CA2294040A1 - Retentate chromatography and protein chip arrays with applications in biology and medicine - Google Patents

Retentate chromatography and protein chip arrays with applications in biology and medicine Download PDF

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Publication number
CA2294040A1
CA2294040A1 CA002294040A CA2294040A CA2294040A1 CA 2294040 A1 CA2294040 A1 CA 2294040A1 CA 002294040 A CA002294040 A CA 002294040A CA 2294040 A CA2294040 A CA 2294040A CA 2294040 A1 CA2294040 A1 CA 2294040A1
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Prior art keywords
biology
medicine
applications
retentate chromatography
protein chip
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CA002294040A
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French (fr)
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CA2294040C (en
Inventor
T. William Hutchens
Tai-Tung Yip
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Aspira Womens Health Inc
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Individual
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    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction

Abstract

This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectively conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery.
CA002294040A 1997-06-20 1998-06-19 Retentate chromatography and protein chip arrays with applications in biology and medicine Expired - Fee Related CA2294040C (en)

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US5433397P 1997-06-20 1997-06-20
US60/054,333 1997-06-20
US6748497P 1997-12-01 1997-12-01
US60/067,484 1997-12-01
PCT/US1998/012843 WO1998059360A1 (en) 1997-06-20 1998-06-19 Retentate chromatography and protein chip arrays with applications in biology and medicine

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CA2294040C CA2294040C (en) 2008-02-05

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Families Citing this family (461)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ267842A (en) * 1993-05-28 1997-09-22 Baylor College Medicine Apparatus for measuring molecular mass (by mass spectrometry) in which the sample is ionised on the sample holder and desorbed therefrom by laser pulses
US20020037517A1 (en) * 1993-05-28 2002-03-28 Hutchens T. William Methods for sequencing biopolymers
AU708196B2 (en) * 1995-06-20 1999-07-29 Johannes Schumacher Process and device for determining the activity of enzymes in liquids, or the concentration and/or activity of inhibitors in liquids
US7622294B2 (en) * 1997-03-14 2009-11-24 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions
US20030027126A1 (en) 1997-03-14 2003-02-06 Walt David R. Methods for detecting target analytes and enzymatic reactions
NZ516848A (en) * 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
ATE311443T1 (en) * 1997-09-03 2005-12-15 Biovation Ltd METHODS FOR SCREENING PROTEINS
JP2002502977A (en) 1998-02-04 2002-01-29 インビトロジェン コーポレイション Microarrays and their uses
US6780582B1 (en) * 1998-07-14 2004-08-24 Zyomyx, Inc. Arrays of protein-capture agents and methods of use thereof
US20030138973A1 (en) * 1998-07-14 2003-07-24 Peter Wagner Microdevices for screening biomolecules
US6576478B1 (en) * 1998-07-14 2003-06-10 Zyomyx, Inc. Microdevices for high-throughput screening of biomolecules
US20020119579A1 (en) * 1998-07-14 2002-08-29 Peter Wagner Arrays devices and methods of use thereof
US6406921B1 (en) * 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US20040242521A1 (en) * 1999-10-25 2004-12-02 Board Of Regents, The University Of Texas System Thio-siRNA aptamers
US20060172925A1 (en) * 1998-10-26 2006-08-03 Board Of Regents, The University Of Texas System Thio-siRNA aptamers
US6423493B1 (en) * 1998-10-26 2002-07-23 Board Of Regents The University Of Texas System Combinatorial selection of oligonucleotide aptamers
ATE376183T1 (en) * 1999-04-15 2007-11-15 Univ Virginia PROTEOME DEGRADATION
EP1173878B1 (en) 1999-04-27 2011-04-06 Bio-Rad Laboratories, Inc. Probes for a gas phase ion spectrometer
KR20020022653A (en) 1999-04-29 2002-03-27 사이퍼젠 바이오시스템스, 인코오포레이티드 Sample holder with hydrophobic coating for gas phase mass spectrometers
JP4543187B2 (en) * 1999-06-18 2010-09-15 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ Method and apparatus for assaying drug candidates for estimating pharmacokinetic parameters associated with the drug candidate
US20090233806A1 (en) * 1999-07-06 2009-09-17 Carr Francis J Protein isolation and analysis
JP2006509994A (en) * 1999-07-26 2006-03-23 ハーバード アパラタス インコーポレーティッド Surface coated housing for sample preparation
US7138254B2 (en) 1999-08-02 2006-11-21 Ge Healthcare (Sv) Corp. Methods and apparatus for performing submicroliter reactions with nucleic acids or proteins
AU7103500A (en) * 1999-09-01 2001-03-26 Medalys Corporation High throughput chemical profiling
AU7826500A (en) * 1999-09-01 2001-03-26 Medalys Corporation Automated test agent profiling system
US6869572B1 (en) * 1999-09-13 2005-03-22 Millipore Corporation High density cast-in-place sample preparation card
US6783929B1 (en) * 1999-11-02 2004-08-31 Chiron Corporation Biological sample component purification and differential display
US6936424B1 (en) * 1999-11-16 2005-08-30 Matritech, Inc. Materials and methods for detection and treatment of breast cancer
WO2001049414A2 (en) * 2000-01-06 2001-07-12 Caliper Technologies Corp. Ultra high throughput sampling and analysis systems and methods
DE10000629C5 (en) * 2000-01-10 2010-06-02 november Aktiengesellschaft, Gesellschaft für Molekulare Medizin Method of identifying a label applied to a solid
US20030087265A1 (en) * 2000-01-21 2003-05-08 Edward Sauter Specific microarrays for breast cancer screening
MXPA02007665A (en) * 2000-02-08 2004-08-23 Univ Michigan Mapping of differential display of proteins.
CN1444646A (en) 2000-02-23 2003-09-24 齐翁米克斯股份有限公司 Chips having elevated sample surfaces
US6815215B2 (en) * 2000-02-28 2004-11-09 Hitachi, Ltd. Method of recovering a plurality of nucleic acids by an identical stationary phase and an apparatus thereof
US6569383B1 (en) * 2000-03-11 2003-05-27 Intrinsic Bioprobes, Inc. Bioactive chip mass spectrometry
US7351540B1 (en) * 2000-03-17 2008-04-01 Merck Patent Gmbh Protein isolation and analysis
CA2301451A1 (en) * 2000-03-20 2001-09-21 Thang T. Pham Method for analysis of analytes by mass spectrometry
AU5951201A (en) * 2000-05-04 2001-11-12 Univ Yale High density protein arrays for screening of protein activity
US7153682B2 (en) * 2000-06-05 2006-12-26 Chiron Corporation Microarrays on mirrored substrates for performing proteomic analyses
EP1297338B1 (en) * 2000-06-05 2007-04-18 Novartis Vaccines and Diagnostics, Inc. Microarrays for performing proteomic analyses
US7148058B2 (en) 2000-06-05 2006-12-12 Chiron Corporation Protein microarrays on mirrored surfaces for performing proteomic analyses
NZ522859A (en) * 2000-06-19 2005-08-26 Correlogic Systems Inc Heuristic method of classifying objects using a vector space having multiple preclassified data clusters
KR101054732B1 (en) * 2000-07-18 2011-08-05 더 유나이티드 스테이츠 오브 아메리카 애즈 리프리젠티드 바이 더 세크레터리 오브 더 디파트먼트 오브 헬쓰 앤드 휴먼 써비시즈 How to Identify Biological Conditions Based on Hidden Patterns of Biological Data
DE60107022T2 (en) 2000-07-24 2005-11-24 Health Research Inc. Method for the detection of prostate-specific membrane antigen in serum
US6379550B1 (en) * 2000-07-24 2002-04-30 Health Research, Inc. Method for detecting PSA and its molecular forms using thiophilic gel
US6610499B1 (en) * 2000-08-31 2003-08-26 The Regents Of The University Of California Capillary array and related methods
AU2001288751A1 (en) * 2000-09-05 2002-03-22 Illumina, Inc. Cellular arrays comprising encoded cells
WO2002022264A2 (en) * 2000-09-18 2002-03-21 President And Fellows Of Harvard College Method and apparatus for gradient generation
CA2320549A1 (en) * 2000-09-25 2002-03-25 Eastern Virginia Medical College Biomarkers of transitional cell carcinoma of the bladder
WO2002031484A2 (en) * 2000-10-11 2002-04-18 Ciphergen Biosystems, Inc. Methods for characterizing molecular interactions using affinity capture tandem mass spectrometry
DE10054055A1 (en) * 2000-10-31 2002-05-23 Nmi Univ Tuebingen Methods for analyzing proteins
US6585646B2 (en) * 2000-11-29 2003-07-01 Hermetic Diagnostics, Inc. Screening test and procedure using skin patches
AU2002230788A1 (en) * 2000-12-11 2002-06-24 Hk Pharmaceuticals, Inc. Multiplexed protein expression and activity assay
EP1344065A2 (en) 2000-12-14 2003-09-17 Paul Stroobant Differential phage capture proteomics
US20020115056A1 (en) * 2000-12-26 2002-08-22 Goodlett David R. Rapid and quantitative proteome analysis and related methods
US20020119490A1 (en) * 2000-12-26 2002-08-29 Aebersold Ruedi H. Methods for rapid and quantitative proteome analysis
US20060051741A1 (en) * 2002-10-04 2006-03-09 Protosera Inc. Plate for mass spectrometry, process for preparing the same and use thereof
US7691645B2 (en) * 2001-01-09 2010-04-06 Agilent Technologies, Inc. Immunosubtraction method
US20030129666A1 (en) * 2001-01-09 2003-07-10 Mitsubishi Pharma Corporation Novel proteome analysis method and devices therefor
