CA2278782A1 - Methods for the diagnosis, prognosis and treatment of glaucoma and related disorders - Google Patents

Methods for the diagnosis, prognosis and treatment of glaucoma and related disorders Download PDF

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Publication number
CA2278782A1
CA2278782A1 CA002278782A CA2278782A CA2278782A1 CA 2278782 A1 CA2278782 A1 CA 2278782A1 CA 002278782 A CA002278782 A CA 002278782A CA 2278782 A CA2278782 A CA 2278782A CA 2278782 A1 CA2278782 A1 CA 2278782A1
Authority
CA
Canada
Prior art keywords
glaucoma
prognosis
diagnosis
treatment
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002278782A
Other languages
French (fr)
Other versions
CA2278782C (en
Inventor
Thai D. Nguyen
Jon R. Polansky
Pu Chen
Hua Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
The Regents Of The University Of California
Thai D. Nguyen
Jon R. Polansky
Pu Chen
Hua Chen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Regents Of The University Of California, Thai D. Nguyen, Jon R. Polansky, Pu Chen, Hua Chen filed Critical The Regents Of The University Of California
Priority to CA002456777A priority Critical patent/CA2456777A1/en
Publication of CA2278782A1 publication Critical patent/CA2278782A1/en
Application granted granted Critical
Publication of CA2278782C publication Critical patent/CA2278782C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers

Abstract

The nucleic acid upstream of the TIGR protein encoding sequence can be used to diagnose glaucoma. Polymorphisms, base substitutions, base additions located with the upstream and within TIGR exons can also be used to diagnose glaucoma. In addition, polymorphisms, base substitutions, base additions located with the upstream and within TIGR exons can also be used to prognose glaucoma.
CA002278782A 1997-01-28 1998-01-09 Methods for the diagnosis, prognosis and treatment of glaucoma and related disorders Expired - Fee Related CA2278782C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002456777A CA2456777A1 (en) 1997-01-28 1998-01-09 Methods for the diagnosis, prognosis and treatment of glaucoma and related disorders

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US79115497A 1997-01-28 1997-01-28
US08/791,154 1997-01-28
US08/938,669 US6171788B1 (en) 1997-01-28 1997-09-26 Methods for the diagnosis, prognosis and treatment of glaucoma and related disorders
US08/938,669 1997-09-26
PCT/US1998/000468 WO1998032850A1 (en) 1997-01-28 1998-01-09 Methods for the diagnosis, prognosis and treatment of glaucoma and related disorders

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA002456777A Division CA2456777A1 (en) 1997-01-28 1998-01-09 Methods for the diagnosis, prognosis and treatment of glaucoma and related disorders

Publications (2)

Publication Number Publication Date
CA2278782A1 true CA2278782A1 (en) 1998-07-30
CA2278782C CA2278782C (en) 2004-05-25

Family

ID=27121110

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002278782A Expired - Fee Related CA2278782C (en) 1997-01-28 1998-01-09 Methods for the diagnosis, prognosis and treatment of glaucoma and related disorders

Country Status (10)

Country Link
US (1) US6171788B1 (en)
EP (1) EP1012271B1 (en)
JP (1) JP2001509669A (en)
AT (1) ATE375389T1 (en)
AU (1) AU742405B2 (en)
CA (1) CA2278782C (en)
DE (1) DE69838553T2 (en)
NO (1) NO993653L (en)
NZ (1) NZ336860A (en)
WO (1) WO1998032850A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
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US6956103B2 (en) 1994-04-28 2005-10-18 The University Of Iowa Research Foundation Glaucoma therapeutics and diagnostics
US6403307B1 (en) 1997-03-21 2002-06-11 University Of Iowa Research Foundation Glaucoma therapeutics and diagnostics
US7138511B1 (en) * 1997-01-28 2006-11-21 The Regents Of The University Of California Nucleic acids, kits and methods for the diagnosis, prognosis and treatment of glaucoma and related disorders
US6475724B1 (en) * 1997-01-28 2002-11-05 The Regents Of The University Of California Nucleic acids, kits, and methods for the diagnosis, prognosis and treatment of glaucoma and related disorders
US6171788B1 (en) 1997-01-28 2001-01-09 The Regents Of The University Of California Methods for the diagnosis, prognosis and treatment of glaucoma and related disorders
JP2002306165A (en) * 2000-05-17 2002-10-22 Tsubota:Kk Gene related with open-angle glaucoma including normal tension glaucoma
US20020168639A1 (en) * 2000-09-22 2002-11-14 Muraca Patrick J. Profile array substrates
US20030119000A1 (en) * 2001-11-05 2003-06-26 Jon Polansky Methods to screen and treat individuals with glaucoma or the propensity to develop glaucoma
US6727354B2 (en) * 2001-12-12 2004-04-27 Quest Diagnostics Investments, Inc. Compositions and methods for TIGR genotyping assays
WO2020118293A2 (en) * 2018-12-07 2020-06-11 Georgia Tech Research Corporation Antibodies that bind to natively folded myocilin

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Also Published As

Publication number Publication date
NZ336860A (en) 2001-06-29
US6171788B1 (en) 2001-01-09
NO993653D0 (en) 1999-07-27
WO1998032850A1 (en) 1998-07-30
DE69838553T2 (en) 2008-07-03
NO993653L (en) 1999-09-28
ATE375389T1 (en) 2007-10-15
DE69838553D1 (en) 2007-11-22
AU5820498A (en) 1998-08-18
EP1012271A1 (en) 2000-06-28
JP2001509669A (en) 2001-07-24
AU742405B2 (en) 2002-01-03
EP1012271B1 (en) 2007-10-10
CA2278782C (en) 2004-05-25

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