CA2290777A1 - Injection apparatus - Google Patents

Injection apparatus Download PDF

Info

Publication number
CA2290777A1
CA2290777A1 CA002290777A CA2290777A CA2290777A1 CA 2290777 A1 CA2290777 A1 CA 2290777A1 CA 002290777 A CA002290777 A CA 002290777A CA 2290777 A CA2290777 A CA 2290777A CA 2290777 A1 CA2290777 A1 CA 2290777A1
Authority
CA
Canada
Prior art keywords
syringe
injection
met
control system
injection condition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002290777A
Other languages
French (fr)
Other versions
CA2290777C (en
Inventor
Michael F. Deily
James J. Bunch
Thomas J. Drach
James M. Bonicatto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioject Inc
Original Assignee
Bioject, Inc.
Michael F. Deily
James J. Bunch
Thomas J. Drach
James M. Bonicatto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioject, Inc., Michael F. Deily, James J. Bunch, Thomas J. Drach, James M. Bonicatto filed Critical Bioject, Inc.
Publication of CA2290777A1 publication Critical patent/CA2290777A1/en
Application granted granted Critical
Publication of CA2290777C publication Critical patent/CA2290777C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2073—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically preventing premature release, e.g. by making use of a safety lock
    • A61M2005/208—Release is possible only when device is pushed against the skin, e.g. using a trigger which is blocked or inactive when the device is not pushed against the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2053—Media being expelled from injector by pressurised fluid or vacuum

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

The present invention comprises a non-needle injector (2) having the following components: a non-needle syringe (126) installed in the injector (2) for holding medication prior to injection, the syringe (126) including an injection aperture (20) at the forward end thereof; a syringe plunger (130) slidable mounted to the rear end of the syringe (126) for forcing medication out the syringe aperture (20); a cartridge pressure control system (14) providing power to drive the syringe plunger (130), and thereby force medication out of the syringe (126); and a syringe control system (18) for controlling the activation of the syringe, the syringe control system (18) including a warning system which warns the user if a pre-injection condition is not met, an interlock system which prevents injection from taking place if the pre-injection condition is not met, and a sensing system which senses whether the pre-injection condition is not met, and conveys a signal to the warning and interlock systems informing as to whether the pre-injection condition is met.
CA002290777A 1997-05-19 1998-04-22 Injection apparatus Expired - Fee Related CA2290777C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/858,249 US5993412A (en) 1997-05-19 1997-05-19 Injection apparatus
US08/858,249 1997-05-19
PCT/US1998/008161 WO1998052632A1 (en) 1997-05-19 1998-04-22 Injection apparatus

Publications (2)

Publication Number Publication Date
CA2290777A1 true CA2290777A1 (en) 1998-11-26
CA2290777C CA2290777C (en) 2006-07-11

Family

ID=25327861

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002290777A Expired - Fee Related CA2290777C (en) 1997-05-19 1998-04-22 Injection apparatus

Country Status (7)

Country Link
US (1) US5993412A (en)
EP (1) EP1011763B1 (en)
AU (1) AU7254998A (en)
CA (1) CA2290777C (en)
DE (1) DE69820460T2 (en)
GB (1) GB9927246D0 (en)
WO (1) WO1998052632A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8403888B2 (en) 2010-04-15 2013-03-26 Teneo Innovations Inc. Device and electronic controller for syringe piston control