US6969757B2 (en) * 2001-01-26 2005-11-29 Syngenta Participations Ag Differential labeling for quantitative analysis of complex protein mixtures
US7166436B2 (en) 2001-01-26 2007-01-23 Syngenta Participations, Ag Differential labeling for quantitative analysis of complex protein mixtures
US20020169562A1 (en) * 2001-01-29 2002-11-14 Gregory Stephanopoulos Defining biological states and related genes, proteins and patterns
US7332286B2 (en) * 2001-02-02 2008-02-19 University Of Pennsylvania Peptide or protein microassay method and apparatus
JP3640387B2 (en) 2001-02-27 2005-04-20 独立行政法人理化学研究所 Polymer analysis method and system using laser ablation
WO2002073180A1 (en) * 2001-03-08 2002-09-19 Ruo-Pan Huang An antibody-based protein array system
US20030228639A1 (en) * 2001-03-19 2003-12-11 Wright George L Prostate cancer markers
WO2002074979A2 (en) * 2001-03-20 2002-09-26 Ortho-Clinical Diagnostics, Inc. Expression profiles and methods of use
US7354733B2 (en) * 2001-03-29 2008-04-08 Cellect Technologies Corp. Method for sorting and separating living cells
US7524635B2 (en) * 2003-04-17 2009-04-28 Biosite Incorporated Methods and compositions for measuring natriuretic peptides and uses thereof
US20030219734A1 (en) * 2001-04-13 2003-11-27 Biosite Incorporated Polypeptides related to natriuretic peptides and methods of their identification and use
AU2002303384A1 (en) * 2001-04-17 2002-10-28 William J. Dower Epitope-captured antibody display
US20020155587A1 (en) 2001-04-20 2002-10-24 Sequenom, Inc. System and method for testing a biological sample
US20020160421A1 (en) * 2001-04-30 2002-10-31 George Jackowski Method for monitoring and validating stress induction of disease state
CA2446867C (en) 2001-05-11 2016-09-20 Yale University Global analysis of protein activities using proteome chips
JP4015992B2 (en) * 2001-05-25 2007-11-28 ウォーターズ・インヴェストメンツ・リミテッド Sample concentration MALDI plate for MALDI mass spectrometer
JP4194370B2 (en) 2001-05-25 2008-12-10 ウォーターズ・インヴェストメンツ・リミテッド Desalting plate for MALDI mass spectrometry
US7723123B1 (en) * 2001-06-05 2010-05-25 Caliper Life Sciences, Inc. Western blot by incorporating an affinity purification zone
US20020197729A1 (en) * 2001-06-21 2002-12-26 Fuji Photo Film Co., Ltd. Biochemical analysis unit and method for manufacturing the same
AU2002316372A1 (en) * 2001-06-22 2003-01-08 Symyx Technologies, Inc. Inverse chromatography methods and apparatus for evaluation of interactions between modifying agents and receptors
JP4500540B2 (en) * 2001-06-29 2010-07-14 ヴェリ‐キュー，インコーポレイテッド Methods and compositions for determining the purity of chemically synthesized nucleic acids and purifying chemically synthesized nucleic acids
US6800449B1 (en) * 2001-07-13 2004-10-05 Syngenta Participations Ag High throughput functional proteomics
US7297553B2 (en) * 2002-05-28 2007-11-20 Nanosphere, Inc. Method for attachment of silylated molecules to glass surfaces
WO2003006676A2 (en) 2001-07-13 2003-01-23 Nanosphere, Inc. Method for immobilizing molecules onto surfaces
JP4264002B2 (en) * 2001-07-17 2009-05-13 バイオ−ラド ラボラトリーズ インコーポレイテッド Latex-based adsorption chip
US7517496B2 (en) * 2001-07-17 2009-04-14 Bio-Rad Laboratories, Inc. Latex based adsorbent chip
US6852727B2 (en) * 2001-08-01 2005-02-08 Merck & Co., Inc. Benzimisazo[4,5-f]isoquinolinone derivatives
WO2004072616A2 (en) * 2003-02-10 2004-08-26 Waters Investments Limited A sample preparation plate for mass spectrometry
GB0120131D0 (en) * 2001-08-17 2001-10-10 Micromass Ltd Maldi target plate
WO2003019193A1 (en) * 2001-08-30 2003-03-06 Ciphergen Biosystems, Inc. Method of diagnosing nephrotic syndrome
AU2002328413B2 (en) * 2001-09-03 2007-03-15 Kyowa Hakko Kogyo Co., Ltd. Method for Determining Target Protein of Medicament
US20040171026A1 (en) * 2001-09-05 2004-09-02 Hochstrasser Denis Francois Diagnostic method for transmissible spongiform encephalopathies
GB2379737A (en) * 2001-09-05 2003-03-19 Univ Geneve Diagnostic method for spongiform encephalopathy disease
US20030068655A1 (en) * 2001-09-12 2003-04-10 Protiveris, Inc. Microcantilever apparatus and methods for detection of enzymes
US20040043436A1 (en) * 2001-09-21 2004-03-04 Antonia Vlahou Biomarkers of transitional cell carcinoma of the bladder
US6756586B2 (en) 2001-10-15 2004-06-29 Vanderbilt University Methods and apparatus for analyzing biological samples by mass spectrometry
US20050064446A1 (en) * 2001-11-01 2005-03-24 Minerva Biotechnologies Corporation Detection of binding species with colloidal and non-colloidal structures
US7842498B2 (en) * 2001-11-08 2010-11-30 Bio-Rad Laboratories, Inc. Hydrophobic surface chip
WO2003062444A2 (en) * 2001-11-13 2003-07-31 Emory University Array systems and methods
US20030091976A1 (en) * 2001-11-14 2003-05-15 Ciphergen Biosystems, Inc. Methods for monitoring polypeptide production and purification using surface enhanced laser desorption/ionization mass spectrometry
US20030162190A1 (en) * 2001-11-15 2003-08-28 Gorenstein David G. Phosphoromonothioate and phosphorodithioate oligonucleotide aptamer chip for functional proteomics
CA2467248A1 (en) * 2001-11-20 2003-05-30 Exact Sciences Corporation Automated sample preparation methods and devices
US7132244B2 (en) * 2001-11-21 2006-11-07 Syn X Pharma, Inc. Betaine/GABA transport protein biopolymer marker indicative of insulin resistance
US7179605B2 (en) * 2001-11-23 2007-02-20 Nanogen Inc. Fibronectin precursor biopolymer markers indicative of alzheimer's disease
US6946653B2 (en) 2001-11-27 2005-09-20 Ciphergen Biosystems, Inc. Methods and apparatus for improved laser desorption ionization tandem mass spectrometry
SE0202398D0 (en) * 2001-12-11 2002-08-13 Thomas Laurell Target plate and use thereof for improved analysis
WO2003049602A2 (en) * 2001-12-11 2003-06-19 University Of Medicine And Dentistry Of New Jersey Diagnostic methods for protein profiling
WO2003054514A2 (en) * 2001-12-19 2003-07-03 Rett Corporation Novel parallel throughput system
US20030116501A1 (en) * 2001-12-21 2003-06-26 Council Of Scientific And Industrial Research Process for preparing immobilized nano-sized metal particles
WO2003065043A2 (en) * 2002-01-29 2003-08-07 King's College London An Institute Incorporated By Royal Charter Of Strand Identification and relative quantification of proteins
US7094579B2 (en) * 2002-02-13 2006-08-22 Xoma Technology Ltd. Eukaryotic signal sequences for prokaryotic expression
GB0203768D0 (en) * 2002-02-18 2002-04-03 Univ Geneve Diagnostic method for stroke
US20050153360A1 (en) * 2002-02-18 2005-07-14 Hochstrasser Denis F. Diagnostic method for stroke
AU2003211157A1 (en) * 2002-02-21 2003-09-09 Eastern Virginia Medical School Protein biomarkers that distinguish prostate cancer from non-malignant cells
US7504364B2 (en) * 2002-03-01 2009-03-17 Receptors Llc Methods of making arrays and artificial receptors
ES2319634T3 (en) * 2002-03-11 2009-05-11 Caprotec Bioanalytics Gmbh COMPOUNDS AND METHODS TO ANALYZE THE PROTEOM.
US20030228709A1 (en) * 2002-03-25 2003-12-11 Kozlowski Roland Zbignieiw Arrays
US6803566B2 (en) 2002-04-16 2004-10-12 Ut-Battelle, Llc Sampling probe for microarray read out using electrospray mass spectrometry
US7371581B2 (en) * 2002-05-03 2008-05-13 Dsm Ip Assets B.V. Process for the monitoring of contaminant removal during the purification process of a pharmaceutical product produced by a host cell
EP1499890B1 (en) * 2002-05-07 2010-04-28 The Research Foundation of State University of New York High throughput method to identify biomolecule delivery formulations
US7618788B2 (en) * 2002-05-10 2009-11-17 Millipore Corporation Proteome epitope tags and methods of use thereof in protein modification analysis
US20040052412A1 (en) * 2002-05-10 2004-03-18 Large Scale Biology Corporation Satellite image enhancement and feature identification using information theory radial-basis bio-marker filter
US7460960B2 (en) * 2002-05-10 2008-12-02 Epitome Biosystems, Inc. Proteome epitope tags and methods of use thereof in protein modification analysis
US7138230B2 (en) 2002-12-06 2006-11-21 Renovar, Inc. Systems and methods for characterizing kidney diseases
AU2003233630A1 (en) * 2002-05-17 2003-12-02 Ciphergen Biosystems, Inc. Detection of kinase substrates and products using ion mass spectrometry
US20040033613A1 (en) * 2002-05-30 2004-02-19 Zwick Michael G. Saliva-based protein profiling
WO2003101394A2 (en) * 2002-05-31 2003-12-11 Ciphergen Biosystems, Inc. Defensins: use as antiviral agents
EP1511843B1 (en) * 2002-06-07 2006-03-29 Sophion Bioscience A/S Screening methods
CA2490522A1 (en) * 2002-06-20 2003-12-31 Paul Stroobant Improved methods for performing differential capture proteomics
JP4380535B2 (en) 2002-06-28 2009-12-09 キヤノン株式会社 Probe carrier and method for analyzing the probe carrier
US20040137491A1 (en) * 2002-06-28 2004-07-15 Tadashi Okamoto Method of analyzing probe carrier using time-of-flight secondary ion mass spectrometry
CN1672040A (en) * 2002-06-28 2005-09-21 佳能株式会社 Method for analyzing probes carrier using time-of-flight secondary ion mass spectrometry with halogen labeling
DE10329928A1 (en) * 2002-07-12 2004-02-05 Benq Corp., Kweishan Process for the preparation of biochips and biochip
US7348184B2 (en) * 2002-07-24 2008-03-25 Bio-Rad Laboratories, Inc. Protein interaction difference mapping
