CA2284929A1 - Implantable delivery device with self adjustable exit port - Google Patents

Implantable delivery device with self adjustable exit port Download PDF

Info

Publication number
CA2284929A1
CA2284929A1 CA002284929A CA2284929A CA2284929A1 CA 2284929 A1 CA2284929 A1 CA 2284929A1 CA 002284929 A CA002284929 A CA 002284929A CA 2284929 A CA2284929 A CA 2284929A CA 2284929 A1 CA2284929 A1 CA 2284929A1
Authority
CA
Canada
Prior art keywords
slit
beneficial agent
chamber
flow
delivery device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002284929A
Other languages
French (fr)
Other versions
CA2284929C (en
Inventor
James E. Brown
Keith E. Dionne
Juan C. Gumucio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Intarcia Therapeutics Inc
Original Assignee
Alza Corporation
James E. Brown
Keith E. Dionne
Juan C. Gumucio
Intarcia Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corporation, James E. Brown, Keith E. Dionne, Juan C. Gumucio, Intarcia Therapeutics, Inc. filed Critical Alza Corporation
Priority to CA002561784A priority Critical patent/CA2561784C/en
Publication of CA2284929A1 publication Critical patent/CA2284929A1/en
Application granted granted Critical
Publication of CA2284929C publication Critical patent/CA2284929C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas

Abstract

A delivery device having a first chamber containing an osmotic agent, 'a membrane forming a wall of the first chamber through which fluid is imbibed by osmosis, a second chamber containing a beneficial agent to be delivered, and a moveable piston separating the two chambers. In fluid communiation with the second chamber is an orifice which comprises a slit valve. In the presence of pressure, the beneficial agent pushes through the slit, opening up a channel for delivery of the beneficial agent and creating flow. Because the slit remains closed in the absence of flow (or when the pressure is below the pressure required to open the slit), back diffusion of external fluids is eliminated when the slit is closed, which prevents contamination of the beneficial agent in the second chamber by external fluids. In addition, forward diffusion of the beneficial agent out of the capsule is prevented when the slit is closed. The slit valve opens only to the minimum dimension required to allow the flow generated by the osmostic pumping rate. The slit valve also allows a flow path to open around any obstruction in the slit valve to prevent clogging.
CA002284929A 1997-03-24 1998-03-10 Implantable delivery device with self adjustable exit port Expired - Fee Related CA2284929C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002561784A CA2561784C (en) 1997-03-24 1998-03-10 Implantable delivery device with self adjustable exit port

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3560797P 1997-03-24 1997-03-24
US60/035,607 1997-03-24
PCT/US1998/004637 WO1998042317A2 (en) 1997-03-24 1998-03-10 Implantable delivery device with self adjustable exit port

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA002561784A Division CA2561784C (en) 1997-03-24 1998-03-10 Implantable delivery device with self adjustable exit port

Publications (2)

Publication Number Publication Date
CA2284929A1 true CA2284929A1 (en) 1998-10-01
CA2284929C CA2284929C (en) 2006-12-19

Family

ID=21883714

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002284929A Expired - Fee Related CA2284929C (en) 1997-03-24 1998-03-10 Implantable delivery device with self adjustable exit port

Country Status (20)

Country Link
US (2) US5997527A (en)
EP (1) EP0969820B1 (en)
JP (1) JP2002513414A (en)
KR (1) KR100572188B1 (en)
CN (2) CN1290590C (en)
AR (1) AR010407A1 (en)
AT (2) ATE284679T1 (en)
AU (1) AU738417B2 (en)
CA (1) CA2284929C (en)
CO (1) CO5021220A1 (en)
DE (2) DE69828157T2 (en)
ES (1) ES2232940T3 (en)
HK (2) HK1025049A1 (en)
IL (1) IL132041A0 (en)
MY (1) MY123359A (en)
NZ (1) NZ338024A (en)
PT (1) PT969820E (en)
TW (1) TW369419B (en)
WO (1) WO1998042317A2 (en)
ZA (1) ZA981610B (en)

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Also Published As

Publication number Publication date
EP0969820B1 (en) 2004-12-15
AU6547298A (en) 1998-10-20
WO1998042317A3 (en) 1998-12-30
ZA981610B (en) 1999-08-26
IL132041A0 (en) 2001-03-19
MY123359A (en) 2006-05-31
CN1504242A (en) 2004-06-16
JP2002513414A (en) 2002-05-08
ATE363897T1 (en) 2007-06-15
US5997527A (en) 1999-12-07
CN1251036A (en) 2000-04-19
WO1998042317A2 (en) 1998-10-01
DE69837894T2 (en) 2008-01-31
CN1139411C (en) 2004-02-25
HK1025049A1 (en) 2000-11-03
AR010407A1 (en) 2000-06-07
HK1067077A1 (en) 2005-04-01
PT969820E (en) 2005-02-28
DE69828157D1 (en) 2005-01-20
DE69828157T2 (en) 2005-12-22
TW369419B (en) 1999-09-11
EP0969820A2 (en) 2000-01-12
NZ338024A (en) 2001-06-29
KR20010005657A (en) 2001-01-15
KR100572188B1 (en) 2006-04-18
ES2232940T3 (en) 2005-06-01
CA2284929C (en) 2006-12-19
US6217906B1 (en) 2001-04-17
CN1290590C (en) 2006-12-20
AU738417B2 (en) 2001-09-20
CO5021220A1 (en) 2001-03-27
ATE284679T1 (en) 2005-01-15
DE69837894D1 (en) 2007-07-19

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