Families Citing this family (482)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020147143A1 (en) 1998-03-18 2002-10-10 Corixa Corporation Compositions and methods for the therapy and diagnosis of lung cancer
US6156008A (en) * 1998-05-04 2000-12-05 Castellano; Thomas P. Device for avoiding subdermal hematomas from an injection
US6129361A (en) * 1998-07-06 2000-10-10 Ford Global Technologies, Inc. Fluid conduit seal
US6315777B1 (en) * 1998-07-07 2001-11-13 Medtronic, Inc. Method and apparatus for creating a virtual electrode used for the ablation of tissue
US20030235557A1 (en) 1998-09-30 2003-12-25 Corixa Corporation Compositions and methods for WT1 specific immunotherapy
US6783509B1 (en) 1998-11-18 2004-08-31 Bioject Inc. Single-use needle-less hypodermic jet injection apparatus and method
AU1744200A (en) * 1998-11-24 2000-06-13 Jerry R. Pickrell Improved multi-dose non-needle jet injection device
US6406455B1 (en) * 1998-12-18 2002-06-18 Biovalve Technologies, Inc. Injection devices
US7060048B1 (en) * 1999-04-16 2006-06-13 Powerject Research Limited Needleless syringe
AU4656000A (en) 1999-04-22 2000-11-10 Gilbert Garitano Needleless permanent makeup and tattoo device
US7192713B1 (en) 1999-05-18 2007-03-20 President And Fellows Of Harvard College Stabilized compounds having secondary structure motifs
US20050027239A1 (en) * 1999-08-20 2005-02-03 Stout Richard R. Intradermal injection system for injecting DNA-based injectables into humans
US6319224B1 (en) * 1999-08-20 2001-11-20 Bioject Medical Technologies Inc. Intradermal injection system for injecting DNA-based injectables into humans
US6843781B2 (en) * 1999-10-14 2005-01-18 Becton, Dickinson And Company Intradermal needle
US6569123B2 (en) 1999-10-14 2003-05-27 Becton, Dickinson And Company Prefillable intradermal injector
US6776776B2 (en) * 1999-10-14 2004-08-17 Becton, Dickinson And Company Prefillable intradermal delivery device
US6494865B1 (en) 1999-10-14 2002-12-17 Becton Dickinson And Company Intradermal delivery device including a needle assembly
US20020193740A1 (en) 1999-10-14 2002-12-19 Alchas Paul G. Method of intradermally injecting substances
US6569143B2 (en) 1999-10-14 2003-05-27 Becton, Dickinson And Company Method of intradermally injecting substances
WO2001051109A1 (en) 2000-01-07 2001-07-19 Biovalve Technologies, Inc. Injection device
DE60143425D1 (en) 2000-02-23 2010-12-23 Smithkline Beecham Biolog NEW CONNECTIONS
US7811282B2 (en) 2000-03-06 2010-10-12 Salient Surgical Technologies, Inc. Fluid-assisted electrosurgical devices, electrosurgical unit with pump and methods of use thereof
ES2643763T3 (en) 2000-03-06 2017-11-24 Salient Surgical Technologies, Inc. Fluid supply system and controller for electrosurgical devices
US8083736B2 (en) 2000-03-06 2011-12-27 Salient Surgical Technologies, Inc. Fluid-assisted medical devices, systems and methods
US6558385B1 (en) 2000-09-22 2003-05-06 Tissuelink Medical, Inc. Fluid-assisted medical device
US6689131B2 (en) 2001-03-08 2004-02-10 Tissuelink Medical, Inc. Electrosurgical device having a tissue reduction sensor
US8048070B2 (en) 2000-03-06 2011-11-01 Salient Surgical Technologies, Inc. Fluid-assisted medical devices, systems and methods
US6645169B1 (en) * 2000-06-08 2003-11-11 Avant Drug Delivery Systems, Inc. Air-in-tip jet injector
JP2004513615A (en) 2000-06-28 2004-05-13 コリクサ　コーポレイション Compositions and methods for treatment and diagnosis of lung cancer
US6440096B1 (en) * 2000-07-14 2002-08-27 Becton, Dickinson And Co. Microdevice and method of manufacturing a microdevice
GB0022742D0 (en) 2000-09-15 2000-11-01 Smithkline Beecham Biolog Vaccine
US20050019340A1 (en) 2000-10-18 2005-01-27 Nathalie Garcon Vaccines
US6652483B2 (en) * 2000-11-07 2003-11-25 Avant Drug Delivery Systems, Inc. Needleless jet injector system with separate drug reservoir
EP1339442A4 (en) * 2000-11-30 2006-12-27 Biovalve Technologies Inc Injection systems
GB0100756D0 (en) 2001-01-11 2001-02-21 Powderject Res Ltd Needleless syringe
GB2371754B (en) * 2001-02-02 2005-09-21 Biocompatibles Ltd Balloon catheter inflation
JP5208347B2 (en) 2001-02-23 2013-06-12 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム New vaccine
US6645170B2 (en) * 2001-03-05 2003-11-11 Bioject Medical Technologies, Inc. Simplified disposable needle-free injection apparatus and method
US6471669B2 (en) 2001-03-05 2002-10-29 Bioject Medical Technologies Inc. Disposable needle-free injection apparatus and method
JP2002263106A (en) * 2001-03-12 2002-09-17 Olympus Optical Co Ltd Optical probe device
US6500239B2 (en) 2001-03-14 2002-12-31 Penjet Corporation System and method for removing dissolved gas from a solution
ZA200200808B (en) * 2001-03-22 2002-08-12 Roche Diagnostics Gmbh Needleless hypodermic injection system, application device and medication cartridge therefor.
GB0109297D0 (en) 2001-04-12 2001-05-30 Glaxosmithkline Biolog Sa Vaccine
US6613010B2 (en) 2001-04-13 2003-09-02 Penjet Corporation Modular gas-pressured needle-less injector
US6755220B2 (en) 2001-04-27 2004-06-29 Penjet Corporation Method and apparatus for filling or refilling a needle-less injector
JP2005504513A (en) 2001-05-09 2005-02-17 コリクサ コーポレイション Compositions and methods for treatment and diagnosis of prostate cancer
MY134424A (en) 2001-05-30 2007-12-31 Saechsisches Serumwerk Stable influenza virus preparations with low or no amount of thiomersal
US20100221284A1 (en) 2001-05-30 2010-09-02 Saech-Sisches Serumwerk Dresden Novel vaccine composition
US20060018877A1 (en) * 2001-06-29 2006-01-26 Mikszta John A Intradermal delivery of vacccines and therapeutic agents
JP2004531578A (en) 2001-06-29 2004-10-14 ベクトン・ディキンソン・アンド・カンパニー Intradermal delivery of vaccines and gene therapeutics by microcannula
US7767872B2 (en) * 2001-09-06 2010-08-03 Mpg Biotechnologies, Llc Thimerosal removal device
US8440791B2 (en) * 2001-09-06 2013-05-14 Mgp Biotechnologies, Llc Thimerosal removal device
US20070015721A1 (en) * 2001-09-20 2007-01-18 Andrew Beaton Hiv-gag codon-optimised dna vaccines
US6824526B2 (en) 2001-10-22 2004-11-30 Penjet Corporation Engine and diffuser for use with a needle-less injector
US6607510B2 (en) 2001-11-09 2003-08-19 Bioject Medical Technologies Inc. Disposable needle-free injection apparatus and method
ES2405790T3 (en) 2001-12-17 2013-06-03 Corixa Corporation Compositions and methods for therapy and diagnosis of inflammatory bowel disease
US7074220B2 (en) * 2002-04-03 2006-07-11 Thomas J. Fogarty Methods and systems for vein harvesting and fistula creation
US20040049208A1 (en) * 2002-04-03 2004-03-11 Thomas Fogarty, M.D. Methods and systems for vein harvesting and fistula creation
US6551314B1 (en) 2002-04-03 2003-04-22 Thomas J. Fogarty Methods and systems for vein harvesting
US7238167B2 (en) * 2002-06-04 2007-07-03 Bioject Inc. Needle-free injection system
US6676630B2 (en) 2002-06-04 2004-01-13 Bioject Medical Technologies, Inc. Needle-free injection system
US7156823B2 (en) * 2002-06-04 2007-01-02 Bioject Inc. High workload needle-free injection system
US6883222B2 (en) * 2002-10-16 2005-04-26 Bioject Inc. Drug cartridge assembly and method of manufacture
WO2004039416A2 (en) 2002-10-29 2004-05-13 Tissuelink Medical, Inc. Fluid-assisted electrosurgical scissors and methods
WO2004043534A1 (en) * 2002-11-12 2004-05-27 Collegium Pharmaceutical, Inc. Inertial drug delivery system
US7960522B2 (en) 2003-01-06 2011-06-14 Corixa Corporation Certain aminoalkyl glucosaminide phosphate compounds and their use
WO2004062599A2 (en) 2003-01-06 2004-07-29 Corixa Corporation Certain aminoalkyl glucosaminide phosphate compounds and their use
US6935384B2 (en) * 2003-02-19 2005-08-30 Bioject Inc. Needle-free injection system
US20060184101A1 (en) * 2003-04-21 2006-08-17 Ravi Srinivasan Microjet devices and methods for drug delivery
EP1620147A4 (en) * 2003-04-21 2008-06-11 Corium Internat Inc Apparatus and methods for repetitive microjet drug delivery
IL155967A0 (en) * 2003-05-18 2003-12-23 Menachem Hartman Automatic injector for mass injections
AU2004272972A1 (en) 2003-05-22 2005-03-24 Fraunhofer Usa, Inc. Recombinant carrier molecule for expression, delivery and purification of target polypeptides
ES2356154T3 (en) 2003-07-21 2011-04-05 Transgene S.A. MULTIFUNCTIONAL CYTOKINS.
WO2005034949A1 (en) * 2003-09-09 2005-04-21 University Of Florida Desferrithiocin derivatives and their use as iron chelators
KR20060096433A (en) 2003-10-21 2006-09-11 바스프 악티엔게젤샤프트 Method for the continuous production of aldehydes
US7727232B1 (en) 2004-02-04 2010-06-01 Salient Surgical Technologies, Inc. Fluid-assisted medical devices and methods
US7717874B2 (en) * 2004-05-28 2010-05-18 Bioject, Inc. Needle-free injection system
US20060005844A1 (en) * 2004-07-08 2006-01-12 Coulter George G Rolling tube apparatus and method for treating a wound
KR101508563B1 (en) 2004-09-22 2015-04-07 글락소스미스클라인 바이오로지칼즈 에스.에이. Immunogenic composition for use in vaccination against staphylococcei
WO2007001448A2 (en) 2004-11-04 2007-01-04 Massachusetts Institute Of Technology Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals
US7947017B2 (en) 2004-11-22 2011-05-24 Intelliject, Inc. Devices, systems and methods for medicament delivery
US7648483B2 (en) 2004-11-22 2010-01-19 Intelliject, Inc. Devices, systems and methods for medicament delivery
CA2891057C (en) 2004-11-22 2018-11-13 Kaleo, Inc. Medicament delivery apparatus and movable indicator
US10737028B2 (en) 2004-11-22 2020-08-11 Kaleo, Inc. Devices, systems and methods for medicament delivery
US11590286B2 (en) 2004-11-22 2023-02-28 Kaleo, Inc. Devices, systems and methods for medicament delivery
WO2006058426A1 (en) 2004-12-01 2006-06-08 Wlt Distributors Inc. Needle-free injector
DE102004063650B4 (en) 2004-12-31 2022-10-20 Ypsomed Ag Lifetime indicator for a product metering device
US8231573B2 (en) 2005-02-01 2012-07-31 Intelliject, Inc. Medicament delivery device having an electronic circuit system
US9022980B2 (en) 2005-02-01 2015-05-05 Kaleo, Inc. Medical injector simulation device
US8206360B2 (en) 2005-02-01 2012-06-26 Intelliject, Inc. Devices, systems and methods for medicament delivery
JP4948422B2 (en) 2005-02-01 2012-06-06 インテリジェクト，インコーポレイテッド Drug delivery apparatus, system and method
US8361026B2 (en) 2005-02-01 2013-01-29 Intelliject, Inc. Apparatus and methods for self-administration of vaccines and other medicaments
US7993300B2 (en) 2005-02-21 2011-08-09 Novo Nordisk As Method for ensuring constant speed of a motor in an injection device
CA2601022C (en) 2005-03-23 2023-03-07 Glaxosmithkline Biologicals S.A. Use of an influenza virus an oil-in-water emulsion adjuvant to induce cd4 t-cell and/or improved b-memory cell response
TR201910900T4 (en) 2005-04-04 2019-08-21 Univ Florida Desferritiokine polyether analogs.
US7618393B2 (en) 2005-05-03 2009-11-17 Pharmajet, Inc. Needle-less injector and method of fluid delivery
US20070118093A1 (en) * 2005-06-20 2007-05-24 Von Muhlen Marcio G High-speed jet devices for drug delivery
BRPI0614475B8 (en) * 2005-08-03 2021-05-25 Fraunhofer Usa Inc polypeptide, antibody, nucleic acid, vectors, host cell, antibody composition and production processes
US8591457B2 (en) 2005-08-10 2013-11-26 Alza Corporation Method for making a needle-free jet injection drug delivery device