GB0305796D0 (en) * 2002-07-24 2003-04-16 Micromass Ltd Method of mass spectrometry and a mass spectrometer
FR2842826B1 (en) * 2002-07-25 2006-01-20 Centre Nat Rech Scient PROCESS FOR PRODUCING BIOLOGICAL CHIPS
AU2003304161A1 (en) 2002-07-29 2005-01-21 Correlogic Systems, Inc. Quality assurance/quality control for high throughput bioassay process
US7655474B2 (en) * 2002-07-29 2010-02-02 The United States Of America As Represented By The Secretary Of The Navy Trioxyethylene gold nanoclusters functionalized with a single DNA
AU2003257109A1 (en) * 2002-08-05 2004-02-23 Invitrogen Corporation Compositions and methods for molecular biology
ATE468534T1 (en) * 2002-08-06 2010-06-15 Univ Johns Hopkins USE OF BIOMARKERS FOR DETECTING Ovarian CANCER
US20040153249A1 (en) * 2002-08-06 2004-08-05 The Johns Hopkins University System, software and methods for biomarker identification
GB2391867A (en) * 2002-08-13 2004-02-18 Smartbead Technologies Ltd Analysis system using coded supports
US20050233473A1 (en) * 2002-08-16 2005-10-20 Zyomyx, Inc. Methods and reagents for surface functionalization
AU2003263853A1 (en) * 2002-08-16 2004-03-03 Board Of Regents The University Of Texas System Compositions and methods related to flavivirus envelope protein domain iii antigens
US20060292701A1 (en) * 2002-09-13 2006-12-28 Ciphergen Biosystems Inc. Photocrosslinked hydrogel blend surface coatings
US7144743B2 (en) 2002-09-13 2006-12-05 Pall Corporation Preparation and use of mixed mode solid substrates for chromatography adsorbents and biochip arrays
US7045366B2 (en) * 2003-09-12 2006-05-16 Ciphergen Biosystems, Inc. Photocrosslinked hydrogel blend surface coatings
US20060051802A1 (en) * 2002-09-16 2006-03-09 Receptors Llc Artificial receptors, building blocks, and methods
US20050136483A1 (en) * 2003-09-03 2005-06-23 Receptors Llc Nanodevices employing combinatorial artificial receptors
US20050170385A1 (en) * 2002-09-16 2005-08-04 Receptors Llc Artificial receptors including gradients
US20050037429A1 (en) * 2003-03-28 2005-02-17 Receptors Llc Artificial receptors including reversibly immobilized building blocks and methods
US20040137481A1 (en) * 2002-09-16 2004-07-15 Receptors Llc Artificial receptor building blocks, components, and kits
US20050037381A1 (en) * 2002-09-16 2005-02-17 Receptors Llc Artificial receptors, building blocks, and methods
CA2502246A1 (en) * 2002-10-15 2004-04-29 Abmetrix, Inc. Sets of digital antibodies directed against short epitopes, and methods using same
EP1572978A4 (en) * 2002-10-16 2006-05-24 Univ Texas Bead bound combinatorial oligonucleoside phosphorothioate and phosphorodithioate aptamer libraries
EP2211181A1 (en) 2002-10-30 2010-07-28 Proteome Sciences Plc Diagnostic method for transmissible spongiform encephalopathies
US7122384B2 (en) * 2002-11-06 2006-10-17 E. I. Du Pont De Nemours And Company Resonant light scattering microparticle methods
US20030153013A1 (en) * 2002-11-07 2003-08-14 Ruo-Pan Huang Antibody-based protein array system
EP1590469A4 (en) 2002-11-12 2005-12-28 Becton Dickinson Co Diagnosis of sepsis or sirs using biomarker profiles
CA2505902A1 (en) * 2002-11-12 2004-05-27 Becton, Dickinson And Company Diagnosis of sepsis or sirs using biomarker profiles
AU2003291483A1 (en) * 2002-11-12 2004-06-03 Becton, Dickinson And Company Diagnosis of sepsis or sirs using biomarker profiles
US20040241775A1 (en) * 2002-11-14 2004-12-02 The Govt. Of The Usa As Represented By The Secretary Of The Dept. Of Health & Human Services Methods and kits for determining risk of pre-term delivery
US7846748B2 (en) * 2002-12-02 2010-12-07 The University Of North Carolina At Chapel Hill Methods of quantitation and identification of peptides and proteins
DE10258674A1 (en) * 2002-12-13 2004-06-24 Sunyx Surface Nanotechnologies Gmbh Manufacturing sample carrier with points for matrix-assisted laser desorption and ionization, forms MALDI matrix points by gas phase sublimation
EP1573044A4 (en) 2002-12-18 2006-07-05 Ciphergen Biosystems Inc Serum biomarkers in lung cancer
US7422865B2 (en) * 2003-01-13 2008-09-09 Agilent Technologies, Inc. Method of identifying peptides in a proteomic sample
JP4741458B2 (en) 2003-01-16 2011-08-03 カプロテック・バイオアナリティクス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Method for analyzing capture compounds, collections thereof, and proteomes and composite compositions
US6909981B2 (en) * 2003-01-27 2005-06-21 Ciphergen Biosystems, Inc. Data management system and method for processing signals from sample spots
WO2004067162A2 (en) * 2003-01-30 2004-08-12 Ciphergen Biosystems Inc. Apparatus for microfluidic processing and reading of biochip arrays
WO2004073492A2 (en) * 2003-02-14 2004-09-02 Massachusetts Eye And Ear Infirmary Chlamydia pneumoniae associated chronic intraocular disorders and treatment thereof
DE10311384A1 (en) * 2003-03-11 2004-09-30 Universität Potsdam Detection method for plant molecules
GB0305656D0 (en) * 2003-03-12 2003-04-16 Bioinvent Int Ab Screening assay
CA2519086A1 (en) * 2003-03-14 2004-09-23 Kitakyushu Foundation For The Advancement Of Industry Science And Techno Logy Biological molecule-immobilized chip and its use
JP4673836B2 (en) * 2003-03-25 2011-04-20 インストラクション・ゲーエムベーハー A method for selective binding of a substrate to a sorbent by at least a divalent bond.
EP1613737A4 (en) * 2003-03-28 2008-12-03 Receptors Llc Artificial receptors including reversibly immobilized building blocks and methods
WO2004089972A2 (en) * 2003-04-02 2004-10-21 Merck & Co., Inc. Mass spectrometry data analysis techniques
US6977370B1 (en) 2003-04-07 2005-12-20 Ciphergen Biosystems, Inc. Off-resonance mid-IR laser desorption ionization
WO2004094460A2 (en) 2003-04-17 2004-11-04 Ciphergen Biosystems, Inc. Polypeptides related to natriuretic peptides and methods of their identification and use
WO2004094989A2 (en) * 2003-04-22 2004-11-04 Ciphergen Biosystems, Inc. Methods of host cell protein analysis
WO2004097368A2 (en) * 2003-04-28 2004-11-11 Ciphergen Biosystems, Inc. Improved immunoassays
US20040219589A1 (en) * 2003-04-29 2004-11-04 Taehoon Lee Ligand profiling and identification
US20050037386A1 (en) * 2003-05-05 2005-02-17 Drug Risk Solutions, L.L.C. Composition and processes for analysis of pharmacologic agents in biological samples
US20040236603A1 (en) * 2003-05-22 2004-11-25 Biospect, Inc. System of analyzing complex mixtures of biological and other fluids to identify biological state information
US7425700B2 (en) * 2003-05-22 2008-09-16 Stults John T Systems and methods for discovery and analysis of markers
WO2005037053A2 (en) * 2003-05-23 2005-04-28 Board Of Regents - The University Of Texas System High throughput screening of aptamer libraries for specific binding to proteins on viruses and other pathogens
US7910523B2 (en) * 2003-05-23 2011-03-22 Board Of Regents, The University Of Texas System Structure based and combinatorially selected oligonucleoside phosphorothioate and phosphorodithioate aptamer targeting AP-1 transcription factors
US20040241880A1 (en) * 2003-05-30 2004-12-02 Leproust Eric M. Ligand array assays having reduced fluorescent dye degradation and compositions for practicing the same
US20040241742A1 (en) * 2003-05-30 2004-12-02 Peck Bill J. Ligand array processing methods that include a low surface tension fluid deposition step and compositions for practicing the same
US20040241668A1 (en) * 2003-05-30 2004-12-02 Amorese Douglas A. Ligand array assays that include a low surface tension fluid wash step and compositions for practicing the same
US20040248323A1 (en) * 2003-06-09 2004-12-09 Protometrix, Inc. Methods for conducting assays for enzyme activity on protein microarrays
US20050100967A1 (en) * 2003-07-11 2005-05-12 Science & Technology Corporation @ Unm Detection of endometrial pathology
US20050032113A1 (en) * 2003-07-17 2005-02-10 Mitsubishi Pharma Corporation Membrane protein library for proteome analysis and method for preparing same
WO2005010016A2 (en) * 2003-07-24 2005-02-03 Board Of Regents Thioaptamers enable discovery of physiological pathways and new therapeutic strategies
US20050026304A1 (en) * 2003-07-30 2005-02-03 Laurakay Bruhn Microarray based affinity purification and analysis device coupled with secondary analysis technologies
WO2005011474A2 (en) * 2003-08-01 2005-02-10 Correlogic Systems, Inc. Multiple high-resolution serum proteomic features for ovarian cancer detection
US20050037424A1 (en) * 2003-08-13 2005-02-17 Schembri Carol T. Selectable length linear microarrays
AU2004267802B2 (en) * 2003-08-18 2011-03-17 Tethys Bioscience, Inc. Methods for reducing complexity of a sample using small epitope antibodies
WO2005019875A2 (en) * 2003-08-22 2005-03-03 Stratos Biosystems, Llc Electrowetting sample presentation device
US20080070791A1 (en) * 2003-09-09 2008-03-20 Zephyr Proteomix Ltd. Libraries Of Chimeric Cellulose Binding Proteins And Methods Of Use Thereof
AU2004276760B2 (en) * 2003-09-22 2010-03-04 Becton, Dickinson And Company Quantification of analytes using internal standards
US20050084867A1 (en) * 2003-10-15 2005-04-21 Caren Michael P. Hybridization and scanning apparatus
WO2005047851A2 (en) * 2003-10-15 2005-05-26 The Trustees Of Columbia University In The City Of New York Device for measuring nanometer level pattern-dependent binding reactions
US20050084866A1 (en) * 2003-10-15 2005-04-21 Caren Michael P. Methods and apparatus for sample mixing
US8137548B2 (en) * 2003-10-17 2012-03-20 Zirchrom Separations, Inc. Chelator-modified inorganic oxide particles
US20050112650A1 (en) * 2003-10-20 2005-05-26 Ciphergen Biosystems, Inc. Reactive polyurethane-based polymers
US7858071B2 (en) 2003-10-23 2010-12-28 University of Pittsburgh—of the Commonwealth System of Higher Education Biomarkers for amyotrophic lateral sclerosis
WO2005040163A1 (en) * 2003-10-28 2005-05-06 Dr. Reddy's Laboratories Ltd Heterocyclic compounds that block the effects of advanced glycation end products (age)
US20050214803A1 (en) * 2003-11-06 2005-09-29 Sru Biosystems, Llc High-density amine-functionalized surface
JP4796967B2 (en) 2003-11-07 2011-10-19 ヴァーミリオン インコーポレイテッド Biomarkers for Alzheimer's disease
US20050158745A1 (en) * 2003-11-25 2005-07-21 Ye Jack Z. Methods and compositions for detection of nasopharyngeal carcinoma
US20050112588A1 (en) * 2003-11-25 2005-05-26 Caren Michael P. Methods and apparatus for analyzing arrays
WO2005055812A2 (en) 2003-12-05 2005-06-23 Ciphergen Biosystems, Inc. Serum biomarkers for chagas disease
EP1711819A4 (en) * 2003-12-15 2008-04-16 Univ Pennsylvania Ct For Techn Method and devices for running reactions on a target plate for maldi mass spectrometry
WO2005061532A1 (en) * 2003-12-23 2005-07-07 Berthet Francois Xavier Pathogenic infection detection compositions and methods
DE102004062281A1 (en) * 2003-12-29 2005-07-28 Siemens Ag Producing a microarray of spots e.g. for use on a biochip, comprises applying a solution of a polymer and special molecules and then solidifying the polymer, especially by a non-radical method
US7183544B2 (en) * 2003-12-31 2007-02-27 Ciphergen Biosystems Inc. Bi-functional polymer chip
US20050181398A1 (en) * 2004-01-16 2005-08-18 Fung Eric T. Specific detection of host response protein clusters
EP1715948B1 (en) * 2004-01-20 2016-11-23 Pall Corporation Chromatographic material for the absorption of proteins at physiological ionic strength
US20050181513A1 (en) * 2004-02-18 2005-08-18 Viorica Lopez-Avila Methods and compositions for assessing a sample by MAILDI mass spectrometry
US20050178959A1 (en) * 2004-02-18 2005-08-18 Viorica Lopez-Avila Methods and compositions for assessing a sample by maldi mass spectrometry
US7138642B2 (en) * 2004-02-23 2006-11-21 Gemio Technologies, Inc. Ion source with controlled superposition of electrostatic and gas flow fields
US8003934B2 (en) * 2004-02-23 2011-08-23 Andreas Hieke Methods and apparatus for ion sources, ion control and ion measurement for macromolecules
US20050233400A1 (en) * 2004-03-03 2005-10-20 Weiner Carl P Proteomic method for predicting success of rescue cerclage
US20050202485A1 (en) * 2004-03-03 2005-09-15 Ye Jack Z. Method and compositions for detection of liver cancer
EP1580559B1 (en) * 2004-03-23 2013-12-25 Bio-Rad Laboratories, Inc. Methods for reducing the variance between analyte concentrations taken from complex sample mixtures
US20060275923A1 (en) * 2004-03-23 2006-12-07 Hammond David J Methods for reducing the range in concentrations of analyte species in a sample
US20090206245A1 (en) * 2004-03-31 2009-08-20 Shionogi Co., Ltd Mass analysis method using fine metal particles
GB0408351D0 (en) * 2004-04-15 2004-05-19 Plasso Technology Ltd Reversible binding surface
EP2207033B1 (en) 2004-04-15 2014-06-18 University of Florida Research Foundation, Inc. Neural proteins as biomarkers for nervous system injury and other neural disorders
US20050239134A1 (en) * 2004-04-21 2005-10-27 Board Of Regents, The University Of Texas System Combinatorial selection of phosphorothioate single-stranded DNA aptamers for TGF-beta-1 protein
WO2005103281A2 (en) 2004-04-26 2005-11-03 Children's Medical Center Corporation Platelet biomarkers for the detection of disease
US20050244973A1 (en) * 2004-04-29 2005-11-03 Predicant Biosciences, Inc. Biological patterns for diagnosis and treatment of cancer
US7749716B2 (en) * 2004-05-18 2010-07-06 Vermilllion, Inc. Methods of detecting a fragment of neurosecretory protein VGF for diagnosing alzheimer's disease
US20060003204A1 (en) * 2004-07-01 2006-01-05 Callahan Christopher W Controlling fuel cell fuel purge in response to recycle fuel blower operating conditions
EP2848942B1 (en) 2004-07-14 2017-03-08 The Regents of The University of California Biomarkers for early detection of ovarian cancer
US20060024725A1 (en) 2004-07-30 2006-02-02 Robert Hussa Oncofetal fibronectin as a marker for pregnancy-related indications
WO2006029234A1 (en) * 2004-09-03 2006-03-16 Receptors Llc Combinatorial artificial receptors including tether building blocks
WO2006029383A2 (en) * 2004-09-11 2006-03-16 Receptors Llc Combinatorial artificial receptors including peptide building blocks
WO2006034278A2 (en) * 2004-09-21 2006-03-30 Matritech, Inc. Methods and compositions for detecting cancer using components of the u2 spliceosomal particle
WO2006047417A2 (en) 2004-10-21 2006-05-04 University Of Florida Research Foundation, Inc. Detection of cannabinoid receptor biomarkers and uses thereof
US7332296B2 (en) * 2004-12-02 2008-02-19 Wright State University Screening assay for enzymes involved in pathophysiology using SELDI-TOF mass spectrometry
US7572596B2 (en) 2004-12-02 2009-08-11 University Of Pittsburgh Of The Commonwealth System Of Higher Education Modulation of the neuroendoctrine system as a therapy for motor neuron disease
CA2590188A1 (en) 2004-12-08 2006-06-15 Lyotropic Therapeutics, Inc. Compositions for binding to assay substrata and methods of using
US20060128031A1 (en) * 2004-12-15 2006-06-15 Robotti Karla M Addressable recovery of bound analytes from an evanescent wave sensor
WO2006074360A2 (en) * 2005-01-06 2006-07-13 Eastern Virginia Medical School Apolipoprotein a-ii isoform as a biomarker for prostate cancer
US20060157647A1 (en) * 2005-01-18 2006-07-20 Becton, Dickinson And Company Multidimensional liquid chromatography/spectrometry
WO2006081135A2 (en) * 2005-01-25 2006-08-03 Oscillogy Llc Temperature controller for small fluid samples having different heat capacities
CA2595377A1 (en) 2005-01-28 2006-08-03 Children's Medical Center Corporation Methods for diagnosis and prognosis of epithelial cancers
US7358485B2 (en) * 2005-02-08 2008-04-15 Perkinelmer Las, Inc. Zirconia toughened alumina composition and use in ion and electron optical systems
JP2008530555A (en) * 2005-02-09 2008-08-07 コレロジック システムズ，インコーポレイテッド Identification of bacteria and spores
US20060183863A1 (en) * 2005-02-14 2006-08-17 Ciphergen Biosystems, Inc. Zwitterionic polymers
US20060234265A1 (en) * 2005-03-21 2006-10-19 Jim Richey Microarrays having multi-functional, compartmentalized analysis areas and methods of use
US20090247421A1 (en) * 2005-03-23 2009-10-01 Egisto Boschetti Diverse chemical libraries bound to small particles with paramagnetic properties
JP2008538112A (en) 2005-03-23 2008-10-09 バイオ−ラッド ラボラトリーズ インコーポレーティッド Diverse chemical libraries bound to small particles with paramagnetic properties
JP4841618B2 (en) * 2005-03-23 2011-12-21 バイオ−ラッド ラボラトリーズ インコーポレーティッド Methods for purifying proteins
US8048638B2 (en) * 2005-04-01 2011-11-01 University Of Florida Research Foundation, Inc. Biomarkers of liver injury
AU2006232370B2 (en) * 2005-04-01 2011-10-06 Banyan Biomarkers Biomakers of liver injury
BRPI0609302A2 (en) 2005-04-15 2011-10-11 Becton Dickinson Co methods for predicting the development of sepsis and for diagnosing sepsis in an individual to be tested, microarray, kit for predicting the development of sepsis in an individual to be tested, computer program product, computer, computer system for determining if an individual is likely to develop sepsis, digital signal embedded in a carrier wave, and, graphical user interface to determine if an individual is likely to develop sepsis
US20070087387A1 (en) 2005-04-21 2007-04-19 Prasad Devarajan Method for the Early Detection of Renal Disease Using Proteomics
JP4577083B2 (en) * 2005-04-28 2010-11-10 味の素株式会社 How to diagnose Crohn's disease
US7622273B2 (en) * 2005-05-11 2009-11-24 Gibbs Bernard F Method for chemical and enzymatic treatment of posttranslationally modified proteins bound to a protein chip
US20070003954A1 (en) * 2005-05-12 2007-01-04 The Board Of Regents Of The University Of Texas System Protein and antibody profiling using small molecule microarrays
US20080312514A1 (en) * 2005-05-12 2008-12-18 Mansfield Brian C Serum Patterns Predictive of Breast Cancer
WO2006125094A2 (en) * 2005-05-18 2006-11-23 Board Of Regents, The University Of Texas System Combinatorial selection of phosphorothioate aptamers for rnases
JP2008547003A (en) * 2005-06-16 2008-12-25 バーミリオン， インコーポレイテッド Fragment of neurosecretory protein VGF as a biomarker for Alzheimer's disease
EP1896493A1 (en) 2005-06-17 2008-03-12 North Carolina A & T State University A device including a proteinaceous factor, a recombinant proteinaceous factor, and a nucleotide sequence encoding the proteinaceous factor
GB0512401D0 (en) * 2005-06-17 2005-07-27 Randox Lab Ltd Method
US20100173788A1 (en) * 2005-06-21 2010-07-08 Vermillion, Inc. Biomarkers for breast cancer
WO2007002527A2 (en) 2005-06-24 2007-01-04 Ciphergen Biosystems, Inc. BIOMARKERS FOR OVARIAN CANCER: β-2 MICROGLOBULIN
US8465983B1 (en) * 2005-08-19 2013-06-18 Gabriel P. Lopez Detection and delivery systems utilizing supported lipid bilayers
US20070048786A1 (en) * 2005-09-01 2007-03-01 Arnon Chait Systems and methods for fractionation of protein mixtures
WO2007033253A1 (en) * 2005-09-14 2007-03-22 Symyx Technologies, Inc. High throughput chemical speciation
US7972802B2 (en) * 2005-10-31 2011-07-05 University Of Washington Lipoprotein-associated markers for cardiovascular disease
EP1951906B1 (en) 2005-11-10 2010-12-22 Bristol-Myers Squibb Pharma Company Moesin, caveolin 1 and yes associated protein 1 as predictive markers of response to dasatinib in breast cancers
US7889347B2 (en) * 2005-11-21 2011-02-15 Plexera Llc Surface plasmon resonance spectrometer with an actuator driven angle scanning mechanism
US7463358B2 (en) 2005-12-06 2008-12-09 Lumera Corporation Highly stable surface plasmon resonance plates, microarrays, and methods
WO2007070809A2 (en) * 2005-12-12 2007-06-21 Mcgill University Biomarkers for babesia
AU2007209980A1 (en) * 2006-01-27 2007-08-09 Eastern Virginia Medical School Proteomic fingerprinting of human IVF-derived embryos: identification of biomarkers of developmental potential
CA2642833A1 (en) 2006-02-17 2007-08-30 Children's Medical Center Corporation Free ngal as a biomarker for cancer
DE102006009083B4 (en) * 2006-02-28 2018-05-30 Bruker Daltonik Gmbh Mass spectrometric determination of the activity of blood enzymes
WO2007120999A2 (en) * 2006-03-06 2007-10-25 Bio-Rad Laboratories, Inc. Chelating monomers and polymers
EP1996942A1 (en) * 2006-03-10 2008-12-03 Tethys Bioscience, Inc. Multiplex protein fractionation
WO2007106466A2 (en) 2006-03-11 2007-09-20 The Board Of Trustees Of The Leland Stanford Junior University Beta-2 microglobulin as a biomarker for peripheral artery disease
US7855057B2 (en) * 2006-03-23 2010-12-21 Millipore Corporation Protein splice variant/isoform discrimination and quantitative measurements thereof
JP2009531716A (en) * 2006-03-29 2009-09-03 キャンジェン バイオテクノロジーズ，インコーポレーテッド Filtration apparatus and method for improved peak detection
KR100754399B1 (en) * 2006-04-05 2007-08-31 삼성전자주식회사 Method and apparatus for disrupting cells and purifying nucleic acids using one chamber
EP2010910A2 (en) 2006-04-21 2009-01-07 Wyeth Differential expression profiling analysis of cell culture phenotypes and the uses thereof
WO2007139989A2 (en) 2006-05-26 2007-12-06 Brandeis University Tissue sample preparation, and maldi ms imaging thereof
US8084734B2 (en) * 2006-05-26 2011-12-27 The George Washington University Laser desorption ionization and peptide sequencing on laser induced silicon microcolumn arrays
US20080193772A1 (en) * 2006-07-07 2008-08-14 Bio-Rad Laboratories, Inc Mass spectrometry probes having hydrophobic coatiings
US20100003189A1 (en) 2006-07-14 2010-01-07 The Regents Of The University Of California Cancer biomarkers and methods of use thereof
US7879799B2 (en) * 2006-08-10 2011-02-01 Institute For Systems Biology Methods for characterizing glycoproteins and generating antibodies for same
ES2655564T3 (en) 2006-09-07 2018-02-20 Otago Innovation Limited Biomarker for the early detection of acute heart disorders
CN101646943A (en) * 2006-10-31 2010-02-10 Sru生物系统公司 Method for blocking non-specific protein binding on a functionalized surface
JP2010514804A (en) * 2006-12-29 2010-05-06 ザ・ソーク・インスティチュート・フォー・バイオロジカル・スタディーズ Ways to increase athletic performance
GB0700475D0 (en) * 2007-01-10 2007-02-21 Cole Polytechnique Federale De Ionization device
US8519148B2 (en) 2007-03-14 2013-08-27 Knopp Neurosciences, Inc. Synthesis of chirally purified substituted benzothiazole diamines
EP2210099A4 (en) 2007-03-27 2011-03-16 Vermillion Inc Biomarkers for ovarian cancer
US20100113746A1 (en) * 2007-04-23 2010-05-06 Arvind Mallinath Lali Process for purification of immunoglobulins using a pseudobioaffinity adsorbent
EP2162552A4 (en) 2007-05-11 2010-06-30 Univ Johns Hopkins Biomarkers for melanoma
US20100184110A1 (en) * 2007-06-06 2010-07-22 Siemens Healthcare Diagnostics Inc. Predictive diagnostics for kidney disease
US20090017460A1 (en) * 2007-06-15 2009-01-15 Wyeth Differential expression profiling analysis of cell culture phenotypes and uses thereof
EP3666284A1 (en) 2007-06-22 2020-06-17 Children's Medical Center, Corp. Methods and uses thereof of a fragment of saposin a
EP2637020A3 (en) 2007-06-29 2014-01-08 Correlogic Systems Inc. Predictive markers for ovarian cancer
EP2183592A4 (en) * 2007-08-08 2011-03-16 Renovar Inc Systems and methods for characterizing lupus erythematosus
JP2009047956A (en) * 2007-08-21 2009-03-05 Sony Corp Imaging apparatus
US20090060786A1 (en) * 2007-08-29 2009-03-05 Gibum Kim Microfluidic apparatus for wide area microarrays
WO2009058331A2 (en) 2007-10-29 2009-05-07 Vermilllion, Inc. Biomarkers for the detection of early stage ovarian cancer
EP3536336A1 (en) 2007-11-30 2019-09-11 Siemens Healthcare Diagnostics Inc. Adiponectin receptor fragments and methods of use
US8004669B1 (en) 2007-12-18 2011-08-23 Plexera Llc SPR apparatus with a high performance fluid delivery system
WO2009086215A2 (en) * 2007-12-21 2009-07-09 Wyeth Pathway analysis of cell culture phenotypes and uses thereof
US8569006B2 (en) 2008-02-29 2013-10-29 Imec Cell-enzyme based biosensors
EP3156925A3 (en) 2008-03-10 2017-06-21 Lineagen, Inc. Copd biomarker signatures
CA2715914C (en) 2008-03-12 2019-01-22 Otago Innovation Limited Insulin signal peptide fragment biomarkers
AU2009224114B2 (en) 2008-03-12 2013-02-21 Otago Innovation Limited Biomarkers
EP2260305A1 (en) * 2008-03-27 2010-12-15 INSERM (Institut National de la Santé et de la Recherche Medicale) Methods and kits for determining the occurrence of a liver disease in a subject
US8669113B2 (en) 2008-04-03 2014-03-11 Becton, Dickinson And Company Advanced detection of sepsis
SG190572A1 (en) 2008-04-29 2013-06-28 Abbott Lab Dual variable domain immunoglobulins and uses thereof
US8673644B2 (en) 2008-05-13 2014-03-18 Battelle Memorial Institute Serum markers for type II diabetes mellitus
WO2009149124A1 (en) * 2008-06-02 2009-12-10 Bio-Rad Laboratories, Inc. Mass spectrometric detection of material transferred to a surface
CA2726087A1 (en) 2008-06-03 2009-12-10 Tariq Ghayur Dual variable domain immunoglobulins and uses thereof
US20110210074A1 (en) * 2008-06-26 2011-09-01 Winchester James F Removal of myoglobin from blood and/or physiological fluids
US8241861B1 (en) 2008-07-08 2012-08-14 Insilicos, Llc Methods and compositions for diagnosis or prognosis of cardiovascular disease
WO2010123720A1 (en) 2009-04-23 2010-10-28 Siemens Healthcare Diagnostics Inc. Monomeric and dimeric forms of adiponectin receptor fragments and methods of use
CN102119179B (en) * 2008-08-12 2013-10-30 和光纯药工业株式会社 Polymer for filler for preprocessing column
KR20110071064A (en) 2008-08-19 2011-06-28 크놉 뉴로사이언시스 인코포레이티드 Compositions and methods of using (r)-pramipexole
WO2010054379A2 (en) 2008-11-10 2010-05-14 The United States Of America, As Represensted By The Secretary, Department Of Health And Human Services Gene signature for predicting prognosis of patients with solid tumors
CN105866426B (en) 2008-12-01 2018-11-23 小利兰·斯坦福大学托管委员会 For detecting the method and composition of complement-binding antibody
US8349325B2 (en) 2008-12-23 2013-01-08 Abbott Laboratories Soluble FMS-like tyrosine kinase-1 (sFLT-1) antibody and related composition, kit, methods of using, and materials and method for making
JP5684724B2 (en) 2008-12-30 2015-03-18 ヤンセン バイオテツク，インコーポレーテツド Serum markers to predict clinical response to anti-TNFα antibodies in patients with ankylosing spondylitis
CA3013992A1 (en) 2008-12-30 2010-07-08 Children's Medical Center Corporation Method of predicting acute appendicitis
DE102009004371A1 (en) * 2009-01-08 2010-07-15 Papst Licensing Gmbh & Co. Kg Apparatus and method for measuring the activity of enzymes after inhibitor withdrawal
WO2010079253A2 (en) 2009-01-09 2010-07-15 Proyecto De Biomedicina Cima, S.L. Bio-markers for diagnosing fibrosis
US8110796B2 (en) 2009-01-17 2012-02-07 The George Washington University Nanophotonic production, modulation and switching of ions by silicon microcolumn arrays
WO2010087985A2 (en) 2009-01-28 2010-08-05 Yale University Novel markers for detection of complications resulting from in utero encounters
EP2394175B1 (en) 2009-02-09 2016-02-03 caprotec bioanalytics GmbH Devices, systems and methods for separating magnetic particles
WO2010093872A2 (en) 2009-02-13 2010-08-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Molecular-based method of cancer diagnosis and prognosis
US20100227776A1 (en) * 2009-03-05 2010-09-09 The Ohio State University Rapid Genotyping of SNPs
EP2810652A3 (en) 2009-03-05 2015-03-11 AbbVie Inc. IL-17 binding proteins
US9490113B2 (en) * 2009-04-07 2016-11-08 The George Washington University Tailored nanopost arrays (NAPA) for laser desorption ionization in mass spectrometry
EP2422354B1 (en) * 2009-04-21 2020-12-16 Excellims Corporation Intelligently controlled spectrometer methods and apparatus
