CA2284929A1 - Implantable delivery device with self adjustable exit port - Google Patents
Implantable delivery device with self adjustable exit port Download PDFInfo
- Publication number
- CA2284929A1 CA2284929A1 CA002284929A CA2284929A CA2284929A1 CA 2284929 A1 CA2284929 A1 CA 2284929A1 CA 002284929 A CA002284929 A CA 002284929A CA 2284929 A CA2284929 A CA 2284929A CA 2284929 A1 CA2284929 A1 CA 2284929A1
- Authority
- CA
- Canada
- Prior art keywords
- slit
- beneficial agent
- chamber
- flow
- delivery device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
Abstract
A delivery device having a first chamber containing an osmotic agent, 'a membrane forming a wall of the first chamber through which fluid is imbibed by osmosis, a second chamber containing a beneficial agent to be delivered, and a moveable piston separating the two chambers. In fluid communiation with the second chamber is an orifice which comprises a slit valve. In the presence of pressure, the beneficial agent pushes through the slit, opening up a channel for delivery of the beneficial agent and creating flow. Because the slit remains closed in the absence of flow (or when the pressure is below the pressure required to open the slit), back diffusion of external fluids is eliminated when the slit is closed, which prevents contamination of the beneficial agent in the second chamber by external fluids. In addition, forward diffusion of the beneficial agent out of the capsule is prevented when the slit is closed. The slit valve opens only to the minimum dimension required to allow the flow generated by the osmostic pumping rate. The slit valve also allows a flow path to open around any obstruction in the slit valve to prevent clogging.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002561784A CA2561784C (en) | 1997-03-24 | 1998-03-10 | Implantable delivery device with self adjustable exit port |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3560797P | 1997-03-24 | 1997-03-24 | |
US60/035,607 | 1997-03-24 | ||
PCT/US1998/004637 WO1998042317A2 (en) | 1997-03-24 | 1998-03-10 | Implantable delivery device with self adjustable exit port |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002561784A Division CA2561784C (en) | 1997-03-24 | 1998-03-10 | Implantable delivery device with self adjustable exit port |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2284929A1 true CA2284929A1 (en) | 1998-10-01 |
CA2284929C CA2284929C (en) | 2006-12-19 |
Family
ID=21883714
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002284929A Expired - Fee Related CA2284929C (en) | 1997-03-24 | 1998-03-10 | Implantable delivery device with self adjustable exit port |
Country Status (20)
Country | Link |
---|---|
US (2) | US5997527A (en) |
EP (1) | EP0969820B1 (en) |
JP (1) | JP2002513414A (en) |
KR (1) | KR100572188B1 (en) |
CN (2) | CN1290590C (en) |
AR (1) | AR010407A1 (en) |
AT (2) | ATE284679T1 (en) |
AU (1) | AU738417B2 (en) |
CA (1) | CA2284929C (en) |
CO (1) | CO5021220A1 (en) |
DE (2) | DE69837894T2 (en) |
ES (1) | ES2232940T3 (en) |
HK (2) | HK1025049A1 (en) |
IL (1) | IL132041A0 (en) |
MY (1) | MY123359A (en) |
NZ (1) | NZ338024A (en) |
PT (1) | PT969820E (en) |
TW (1) | TW369419B (en) |
WO (1) | WO1998042317A2 (en) |
ZA (1) | ZA981610B (en) |
Families Citing this family (87)
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ATE234603T1 (en) | 1998-12-31 | 2003-04-15 | Alza Corp | OSMOTIC ADMINISTRATION SYSTEM WITH SPACE-SAVING PISTONS |
US7919109B2 (en) | 1999-02-08 | 2011-04-05 | Intarcia Therapeutics, Inc. | Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles |
US7258869B1 (en) * | 1999-02-08 | 2007-08-21 | Alza Corporation | Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle |
WO2001045675A2 (en) * | 1999-12-21 | 2001-06-28 | Alza Corporation | Valve for osmotic devices |