US8202249B2 (en) 2005-09-20 2012-06-19 Panasonic Corporation Injection device with puncture function, method for controlling injection device with puncture function, chemical solution administration device, and method for controlling chemical solution administration device
TWI457133B (en) 2005-12-13 2014-10-21 Glaxosmithkline Biolog Sa Novel composition
WO2007070682A2 (en) 2005-12-15 2007-06-21 Massachusetts Institute Of Technology System for screening particles
US7988660B2 (en) * 2005-12-20 2011-08-02 Eli Lilly And Company Needle-free injection device
CA2816182C (en) 2005-12-22 2018-02-20 Glaxosmithkline Biologicals S.A. Pneumococcal polysaccharide conjugate vaccine
GB0607088D0 (en) 2006-04-07 2006-05-17 Glaxosmithkline Biolog Sa Vaccine
CA2636424A1 (en) 2006-01-09 2007-10-25 The Regents Of The University Of California Immunostimulatory combinations of tnfrsf, tlr, nlr, rhr, purinergic receptor, and cytokine receptor agonists for vaccines and tumor immunotherapy
US8277816B2 (en) * 2006-02-13 2012-10-02 Fraunhofer Usa, Inc. Bacillus anthracis antigens, vaccine compositions, and related methods
KR20080106433A (en) * 2006-02-13 2008-12-05 프라운호퍼 유에스에이, 인코포레이티드 Influenza antigens, vaccine compositions, and related methods
CA2642056A1 (en) * 2006-02-13 2007-08-23 Fraunhofer Usa, Inc. Hpv antigens, vaccine compositions, and related methods
EP1998684A4 (en) * 2006-03-10 2014-09-17 Massachusetts Inst Technology Triggered self-assembly conjugates and nanosystems
WO2007111806A2 (en) * 2006-03-23 2007-10-04 Massachusetts Eye And Ear Infirmary Cyclopentane heptanoic acid compounds for reducing body fat
US20100021503A1 (en) 2006-03-30 2010-01-28 Glaxosmithkline Biologicals S.A. Immunogenic composition
WO2008105773A2 (en) 2006-03-31 2008-09-04 Massachusetts Institute Of Technology System for targeted delivery of therapeutic agents
US20090325944A1 (en) * 2006-04-12 2009-12-31 Suzanne Walker Kahne Methods and Compositions for Modulating Glycosylation
CA2652280C (en) 2006-05-15 2014-01-28 Massachusetts Institute Of Technology Polymers for functional particles
ES2570334T3 (en) 2006-06-02 2016-05-17 Harvard College Surface protein remodeling
WO2007150030A2 (en) 2006-06-23 2007-12-27 Massachusetts Institute Of Technology Microfluidic synthesis of organic nanoparticles
CN105727276A (en) 2006-07-17 2016-07-06 葛兰素史密丝克莱恩生物有限公司 Influenza vaccine
US7618396B2 (en) * 2006-08-09 2009-11-17 Avant Medical Corp. Injection system with hidden needles
US9115358B2 (en) 2006-08-11 2015-08-25 President And Fellows Of Harvard College Moenomycin biosynthesis-related compositions and methods of use thereof
JP2010500880A (en) * 2006-08-14 2010-01-14 マサチューセッツ・インスティテュート・オブ・テクノロジー Hemagglutinin polypeptide and reagents and methods related to hemagglutinin polypeptide
US20090269342A1 (en) * 2006-08-14 2009-10-29 Massachusetts Institute Of Technology Hemagglutinin Polypeptides, and Reagents and Methods Relating Thereto
US7942845B2 (en) * 2006-09-19 2011-05-17 Bioject, Inc. Needle-free injector and process for providing serial injections
US7547293B2 (en) 2006-10-06 2009-06-16 Bioject, Inc. Triggering mechanism for needle-free injector
JO3598B1 (en) * 2006-10-10 2020-07-05 Infinity Discovery Inc Boronic acids and esters as inhibitors of fatty acid amide hydrolase
EP2433648A3 (en) 2006-10-12 2012-04-04 GlaxoSmithKline Biologicals S.A. Vaccine comprising an oil in water emulsion adjuvant
BRPI0717219B8 (en) 2006-10-12 2021-05-25 Glaxosmithkline Biologicals Sa immunogenic composition, and, use of an immunogenic composition
US8870821B2 (en) * 2006-10-13 2014-10-28 Michael D. Laufer Device for tissue injection
US7637889B2 (en) * 2006-11-15 2009-12-29 Glynntech, Inc. Drug delivery device with sliding valve and methodology
US20100150994A1 (en) 2006-12-01 2010-06-17 Anterios, Inc. Amphiphilic entity nanoparticles
AU2007333225B2 (en) * 2006-12-08 2014-06-12 Massachusetts Institute Of Technology Delivery of nanoparticles and/or agents to cells
ATE501747T1 (en) * 2006-12-22 2011-04-15 Fraunhofer Ges Forschung DEVICE AND METHOD FOR CONTROLLING AND MONITORING THE PRESSURE IN PRESSURE LINES OR PIPES
TWI618544B (en) 2006-12-26 2018-03-21 藍瑟斯醫學影像公司 Ligands for imaging cardiac innervation
WO2008091838A2 (en) 2007-01-22 2008-07-31 Intelliject, Inc. Medical injector with compliance tracking and monitoring
PT2118123E (en) 2007-01-31 2016-02-10 Harvard College Stabilized p53 peptides and uses thereof
WO2008098165A2 (en) 2007-02-09 2008-08-14 Massachusetts Institute Of Technology Oscillating cell culture bioreactor
WO2008103997A2 (en) 2007-02-23 2008-08-28 Bioject Inc. Needle-free injection devices and drug delivery systems therefor
CA2680592C (en) 2007-03-15 2016-07-05 University Of Florida Research Foundation, Inc. Desferrithiocin polyether analogues and uses thereof in treating pathological conditions
US7960139B2 (en) 2007-03-23 2011-06-14 Academia Sinica Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells
EP2508531B1 (en) 2007-03-28 2016-10-19 President and Fellows of Harvard College Stitched polypeptides
WO2008124634A1 (en) 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Polymer-encapsulated reverse micelles
EP2144600A4 (en) 2007-04-04 2011-03-16 Massachusetts Inst Technology Poly (amino acid) targeting moieties
DE102007016811A1 (en) * 2007-04-05 2008-10-09 Tecpharma Licensing Ag Device for administering a fluid substance from a multi-chamber ampoule
CA2685558A1 (en) * 2007-04-28 2008-11-06 Fraunhofer Usa, Inc. Trypanosoma antigens, vaccine compositions, and related methods
WO2008137747A1 (en) 2007-05-02 2008-11-13 The Regents Of The University Of Michigan Nanoemulsion therapeutic compositions and methods of using the same
GB0708758D0 (en) 2007-05-04 2007-06-13 Powderject Res Ltd Particle cassettes and process thereof
DK2175881T3 (en) * 2007-06-14 2012-10-22 Crucell Switzerland Ag Intradermal influenza vaccine
US8524444B2 (en) 2007-06-15 2013-09-03 President And Fellows Of Harvard College Methods and compositions for detections and modulating O-glycosylation
KR101579947B1 (en) 2007-06-26 2015-12-28 글락소스미스클라인 바이오로지칼즈 에스.에이. Vaccine comprising streptococcus pneumoniae capsular polysaccharide conjugates
CA2692933C (en) * 2007-07-11 2016-10-18 Fraunhofer Usa, Inc. Yersinia pestis antigens, vaccine compositions, and related methods
EP2205074A4 (en) * 2007-10-04 2013-07-31 Harvard College Moenomycin analogs, methods of synthesis, and uses thereof
ES2627233T3 (en) 2007-10-12 2017-07-27 Massachusetts Institute Of Technology Vaccine Nanotechnology
US20120040367A1 (en) * 2007-10-15 2012-02-16 The University Of Queensland Construct system and uses therefor
JP5067110B2 (en) * 2007-10-17 2012-11-07 マックス株式会社 Gas fired driving tool
US8617099B2 (en) * 2007-11-26 2013-12-31 Bioject Inc. Injection device plunger auto-disable
US20090137949A1 (en) * 2007-11-26 2009-05-28 Bioject Inc. Needle-free injection device with nozzle auto-disable
WO2009086448A1 (en) 2007-12-28 2009-07-09 Salient Surgical Technologies, Inc. Fluid-assisted electrosurgical devices, methods and systems
EP2237787A4 (en) * 2008-01-03 2012-03-21 Massachusetts Inst Technology Decoy influenza therapies
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
CA2721060A1 (en) * 2008-04-09 2009-10-15 Infinity Pharmaceuticals, Inc. Inhibitors of fatty acid amide hydrolase
MX2010011412A (en) 2008-04-16 2010-11-12 Glaxosmithkline Biolog Sa Vaccine.
AU2009243187C1 (en) * 2008-04-28 2015-12-24 President And Fellows Of Harvard College Supercharged proteins for cell penetration
US8021344B2 (en) 2008-07-28 2011-09-20 Intelliject, Inc. Medicament delivery device configured to produce an audible output
USD994111S1 (en) 2008-05-12 2023-08-01 Kaleo, Inc. Medicament delivery device cover
US8052645B2 (en) 2008-07-23 2011-11-08 Avant Medical Corp. System and method for an injection using a syringe needle
CA2724641C (en) * 2008-05-20 2020-03-24 Avant Medical Corp. Autoinjector system
WO2009158687A1 (en) 2008-06-26 2009-12-30 Anterios, Inc. Dermal delivery
DK2318832T3 (en) 2008-07-15 2014-01-20 Academia Sinica Glycan arrays on PTFE-like aluminum coated slides and related methods
CA2734991A1 (en) * 2008-07-23 2010-01-28 Massachusetts Institute Of Technology Activation of histone deacetylase 1 (hdac1) protects against dna damage and increases neuronal survival
US20110144306A1 (en) * 2008-07-23 2011-06-16 President And Fellows Of Harvard College Ligation of stapled polypeptides
DE102008048981A1 (en) * 2008-09-25 2010-04-15 Lts Lohmann Therapie-Systeme Ag Injector and two-chamber system with sterile components
US20100092526A1 (en) 2008-09-26 2010-04-15 Nanobio Corporation Nanoemulsion therapeutic compositions and methods of using the same
WO2010037046A1 (en) 2008-09-28 2010-04-01 Fraunhofer Usa, Inc. Humanized neuraminidase antibody and methods of use thereof
US8591905B2 (en) 2008-10-12 2013-11-26 The Brigham And Women's Hospital, Inc. Nicotine immunonanotherapeutics
US8343498B2 (en) 2008-10-12 2013-01-01 Massachusetts Institute Of Technology Adjuvant incorporation in immunonanotherapeutics
US8277812B2 (en) 2008-10-12 2012-10-02 Massachusetts Institute Of Technology Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
US8343497B2 (en) 2008-10-12 2013-01-01 The Brigham And Women's Hospital, Inc. Targeting of antigen presenting cells with immunonanotherapeutics
WO2010057197A1 (en) 2008-11-17 2010-05-20 The Regents Of The University Of Michigan Cancer vaccine compositions and methods of using the same
WO2010077806A1 (en) 2008-12-15 2010-07-08 Greenlight Biosciences, Inc. Methods for control of flux in metabolic pathways
CN105132387A (en) * 2008-12-22 2015-12-09 绿光生物科学公司 Compositions and methods for the production of a compound
US9254168B2 (en) 2009-02-02 2016-02-09 Medtronic Advanced Energy Llc Electro-thermotherapy of tissue using penetrating microelectrode array
JP5592409B2 (en) 2009-02-23 2014-09-17 サリエント・サージカル・テクノロジーズ・インコーポレーテッド Fluid-assisted electrosurgical device and method of use thereof
EP2416660B1 (en) 2009-04-07 2014-07-02 Infinity Pharmaceuticals, Inc. Inhibitors of fatty acid amide hydrolase
JP2012523425A (en) 2009-04-07 2012-10-04 インフイニトイ プハルマセウトイカルス インコーポレイテッド Inhibitors of fatty acid amide hydrolase
US9221886B2 (en) 2009-04-28 2015-12-29 President And Fellows Of Harvard College Supercharged proteins for cell penetration
US8927551B2 (en) * 2009-05-18 2015-01-06 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
US9149465B2 (en) * 2009-05-18 2015-10-06 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
US8765735B2 (en) * 2009-05-18 2014-07-01 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
JP2012528858A (en) 2009-06-01 2012-11-15 プレジデント アンド フェロウズ オブ ハーバード カレッジ O-GlcNAc transferase inhibitor and use thereof
EP2442827B1 (en) 2009-06-16 2016-01-06 The Regents of the University of Michigan Nanoemulsion vaccines
US9163330B2 (en) 2009-07-13 2015-10-20 President And Fellows Of Harvard College Bifunctional stapled polypeptides and uses thereof
GB0913681D0 (en) 2009-08-05 2009-09-16 Glaxosmithkline Biolog Sa Immunogenic composition
WO2011031748A1 (en) 2009-09-08 2011-03-17 Salient Surgical Technologies, Inc. Cartridge assembly for electrosurgical devices, electrosurgical unit and methods of use thereof
CA2774973A1 (en) 2009-09-22 2011-03-31 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