WO2010135356A1 (en) 2009-05-20 2010-11-25 Xyleco, Inc. Bioprocessing
CN102449481B (en) * 2009-05-29 2016-05-25 德克萨斯大学系统董事会 For separating of with the class peptide part of processing autoimmune T cell
AU2010256880B2 (en) * 2009-06-02 2015-01-22 Opko Health, Inc. Identification of small molecules recognized by antibodies in subjects with neurodegenerative diseases
KR101099089B1 (en) 2009-06-12 2011-12-27 한국항공대학교산학협력단 Microbead separator using a multilayered bus bar and manufacturing method thereof
EP2459742B1 (en) 2009-07-29 2016-04-06 Pharnext New diagnostic tools for alzheimer disease
DE102009040186A1 (en) * 2009-09-07 2011-03-24 Dionex Benelux B.V. chromatographic
WO2011047257A1 (en) 2009-10-16 2011-04-21 The Board Of Regents Of The University Of Texas System Compositions and methods for producing cyclic peptoid libraries
US8415619B2 (en) 2009-11-13 2013-04-09 University of Glascgow Methods and systems for mass spectrometry
US8304248B2 (en) * 2009-11-16 2012-11-06 Torres Anthony R Protein separation via ion-exchange chromatography and associated methods, systems, and devices
CA2822026C (en) 2009-12-17 2018-06-12 Children's Medical Center Corporation Saposin-a derived peptides and uses thereof
EP2531224B1 (en) 2010-01-26 2019-06-05 Bioregency, Inc. Compositions and methods relating to argininosuccinate synthetase
US20110229921A1 (en) 2010-03-18 2011-09-22 Abbott Laboratories METHODS OF ASSAYING URINARY NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (uNGAL) IN THE PROGNOSIS OF CADAVERIC KIDNEY TRANSPLANT FUNCTION IN A PATIENT, INCLUDING A PATIENT DIAGNOSED WITH DELAYED GRAFT FUNCTION (DGF), A METHOD OF ASSAYING uNGAL IN THE ASSESSMENT OF RISK OF DGF IN A PATIENT DIAGNOSED WITH EARLY GRAFT FUNCTION (EGF), AND RELATED KITS
US10706955B2 (en) 2010-03-23 2020-07-07 Iogenetics, Llc Bioinformatic processes for determination of peptide binding
EP3508854A1 (en) 2010-04-27 2019-07-10 The Regents of The University of California Cancer biomarkers and methods of use thereof
SI2571532T1 (en) 2010-05-14 2017-10-30 Abbvie Inc. Il-1 binding proteins
WO2011149943A1 (en) 2010-05-24 2011-12-01 Ventana Midical Systems, Inc. Method for differentiation of non-small cellung carcinoma
US9551714B2 (en) 2010-06-25 2017-01-24 Abbott Laboratories Materials and methods for assay of anti-hepatitis C virus (HCV) antibodies
WO2012006500A2 (en) 2010-07-08 2012-01-12 Abbott Laboratories Monoclonal antibodies against hepatitis c virus core protein
UY33492A (en) 2010-07-09 2012-01-31 Abbott Lab IMMUNOGLOBULINS WITH DUAL VARIABLE DOMAIN AND USES OF THE SAME
EP3246335A3 (en) 2010-07-19 2017-12-27 Otago Innovation Limited Signal biomarkers
KR20130100118A (en) 2010-08-03 2013-09-09 아비에 인코포레이티드 Dual variable domain immunoglobulins and uses therof
US20140031250A1 (en) 2010-10-07 2014-01-30 David Tsai Ting Biomarkers of Cancer
JP6071886B2 (en) 2010-10-14 2017-02-01 ザ・ジョンズ・ホプキンス・ユニバーシティ Brain injury biomarkers
US20120115244A1 (en) 2010-11-09 2012-05-10 Abbott Laboratories Materials and methods for immunoassay of pterins
DE102010054767B4 (en) * 2010-12-16 2013-02-21 Previpharma Ag Process for the separation, concentration and / or purification of (blood) plasma protein, viruses or viral components
KR20130133247A (en) 2010-12-21 2013-12-06 애브비 인코포레이티드 Il-1-alpha and -beta bispecific dual variable domain immunoglobulins and their use
CA2766675A1 (en) * 2011-02-07 2012-08-07 Laboratory Corporation Of America Holdings Methods and systems for multiplex analysis of biomolecules by liquid chromatography-mass spectrometry
RU2013145890A (en) 2011-03-15 2015-04-20 Юниверсити Оф Юта Рисерч Фаундейшн METHODS FOR DIAGNOSIS AND TREATMENT OF VASCULAR ASSOCIATED MACULOPATHY AND ITS SYMPTOMS
EP2699906B1 (en) 2011-04-20 2017-11-29 Access Medical Systems, Ltd. Luminescent polymer cyclic amplification
EP2707389B1 (en) 2011-05-12 2019-10-30 The Johns Hopkins University Assay reagents for a neurogranin diagnostic kit
US9024254B2 (en) 2011-06-03 2015-05-05 Purdue Research Foundation Enclosed desorption electrospray ionization probes and method of use thereof
JP2014527036A (en) 2011-06-27 2014-10-09 ザ ジャクソン ラボラトリー Methods and compositions for the treatment of cancer and autoimmune diseases
EP2771349B1 (en) 2011-09-16 2020-02-26 Iogenetics, LLC. Bioinformatic processes for determination of peptide binding
US9966162B2 (en) * 2011-10-10 2018-05-08 Siemens Medical Solutions Usa, Inc. Metal halide scintillators with reduced hygroscopicity and method of making the same
WO2013055911A1 (en) 2011-10-14 2013-04-18 Dana-Farber Cancer Institute, Inc. Znf365/zfp365 biomarker predictive of anti-cancer response
RU2014121043A (en) 2011-10-24 2015-12-10 Эббви Инк. BISPECIFIC IMMUNO-BINDING AGENTS AIMED AGAINST TNF AND IL-17
MX2014004977A (en) 2011-10-24 2014-09-11 Abbvie Inc Immunobinders directed against sclerostin.
JP6285865B2 (en) 2011-11-14 2018-02-28 アルファシグマ ソシエタ ペル アチオニ Assays and methods for selecting treatment regimens for subjects with depression
US9512096B2 (en) 2011-12-22 2016-12-06 Knopp Biosciences, LLP Synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
AU2012358269B2 (en) 2011-12-22 2017-11-02 Children's Medical Center Corporation Saposin-A derived peptides and uses thereof
US8993248B2 (en) 2011-12-31 2015-03-31 Abbott Laboratories Truncated human vitamin D binding protein and mutation and fusion thereof and related materials and methods of use
DK2800578T3 (en) 2012-01-05 2019-03-25 Boston Medical Ct Corp SLIT-ROBO SIGNAL FOR DIAGNOSIS AND TREATMENT OF Kidney Diseases
WO2013106886A1 (en) 2012-01-20 2013-07-25 Adelaide Research & Innovation Pty Ltd Biomarkers for gastric cancer and uses thereof
EP2807271B1 (en) 2012-01-24 2018-08-22 CD Diagnostics, Inc. System for detecting infection in synovial fluid
EP2812704A4 (en) 2012-02-07 2016-03-23 Intuitive Biosciences Inc Mycobacterium tuberculosis specific peptides for detection of infection or immunization in non-human primates
DK2828282T3 (en) 2012-03-20 2018-03-05 Otago Innovation Ltd Biomarkers
BR112014024023A2 (en) 2012-03-28 2017-07-18 Genentech Inc anti-hcmv idiotypic antibodies and their uses
WO2013192616A1 (en) 2012-06-22 2013-12-27 Htg Molecular Diagnostics, Inc. Molecular malignancy in melanocytic lesions
WO2014011955A2 (en) 2012-07-12 2014-01-16 Abbvie, Inc. Il-1 binding proteins
WO2014014353A1 (en) 2012-07-18 2014-01-23 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno New classification method for spectral data
US20150309036A1 (en) 2012-08-16 2015-10-29 The Trustees Of Columbia University In The City Of New York Diagnostic Markers of Indolent Prostate Cancer
AU2013202668B2 (en) 2012-12-24 2014-12-18 Adelaide Research & Innovation Pty Ltd Inhibition of cancer growth and metastasis
CN105074432A (en) * 2013-01-10 2015-11-18 生物辐射实验室股份有限公司 Chromatography system with led-based light source
US9662313B2 (en) 2013-02-28 2017-05-30 Knopp Biosciences Llc Compositions and methods for treating amyotrophic lateral sclerosis in responders
EP2972337B1 (en) * 2013-03-13 2018-11-21 The Government of the United States of America, as represented by the Secretary of the Navy Nanoplasmonic imaging technique for the spatio-temporal mapping of single cell secretions in real time
EP2968526A4 (en) 2013-03-14 2016-11-09 Abbott Lab Hcv antigen-antibody combination assay and methods and compositions for use therein
JP2016512241A (en) 2013-03-14 2016-04-25 アボット・ラボラトリーズＡｂｂｏｔｔ Ｌａｂｏｒａｔｏｒｉｅｓ HCVNS3 recombinant antigen for improved antibody detection and mutants thereof
CA2905954C (en) 2013-03-14 2022-03-22 The Board Of Trustees Of The Leland Stanford Junior University Methods of detecting donor-specific antibodies and systems for practicing the same
JP6739329B2 (en) 2013-03-14 2020-08-12 アボット・ラボラトリーズＡｂｂｏｔｔ Ｌａｂｏｒａｔｏｒｉｅｓ HCV core lipid binding domain monoclonal antibody
US9005901B2 (en) 2013-03-15 2015-04-14 Abbott Laboratories Assay with internal calibration
US9157910B2 (en) 2013-03-15 2015-10-13 Abbott Laboratories Assay with increased dynamic range
EP2976645B1 (en) 2013-03-20 2017-07-05 Koninklijke Philips N.V. Clinical decision support (cds) for radiotherapy in prostate cancer
CA3026548C (en) 2013-04-15 2022-01-04 Becton, Dickinson And Company Medical device for collection of a biological sample
EP4286853A3 (en) 2013-05-10 2024-03-06 Johns Hopkins University Compositions for ovarian cancer assessment having improved specificity
RS61539B1 (en) 2013-07-12 2021-04-29 Knopp Biosciences Llc Treating elevated levels of eosinophils and/or basophils
US9468630B2 (en) 2013-07-12 2016-10-18 Knopp Biosciences Llc Compositions and methods for treating conditions related to increased eosinophils
EP3022322A4 (en) 2013-07-17 2017-05-17 The Johns Hopkins University A multi-protein biomarker assay for brain injury detection and outcome
CA2921381A1 (en) 2013-08-13 2015-02-19 Knopp Biosciences Llc Compositions and methods for treating chronic urticaria
WO2015023786A1 (en) 2013-08-13 2015-02-19 Knopp Biosciences Llc Compositions and methods for treating plasma cell disorders and b-cell prolymphocytic disorders
MX2016003674A (en) * 2013-09-24 2016-10-13 Entopsis Detectable arrays, systems for diagnosis, and methods of making and using the same.
WO2015073709A2 (en) 2013-11-14 2015-05-21 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Detection of atherosclerotic cardiovascular disease risk and heart failure risk
HUE051159T2 (en) 2013-12-20 2021-03-01 Univ Lausanne Diagnostic, prognostic and therapeutic uses of long noncoding rnas for heart disease and regenerative medicine
US10398772B2 (en) 2014-01-08 2019-09-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Ras pathways as markers of protection against HIV and methods to improve vaccine efficacy
US11624093B2 (en) 2014-04-24 2023-04-11 Dana-Farber Cancer Institute, Inc. Tumor suppressor and oncogene biomarkers predictive of anti-immune checkpoint inhibitor response
EP3161159B1 (en) 2014-06-25 2020-08-05 The General Hospital Corporation Targeting human satellite ii (hsatii)
CN107209188A (en) 2014-06-27 2017-09-26 雅培制药有限公司 Composition and method for detecting people Pegivirus 2 (HPgV 2)
CZ2014631A3 (en) 2014-09-16 2016-03-30 Petr Novák Modification method of surfaces with proteins for preconcentration of analyte for desorption-ionization techniques of mass spectrometry and immunochemical assays
US10222386B2 (en) 2014-09-19 2019-03-05 The Johns Hopkins University Biomarkers of congnitive dysfunction
ES2833543T3 (en) 2014-10-24 2021-06-15 Koninklijke Philips Nv Evaluation of the activity of the TGF cell signaling pathway using mathematical models of target gene expression
AU2015334842B2 (en) 2014-10-24 2022-02-17 Koninklijke Philips N.V. Medical prognosis and prediction of treatment response using multiple cellular signaling pathway activities
CA2965217A1 (en) 2014-10-24 2016-04-28 Koninklijke Philips N.V. Medical prognosis and prediction of treatment response using multiple cellular signaling pathway activities
BR112017009029A2 (en) 2014-10-29 2018-02-06 Abbott Lab anti-hcv antibody detection assays of an individual using ns3 capture peptides
US11543411B2 (en) 2014-12-05 2023-01-03 Prelude Corporation DCIS recurrence and invasive breast cancer
US9607816B2 (en) 2014-12-17 2017-03-28 Micromass Uk Limited Two-dimensional separation and imaging technique for the rapid analysis of biological samples
GB2535835B (en) * 2014-12-17 2019-09-04 Micromass Ltd A two-dimensional separation and imaging technique for the rapid analysis of biological samples
EP3259594A4 (en) 2015-02-20 2018-12-26 The Johns Hopkins University Biomarkers of myocardial injury
WO2016149522A1 (en) * 2015-03-18 2016-09-22 Bio-Rad Laboratories, Inc. Sample analysis systems and methods
KR101821747B1 (en) * 2015-05-13 2018-01-24 한국과학기술연구원 High performance liquid chromatography apparatus and method for screening substance using thereof
WO2016183585A1 (en) 2015-05-14 2016-11-17 Joslin Diabetes Center, Inc. Retinol-binding protein 3 (rbp3) as a protective factor in non-diabetic retinal degeneration
AU2016291558A1 (en) 2015-07-10 2018-02-08 West Virginia University Markers of stroke and stroke severity
EP3331572A4 (en) 2015-08-04 2019-05-01 CD Diagnostics, Inc. Methods for detecting adverse local tissue reaction (altr) necrosis
CN108138237B (en) 2015-08-14 2022-04-05 皇家飞利浦有限公司 Assessment of NFkB cell signaling pathway activity using mathematical modeling of target gene expression
US10527613B2 (en) 2015-11-10 2020-01-07 The Board Of Trustees Of The Leland Stanford Junior University Biomarker detection methods and systems and kits for practicing same
US20180364243A1 (en) 2015-12-09 2018-12-20 Intuitive Biosciences, Inc. Automated silver enhancement system
WO2017099829A1 (en) 2015-12-11 2017-06-15 The General Hospital Corporation Compositions and methods for treating drug-tolerant glioblastoma
CN105590079B (en) * 2015-12-23 2018-02-16 上海百傲科技股份有限公司 A kind of method and apparatus of multiple continuous automatically identifying and readings of biochip transmission signal
US11408900B2 (en) 2016-01-15 2022-08-09 Massachusetts Eye And Ear Infirmary Secreted P-glycoprotein is a non-invasive biomarker of chronic rhinosinusitis
US11306362B2 (en) 2016-02-08 2022-04-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Gene signature predictive of hepatocellular carcinoma response to transcatheter arterial chemoembolization (TACE)
US20200200735A9 (en) 2016-02-22 2020-06-25 Ursure, Inc. System and method for detecting therapeutic agents to monitor adherence to a treatment regimen
WO2018089764A1 (en) 2016-11-11 2018-05-17 Ascendant Dx, Llc Compositions and methods for diagnosing and differentiating systemic juvenile idiopathic arthritis and kawasaki disease
EP3343214A1 (en) * 2016-12-30 2018-07-04 Università degli Studi di Bari "Aldo Moro" Method of bio-functionalization of a gate electrode of a field-effect transistor sensor with a sam and blocking of non-specific binding
MX2019008348A (en) 2017-01-18 2019-10-21 Genentech Inc Idiotypic antibodies against anti-pd-l1 antibodies and uses thereof.
CN107315851B (en) * 2017-05-19 2020-06-23 中国科学院长春光学精密机械与物理研究所 Robust film system design method of broad-spectrum extreme ultraviolet multilayer film
CN107024436A (en) * 2017-05-27 2017-08-08 北京环境特性研究所 A kind of method for analyzing medicine to cytosis point
AU2018318435A1 (en) 2017-08-16 2020-04-02 Medimmune, Llc Compositions and methods for treatment of atopic dermatitis and treatment selection
EP4339298A3 (en) 2017-09-25 2024-04-17 Fred Hutchinson Cancer Center High efficiency targeted in situ genome-wide profiling
EP3461915A1 (en) 2017-10-02 2019-04-03 Koninklijke Philips N.V. Assessment of jak-stat1/2 cellular signaling pathway activity using mathematical modelling of target gene expression
EP3502279A1 (en) 2017-12-20 2019-06-26 Koninklijke Philips N.V. Assessment of mapk-ap 1 cellular signaling pathway activity using mathematical modelling of target gene expression
KR101921628B1 (en) * 2018-01-15 2018-11-26 한국과학기술연구원 High performance liquid chromatography apparatus and method for screening substance using thereof
CA3090652A1 (en) 2018-02-06 2019-08-15 The General Hospital Corporation Repeat rna as biomarkers of tumor immune response
CN108715844A (en) * 2018-04-11 2018-10-30 河北工业大学 A kind of preparation method and biomimetic mineralization immobilised enzymes and co-factor of biomimetic mineralization immobilised enzymes and co-factor
WO2019236632A1 (en) 2018-06-04 2019-12-12 Avon Products. Inc. Protein biomarkers for identifying and treating aging skin and skin conditions
WO2020056338A1 (en) 2018-09-14 2020-03-19 Prelude Corporation Method of selection for treatment of subjects at risk of invasive breast cancer
EP3677693A1 (en) 2019-01-03 2020-07-08 Ecole Polytechnique Federale De Lausanne (EPFL) EPFL-TTO Transpochimeric gene trancripts (tcgts) as cancer biomarkers
EP3966572A4 (en) * 2019-05-10 2023-01-25 Quest Diagnostics Investments LLC Multiplex assay for determining the beta-amyloid 42/40 ratio in human plasma specimens
AU2020326698A1 (en) 2019-08-05 2022-02-24 Seer, Inc. Systems and methods for sample preparation, data generation, and protein corona analysis
AU2020353178A1 (en) * 2019-09-27 2022-04-14 Regeneron Pharmaceuticals, Inc. Hydrophobic interaction chromatography-coupled native mass spectrometry for antibody analysis
WO2022086852A2 (en) 2020-10-19 2022-04-28 Dana-Farber Cancer Institute, Inc. Germline biomarkers of clinical response and benefit to immune checkpoint inhibitor therapy
US20240053355A1 (en) * 2021-03-18 2024-02-15 Complete Omics Inc. Methods and systems for detecting and quantifying large number of molecule biomarkers from a body fluid sample
EP4347889A1 (en) 2021-05-28 2024-04-10 Centre Hospitalier Universitaire Vaudois (CHUV) Novel incrna controlling cardiac fibrosis
WO2023122723A1 (en) 2021-12-23 2023-06-29 The Broad Institute, Inc. Panels and methods for diagnosing and treating lung cancer

Family Cites Families (113)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE630478A (en) * 1962-04-02
US3288604A (en) * 1964-09-03 1966-11-29 Xerox Corp Imaging method using an element having a glass overcoating
US3669841A (en) * 1970-02-11 1972-06-13 Monsanto Co Attachment of enzymes to siliceous materials
US3896661A (en) * 1974-01-09 1975-07-29 Stanford Research Inst Method of coupling thin layer chromatograph with mass spectrometer
DE2654057B1 (en) * 1976-11-29 1978-04-27 Varian Mat Gmbh Process for the ionization of organic substances, as well as analyzer using this process
US4126554A (en) 1977-09-02 1978-11-21 Analtech, Inc. Selectively marked thin-layer chromatographic plate
US4313906A (en) 1979-08-17 1982-02-02 Whatman, Inc. Two dimensional two phase thin layer chromatography plate and method
US4313908A (en) 1980-10-20 1982-02-02 Exxon Research & Engineering Co. Catalytic reactor having bed bypass
US4752562A (en) 1981-01-23 1988-06-21 Baxter Travenol Laboratories, Inc. Detection of serum antibody and surface antigen by radial partition immunoassay
US4444879A (en) * 1981-01-29 1984-04-24 Science Research Center, Inc. Immunoassay with article having support film and immunological counterpart of analyte
DE3125335A1 (en) 1981-06-27 1983-01-13 Alfred Prof. Dr. 4400 Münster Benninghoven METHOD FOR ANALYZING GASES AND LIQUIDS
SE8200442L (en) * 1982-01-27 1983-07-28 Forsvarets Forsknings METHOD OF DETECTION OF ORGANIC MOLECULES, SUCH AS BIOMOLECULES
JPS6042653A (en) * 1983-08-17 1985-03-06 Shionogi & Co Ltd Chromatography plate
US4489477A (en) * 1984-02-23 1984-12-25 Northern Telecom Limited Method for screening laser diodes
JPS61187237A (en) * 1985-02-14 1986-08-20 Toshiba Corp Formation of pattern
US4820648A (en) * 1985-08-21 1989-04-11 Spectros Limited Methods for use in the mass analysis of chemical samples
JPS6251144A (en) * 1985-08-29 1987-03-05 Hitachi Ltd Mass spectrometer
US4988879A (en) * 1987-02-24 1991-01-29 The Board Of Trustees Of The Leland Stanford Junior College Apparatus and method for laser desorption of molecules for quantitation
US5338659A (en) 1991-04-02 1994-08-16 Terrapin Technologies, Inc. Method for determining analyte concentration by cross-reactivity profiling
ATE152244T1 (en) 1987-10-13 1997-05-15 Terrapin Tech Inc METHOD FOR PRODUCING IMMUNODIAGNOSIS AGENTS
US4963263A (en) 1988-03-24 1990-10-16 Terrapin Technologies, Inc. Method of identity analyte-binding peptides
US5133866A (en) 1988-03-24 1992-07-28 Terrapin Technologies, Inc. Method to identify analyte-bending ligands
US5300425A (en) 1987-10-13 1994-04-05 Terrapin Technologies, Inc. Method to produce immunodiagnostic reagents
US4891321A (en) * 1987-10-21 1990-01-02 Hubscher Thomas T Apparatus for performing determinations of immune reactants in biological fluids
GB8810400D0 (en) 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
AU628812B2 (en) * 1988-03-24 1992-09-24 Telik, Inc. Paralog affinity chromatography
US5340474A (en) 1988-03-24 1994-08-23 Terrapin Technologies, Inc. Panels of analyte-binding ligands
US5010175A (en) 1988-05-02 1991-04-23 The Regents Of The University Of California General method for producing and selecting peptides with specific properties
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5037611A (en) * 1988-11-29 1991-08-06 Icr Research Associates, Inc. Sample handling technique
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
GB2235529B (en) 1989-08-23 1993-07-28 Finnigan Mat Ltd Method of preparing samples for laser spectrometry analysis
GB2236186B (en) * 1989-08-22 1994-01-05 Finnigan Mat Gmbh Process and device for laser desorption of analyte molecular ions, especially of biomolecules
US5045694A (en) 1989-09-27 1991-09-03 The Rockefeller University Instrument and method for the laser desorption of ions in mass spectrometry
US5035022A (en) * 1989-12-08 1991-07-30 Joseph Iuliano Device for applying coatings to objects having irregular shapes and/or diverse surfaces
US5366862A (en) * 1990-02-14 1994-11-22 Receptor Laboratories, Inc. Method for generating and screening useful peptides
US5288644A (en) * 1990-04-04 1994-02-22 The Rockefeller University Instrument and method for the sequencing of genome
DE69128362T2 (en) 1990-06-01 1998-05-20 Chiron Corp COMPOSITIONS AND METHOD FOR IDENTIFYING MOLECULES WITH BIOLOGICAL EFFECTIVENESS
IE66205B1 (en) 1990-06-14 1995-12-13 Paul A Bartlett Polypeptide analogs
US5723286A (en) 1990-06-20 1998-03-03 Affymax Technologies N.V. Peptide library and screening systems
US5650489A (en) 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
US5135627A (en) 1990-10-15 1992-08-04 Soane Technologies, Inc. Mosaic microcolumns, slabs, and separation media for electrophoresis and chromatography
US5308749A (en) * 1991-01-25 1994-05-03 Eastman Kodak Company Method of preparing biologically active reagents from succinimide-containing polymers, analytical element and methods of use
DE69233750D1 (en) 1991-04-10 2009-01-02 Scripps Research Inst Libraries of heterodimeric receptors using phagemids
US5846708A (en) * 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
US5382793A (en) * 1992-03-06 1995-01-17 Hewlett-Packard Company Laser desorption ionization mass monitor (LDIM)
US5372719A (en) * 1992-03-30 1994-12-13 Perseptive Biosystems, Inc. Molecular imaging
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
JPH07507394A (en) 1992-05-29 1995-08-10 ザ ロックフェラー ユニバーシティ Methods and materials for peptide sequencing using a mass spectrometer
CA2140257A1 (en) 1992-07-27 1994-02-03 Lawrence M. Kauvar Sorbent families
US5288514A (en) 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
DE69333115D1 (en) * 1992-09-22 2003-08-28 Biofocus Discovery Ltd RECOMBINANT VIRUSES PRESENTING A NON-VIRAL POLYPEPTIDE ON THEIR OUTER SURFACE
US5376249A (en) 1992-11-25 1994-12-27 Perseptive Biosystems, Inc. Analysis utilizing isoelectric focusing
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
EP1262564A3 (en) 1993-01-07 2004-03-31 Sequenom, Inc. Dna sequencing by mass spectrometry
CA2158642A1 (en) 1993-03-19 1994-09-29 Hubert Koster Dna sequencing by mass spectrometry via exonuclease degradation
US5356784A (en) 1993-03-30 1994-10-18 Terrapin Technologies, Inc. Determination of concentration by affinity titration
US20020037517A1 (en) * 1993-05-28 2002-03-28 Hutchens T. William Methods for sequencing biopolymers
US6020208A (en) * 1994-05-27 2000-02-01 Baylor College Of Medicine Systems for surface-enhanced affinity capture for desorption and detection of analytes
NZ267842A (en) * 1993-05-28 1997-09-22 Baylor College Medicine Apparatus for measuring molecular mass (by mass spectrometry) in which the sample is ionised on the sample holder and desorbed therefrom by laser pulses
DE69431719T2 (en) 1993-06-25 2003-09-18 Affymetrix Inc N D Ges D Staat HYBRIDIZATION AND SEQUENCING OF NUCLEIC ACIDS
US5496545A (en) * 1993-08-11 1996-03-05 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
GB9317193D0 (en) * 1993-08-18 1993-10-06 Zeneca Ltd Method
ES2207639T3 (en) * 1993-09-09 2004-06-01 Lorus Therapeutics Inc. IMMUNOLOGICAL MODULAR COMPOSITIONS FROM THE BILIS.
US6071610A (en) * 1993-11-12 2000-06-06 Waters Investments Limited Enhanced resolution matrix-laser desorption and ionization TOF-MS sample surface
US5587293A (en) 1994-01-06 1996-12-24 Terrapin Technologies, Inc. Method to identify binding partners
US5539083A (en) 1994-02-23 1996-07-23 Isis Pharmaceuticals, Inc. Peptide nucleic acid combinatorial libraries and improved methods of synthesis
US5538897A (en) 1994-03-14 1996-07-23 University Of Washington Use of mass spectrometry fragmentation patterns of peptides to identify amino acid sequences in databases
DK0751950T3 (en) * 1994-03-23 2001-01-29 Penn State Res Found Method for identifying elements of combinatorial libraries
US5502022A (en) * 1994-05-16 1996-03-26 Biosepra, Inc. Chromatography adsorbents utilizing mercapto heterocyclic ligands
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5498545A (en) * 1994-07-21 1996-03-12 Vestal; Marvin L. Mass spectrometer system and method for matrix-assisted laser desorption measurements
US5599668A (en) * 1994-09-22 1997-02-04 Abbott Laboratories Light scattering optical waveguide method for detecting specific binding events
US6004617A (en) * 1994-10-18 1999-12-21 The Regents Of The University Of California Combinatorial synthesis of novel materials
US6440745B1 (en) * 1994-10-18 2002-08-27 Symyx Technologies Combinatorial synthesis and screening of organometallic compounds and catalysts
US6030917A (en) * 1996-07-23 2000-02-29 Symyx Technologies, Inc. Combinatorial synthesis and analysis of organometallic compounds and catalysts
US6419881B1 (en) * 1994-10-18 2002-07-16 Symyx Technologies, Inc. Combinatorial arrays of organometallic compounds and catalysts
US5985356A (en) * 1994-10-18 1999-11-16 The Regents Of The University Of California Combinatorial synthesis of novel materials
US6207369B1 (en) * 1995-03-10 2001-03-27 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
US5741462A (en) * 1995-04-25 1998-04-21 Irori Remotely programmable matrices with memories
US5624711A (en) * 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
US5770272A (en) * 1995-04-28 1998-06-23 Massachusetts Institute Of Technology Matrix-bearing targets for maldi mass spectrometry and methods of production thereof
JP2001500606A (en) 1995-05-19 2001-01-16 パーセプティブ バイオシステムズ，インコーポレーテッド Method and apparatus for statistically certain polymer sequencing using mass spectrometry
WO1996037777A1 (en) 1995-05-23 1996-11-28 Nelson Randall W Mass spectrometric immunoassay
ATE305969T1 (en) 1995-06-07 2005-10-15 Univ Arizona SAMPLER FOR MASS SPECTROMETRY
US6004770A (en) * 1995-06-07 1999-12-21 Arizona State University Board Of Regents Sample presentation apparatus for mass spectrometry
US6093541A (en) * 1995-06-07 2000-07-25 Arizona State University Board Of Regents Mass spectrometer having a derivatized sample presentation apparatus
US6316266B1 (en) * 1995-06-07 2001-11-13 Arizona State University Board Of Regents Sample presentation apparatus for mass spectrometry
AU5766596A (en) 1995-08-04 1997-03-05 Charles Faraud S.A. Device for packaging and storing ready-made meals
ATE216594T1 (en) * 1995-09-01 2002-05-15 Univ Washington INTERACTIVE MOLECULAR CONJUGATES
GB9518429D0 (en) * 1995-09-08 1995-11-08 Pharmacia Biosensor A rapid method for providing kinetic and structural data in molecular interaction analysis
US5705813A (en) * 1995-11-01 1998-01-06 Hewlett-Packard Company Integrated planar liquid handling system for maldi-TOF MS
US5716825A (en) * 1995-11-01 1998-02-10 Hewlett Packard Company Integrated nucleic acid analysis system for MALDI-TOF MS
US5808300A (en) * 1996-05-10 1998-09-15 Board Of Regents, The University Of Texas System Method and apparatus for imaging biological samples with MALDI MS
US5780232A (en) 1996-05-28 1998-07-14 Atom Sciences, Inc. DNA sequencing, mapping, and diagnostic processes using hybridization and stable isotope labels of DNA
US6660159B1 (en) * 1996-06-07 2003-12-09 Immunivest Corporation Magnetic separation apparatus and methods
US6790366B2 (en) * 1996-06-07 2004-09-14 Immunivest Corporation Magnetic separation apparatus and methods
US6136182A (en) * 1996-06-07 2000-10-24 Immunivest Corporation Magnetic devices and sample chambers for examination and manipulation of cells
US5993665A (en) * 1996-06-07 1999-11-30 Immunivest Corporation Quantitative cell analysis methods employing magnetic separation
US6441901B2 (en) * 1996-07-23 2002-08-27 Symyx Technologies, Inc. Optical systems and methods for rapid screening of libraries of different materials
US5821060A (en) 1996-08-02 1998-10-13 Atom Sciences, Inc. DNA sequencing, mapping, and diagnostic processes using hybridization chips and unlabeled DNA
EP1669738A3 (en) * 1996-10-09 2007-12-12 Symyx Technologies, Inc. Infrared spectroscopy and imaging of libraries
US5854486A (en) * 1996-12-27 1998-12-29 R. T. Hodgson Method and apparatus for MALDI mass spectrometry
US5882496A (en) * 1997-02-27 1999-03-16 The Regents Of The University Of California Porous silicon structures with high surface area/specific pore size
NZ516848A (en) * 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
US6207370B1 (en) * 1997-09-02 2001-03-27 Sequenom, Inc. Diagnostics based on mass spectrometric detection of translated target polypeptides
US6127005A (en) * 1999-01-08 2000-10-03 Rutgers University Method of thermally glazing an article
US6288390B1 (en) * 1999-03-09 2001-09-11 Scripps Research Institute Desorption/ionization of analytes from porous light-absorbing semiconductor
DE19937438C2 (en) * 1999-08-07 2001-09-13 Bruker Daltonik Gmbh Coupling thin layer chromatography and mass spectrometry (TLC / MS)
US7299134B2 (en) * 2001-02-16 2007-11-20 Bio-Rad Laboratories, Inc. Method for correlating gene expression profiles with protein expression profiles
US7155127B2 (en) * 2001-08-15 2006-12-26 Nippon Telegraph And Telephone Corporation Optical communication system, optical communication unit, and optical transceiving package
US6977517B2 (en) * 2002-05-20 2005-12-20 Finisar Corporation Laser production and product qualification via accelerated life testing based on statistical modeling

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