CA2285056A1 - Method for introducing pharmaceutical drugs and nucleic acids into skeletal muscle - Google Patents

Method for introducing pharmaceutical drugs and nucleic acids into skeletal muscle Download PDF

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Publication number
CA2285056A1
CA2285056A1 CA002285056A CA2285056A CA2285056A1 CA 2285056 A1 CA2285056 A1 CA 2285056A1 CA 002285056 A CA002285056 A CA 002285056A CA 2285056 A CA2285056 A CA 2285056A CA 2285056 A1 CA2285056 A1 CA 2285056A1
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CA
Canada
Prior art keywords
muscle
nucleic acids
skeletal muscle
pharmaceutical drugs
drug
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002285056A
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French (fr)
Other versions
CA2285056C (en
Inventor
Iacob Mathiesen
Terje Lomo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Inovio AS
Original Assignee
Iacob Mathiesen
Terje Lomo
Electrofect As
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Publication date
Application filed by Iacob Mathiesen, Terje Lomo, Electrofect As filed Critical Iacob Mathiesen
Publication of CA2285056A1 publication Critical patent/CA2285056A1/en
Application granted granted Critical
Publication of CA2285056C publication Critical patent/CA2285056C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/205—Applying electric currents by contact electrodes continuous direct currents for promoting a biological process
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36017—External stimulators, e.g. with patch electrodes with leads or electrodes penetrating the skin

Abstract

A method is disclosed for delivering molecules such as pharmaceutical drugs and nucleic acids into skeletal muscle in vivo. The pharmaceutical drug or nucleic acid is first injected into the muscle at one or multiple sites. Immediately, or shortly after injection, electrodes are placed flanking the injection site and a specific amount of electrical current is passed through the muscle. The electrical current makes the muscle permeable, thus allowing the pharmaceutical drug or nucleic acid to enter the cell. The efficiency of transfer permits robust immune responses using DNA vaccines and produces sufficient secreted proteins for systemic biological activity to be observed.
The use of a drug for manufacturing a medicament to be used in the delivery method as well as a device for performing the method and the use of such a device is also disclosed.
CA002285056A 1997-04-03 1998-04-03 Method for introducing pharmaceutical drugs and nucleic acids into skeletal muscle Expired - Lifetime CA2285056C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4259497P 1997-04-03 1997-04-03
US60/042,594 1997-04-03
PCT/IB1998/000487 WO1998043702A2 (en) 1997-04-03 1998-04-03 Method for introducing pharmaceutical drugs and nucleic acids into skeletal muscle

Publications (2)

Publication Number Publication Date
CA2285056A1 true CA2285056A1 (en) 1998-10-08
CA2285056C CA2285056C (en) 2004-12-14

Family

ID=21922760

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002285056A Expired - Lifetime CA2285056C (en) 1997-04-03 1998-04-03 Method for introducing pharmaceutical drugs and nucleic acids into skeletal muscle

Country Status (16)

Country Link
US (1) US6110161A (en)
EP (1) EP1023107B1 (en)
JP (2) JP2001520537A (en)
KR (1) KR100427786B1 (en)
CN (1) CN1198665C (en)
AT (1) ATE337794T1 (en)
AU (1) AU733628B2 (en)
CA (1) CA2285056C (en)
DE (1) DE69835761T2 (en)
DK (1) DK1023107T3 (en)
EA (1) EA002087B1 (en)
ES (1) ES2273408T3 (en)
IL (1) IL132103A0 (en)
NO (1) NO327806B1 (en)
NZ (1) NZ337853A (en)
WO (1) WO1998043702A2 (en)

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DE69835761T2 (en) 2007-09-13
KR20010005932A (en) 2001-01-15
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KR100427786B1 (en) 2004-04-30

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