WO2011041391A1 (en) 2009-09-29 2011-04-07 Fraunhofer Usa, Inc. Influenza hemagglutinin antibodies, compositions, and related methods
US11377485B2 (en) 2009-12-02 2022-07-05 Academia Sinica Methods for modifying human antibodies by glycan engineering
US10087236B2 (en) 2009-12-02 2018-10-02 Academia Sinica Methods for modifying human antibodies by glycan engineering
US9180127B2 (en) 2009-12-29 2015-11-10 Dana-Farber Cancer Institute, Inc. Type II Raf kinase inhibitors
AU2011210840B2 (en) 2010-01-27 2014-12-11 Massachusetts Institute Of Technology Engineered polypeptide agents for targeted broad spectrum influenza neutralization
MX361011B (en) * 2010-02-03 2018-11-26 Infinity Pharmaceuticals Inc Fatty acid amide hydrolase inhibitors.
WO2011112635A1 (en) 2010-03-08 2011-09-15 Sloan-Kettering Institute For Cancer Research Cdc7 kinase inhibitors and uses thereof
GB201003920D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Method of treatment
GB201003922D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Conjugation process
EP2544616B1 (en) 2010-03-11 2017-09-06 Medtronic Advanced Energy LLC Bipolar electrosurgical cutter with position insensitive return electrode contact
US9102697B2 (en) 2010-03-22 2015-08-11 President And Fellows Of Harvard College Trioxacarcins and uses thereof
WO2011130332A1 (en) 2010-04-12 2011-10-20 Academia Sinica Glycan arrays for high throughput screening of viruses
US9795658B2 (en) 2010-04-20 2017-10-24 Admedus Vaccines Pty Ltd Expression system for modulating an immune response
WO2011140296A1 (en) 2010-05-05 2011-11-10 Infinity Pharmaceuticals Triazoles as inhibitors of fatty acid synthase
EP2566853B1 (en) 2010-05-05 2017-01-25 Infinity Pharmaceuticals, Inc. Tetrazolones as inhibitors of fatty acid synthase
DK2566953T3 (en) 2010-05-07 2019-04-15 Greenlight Biosciences Inc METHODS OF MANAGING THE POWER BY METABOLIC ROADS USING ENZYMOUS LOCATION
CN106977429B (en) 2010-05-11 2021-08-24 蓝瑟斯医学影像公司 Compositions, methods and systems for synthesis and use of contrast agents
US20110295249A1 (en) * 2010-05-28 2011-12-01 Salient Surgical Technologies, Inc. Fluid-Assisted Electrosurgical Devices, and Methods of Manufacture Thereof
US8658603B2 (en) 2010-06-16 2014-02-25 The Regents Of The University Of Michigan Compositions and methods for inducing an immune response
ES2664872T3 (en) 2010-06-18 2018-04-23 Taiho Pharmaceutical Co., Ltd PRPK-TPRKB modulators and their uses
US9138289B2 (en) 2010-06-28 2015-09-22 Medtronic Advanced Energy Llc Electrode sheath for electrosurgical device
US8920417B2 (en) 2010-06-30 2014-12-30 Medtronic Advanced Energy Llc Electrosurgical devices and methods of use thereof
US8906012B2 (en) 2010-06-30 2014-12-09 Medtronic Advanced Energy Llc Electrosurgical devices with wire electrode
WO2012019168A2 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
PT2603600T (en) 2010-08-13 2019-02-27 Aileron Therapeutics Inc Peptidomimetic macrocycles
WO2012030980A1 (en) 2010-08-31 2012-03-08 Greenlight Biosciences, Inc. Methods for control of flux in metabolic pathways through protease manipulation
JP2013541528A (en) 2010-09-21 2013-11-14 マサチューセッツ インスティテュート オブ テクノロジー Human adaptive HA polypeptides, vaccines, and influenza treatment
US8957026B2 (en) 2010-09-22 2015-02-17 President And Fellows Of Harvard College Beta-catenin targeting peptides and uses thereof
US20120237975A1 (en) 2010-10-01 2012-09-20 Jason Schrum Engineered nucleic acids and methods of use thereof
WO2012047941A2 (en) 2010-10-04 2012-04-12 Massachusetts Institute Of Technology Hemagglutinin polypeptides, and reagents and methods relating thereto
US9023040B2 (en) 2010-10-26 2015-05-05 Medtronic Advanced Energy Llc Electrosurgical cutting devices
CN103298474B (en) 2010-11-10 2016-06-29 无限药品股份有限公司 Heterocyclic compound and application thereof
NZ612909A (en) 2011-01-10 2015-09-25 Infinity Pharmaceuticals Inc Processes for preparing isoquinolinones and solid forms of isoquinolinones
EP2982373B1 (en) 2011-01-19 2018-06-13 Topokine Therapeutics, Inc. Methods and compostions for reducing body fat
KR20230007537A (en) 2011-01-24 2023-01-12 안테리오스, 인코퍼레이티드 Nanoparticle compositions, formulations thereof, and uses therefor
WO2012103035A1 (en) 2011-01-24 2012-08-02 Anterios, Inc. Nanoparticle compositions
JP2014503586A (en) 2011-01-24 2014-02-13 アンテリオス， インコーポレイテッド Oil composition
US8627816B2 (en) 2011-02-28 2014-01-14 Intelliject, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
US9084849B2 (en) 2011-01-26 2015-07-21 Kaleo, Inc. Medicament delivery devices for administration of a medicament within a prefilled syringe
US8939943B2 (en) 2011-01-26 2015-01-27 Kaleo, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
US8703818B2 (en) 2011-03-03 2014-04-22 Tersus Pharmaceuticals, LLC Compositions and methods comprising C16:1n7-palmitoleate
GB201103836D0 (en) 2011-03-07 2011-04-20 Glaxosmithkline Biolog Sa Conjugation process
US9427281B2 (en) 2011-03-11 2016-08-30 Medtronic Advanced Energy Llc Bronchoscope-compatible catheter provided with electrosurgical device
US9193767B2 (en) 2011-03-30 2015-11-24 Brown University Enopeptins, uses thereof, and methods of synthesis thereto
AU2012236099A1 (en) 2011-03-31 2013-10-03 Moderna Therapeutics, Inc. Delivery and formulation of engineered nucleic acids
CN103533953A (en) 2011-05-17 2014-01-22 葛兰素史密丝克莱恩生物有限公司 Vaccine against streptococcus pneumoniae
DK2714147T3 (en) * 2011-05-25 2017-07-24 Sanofi Aventis Deutschland MEDICINAL APPLICATION DEVICE WITH DISPENSING INTERFACE SENSOR AND PROCEDURE TO CONTROL THE DEVICE
TWI417120B (en) * 2011-05-27 2013-12-01 Leader Machine Co Ltd A drug delivery device with built - in quantitative pusher
EP2537546A1 (en) * 2011-06-21 2012-12-26 Sanofi-Aventis Deutschland GmbH Medicament delivery device with dose control mechanism
WO2012177595A1 (en) 2011-06-21 2012-12-27 Oncofactor Corporation Compositions and methods for the therapy and diagnosis of cancer
AU2012272815B2 (en) 2011-06-22 2017-09-07 The General Hospital Corporation Treatment of proteinopathies
US8969363B2 (en) 2011-07-19 2015-03-03 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
MX2014000648A (en) 2011-07-19 2014-09-25 Infinity Pharmaceuticals Inc Heterocyclic compounds and uses thereof.
US9115053B2 (en) 2011-07-22 2015-08-25 Massachusetts Institute Of Technology Activators of class I histone deacetlyases (HDACS) and uses thereof
US9408972B2 (en) 2011-08-02 2016-08-09 Pharmajet, Inc. Needle-free injection device
TW201311663A (en) 2011-08-29 2013-03-16 Infinity Pharmaceuticals Inc Heterocyclic compounds and uses thereof
WO2013036787A2 (en) 2011-09-09 2013-03-14 Greenlight Biosciences, Inc. Cell-free preparation of carbapenems
SG2014013767A (en) 2011-09-09 2014-05-29 Lantheus Medical Imaging Inc Compositions, methods, and systems for the synthesis and use of imaging agents
EP3384938A1 (en) 2011-09-12 2018-10-10 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
WO2013049332A1 (en) 2011-09-29 2013-04-04 Infinity Pharmaceuticals, Inc. Inhibitors of monoacylglycerol lipase and methods of their use
US9750565B2 (en) 2011-09-30 2017-09-05 Medtronic Advanced Energy Llc Electrosurgical balloons
EP3682905B1 (en) 2011-10-03 2021-12-01 ModernaTX, Inc. Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
CA2852468A1 (en) 2011-10-18 2013-04-25 Aileron Therapeutics, Inc. Peptidomimetic macrocyles
US8870864B2 (en) 2011-10-28 2014-10-28 Medtronic Advanced Energy Llc Single instrument electrosurgery apparatus and its method of use
US9382239B2 (en) 2011-11-17 2016-07-05 Dana-Farber Cancer Institute, Inc. Inhibitors of c-Jun-N-terminal kinase (JNK)
GB201120000D0 (en) 2011-11-20 2012-01-04 Glaxosmithkline Biolog Sa Vaccine
GB201119999D0 (en) 2011-11-20 2012-01-04 Glaxosmithkline Biolog Sa Vaccine
RU2627632C2 (en) 2011-12-13 2017-08-09 Фармаджет Инк. Needle-free intradermal injection device
RS63244B1 (en) 2011-12-16 2022-06-30 Modernatx Inc Modified mrna compositions
CN104114170B (en) 2011-12-16 2021-07-06 佛罗里达大学研究基金会 Use of 4' -deferthionin analogues
US8426471B1 (en) 2011-12-19 2013-04-23 Topokine Therapeutics, Inc. Methods and compositions for reducing body fat and adipocytes
CA2864120A1 (en) 2012-02-15 2013-08-22 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
RU2017145921A (en) 2012-02-15 2019-02-21 Эйлерон Терапьютикс, Инк. PEPTIDOMIMETIC MACROCYCLES
US9273084B2 (en) 2012-04-06 2016-03-01 President And Fellows Of Harvard College Moenomycin analogs, methods of synthesis, and uses thereof
EP2850091A1 (en) 2012-04-06 2015-03-25 President and Fellows of Harvard College Methods and compounds for identifying glycosyltransferase inhibitors
EP2850090B1 (en) 2012-04-06 2018-10-03 President and Fellows of Harvard College Chemoenzymatic methods for synthesizing moenomycin analogs
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US10130714B2 (en) 2012-04-14 2018-11-20 Academia Sinica Enhanced anti-influenza agents conjugated with anti-inflammatory activity
US9597385B2 (en) 2012-04-23 2017-03-21 Allertein Therapeutics, Llc Nanoparticles for treatment of allergy
EP2846833A4 (en) 2012-05-10 2016-01-06 Massachusetts Inst Technology Agents for influenza neutralization
US9522235B2 (en) 2012-05-22 2016-12-20 Kaleo, Inc. Devices and methods for delivering medicaments from a multi-chamber container
CA2875683A1 (en) 2012-06-05 2013-12-12 The Australian National University Vaccination with interleukin-4 antagonists
US9226792B2 (en) 2012-06-12 2016-01-05 Medtronic Advanced Energy Llc Debridement device and method
CA2879939A1 (en) 2012-08-06 2014-02-13 Glaxosmithkline Biologicals S.A. Novel method
US20140037680A1 (en) 2012-08-06 2014-02-06 Glaxosmithkline Biologicals, S.A. Novel method
AU2013203000B9 (en) 2012-08-10 2017-02-02 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
AU2013306098A1 (en) 2012-08-18 2015-02-12 Academia Sinica Cell-permeable probes for identification and imaging of sialidases
WO2014052647A2 (en) 2012-09-26 2014-04-03 President And Fellows Of Harvard College Proline-locked stapled peptides and uses thereof
US20150225471A1 (en) 2012-10-01 2015-08-13 President And Fellows Of Harvard College Stabilized polypeptide insulin receptor modulators
US11234760B2 (en) 2012-10-05 2022-02-01 Medtronic Advanced Energy Llc Electrosurgical device for cutting and removing tissue
PT2909204T (en) 2012-10-12 2019-03-21 Dana Farber Cancer Inst Inc Gsk3 inhibitors and methods of use thereof
WO2014063068A1 (en) 2012-10-18 2014-04-24 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 (cdk7)
US10000483B2 (en) 2012-10-19 2018-06-19 Dana-Farber Cancer Institute, Inc. Bone marrow on X chromosome kinase (BMX) inhibitors and uses thereof
USRE48175E1 (en) 2012-10-19 2020-08-25 Dana-Farber Cancer Institute, Inc. Hydrophobically tagged small molecules as inducers of protein degradation
CN109134640A (en) 2012-10-23 2019-01-04 爱默蕾大学 GM-CSF and IL-4 conjugates, composition and relative method
ES2854754T3 (en) 2012-10-24 2021-09-22 Platelet Targeted Therapeutics Llc Platelet Targeted Treatment
BR112015009470A2 (en) 2012-11-01 2019-12-17 Aileron Therapeutics Inc disubstituted amino acids and their methods of preparation and use
SI2914296T2 (en) 2012-11-01 2022-01-31 Infinity Pharmaceuticals, Inc. Treatment of cancers using pi3 kinase isoform modulators
WO2014071247A1 (en) 2012-11-02 2014-05-08 Dana-Farber Cancer Institute, Inc. Pyrrol-1 -yl benzoic acid derivates useful as myc inhibitors
SG11201600237YA (en) 2012-11-21 2016-02-26 Topokine Therapeutics Inc Methods and compositions for locally increasing body fat
WO2014082065A1 (en) 2012-11-26 2014-05-30 President And Fellows Of Harvard College Trioxacarcins, trioxacarcin-antibody conjugates, and uses thereof
ES2921623T3 (en) 2012-11-26 2022-08-30 Modernatx Inc terminally modified RNA
WO2014100695A1 (en) 2012-12-21 2014-06-26 Epizyme, Inc. Prmt5 inhibitors and uses thereof
PL2935222T3 (en) 2012-12-21 2019-02-28 Epizyme Inc Prmt5 inhibitors and uses thereof
CA2899363A1 (en) 2012-12-21 2014-06-26 Epizyme, Inc. Prmt5 inhibitors and uses thereof
WO2014100730A1 (en) 2012-12-21 2014-06-26 Epizyme, Inc. Prmt5 inhibitors containing a dihydro- or tetrahydroisoquinoline and uses thereof
CA2896708A1 (en) 2012-12-27 2014-07-03 Kaleo, Inc. Devices, systems and methods for locating and interacting with medicament delivery systems
WO2014113089A2 (en) 2013-01-17 2014-07-24 Moderna Therapeutics, Inc. Signal-sensor polynucleotides for the alteration of cellular phenotypes
AU2014214844B2 (en) 2013-02-07 2017-12-14 Children's Medical Center Corporation Protein antigens that provide protection against pneumococcal colonization and/or disease
WO2014124319A2 (en) 2013-02-07 2014-08-14 Massachusetts Institute Of Technology Human adaptation of h5 influenza
KR20150131244A (en) 2013-03-13 2015-11-24 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 Stapled and stitched polypeptides and uses thereof
WO2014159813A1 (en) 2013-03-13 2014-10-02 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
EP3593839A1 (en) 2013-03-15 2020-01-15 Amgen Inc. Drug cassette
WO2014151386A1 (en) 2013-03-15 2014-09-25 Infinity Pharmaceuticals, Inc. Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
EP2981285B1 (en) 2013-04-03 2020-06-03 N-Fold Llc Novel nanoparticle compositions
JP6437523B2 (en) 2013-04-04 2018-12-12 プレジデント アンド フェローズ オブ ハーバード カレッジ Macrolides and methods for their preparation and use
US9381253B2 (en) 2013-04-09 2016-07-05 Massachusetts Institute Of Technology Drug delivery polymer and uses thereof
WO2014179464A1 (en) 2013-04-30 2014-11-06 Massachusetts Institute Of Technology Human adaptation of h3 influenza
US9315472B2 (en) 2013-05-01 2016-04-19 Massachusetts Institute Of Technology 1,3,5-triazinane-2,4,6-trione derivatives and uses thereof
NO2753788T3 (en) 2013-05-10 2018-06-16
SG11201509842SA (en) 2013-05-30 2015-12-30 Infinity Pharmaceuticals Inc Treatment of cancers using pi3 kinase isoform modulators
WO2014197723A2 (en) 2013-06-05 2014-12-11 Massachusetts Institute Of Technology Human adaptation of h7 ha
US9212145B2 (en) 2013-06-11 2015-12-15 Kala Pharmaceuticals, Inc. Urea derivatives and uses thereof
CN105492460A (en) 2013-06-14 2016-04-13 哈佛大学的校长及成员们 Stabilized polypeptide insulin receptor modulators
EP3013365B1 (en) 2013-06-26 2019-06-05 Academia Sinica Rm2 antigens and use thereof
WO2014210564A1 (en) 2013-06-27 2014-12-31 Academia Sinica Glycan conjugates and use thereof
AU2014292888B2 (en) 2013-07-25 2018-03-22 Dana-Farber Cancer Institute, Inc. Inhibitors of transcription factors and uses thereof
BR112016002494A2 (en) 2013-08-05 2017-09-05 Greenlight Biosciences Inc PROTEINS CONSTRUCTED WITH A PROTEASE CLEAVAGE SITE, NUCLEIC ACID, VECTOR, CELL AND PROCESS ENGINEERING A RECOMBINANT PROTEIN AND A LARGE NUMBER OF NUCLEIC ACID VARIANTS THAT ENCODE RECOMBINANT PROTEINS
EP3492097A1 (en) 2013-08-05 2019-06-05 GlaxoSmithKline Biologicals S.A. Combination immunogenic compositions
TWI532511B (en) * 2013-08-16 2016-05-11 京華堂實業股份有限公司 A needleless drug-injecting system and a drug-injecting method thereof
CN105682666B (en) 2013-09-06 2021-06-01 中央研究院 Activation of human iNKT cells using glycolipids
US9751888B2 (en) 2013-10-04 2017-09-05 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
NZ718430A (en) 2013-10-04 2021-12-24 Infinity Pharmaceuticals Inc Heterocyclic compounds and uses thereof
WO2015057894A1 (en) 2013-10-15 2015-04-23 Massachusetts Institute Of Technology Methods for treating polycystic kidney disease and polycystic liver disease
US9902986B2 (en) 2013-10-16 2018-02-27 Massachusetts Institute Of Technology Enterobactin conjugates and uses thereof
US10047070B2 (en) 2013-10-18 2018-08-14 Dana-Farber Cancer Institute, Inc. Polycyclic inhibitors of cyclin-dependent kinase 7 (CDK7)
EP3057955B1 (en) 2013-10-18 2018-04-11 Syros Pharmaceuticals, Inc. Heteroaromatic compounds useful for the treatment of prolferative diseases
WO2015061204A1 (en) 2013-10-21 2015-04-30 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
WO2015066482A1 (en) 2013-11-01 2015-05-07 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
US10208102B2 (en) 2013-11-01 2019-02-19 University Of Oslo Albumin variants and uses thereof
CA2929126C (en) 2013-11-13 2020-01-07 University Of Oslo Outer membrane vesicles and uses thereof
WO2015071763A2 (en) 2013-11-15 2015-05-21 Oslo Universitetssykehus Hf Ctl peptide epitopes and antigen-specific t cells, methods for their discovery, and uses thereof
US10314647B2 (en) 2013-12-23 2019-06-11 Medtronic Advanced Energy Llc Electrosurgical cutting instrument
KR20160101162A (en) 2013-12-24 2016-08-24 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 Cortistatin analogues and syntheses and uses thereof
EP3094352B1 (en) 2014-01-16 2020-09-23 Academia Sinica Compositions and methods for treatment and detection of cancers
US10150818B2 (en) 2014-01-16 2018-12-11 Academia Sinica Compositions and methods for treatment and detection of cancers
JP2017504651A (en) 2014-01-31 2017-02-09 ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド Use of diazepan derivatives
US10813686B2 (en) 2014-02-26 2020-10-27 Medtronic Advanced Energy Llc Electrosurgical cutting instrument
EP3119415A4 (en) 2014-03-07 2017-11-29 The Arizona Board of Regents on behalf of the University of Arizona Non-narcotic crmp2 peptides targeting sodium channels for chronic pain
AU2015231413B2 (en) 2014-03-19 2020-04-23 Infinity Pharmaceuticals, Inc. Heterocyclic compounds for use in the treatment of PI3K-gamma mediated disorders
TWI687428B (en) 2014-03-27 2020-03-11 中央研究院 Reactive labelling compounds and uses thereof
ES2868305T3 (en) 2014-03-28 2021-10-21 Univ Washington Through Its Center For Commercialization Vaccines against breast and ovarian cancer
WO2015164614A1 (en) 2014-04-23 2015-10-29 Dana-Farber Cancer Institute, Inc. Janus kinase inhibitors and uses thereof
US9862688B2 (en) 2014-04-23 2018-01-09 Dana-Farber Cancer Institute, Inc. Hydrophobically tagged janus kinase inhibitors and uses thereof
WO2015168079A1 (en) 2014-04-29 2015-11-05 Infinity Pharmaceuticals, Inc. Pyrimidine or pyridine derivatives useful as pi3k inhibitors
US10039816B2 (en) 2014-04-30 2018-08-07 Massachusetts Institute Of Technology Siderophore-based immunization against gram-negative bacteria
US10533039B2 (en) 2014-05-21 2020-01-14 President And Fellows Of Harvard College Ras inhibitory peptides and uses thereof
AU2015267045B2 (en) 2014-05-27 2021-02-25 Academia Sinica Anti-HER2 glycoantibodies and uses thereof
US10118969B2 (en) 2014-05-27 2018-11-06 Academia Sinica Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
KR20220151036A (en) 2014-05-27 2022-11-11 아카데미아 시니카 Anti-cd20 glycoantibodies and uses thereof
AU2015267052A1 (en) 2014-05-27 2016-12-15 Academia Sinica Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
US11332523B2 (en) 2014-05-28 2022-05-17 Academia Sinica Anti-TNF-alpha glycoantibodies and uses thereof
JP6664338B2 (en) 2014-06-13 2020-03-13 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム Immunogenic combination
MA40240B1 (en) 2014-06-19 2019-03-29 Ariad Pharma Inc Heteroaryl compounds of kinase inhibition
WO2015200425A1 (en) 2014-06-27 2015-12-30 Topokine Therapeutics, Inc. Topical dosage regimen
US9840479B2 (en) 2014-07-02 2017-12-12 Massachusetts Institute Of Technology Polyamine-fatty acid derived lipidoids and uses thereof
US9517307B2 (en) 2014-07-18 2016-12-13 Kaleo, Inc. Devices and methods for delivering opioid antagonists including formulations for naloxone
US10759836B2 (en) 2014-07-18 2020-09-01 University Of Washington Cancer vaccine compositions and methods of use thereof
WO2016025643A1 (en) 2014-08-12 2016-02-18 Massachusetts Institute Of Technology Brush-poly(glycoamidoamine)-lipids and uses thereof
US9974599B2 (en) 2014-08-15 2018-05-22 Medtronic Ps Medical, Inc. Multipurpose electrosurgical device
CN107001404B (en) 2014-09-08 2021-06-29 中央研究院 Activation of human iNKT cells using glycolipids
CN112972378A (en) 2014-09-24 2021-06-18 艾瑞朗医疗公司 Peptidomimetic macrocycles and formulations thereof
SG11201702223UA (en) 2014-09-24 2017-04-27 Aileron Therapeutics Inc Peptidomimetic macrocycles and uses thereof
US9708348B2 (en) 2014-10-03 2017-07-18 Infinity Pharmaceuticals, Inc. Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof
ES2924988T3 (en) 2014-10-10 2022-10-13 Univ Michigan Regents Compositions with nanoemulsions to prevent, inhibit or eliminate allergic and inflammatory disease
KR102331856B1 (en) 2014-10-21 2021-11-29 다케다 야쿠힌 고교 가부시키가이샤 Crystalline forms of 5-chloro-n4-[2-(dimethylphosphoryl)phenyl]-n2-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]pyrimidine-2,4-diamine
JP2017533238A (en) 2014-10-28 2017-11-09 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル Compositions and methods for antigen-specific tolerance
AR102547A1 (en) 2014-11-07 2017-03-08 Takeda Vaccines Inc VACCINES AGAINST DISEASE OF HANDS, FEET AND MOUTH AND MANUFACTURING METHODS AND THEIR USE
AR102548A1 (en) 2014-11-07 2017-03-08 Takeda Vaccines Inc VACCINES AGAINST HAND, FEET AND MOUTH DISEASE AND MANUFACTURING AND USE METHODS
EP3041948B1 (en) 2014-11-10 2019-01-09 Modernatx, Inc. Alternative nucleic acid molecules containing reduced uracil content and uses thereof
US10253045B2 (en) 2014-11-26 2019-04-09 Kala Pharmaceuticals, Inc. Crystalline forms of a therapeutic compound and uses thereof
EP3230272B1 (en) 2014-12-10 2020-08-19 Kala Pharmaceuticals, Inc. 1-amino-triazolo(1,5-a)pyridine-substituted urea derivative and uses thereof
AU2015371251B2 (en) 2014-12-23 2020-06-11 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 (CDK7)
JP7358029B2 (en) 2014-12-23 2023-10-10 スローン － ケタリング・インスティテュート・フォー・キャンサー・リサーチ Granaticin B polymorphism
US10495645B2 (en) 2015-01-16 2019-12-03 Academia Sinica Cancer markers and methods of use thereof
US9975965B2 (en) 2015-01-16 2018-05-22 Academia Sinica Compositions and methods for treatment and detection of cancers
KR20170104617A (en) 2015-01-24 2017-09-15 아카데미아 시니카 Novel glycan conjugates and methods for using them
US10188456B2 (en) 2015-02-18 2019-01-29 Medtronic Xomed, Inc. Electrode assembly for RF energy enabled tissue debridement device
WO2016134156A1 (en) 2015-02-18 2016-08-25 Medtronic Xomed, Inc. Rf energy enabled tissue debridement device
US10376302B2 (en) 2015-02-18 2019-08-13 Medtronic Xomed, Inc. Rotating electrical connector for RF energy enabled tissue debridement device
CN107530416A (en) 2015-03-05 2018-01-02 西北大学 Virus that non-nerve infects and application thereof
US20180071380A1 (en) 2015-03-20 2018-03-15 The Regents Of The University Of Michigan Immunogenic compositions for use in vaccination against bordetella
