CA2290957A1 - Non-invasive continuous blood glucose monitoring - Google Patents

Non-invasive continuous blood glucose monitoring Download PDF

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Publication number
CA2290957A1
CA2290957A1 CA002290957A CA2290957A CA2290957A1 CA 2290957 A1 CA2290957 A1 CA 2290957A1 CA 002290957 A CA002290957 A CA 002290957A CA 2290957 A CA2290957 A CA 2290957A CA 2290957 A1 CA2290957 A1 CA 2290957A1
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CA
Canada
Prior art keywords
blood
analyte
concentration
human body
instrument
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002290957A
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French (fr)
Other versions
CA2290957C (en
Inventor
Janusz M. Buchert
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Individual
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Individual
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Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2290957A1 publication Critical patent/CA2290957A1/en
Application granted granted Critical
Publication of CA2290957C publication Critical patent/CA2290957C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A61B5/6814—Head
    • A61B5/6815—Ear
    • A61B5/6817—Ear canal
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J5/00—Radiation pyrometry, e.g. infrared or optical thermometry
    • G01J5/02—Constructional details
    • G01J5/08—Optical arrangements
    • G01J5/0801—Means for wavelength selection or discrimination
    • G01J5/0802—Optical filters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J5/00—Radiation pyrometry, e.g. infrared or optical thermometry
    • G01J5/10—Radiation pyrometry, e.g. infrared or optical thermometry using electric radiation detectors
    • G01J5/12—Radiation pyrometry, e.g. infrared or optical thermometry using electric radiation detectors using thermoelectric elements, e.g. thermocouples
    • G01J5/14—Electrical features thereof

Abstract

A method and an instrument for a continuous non-invasive detection of an analyte, (e.g., glucose) concentration in a human body tissue such as blood, is disclosed. The instrument remote sensor assembly (7) mounted in subject's ear canal continuously measures analyte concentration by detecting the infrared radiation naturally emitted by a human body. It uses an infrared detector (7) with a combination of adequate filters (6) such as, for example, a negative correlation filter or narrow band filters or other detector filter assemblies. The method and instrument is based on the discovery that natural infrared emission from the human body, especially from the tympanic membrane (1), is modulated by the state of the emitting tissue.
Spectral emissivity of human infrared radiation from the tympanic membrane (1) consists of spectral information of the tissue, (e.g., blood) analyte, (e.g., glucose).
This can be directly correlated with the blood analyte concentration, for example, the blood glucose concentration.
CA002290957A 1997-05-20 1998-05-18 Non-invasive continuous blood glucose monitoring Expired - Fee Related CA2290957C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/859,579 1997-05-20
US08/859,579 US5823966A (en) 1997-05-20 1997-05-20 Non-invasive continuous blood glucose monitoring
PCT/US1998/010012 WO1998052469A1 (en) 1997-05-20 1998-05-18 Non-invasive continuous blood glucose monitoring

Publications (2)

Publication Number Publication Date
CA2290957A1 true CA2290957A1 (en) 1998-11-26
CA2290957C CA2290957C (en) 2004-12-14

Family

ID=25331255

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002290957A Expired - Fee Related CA2290957C (en) 1997-05-20 1998-05-18 Non-invasive continuous blood glucose monitoring

Country Status (10)

Country Link
US (1) US5823966A (en)
EP (1) EP0939603A4 (en)
JP (1) JP2001506164A (en)
KR (1) KR100695761B1 (en)
AU (1) AU7491798A (en)
CA (1) CA2290957C (en)
EA (1) EA002288B1 (en)
IL (1) IL128106A (en)
PL (1) PL331145A1 (en)
WO (1) WO1998052469A1 (en)

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Also Published As

Publication number Publication date
EP0939603A4 (en) 2005-12-14
WO1998052469A1 (en) 1998-11-26
AU7491798A (en) 1998-12-11
KR20000029457A (en) 2000-05-25
IL128106A0 (en) 1999-11-30
US5823966A (en) 1998-10-20
KR100695761B1 (en) 2007-03-16
EP0939603A1 (en) 1999-09-08
EA199900145A1 (en) 1999-08-26
JP2001506164A (en) 2001-05-15
IL128106A (en) 2004-08-31
PL331145A1 (en) 1999-06-21
CA2290957C (en) 2004-12-14
EA002288B1 (en) 2002-02-28

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