DE60022394T2 (en) * | 1999-12-27 | 2006-06-29 | Alza Corp., Mountain View | OSMOTIC SYSTEM FOR ACTIVE AGGREGATION |
US6464688B1 (en) | 2000-02-15 | 2002-10-15 | Microsolutions, Inc. | Osmotic pump delivery system with flexible drug compartment |
US6454759B2 (en) * | 2000-02-28 | 2002-09-24 | The Regents Of The University Of California | Microfabricated injectable drug delivery system |
US6375972B1 (en) * | 2000-04-26 | 2002-04-23 | Control Delivery Systems, Inc. | Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof |
US6796972B1 (en) | 2000-07-14 | 2004-09-28 | Edwards Lifesciences Llc | Catheter anchoring balloon structure with irrigation |
US6464662B1 (en) | 2000-07-26 | 2002-10-15 | Image-Guided Neurologics, Inc. | Drug delivery and catheter systems, apparatus and processes |
US6561479B1 (en) * | 2000-08-23 | 2003-05-13 | Micron Technology, Inc. | Small scale actuators and methods for their formation and use |
US6605055B1 (en) | 2000-09-13 | 2003-08-12 | Cardiofocus, Inc. | Balloon catheter with irrigation sheath |
AU2007202144B2 (en) * | 2000-11-29 | 2009-04-23 | Durect Corporation | Devices and methods for controlled delivery from a drug delivery device |
CA2429945A1 (en) * | 2000-11-29 | 2002-06-06 | Durect Corporation | Devices and methods for controlled delivery from a drug delivery device |
WO2002056863A2 (en) * | 2000-12-29 | 2002-07-25 | Bausch & Lomb Incorporated | Sustained release drug delivery devices |
CA2433032C (en) * | 2001-01-03 | 2008-11-25 | Bausch & Lomb Incorporated | Sustained release drug delivery devices with coated drug cores |
EP1347741B1 (en) | 2001-01-03 | 2009-01-21 | Bausch & Lomb Incorporated | Sustained release drug delivery devices with multiple agents |
US6805207B2 (en) * | 2001-01-23 | 2004-10-19 | Black & Decker Inc. | Housing with functional overmold |
US6632217B2 (en) | 2001-04-19 | 2003-10-14 | Microsolutions, Inc. | Implantable osmotic pump |
GB2374905B (en) * | 2001-04-27 | 2004-09-15 | Reckitt Benckiser Uk Ltd | Aerosol delivery system |
US7163688B2 (en) * | 2001-06-22 | 2007-01-16 | Alza Corporation | Osmotic implant with membrane and membrane retention means |
AU2002327596A1 (en) * | 2001-09-17 | 2003-04-01 | Durect Corporation | Device and method for accurate delivery of an active agent |
US8871241B2 (en) | 2002-05-07 | 2014-10-28 | Psivida Us, Inc. | Injectable sustained release delivery devices |
JP2005533782A (en) * | 2002-06-17 | 2005-11-10 | アルザ コーポレイション | An osmotic delivery system having an engine with fast extruding force and zero order including an osmotic agent dispersed in a fluid vehicle |
ES2295642T3 (en) * | 2002-06-26 | 2008-04-16 | Intarcia Therapeutics, Inc. | EFFICIENT VOLUME PISTON OF MINIMUM OCCUPATION FOR MEDICINAL ADMINISTRATION SYSTEMS. |
US20060009739A1 (en) * | 2002-09-06 | 2006-01-12 | Durect Corporation | Implantable flow regulator with failsafe mode and reserve drug supply |
US7014636B2 (en) * | 2002-11-21 | 2006-03-21 | Alza Corporation | Osmotic delivery device having a two-way valve and a dynamically self-adjusting flow channel |
US7731947B2 (en) * | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
KR20050088196A (en) * | 2002-12-19 | 2005-09-02 | 알자 코포레이션 | Stable, non-aqueous, single-phase gels and formulations thereof for delivery from an implantable device |
CN1767815A (en) | 2003-03-31 | 2006-05-03 | 阿尔萨公司 | Non-aqueous single phase vehicles and formulations utilizing such vehicles |
KR20060017749A (en) * | 2003-03-31 | 2006-02-27 | 알자 코포레이션 | Osmotic pump with means for dissipating internal pressure |
CA2520766A1 (en) * | 2003-03-31 | 2004-10-21 | Alza Corporation | Osmotic delivery system and method for decreasing start-up times for osmotic delivery systems |
US7108762B2 (en) | 2003-06-12 | 2006-09-19 | Cordis Corporation | Method for manufacturing an orifice mechanism capable of low fluid flow rates |
US8109922B2 (en) | 2003-06-12 | 2012-02-07 | Cordis Corporation | Orifice device having multiple channels and multiple layers for drug delivery |
US7211076B2 (en) | 2003-06-12 | 2007-05-01 | Cordis Corporation | Medical device for fluid delivery having low fluid flow rate |
US6976983B2 (en) | 2003-06-12 | 2005-12-20 | Cordis Corporation | Implantable device for delivering drugs using orifice mechanism capable of low fluid flow rates |
US8491571B2 (en) | 2003-06-12 | 2013-07-23 | Cordis Corporation | Orifice device having multiple channels with varying flow rates for drug delivery |
US7678103B2 (en) | 2003-06-12 | 2010-03-16 | Cordis Corporation | Orifice device for delivering drugs at low fluid flow rates |
EP1682099A2 (en) | 2003-09-30 | 2006-07-26 | ALZA Corporation | Osmotically driven active agent delivery device providing an ascending release profile |
CN1874763A (en) * | 2003-11-06 | 2006-12-06 | 阿尔扎公司 | Modular imbibition rate reducer for use with implantable osmotic pump |
US20050175701A1 (en) * | 2004-02-10 | 2005-08-11 | Alza Corporation | Capillary moderator for osmotic delivery system |
US20050266087A1 (en) * | 2004-05-25 | 2005-12-01 | Gunjan Junnarkar | Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium |
US7731715B2 (en) | 2004-12-10 | 2010-06-08 | Edwards Lifesciences Corporation | Ablative treatment of atrial fibrillation via the coronary sinus |
WO2006083761A2 (en) | 2005-02-03 | 2006-08-10 | Alza Corporation | Solvent/polymer solutions as suspension vehicles |
EP2361630A1 (en) * | 2005-02-03 | 2011-08-31 | Intarcia Therapeutics, Inc | Implantable drug delivery device comprising particles and an osmotic pump |
US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
US7959938B2 (en) | 2005-03-15 | 2011-06-14 | Intarcia Therapeutics, Inc. | Polyoxaester suspending vehicles for use with implantable delivery systems |
US20070027105A1 (en) * | 2005-07-26 | 2007-02-01 | Alza Corporation | Peroxide removal from drug delivery vehicle |
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JP5143131B2 (en) | 2006-05-30 | 2013-02-13 | インターシア セラピューティクス,インコーポレイティド | Two-piece internal channel flow modulator for osmotic delivery system |
PL2359808T3 (en) * | 2006-08-09 | 2013-10-31 | Intarcia Therapeutics Inc | Osmotic delivery systems and piston assemblies |
US8617143B2 (en) * | 2006-12-07 | 2013-12-31 | The Regents Of The University Of California | Therapeutic agent delivery systems and devices |
MX2009011123A (en) | 2007-04-23 | 2009-11-02 | Intarcia Therapeutics Inc | Suspension formulations of insulinotropic peptides and uses thereof. |
EP2240155B1 (en) | 2008-02-13 | 2012-06-06 | Intarcia Therapeutics, Inc | Devices, formulations, and methods for delivery of multiple beneficial agents |
US20090259112A1 (en) * | 2008-04-09 | 2009-10-15 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Sensors |
US20090259217A1 (en) * | 2008-04-09 | 2009-10-15 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Methods and systems associated with delivery of one or more agents to an individual |
US8028743B2 (en) * | 2008-04-17 | 2011-10-04 | Hewlett-Packard Development Company, L.P. | Passive cooling in response to ambient environmental properties |
EP2349222B1 (en) * | 2008-09-10 | 2016-08-24 | Sandoz AG | Capsule with soluble blocking element |
CN106880596A (en) * | 2008-10-15 | 2017-06-23 | 精达制药公司 | Highly enriched drug particles, preparation, supensoid agent and its application |
NZ598686A (en) | 2009-09-28 | 2014-05-30 | Intarcia Therapeutics Inc | Rapid establishment and/or termination of substantial steady-state drug delivery |
US8038650B2 (en) * | 2010-02-22 | 2011-10-18 | Microsert Ltd. | Slow release liquid drug delivery device |
US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
US8986337B2 (en) | 2012-02-24 | 2015-03-24 | Elwha Llc | Devices, systems, and methods to control stomach volume |
CN104001261A (en) * | 2013-02-27 | 2014-08-27 | 重庆市北碚区精神卫生中心 | Subcutaneous drug administration device |
EP2964310A1 (en) | 2013-03-05 | 2016-01-13 | TARIS Biomedical LLC | Drug delivery devices and methods for controlled drug release through device orifice |
SG11201507134YA (en) * | 2013-03-15 | 2015-10-29 | Taris Biomedical Llc | Drug delivery devices and methods for drug delivery |
US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
AU2016270984B2 (en) | 2015-06-03 | 2021-02-25 | Intarcia Therapeutics, Inc. | Implant placement and removal systems |
PL3370705T3 (en) | 2015-11-05 | 2022-08-01 | The General Hospital Corporation | Intrathecal delivery of nucleic acid sequences encoding abcd1 for treatment of adrenomyeloneuropathy |
CN109310743A (en) | 2016-05-16 | 2019-02-05 | 因塔西亚制药公司 | Glucagon receptor selectivity polypeptide and its application method |
USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
US10406336B2 (en) | 2016-08-03 | 2019-09-10 | Neil S. Davey | Adjustable rate drug delivery implantable device |
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EP3565580B1 (en) | 2017-01-03 | 2024-03-06 | i2o Therapeutics, Inc. | Continuous administration of exenatide and co-adminstration of acetaminophen, ethinylestradiol or levonorgestrel |
RS62459B1 (en) * | 2017-02-01 | 2021-11-30 | Taris Biomedical Llc | In vivo drug delivery devices |
US20200188479A1 (en) | 2017-03-08 | 2020-06-18 | Intarcia Therapeutics, Inc. | Apparatus and methods for administration of a nauseogenic compound from a drug delivery device |
EP3630073A4 (en) * | 2017-05-29 | 2021-09-15 | Bionaut Labs Ltd. | Ultrasound resonance triggering of payload release from miniaturized devices |
CN108339189A (en) * | 2018-02-08 | 2018-07-31 | 孙玉荣 | A kind of oral administration therapeutic device |
USD933219S1 (en) | 2018-07-13 | 2021-10-12 | Intarcia Therapeutics, Inc. | Implant removal tool and assembly |
AU2019357621A1 (en) | 2018-10-11 | 2021-05-27 | Intarcia Therapeutics, Inc. | Human amylin analog polypeptides and methods of use |
WO2020089016A1 (en) * | 2018-10-30 | 2020-05-07 | F. Hoffmann-La Roche Ag | Implantation needle and kit |
CN110613872A (en) * | 2019-10-31 | 2019-12-27 | 厦门大学嘉庚学院 | Remaining needle auxiliary device for preventing blood coagulation and working method thereof |
KR20220140711A (en) | 2020-01-13 | 2022-10-18 | 듀렉트 코퍼레이션 | Reduced Impurity Sustained Release Drug Delivery Systems and Related Methods |
CN112370645A (en) * | 2020-11-25 | 2021-02-19 | 珠海市人民医院 | Medicine applying bottle for skin and using method |
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Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3732865A (en) * | 1971-01-13 | 1973-05-15 | Alza Corp | Osmotic dispenser |
US3987790A (en) * | 1975-10-01 | 1976-10-26 | Alza Corporation | Osmotically driven fluid dispenser |
GB2048710B (en) * | 1979-05-07 | 1983-03-09 | Alza Corp | Osmotically driven fluid dispenser |
US4455143A (en) * | 1982-03-22 | 1984-06-19 | Alza Corporation | Osmotic device for dispensing two different medications |
US4781714A (en) * | 1983-11-02 | 1988-11-01 | Alza Corporation | Dispenser for delivering thermo-responsive composition |
US5034229A (en) * | 1988-12-13 | 1991-07-23 | Alza Corporation | Dispenser for increasing feed conversion of hog |
NZ250183A (en) * | 1990-01-24 | 1995-09-26 | Alza Corp | Process of prehydrating a dispenser so that it provides substantially instantaneous release of beneficial agent, typically within stomach of animal |
US5122128A (en) * | 1990-03-15 | 1992-06-16 | Alza Corporation | Orifice insert for a ruminal bolus |