BR112017019738A2 (en) 2015-03-20 2018-05-29 Aileron Therapeutics Inc peptidomimetic macrocycles and their uses
CA2980004C (en) 2015-03-24 2023-10-10 Kaleo, Inc. Devices and methods for delivering a lyophilized medicament
WO2016160617A2 (en) 2015-03-27 2016-10-06 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinases
JP6843065B2 (en) 2015-03-30 2021-03-17 グリーンライト バイオサイエンシーズ インコーポレーテッドＧｒｅｅｎｌｉｇｈｔ Ｂｉｏｓｃｉｅｎｃｅｓ，Ｉｎｃ． Cell-free production of ribonucleic acid
CN107708693A (en) 2015-04-27 2018-02-16 佛罗里达大学研究基金会 Metal-chelator of Metabolic programming and application thereof
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
EP3307728A4 (en) 2015-06-12 2019-07-17 Dana Farber Cancer Institute, Inc. Combination therapy of transcription inhibitors and kinase inhibitors
CA2990172A1 (en) 2015-06-19 2016-12-22 Massachusetts Institute Of Technology Alkenyl substituted 2,5-piperazinediones and their use in compositions for delivering an agent to a subject or cell
GB2556479B (en) 2015-06-30 2022-09-07 Kaleo Inc Auto-injectors for administration of a medicament within a prefilled syringe
US10059741B2 (en) 2015-07-01 2018-08-28 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US11389227B2 (en) 2015-08-20 2022-07-19 Medtronic Advanced Energy Llc Electrosurgical device with multivariate control
US11051875B2 (en) 2015-08-24 2021-07-06 Medtronic Advanced Energy Llc Multipurpose electrosurgical device
CA2996978A1 (en) 2015-09-09 2017-03-16 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinases
WO2017044633A1 (en) 2015-09-10 2017-03-16 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of mcl-1
WO2017044849A1 (en) 2015-09-11 2017-03-16 Dana-Farber Cancer Institute, Inc. Cyano thienotriazolodiazepines and uses thereof
WO2017044792A1 (en) 2015-09-11 2017-03-16 Dana-Farber Cancer Institute, Inc. Acetamide thienotriazoldiazepines and uses thereof
EP3350333B1 (en) 2015-09-17 2021-10-27 ModernaTX, Inc. Polynucleotides containing a stabilizing tail region
AU2016324310B2 (en) 2015-09-17 2021-04-08 Modernatx, Inc. Compounds and compositions for intracellular delivery of therapeutic agents
US9925170B2 (en) 2015-10-01 2018-03-27 Kythera Biopharmaceuticals, Inc. Methods of adipolysis and compositions useful therein
GB201518684D0 (en) 2015-10-21 2015-12-02 Glaxosmithkline Biolog Sa Vaccine
SG11201803210YA (en) 2015-11-25 2018-05-30 Dana Farber Cancer Inst Inc Bivalent bromodomain inhibitors and uses thereof
WO2017096432A1 (en) 2015-12-09 2017-06-15 Admedus Vaccines Pty Ltd Immunomodulating composition for treatment
US10716612B2 (en) 2015-12-18 2020-07-21 Medtronic Advanced Energy Llc Electrosurgical device with multiple monopolar electrode assembly
JP7114465B2 (en) 2015-12-22 2022-08-08 モデルナティエックス インコーポレイテッド Compounds and compositions for intracellular delivery of drugs
AU2017231749A1 (en) 2016-03-08 2018-09-20 Academia Sinica Methods for modular synthesis of N-glycans and arrays thereof
WO2017161116A1 (en) 2016-03-17 2017-09-21 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors
CR20180525A (en) 2016-04-06 2019-02-14 Greenlight Biosciences Inc RIBONUCLEIC ACID PRODUCTION FREE OF CELLS
WO2017201390A1 (en) 2016-05-19 2017-11-23 The Regents Of The University Of Michigan Novel adjuvant compositions
JP7110119B2 (en) 2016-06-03 2022-08-01 サノフィ パスツール インコーポレイティッド Modifications of Engineered Influenza Hemagglutinin Polypeptides
US10105449B2 (en) 2016-06-07 2018-10-23 Massachusetts Institute Of Technology Drug delivery polymers and uses thereof
WO2017214269A1 (en) 2016-06-08 2017-12-14 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
WO2017218704A1 (en) 2016-06-14 2017-12-21 Modernatx, Inc. Stabilized formulations of lipid nanoparticles
GB201610599D0 (en) 2016-06-17 2016-08-03 Glaxosmithkline Biologicals Sa Immunogenic Composition
WO2018018082A1 (en) 2016-07-26 2018-02-01 The Australian National University Immunostimulatory compositions and uses therefor
BR112019001971A2 (en) 2016-08-05 2019-05-07 Sanofi Pasteur, Inc. multivalent pneumococcal polysaccharide-protein conjugate composition
WO2018027123A1 (en) 2016-08-05 2018-02-08 Sanofi Pasteur, Inc. Multivalent pneumococcal polysaccharide-protein conjugate composition
CN109963868B (en) 2016-08-22 2023-11-14 醣基生医股份有限公司 Antibodies, binding fragments, and methods of use
US11583504B2 (en) 2016-11-08 2023-02-21 Modernatx, Inc. Stabilized formulations of lipid nanoparticles
WO2018096396A1 (en) 2016-11-22 2018-05-31 University Of Oslo Albumin variants and uses thereof
WO2018106738A1 (en) 2016-12-05 2018-06-14 Massachusetts Institute Of Technology Brush-arm star polymers, conjugates and particles, and uses thereof
EP3558420A4 (en) 2016-12-23 2020-05-27 Kaleo, Inc. Medicament delivery device and methods for delivering drugs to infants and children
WO2018136413A2 (en) 2017-01-17 2018-07-26 Kaleo, Inc. Medicament delivery devices with wireless connectivity and event detection
CA3055653A1 (en) 2017-03-15 2018-09-20 Modernatx, Inc. Lipid nanoparticle formulation
AU2018234692B2 (en) 2017-03-15 2022-06-02 Modernatx, Inc. Compounds and compositions for intracellular delivery of therapeutic agents
US11555031B2 (en) 2017-03-20 2023-01-17 The Broad Institute, Inc. Compounds and methods for regulating insulin secretion
BR112019020810A2 (en) 2017-04-05 2020-04-28 Biogen Ma Inc tricyclic compounds as glycogen synthase kinase 3 (gsk3) inhibitors and uses thereof
EP3638678A1 (en) 2017-06-14 2020-04-22 Modernatx, Inc. Compounds and compositions for intracellular delivery of agents
US11612647B2 (en) 2017-06-23 2023-03-28 University Of Maryland, Baltimore Immunogenic compositions
KR102494471B1 (en) 2017-06-29 2023-02-06 리제너론 파아마슈티컬스, 인크. Device and method for overfilling drug containers
WO2019013789A1 (en) 2017-07-12 2019-01-17 Curza Global, Llc Antimicrobial compounds
WO2019013790A1 (en) 2017-07-12 2019-01-17 Curza Global, Llc Antimicrobial compounds and uses thereof
MX2020002348A (en) 2017-08-31 2020-10-08 Modernatx Inc Methods of making lipid nanoparticles.
WO2019048936A1 (en) 2017-09-07 2019-03-14 University Of Oslo Vaccine molecules
EP3678698A1 (en) 2017-09-07 2020-07-15 University Of Oslo Vaccine molecules
CA3078726A1 (en) 2017-10-11 2019-04-18 Greenlight Biosciences, Inc. Methods and compositions for nucleoside triphosphate and ribonucleic acid production
MY194449A (en) 2017-11-03 2022-11-30 Takeda Vaccines Inc Zika vaccines and immunogenic compositions, and methods of using the same
EP3717033A4 (en) 2017-12-01 2021-08-25 North Carolina State University Fibrin particles and methods of making the same
GB201721582D0 (en) 2017-12-21 2018-02-07 Glaxosmithkline Biologicals Sa S aureus antigens and immunogenic compositions
GB201721576D0 (en) 2017-12-21 2018-02-07 Glaxosmithkline Biologicals Sa Hla antigens and glycoconjugates thereof
WO2020018433A1 (en) 2018-07-16 2020-01-23 Kaleo, Inc. Medicament delivery devices with wireless connectivity and compliance detection
JP7410135B2 (en) 2018-09-19 2024-01-09 モデルナティエックス インコーポレイテッド Compounds and compositions for intracellular delivery of therapeutic agents
WO2020061457A1 (en) 2018-09-20 2020-03-26 Modernatx, Inc. Preparation of lipid nanoparticles and methods of administration thereof
CN113924292A (en) 2019-01-16 2022-01-11 库扎环球有限责任公司 Antimicrobial compounds and methods
US20230072397A1 (en) 2019-01-16 2023-03-09 Curza Global, Llc Antimicrobial Compounds and Methods
CA3128215A1 (en) 2019-01-31 2020-08-06 Modernatx, Inc. Methods of preparing lipid nanoparticles
WO2020168466A1 (en) 2019-02-19 2020-08-27 Stemirna Therapeutics Co., Ltd. Modified nucleoside and synthetic methods thereof
JP2022543773A (en) 2019-07-31 2022-10-14 モデルナティエックス インコーポレイテッド Compositions and methods for delivery of RNA interfering agents to immune cells
KR20220042378A (en) 2019-07-31 2022-04-05 사노피 파스퇴르 인코포레이티드 Polyvalent pneumococcal polysaccharide-protein conjugate composition and method of use thereof
JP2022543523A (en) 2019-08-09 2022-10-13 カレオ，インコーポレイテッド Device and method for delivery of substances in pre-filled syringes
JP2023501575A (en) 2019-11-13 2023-01-18 カーザ グローバル， エルエルシー Antimicrobial compounds and methods
KR20220087563A (en) 2019-12-19 2022-06-24 생-고뱅 퍼포먼스 플라스틱스 코포레이션 Poppet, assembly and method of assembly and use thereof
TW202139976A (en) 2020-01-31 2021-11-01 美商現代公司 Methods of preparing lipid nanoparticles
WO2021173965A1 (en) 2020-02-28 2021-09-02 Massachusetts Institute Of Technology Identification of variable influenza residues and uses thereof
WO2021195089A1 (en) 2020-03-23 2021-09-30 Sorrento Therapeutics, Inc. Fc-coronavirus antigen fusion proteins, and nucleic acids, vectors, compositions and methods of use thereof
WO2021231729A1 (en) 2020-05-13 2021-11-18 Sanofi Adjuvanted stabilized stem hemagglutinin nanoparticles and methods of using the same to induce broadly neutralizing antibodies against influenza
JPWO2022092294A1 (en) 2020-10-30 2022-05-05
JPWO2022092295A1 (en) 2020-10-30 2022-05-05
AR124267A1 (en) 2020-12-09 2023-03-01 Genentech Inc HIGH THROUGH METHODS FOR PREPARING LIPID NANOPARTICLES AND THEIR USES
WO2022192176A1 (en) 2021-03-09 2022-09-15 Massachusetts Institute Of Technology Branched poly(-amino esters) for the delivery of nucleic acids
TW202313065A (en) 2021-05-28 2023-04-01 美商季卡尼醫療公司 Compounds for treating genetic diseases
WO2023018817A1 (en) 2021-08-11 2023-02-16 Sanofi Pasteur Inc. Truncated influenza neuraminidase and methods of using the same
WO2023039108A1 (en) 2021-09-08 2023-03-16 Affinivax, Inc. Coronavirus vaccine
TW202333778A (en) 2021-10-08 2023-09-01 美商賽諾菲巴斯德公司 Multivalent influenza vaccines
WO2023081798A1 (en) 2021-11-05 2023-05-11 Sanofi Pasteur Inc. Multivalent influenza vaccines comprising recombinant hemagglutinin and neuraminidase and methods of using the same
WO2023079113A1 (en) 2021-11-05 2023-05-11 Sanofi Hybrid multivalent influenza vaccines comprising hemagglutinin and neuraminidase and methods of using the same
TW202333654A (en) 2021-12-16 2023-09-01 美商現代公司 Processes for preparing lipid nanoparticles
WO2023129963A1 (en) 2021-12-30 2023-07-06 Curza Global, Llc Antimicrobial compounds and methods
WO2023144206A1 (en) 2022-01-27 2023-08-03 Sanofi Pasteur Modified vero cells and methods of using the same for virus production
WO2023177577A1 (en) 2022-03-14 2023-09-21 Sanofi Pasteur Inc. Machine-learning techniques in protein design for vaccine generation
WO2023193002A1 (en) 2022-04-01 2023-10-05 Modernatx, Inc. Cross mixers for lipid nanoparticle production, and methods of operating the same
WO2023235380A1 (en) 2022-06-01 2023-12-07 Zikani Therapeutics, Inc. Macrolides for treating genetic diseases
WO2023250513A1 (en) 2022-06-24 2023-12-28 Zikani Therapeutics, Inc. 13-membered macrolide compounds for treating diseases mediated by abnormal protein translation
WO2024026475A1 (en) 2022-07-29 2024-02-01 Modernatx, Inc. Compositions for delivery to hematopoietic stem and progenitor cells (hspcs) and related uses
WO2024026482A1 (en) 2022-07-29 2024-02-01 Modernatx, Inc. Lipid nanoparticle compositions comprising surface lipid derivatives and related uses
WO2024026487A1 (en) 2022-07-29 2024-02-01 Modernatx, Inc. Lipid nanoparticle compositions comprising phospholipid derivatives and related uses
WO2024049994A1 (en) 2022-09-01 2024-03-07 Zikani Therapeutics, Inc. Treatment of familial adenomatous polyopsis using a 13-membered macrolide

Family Cites Families (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2704543A (en) * 1955-03-22 Hypo jet injector
US1742497A (en) * 1925-01-15 1930-01-07 Fairleigh S Dickinson Hypodermic syringe
US2025219A (en) * 1927-03-25 1935-12-24 Arthur E Smith Hypodermic syringe
US2101140A (en) * 1935-03-23 1937-12-07 Raymond W Hege Automatic injecting syringe device
US2322245A (en) * 1943-05-20 1943-06-22 Marshall L Lockhart Ypodermic injector and method of use thereof
US2380534A (en) * 1941-04-26 1945-07-31 Marshall L Lockhart Hypodermic injector
US2547009A (en) * 1944-10-17 1951-04-03 William D Huston Telemetering system
US2605763A (en) * 1948-01-31 1952-08-05 Becton Dickinson Co Injection device
US2680439A (en) * 1948-09-08 1954-06-08 Arnold K Sutermeister High-pressure injection device
US2688968A (en) * 1949-05-14 1954-09-14 Scherer Corp R P Hypo jet ampoule
US2737946A (en) * 1949-09-01 1956-03-13 Jr George N Hein Hypodermic injection apparatus
US2653602A (en) * 1950-06-17 1953-09-29 Becton Dickinson Co Injection device
US2754818A (en) * 1950-06-24 1956-07-17 Scherer Corp R P Hypo jet injector
US2764977A (en) * 1951-05-24 1956-10-02 Becton Dickinson Co Hypodermic injection mechanism
US2821193A (en) * 1952-07-22 1958-01-28 Geoffrey W Walker Multiple injection inoculator instrument
US2714887A (en) * 1954-04-26 1955-08-09 Scherer Corp R P Intradermal injector
US2816543A (en) * 1954-07-12 1957-12-17 Scherer Corp R P Hypodermic injector
US2821981A (en) * 1954-07-21 1958-02-04 Geoffrey W Walker Multi-shot inoculant injector instrument with adjustable ejection pressure control
US2902995A (en) * 1954-10-11 1959-09-08 Abbott Lab Hypodermic syringe and needle hub structure
US3110309A (en) * 1960-08-15 1963-11-12 Brunswick Corp Plastic cartridge needle assembly
NL268186A (en) * 1960-08-15
US3167071A (en) * 1961-07-17 1965-01-26 Scherer Corp R P Apparatus for administering intradermal injections
US3179107A (en) * 1962-11-21 1965-04-20 Becton Dickinson Co Hypodermic unit with an improved mounting for a replaceable needle assembly
BE643768A (en) * 1963-02-18
US3292621A (en) * 1963-07-19 1966-12-20 Oscar H Banker Jet type protable inoculator
US3292622A (en) * 1964-09-21 1966-12-20 Oscar H Banker Power operated inoculator
US3424154A (en) * 1965-11-08 1969-01-28 Charles W Kinsley Injection system
US3515130A (en) * 1966-09-21 1970-06-02 Yuryo Kikakuhin Kenkyusho Kk Jet-injection hypodermic device
US3490451A (en) * 1967-11-13 1970-01-20 Scherer Corp R P Hypodermic jet injector nozzle
US3561443A (en) * 1968-09-06 1971-02-09 Oscar H Banker Inoculator gun with delayed action
US3557784A (en) * 1968-12-24 1971-01-26 Walter A Shields Syringe
US3688765A (en) * 1969-10-03 1972-09-05 Jack S Gasaway Hypodermic injection device
US3695266A (en) * 1970-06-18 1972-10-03 Maurice G Lussier Needleless sequential dosing syringe
US3714943A (en) * 1970-12-01 1973-02-06 H Yanof Medicament injectors
US3855380A (en) * 1971-06-09 1974-12-17 Wheeling Stamping Co Method for manufacturing unitary, seamless, collapsible thermoplastic tubes
US3853125A (en) * 1971-10-05 1974-12-10 W Clark Disposable needleless injector
US3802430A (en) * 1972-06-30 1974-04-09 L Arnold Disposable pyrotechnically powered injector
US3945383A (en) * 1974-08-08 1976-03-23 Smithkline Corporation Unit dose ampul for jet injector
US3945379A (en) * 1974-08-08 1976-03-23 Smithkline Corporation Injection device
JPS51130094A (en) * 1975-05-08 1976-11-12 Asahi Chemical Ind Twoostage pressure injector
US4124024A (en) * 1977-03-03 1978-11-07 Schwebel Paul R Disposable hypodermic injection ampule
US4284459A (en) * 1978-07-03 1981-08-18 The Kendall Company Method for making a molded catheter
BR7806153A (en) * 1978-09-19 1980-04-01 Halen Elliot Brasil Ind Com Eq HYPODERMIC PRESSURE INJECTOR FOR INTERMITTENT VACCINATION
US4252159A (en) * 1979-04-02 1981-02-24 Maki Eugene B Dosage device
US4329988A (en) * 1980-12-23 1982-05-18 Survival Technology, Inc. Plural injection assembly
US4421508A (en) * 1981-02-24 1983-12-20 Cohen Edgar C Vacuum-compression injector
US4403989A (en) * 1981-09-14 1983-09-13 Syntex (U.S.A.) Inc. Injection device
US4516967A (en) * 1981-12-21 1985-05-14 Kopfer Rudolph J Wet-dry compartmental syringe
CA1178503A (en) * 1982-05-27 1984-11-27 Health-Mor Personal Care Corporation Needleless hypodermic injector
US4475905A (en) * 1982-09-30 1984-10-09 Himmelstrup Anders B Injection device
DE3372172D1 (en) * 1982-10-27 1987-07-30 Duphar Int Res Hypodermic syringe having a telescopic assembly between cartridge and medicament holder
US4507113A (en) * 1982-11-22 1985-03-26 Derata Corporation Hypodermic jet injector
HU186718B (en) * 1983-06-29 1985-09-30 Radelkis Electrokemiai Automatic needleless syringe operable by cardox cylinder suitable for personal giving injection e.g. insulin
US4581014A (en) * 1984-04-03 1986-04-08 Ivac Corporation Fluid infusion system
BR8404286A (en) * 1984-08-28 1986-04-08 Sergio Landau PRESSURE HYPODERMIC SYRINGE
US4759756A (en) * 1984-09-14 1988-07-26 Baxter Travenol Laboratories, Inc. Reconstitution device
US4596556A (en) * 1985-03-25 1986-06-24 Bioject, Inc. Hypodermic injection apparatus
US4680027A (en) * 1985-12-12 1987-07-14 Injet Medical Products, Inc. Needleless hypodermic injection device
EP0250022A3 (en) * 1986-06-17 1988-06-22 SICIM SpA Portable endermic injector
US4717384A (en) * 1987-01-15 1988-01-05 Pneu Dart Inc. Pneumatic hypodermic syringe pole
US4722728A (en) * 1987-01-23 1988-02-02 Patents Unlimited, Ltd. Needleless hypodermic injector
US4886495A (en) * 1987-07-08 1989-12-12 Duoject Medical Systems Inc. Vial-based prefilled syringe system for one or two component medicaments
JPH0622637B2 (en) * 1987-05-26 1994-03-30 アカリス，クロード Needleless liquid injection device especially for dental treatment
US5080648A (en) * 1987-06-08 1992-01-14 Antonio Nicholas F D Hypodermic fluid dispenser
US5569190A (en) * 1987-06-08 1996-10-29 D'antonio; Nicholas F. Hypodermic fluid dispenser
US4790824A (en) * 1987-06-19 1988-12-13 Bioject, Inc. Non-invasive hypodermic injection device
US4940460A (en) * 1987-06-19 1990-07-10 Bioject, Inc. Patient-fillable and non-invasive hypodermic injection device assembly
US4941880A (en) * 1987-06-19 1990-07-17 Bioject, Inc. Pre-filled ampule and non-invasive hypodermic injection device assembly
CA1310870C (en) * 1987-11-16 1992-12-01 Medhi-Tek International Limited Apparatus for hypodermic injection of liquids
US5073165A (en) * 1988-02-05 1991-12-17 Marpam International, Inc. Hypodermic jet injector and cartridge therefor
US4874367A (en) * 1988-02-05 1989-10-17 Marpam International, Inc. Hypodermic jet injector and cartridge therefor
FR2627698A1 (en) * 1988-02-26 1989-09-01 Vci Corp Medicament cartridge for vacuum compression injector
US4913699A (en) * 1988-03-14 1990-04-03 Parsons James S Disposable needleless injection system
BR8801952A (en) * 1988-04-22 1989-11-14 Sergio Landau DISPOSABLE CAPSULE, NOT RE-USABLE, CONTAINING INDIVIDUAL DOSE OF VACCINE TO BE HYPODERMICALLY INJECTED, WITHOUT NEEDLE, WITH PRESSURE INJECTOR
US5024656A (en) * 1988-08-30 1991-06-18 Injet Medical Products, Inc. Gas-pressure-regulated needleless injection system
US4944726A (en) * 1988-11-03 1990-07-31 Applied Vascular Devices Device for power injection of fluids
FR2648352A1 (en) * 1989-06-16 1990-12-21 Merieux Inst IMPROVEMENT IN DOSAGE-FREE NEEDLE INJECTION DEVICES CONTAINED IN CARTRIDGES AND CARTRIDGES FOR USE IN SUCH AN APPARATUS
US4944736A (en) * 1989-07-05 1990-07-31 Holtz Leonard J Adaptor cap for centering, sealing, and holding a syringe to a bottle
CA1325149C (en) * 1989-08-31 1993-12-14 Gavin Mcgregor Variable intensity remote controlled needleless injector
US4997430A (en) * 1989-09-06 1991-03-05 Npbi Nederlands Produktielaboratorium Voor Bloedtransfusieapparatuur En Infusievloeistoffen B.V. Method of and apparatus for administering medicament to a patient
US5312335A (en) * 1989-11-09 1994-05-17 Bioject Inc. Needleless hypodermic injection device
US5064413A (en) * 1989-11-09 1991-11-12 Bioject, Inc. Needleless hypodermic injection device
US5078690A (en) * 1990-01-11 1992-01-07 Accumed Systems, Incorporated High pressure syringe
US5062830A (en) * 1990-04-04 1991-11-05 Derata Corporation Dry disposable nozzle assembly for medical jet injector
GB9118204D0 (en) * 1991-08-23 1991-10-09 Weston Terence E Needle-less injector
US5312577A (en) * 1992-05-08 1994-05-17 Bioject Inc. Method for manufacturing an ampule
US5383851A (en) * 1992-07-24 1995-01-24 Bioject Inc. Needleless hypodermic injection device
US5472022A (en) * 1993-11-02 1995-12-05 Genentech, Inc. Injection pen solution transfer apparatus and method
US5505697A (en) * 1994-01-14 1996-04-09 Mckinnon, Jr.; Charles N. Electrically powered jet injector
US5466220A (en) * 1994-03-08 1995-11-14 Bioject, Inc. Drug vial mixing and transfer device

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8403888B2 (en) 2010-04-15 2013-03-26 Teneo Innovations Inc. Device and electronic controller for syringe piston control

Also Published As

Publication number Publication date
EP1011763B1 (en) 2003-12-10
WO1998052632A1 (en) 1998-11-26
AU7254998A (en) 1998-12-11
DE69820460T2 (en) 2004-10-07
CA2290777C (en) 2006-07-11
EP1011763A1 (en) 2000-06-28
GB9927246D0 (en) 2000-01-12
EP1011763A4 (en) 2001-03-21
DE69820460D1 (en) 2004-01-22
US5993412A (en) 1999-11-30

Similar Documents

Publication Publication Date Title
CA2290777A1 (en) Injection apparatus
WO2001037905A3 (en) Injectors, injector systems, syringes and methods of connecting a syringe to an injector
CA2354769C (en) Syringe pumps
EP1875935A3 (en) Automatic injection device
CA2328163A1 (en) Pressure/force computer controlled drug delivery system and the like
CA2382422A1 (en) Intradermal injection system for injecting dna-based injectables into humans
CA2125179A1 (en) Medicament injectors and methods
AU3335697A (en) Automatic needle insertion mechanism
WO1998020920A3 (en) Prefillable syringes, plungers and injectors for use therewith
MXPA03005591A (en) Pen-type injector having an electronic control unit.
CA2209534A1 (en) Prefilled syringe for medical use
ATE181676T1 (en) FRONT-LOADING MEDICAL INJECTOR AND SYRINGE USED WITH IT
IL148609A0 (en) Dose setting limiter
ZA947608B (en) Injection cartridges
WO1999021481A3 (en) Angiographic injector system with automatic high/low pressure switching
GB0302393D0 (en) Medical needle assemblies
CA2106363A1 (en) Device for monitoring and controlling an intravenous infusion system
IL110558A0 (en) Reloadable injector
EP2514458A3 (en) Hypodermic injection system
WO2000069488A3 (en) Self-injection device and method for its operation
CA2163005A1 (en) Reloadable Automatic or Manual Emergency Injection System
CA2167787A1 (en) Non-reusable syringe
AU4860497A (en) Device for introducing a needle
MX9709307A (en) Injection dart system.
CN215079343U (en) Novel ligation anastomat capable of automatically tightening and cutting elastic thread

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed