | 2013-08-20 | Isto Technologies, Inc. | Methods of tissue repair and compositions therefor |
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US8697139B2 (en) | 2004-09-21 | 2014-04-15 | Frank M. Phillips | Method of intervertebral disc treatment using articular chondrocyte cells |
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US7837740B2 (en) | 2007-01-24 | 2010-11-23 | Musculoskeletal Transplant Foundation | Two piece cancellous construct for cartilage repair |
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US7815926B2 (en) | 2005-07-11 | 2010-10-19 | Musculoskeletal Transplant Foundation | Implant for articular cartilage repair |
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US8921109B2 (en) | 2005-09-19 | 2014-12-30 | Histogenics Corporation | Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof |
CN100428960C (en) * | 2005-09-23 | 2008-10-29 | 南开大学 | Method for preparing nano liver-target biodegradating medicine carrier material |
US8444968B2 (en) * | 2005-12-07 | 2013-05-21 | Isto Technologies, Inc. | Cartilage repair methods |
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US8435551B2 (en) | 2007-03-06 | 2013-05-07 | Musculoskeletal Transplant Foundation | Cancellous construct with support ring for repair of osteochondral defects |
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US8846095B2 (en) | 2007-11-14 | 2014-09-30 | Actamax Surgical Materials, Llc | Dextran-based polymer tissue adhesive for medical use |
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CN102321248B (en) * | 2011-06-10 | 2013-04-24 | 冯淑芹 | Injectable temperature sensitive gel used for filling and repairing damaged tissues |
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US10245306B2 (en) | 2012-11-16 | 2019-04-02 | Isto Technologies Ii, Llc | Flexible tissue matrix and methods for joint repair |
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CZ2012842A3 (en) | 2012-11-27 | 2014-08-20 | Contipro Biotech S.R.O. | C6-C18-acylated hyaluronate-based nanomicellar composition, process for preparing C6-C18-acylated hyaluronate, process for preparing nanomicellar composition and stabilized nanomicellar composition as well as use thereof |
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EP3027659B1 (en) | 2013-07-29 | 2020-12-09 | Actamax Surgical Materials LLC | Low swell tissue adhesive and sealant formulations |
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US10179191B2 (en) | 2014-10-09 | 2019-01-15 | Isto Technologies Ii, Llc | Flexible tissue matrix and methods for joint repair |
CN104356254A (en) * | 2014-10-23 | 2015-02-18 | 深圳先进技术研究院 | Modified hyaluronicacid and preparation method thereof |
US10077420B2 (en) | 2014-12-02 | 2018-09-18 | Histogenics Corporation | Cell and tissue culture container |
CZ309295B6 (en) | 2015-03-09 | 2022-08-10 | Contipro A.S. | Self-supporting, biodegradable film based on hydrophobized hyaluronic acid, method of its preparation and use |
CZ306479B6 (en) | 2015-06-15 | 2017-02-08 | Contipro A.S. | A method of crosslinking polysaccharides by using photolabile protecting groups |
CZ306662B6 (en) | 2015-06-26 | 2017-04-26 | Contipro A.S. | Sulphated polysaccharides derivatives, the method of their preparation, the method of their modification and the use |
JP7025021B2 (en) | 2015-10-26 | 2022-02-24 | プレジデント アンド フェローズ オブ ハーバード カレッジ | Reduced and oxidized polysaccharides and methods of their use |
CZ308106B6 (en) | 2016-06-27 | 2020-01-08 | Contipro A.S. | Unsaturated derivatives of polysaccharides, preparing and using them |
WO2018067545A1 (en) * | 2016-10-04 | 2018-04-12 | University Of Florida Research Foundation, Inc. | Chondroprotective nanoparticles for the treatment of osteoarthritis |
SG10202107829YA (en) | 2017-03-22 | 2021-08-30 | Genentech Inc | Hydrogel cross-linked hyaluronic acid prodrug compositions and methods |
CN107252501A (en) * | 2017-04-13 | 2017-10-17 | 广州贝奥吉因生物科技有限公司 | A kind of composite aquogel support for loading sanguinarine/gelatine microsphere and its preparation method and application |
CZ309355B6 (en) * | 2018-09-10 | 2022-09-28 | Univerzita Tomáše Bati ve Zlíně | Method of preparing conjugates with a controlled release rate of the drug with antitumor drug carriers based on selectively oxidized polysaccharides |
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US5128326A (en) * | 1984-12-06 | 1992-07-07 | Biomatrix, Inc. | Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same |
US5904717A (en) * | 1986-01-28 | 1999-05-18 | Thm Biomedical, Inc. | Method and device for reconstruction of articular cartilage |
FR2601371B1 (en) | 1986-07-11 | 1989-05-12 | Merieux Inst | PROCESS FOR TREATING COLLAGEN WITH A VIEW TO, IN PARTICULAR, FACILITATING CROSS-LINKING AND COLLAGEN OBTAINED BY APPLICATION OF SAID PROCESS |
DE4200080A1 (en) * | 1992-01-03 | 1993-09-30 | Reinmueller Johannes | Pharmaceutical composition for wound, scar and keloid treatment |
WO1996041813A2 (en) * | 1994-11-09 | 1996-12-27 | Offord Robin E | Functionalized polymers for site-specific attachment |
US5677276A (en) * | 1994-12-23 | 1997-10-14 | La Jolla Cancer Research Foundation | Immobilization of peptides to hyaluronate |
JP4193917B2 (en) * | 1995-12-18 | 2008-12-10 | アンジオデバイス インターナショナル ゲーエムベーハー | Crosslinked polymer composition and method of use thereof |
US5645587A (en) * | 1996-06-05 | 1997-07-08 | Chanda; Jyotirmay | Prevention of calcification and degeneration of biological tissue grafts for implantation in humans |
EP1011690A4 (en) * | 1997-07-03 | 2006-08-23 | Depuy Spine Inc | Cross-linked polysaccharide drug carrier |
US6378527B1 (en) * | 1998-04-08 | 2002-04-30 | Chondros, Inc. | Cell-culture and polymer constructs |
-
1998
- 1998-07-01 EP EP98933196A patent/EP1011690A4/en not_active Withdrawn
- 1998-07-01 JP JP50745999A patent/JP4247846B2/en not_active Expired - Fee Related
- 1998-07-01 WO PCT/US1998/013997 patent/WO1999001143A1/en active IP Right Grant
- 1998-07-01 AU AU82909/98A patent/AU752800B2/en not_active Ceased
- 1998-07-01 US US09/110,381 patent/US6303585B1/en not_active Expired - Fee Related
- 1998-07-01 CN CNB988084392A patent/CN1161127C/en not_active Expired - Fee Related
- 1998-07-01 CA CA002294756A patent/CA2294756C/en not_active Expired - Fee Related
- 1998-07-01 NZ NZ502134A patent/NZ502134A/en unknown
-
2001
- 2001-09-17 US US09/954,855 patent/US6683064B2/en not_active Expired - Fee Related
-
2003
- 2003-10-03 US US10/679,110 patent/US6953784B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO1999001143A1 (en) | 1999-01-14 |
AU8290998A (en) | 1999-01-25 |
US6683064B2 (en) | 2004-01-27 |
CN1268057A (en) | 2000-09-27 |
US6953784B2 (en) | 2005-10-11 |
US20030012765A1 (en) | 2003-01-16 |
AU752800B2 (en) | 2002-10-03 |
JP4247846B2 (en) | 2009-04-02 |
US20040077592A1 (en) | 2004-04-22 |
EP1011690A4 (en) | 2006-08-23 |
EP1011690A1 (en) | 2000-06-28 |
CN1161127C (en) | 2004-08-11 |
CA2294756C (en) | 2008-04-29 |
JP2002509538A (en) | 2002-03-26 |
US6303585B1 (en) | 2001-10-16 |
NZ502134A (en) | 2002-03-28 |
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