US5861166A (en) * | 1991-03-12 | 1999-01-19 | Alza Corporation | Delivery device providing beneficial agent stability |
MX9205850A (en) * | 1991-10-10 | 1993-06-01 | Alza Corp | PHARMACEUTICAL OSMOTIC ASSORTMENT DEVICES WITH HYDROPHOBIC WALL MATERIALS |
US5456679A (en) * | 1992-02-18 | 1995-10-10 | Alza Corporation | Delivery devices with pulsatile effect |
US5308348A (en) * | 1992-02-18 | 1994-05-03 | Alza Corporation | Delivery devices with pulsatile effect |
US5221278A (en) * | 1992-03-12 | 1993-06-22 | Alza Corporation | Osmotically driven delivery device with expandable orifice for pulsatile delivery effect |
US5639477A (en) * | 1993-06-23 | 1997-06-17 | Alza Corporation | Ruminal drug delivery device |
CZ293808B6 (en) * | 1996-02-02 | 2004-08-18 | Alzaácorporation | Implantable device for delivering leuprolide to a fluid environment of use |
-
1998
- 1998-02-26 ZA ZA9801610A patent/ZA981610B/en unknown
- 1998-03-10 IL IL13204198A patent/IL132041A0/en not_active IP Right Cessation
- 1998-03-10 CA CA002284929A patent/CA2284929C/en not_active Expired - Fee Related
- 1998-03-10 JP JP54573998A patent/JP2002513414A/en not_active Ceased
- 1998-03-10 DE DE69837894T patent/DE69837894T2/en not_active Expired - Lifetime
- 1998-03-10 ES ES98911539T patent/ES2232940T3/en not_active Expired - Lifetime
- 1998-03-10 CN CNB2004100013402A patent/CN1290590C/en not_active Expired - Fee Related
- 1998-03-10 PT PT98911539T patent/PT969820E/en unknown
- 1998-03-10 DE DE69828157T patent/DE69828157T2/en not_active Expired - Lifetime
- 1998-03-10 EP EP98911539A patent/EP0969820B1/en not_active Expired - Lifetime
- 1998-03-10 AT AT98911539T patent/ATE284679T1/en not_active IP Right Cessation
- 1998-03-10 CN CNB988036940A patent/CN1139411C/en not_active Expired - Fee Related
- 1998-03-10 WO PCT/US1998/004637 patent/WO1998042317A2/en active IP Right Grant
- 1998-03-10 NZ NZ338024A patent/NZ338024A/en unknown
- 1998-03-10 KR KR1019997008725A patent/KR100572188B1/en not_active IP Right Cessation
- 1998-03-10 AU AU65472/98A patent/AU738417B2/en not_active Ceased
- 1998-03-10 AT AT03075936T patent/ATE363897T1/en not_active IP Right Cessation
- 1998-03-16 AR ARP980101171A patent/AR010407A1/en unknown
- 1998-03-18 MY MYPI98001172A patent/MY123359A/en unknown
- 1998-03-23 US US09/045,944 patent/US5997527A/en not_active Expired - Lifetime
- 1998-03-24 CO CO98016383A patent/CO5021220A1/en unknown
- 1998-06-12 TW TW087104427A patent/TW369419B/en not_active IP Right Cessation
-
1999
- 1999-09-17 US US09/397,507 patent/US6217906B1/en not_active Expired - Lifetime
-
2000
- 2000-07-10 HK HK00104216A patent/HK1025049A1/en not_active IP Right Cessation
-
2004
- 2004-12-16 HK HK04109990A patent/HK1067077A1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR20010005657A (en) | 2001-01-15 |
KR100572188B1 (en) | 2006-04-18 |
HK1067077A1 (en) | 2005-04-01 |
AU738417B2 (en) | 2001-09-20 |
DE69828157T2 (en) | 2005-12-22 |
CN1251036A (en) | 2000-04-19 |
CA2284929C (en) | 2006-12-19 |
US5997527A (en) | 1999-12-07 |
CN1504242A (en) | 2004-06-16 |
TW369419B (en) | 1999-09-11 |
DE69828157D1 (en) | 2005-01-20 |
US6217906B1 (en) | 2001-04-17 |
ES2232940T3 (en) | 2005-06-01 |
DE69837894T2 (en) | 2008-01-31 |
HK1025049A1 (en) | 2000-11-03 |
CO5021220A1 (en) | 2001-03-27 |
EP0969820A2 (en) | 2000-01-12 |
WO1998042317A2 (en) | 1998-10-01 |
AU6547298A (en) | 1998-10-20 |
CN1290590C (en) | 2006-12-20 |
PT969820E (en) | 2005-02-28 |
NZ338024A (en) | 2001-06-29 |
MY123359A (en) | 2006-05-31 |
ATE363897T1 (en) | 2007-06-15 |
EP0969820B1 (en) | 2004-12-15 |
ATE284679T1 (en) | 2005-01-15 |
JP2002513414A (en) | 2002-05-08 |
ZA981610B (en) | 1999-08-26 |
IL132041A0 (en) | 2001-03-19 |
CN1139411C (en) | 2004-02-25 |
WO1998042317A3 (en) | 1998-12-30 |
AR010407A1 (en) | 2000-06-07 |
DE69837894D1 (en) | 2007-07-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |