CA2278782A1 - Methods for the diagnosis, prognosis and treatment of glaucoma and related disorders - Google Patents
Methods for the diagnosis, prognosis and treatment of glaucoma and related disorders Download PDFInfo
- Publication number
- CA2278782A1 CA2278782A1 CA002278782A CA2278782A CA2278782A1 CA 2278782 A1 CA2278782 A1 CA 2278782A1 CA 002278782 A CA002278782 A CA 002278782A CA 2278782 A CA2278782 A CA 2278782A CA 2278782 A1 CA2278782 A1 CA 2278782A1
- Authority
- CA
- Canada
- Prior art keywords
- glaucoma
- prognosis
- diagnosis
- treatment
- methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Abstract
The nucleic acid upstream of the TIGR protein encoding sequence can be used to diagnose glaucoma. Polymorphisms, base substitutions, base additions located with the upstream and within TIGR exons can also be used to diagnose glaucoma. In addition, polymorphisms, base substitutions, base additions located with the upstream and within TIGR exons can also be used to prognose glaucoma.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002456777A CA2456777A1 (en) | 1997-01-28 | 1998-01-09 | Methods for the diagnosis, prognosis and treatment of glaucoma and related disorders |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79115497A | 1997-01-28 | 1997-01-28 | |
US08/791,154 | 1997-01-28 | ||
US08/938,669 US6171788B1 (en) | 1997-01-28 | 1997-09-26 | Methods for the diagnosis, prognosis and treatment of glaucoma and related disorders |
US08/938,669 | 1997-09-26 | ||
PCT/US1998/000468 WO1998032850A1 (en) | 1997-01-28 | 1998-01-09 | Methods for the diagnosis, prognosis and treatment of glaucoma and related disorders |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002456777A Division CA2456777A1 (en) | 1997-01-28 | 1998-01-09 | Methods for the diagnosis, prognosis and treatment of glaucoma and related disorders |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2278782A1 true CA2278782A1 (en) | 1998-07-30 |
CA2278782C CA2278782C (en) | 2004-05-25 |
Family
ID=27121110
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002278782A Expired - Fee Related CA2278782C (en) | 1997-01-28 | 1998-01-09 | Methods for the diagnosis, prognosis and treatment of glaucoma and related disorders |
Country Status (10)
Country | Link |
---|---|
US (1) | US6171788B1 (en) |
EP (1) | EP1012271B1 (en) |
JP (1) | JP2001509669A (en) |
AT (1) | ATE375389T1 (en) |
AU (1) | AU742405B2 (en) |
CA (1) | CA2278782C (en) |
DE (1) | DE69838553T2 (en) |
NO (1) | NO993653L (en) |
NZ (1) | NZ336860A (en) |
WO (1) | WO1998032850A1 (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6956103B2 (en) | 1994-04-28 | 2005-10-18 | The University Of Iowa Research Foundation | Glaucoma therapeutics and diagnostics |
US6403307B1 (en) | 1997-03-21 | 2002-06-11 | University Of Iowa Research Foundation | Glaucoma therapeutics and diagnostics |
US7138511B1 (en) * | 1997-01-28 | 2006-11-21 | The Regents Of The University Of California | Nucleic acids, kits and methods for the diagnosis, prognosis and treatment of glaucoma and related disorders |
US6475724B1 (en) * | 1997-01-28 | 2002-11-05 | The Regents Of The University Of California | Nucleic acids, kits, and methods for the diagnosis, prognosis and treatment of glaucoma and related disorders |
US6171788B1 (en) | 1997-01-28 | 2001-01-09 | The Regents Of The University Of California | Methods for the diagnosis, prognosis and treatment of glaucoma and related disorders |
JP2002306165A (en) * | 2000-05-17 | 2002-10-22 | Tsubota:Kk | Gene related with open-angle glaucoma including normal tension glaucoma |
US20020168639A1 (en) * | 2000-09-22 | 2002-11-14 | Muraca Patrick J. | Profile array substrates |
US20030119000A1 (en) * | 2001-11-05 | 2003-06-26 | Jon Polansky | Methods to screen and treat individuals with glaucoma or the propensity to develop glaucoma |
US6727354B2 (en) * | 2001-12-12 | 2004-04-27 | Quest Diagnostics Investments, Inc. | Compositions and methods for TIGR genotyping assays |
WO2020118293A2 (en) * | 2018-12-07 | 2020-06-11 | Georgia Tech Research Corporation | Antibodies that bind to natively folded myocilin |
Family Cites Families (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3887699A (en) | 1969-03-24 | 1975-06-03 | Seymour Yolles | Biodegradable polymeric article for dispensing drugs |
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
WO1982001011A1 (en) | 1980-09-24 | 1982-04-01 | Corp Cetus | Diagnostic method and probe |
PH19942A (en) | 1980-11-18 | 1986-08-14 | Sintex Inc | Microencapsulation of water soluble polypeptides |
IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
ATE53862T1 (en) | 1982-01-22 | 1990-06-15 | Cetus Corp | METHODS FOR THE CHARACTERIZATION OF HLA AND THE CDNS TEST AGENTS USED THEREIN. |
US4582788A (en) | 1982-01-22 | 1986-04-15 | Cetus Corporation | HLA typing method and cDNA probes used therein |
IL71064A (en) | 1983-02-28 | 1989-10-31 | Lifecodes Corp | Paternity and forensic test involving analysis of dna polymorphic genetic regions |
US4617299A (en) | 1983-12-19 | 1986-10-14 | Knepper Paul A | Method for the prevention of ocular hypertension, treatment of glaucoma and treatment of ocular hypertension |
DE3413608A1 (en) | 1984-04-11 | 1985-10-24 | Hoechst Ag, 6230 Frankfurt | IMPLANTABLE PREPARATIONS OF REGULATORY PEPTIDES WITH CONTROLLED RELEASE AND METHOD FOR THE PRODUCTION THEREOF |
US4683194A (en) | 1984-05-29 | 1987-07-28 | Cetus Corporation | Method for detection of polymorphic restriction sites and nucleic acid sequences |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4757089A (en) | 1985-06-14 | 1988-07-12 | Massachusetts Eye And Ear Infirmary | Increasing aqueous humor outflow |
CA1284931C (en) | 1986-03-13 | 1991-06-18 | Henry A. Erlich | Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids |
GB8606719D0 (en) | 1986-03-19 | 1986-04-23 | Lister Preventive Med | Genetic probes |
DE3612537C1 (en) | 1986-04-14 | 1987-07-16 | Dispersa Ag | Medicines used to treat inflammation in the eye |
CA1338457C (en) | 1986-08-22 | 1996-07-16 | Henry A. Erlich | Purified thermostable enzyme |
IL86724A (en) | 1987-06-19 | 1995-01-24 | Siska Diagnostics Inc | Method and kits for the amplification and detection of nucleic acid sequences |
WO1989006700A1 (en) | 1988-01-21 | 1989-07-27 | Genentech, Inc. | Amplification and detection of nucleic acid sequences |
IE63392B1 (en) | 1988-02-08 | 1995-04-19 | Insite Vision Inc | Ophthalmic suspensions |
US5192535A (en) | 1988-02-08 | 1993-03-09 | Insite Vision Incorporated | Ophthalmic suspensions |
CA1340807C (en) | 1988-02-24 | 1999-11-02 | Lawrence T. Malek | Nucleic acid amplification process |
US5130238A (en) | 1988-06-24 | 1992-07-14 | Cangene Corporation | Enhanced nucleic acid amplification process |
US5190762A (en) | 1988-07-06 | 1993-03-02 | Applied Genetics, Inc. | Method of administering proteins to living skin cells |
EP0425563B1 (en) | 1988-07-20 | 1996-05-15 | David Segev | Process for amplifying and detecting nucleic acid sequences |
GB2228086A (en) | 1988-11-25 | 1990-08-15 | Ici Plc | Characterisation of genomic DNA |
KR920700360A (en) | 1989-03-22 | 1992-02-19 | 하리크 프리드리히 | Sliding bearing |
US5075217A (en) | 1989-04-21 | 1991-12-24 | Marshfield Clinic | Length polymorphisms in (dC-dA)n ·(dG-dT)n sequences |
AU5645690A (en) | 1989-05-05 | 1990-11-29 | Lifecodes Corporation | Method for genetic analysis of a nucleic acid sample |
AU6521790A (en) | 1989-10-13 | 1991-05-16 | Hans Schreier | Lipophilic acylpyrazinamide prodrugs |
US5124154A (en) | 1990-06-12 | 1992-06-23 | Insite Vision Incorporated | Aminosteroids for ophthalmic use |
US5270052A (en) | 1991-04-19 | 1993-12-14 | New England Medical Center Hospitals, Inc. | Methods and compositions for treatment of infection by intracellular parasites |
US5169766A (en) | 1991-06-14 | 1992-12-08 | Life Technologies, Inc. | Amplification of nucleic acid molecules |
WO1993012230A1 (en) | 1991-12-13 | 1993-06-24 | Sri International | Triple-helix formation at (punpyn).(punpyn) tracts |
JPH08502244A (en) | 1992-08-11 | 1996-03-12 | プレジデント アンド フェローズ オブ ハーバード カレッジ | Immunomodulatory peptide |
US5420120A (en) | 1993-12-17 | 1995-05-30 | Alcon Laboratories, Inc. | Anti-inflammatory glucocorticoid compounds for topical ophthalmic use |
US5474985A (en) | 1993-12-22 | 1995-12-12 | The Regents Of The University Of California | Preventing and treating elevated intraocular pressure associated with administered or endogenous steroids using non-steroidal cyclooxygenase inhibitors |
US5916778A (en) | 1994-04-28 | 1999-06-29 | University Of Iowa Research Foundation | Diagnostics based on a glaucoma causing gene |
US5885776A (en) | 1997-01-30 | 1999-03-23 | University Of Iowa Research Foundation | Glaucoma compositions and therapeutic and diagnositic uses therefor |
US5925748A (en) | 1994-04-28 | 1999-07-20 | The University Of Iowa Research Foundation | DNA diagnostics for glaucoma |
US5606043A (en) | 1994-11-03 | 1997-02-25 | The Regents Of The University Of California | Methods for the diagnosis of glaucoma |
US5789169A (en) * | 1994-11-03 | 1998-08-04 | Regents Of The University Of California | Methods for the diagnosis of glaucoma |
FR2733251B1 (en) | 1995-04-18 | 1997-07-04 | Inst Nat Sante Rech Med | Screening for juvenile glaucoma |
US5674888A (en) | 1995-06-07 | 1997-10-07 | University Of California | Method for the treatment of a trabecular meshwork whose cells are subject to inhibition of cell division |
US5599535A (en) | 1995-06-07 | 1997-02-04 | Regents Of The University Of California | Methods for the cyto-protection of the trabecular meshwork |
AU5436498A (en) | 1996-11-08 | 1998-05-29 | University Of Iowa Research Foundation, The | Glaucoma-associated protein and corresponding nucleic acid and their therapeut ic and diagnostic uses |
US6171788B1 (en) | 1997-01-28 | 2001-01-09 | The Regents Of The University Of California | Methods for the diagnosis, prognosis and treatment of glaucoma and related disorders |
CA2216997A1 (en) | 1997-09-30 | 1999-03-30 | Jean Morissette | Molecular diagnostic of glaucomas associated with chromosomes 1 |
WO1999016898A1 (en) | 1997-09-30 | 1999-04-08 | Universite Laval | Molecular diagnostic of glaucomas associated with chromosomes 1, and method of treatment thereof |
-
1997
- 1997-09-26 US US08/938,669 patent/US6171788B1/en not_active Expired - Fee Related
-
1998
- 1998-01-09 WO PCT/US1998/000468 patent/WO1998032850A1/en active IP Right Grant
- 1998-01-09 NZ NZ336860A patent/NZ336860A/en unknown
- 1998-01-09 EP EP98901761A patent/EP1012271B1/en not_active Expired - Lifetime
- 1998-01-09 JP JP53201798A patent/JP2001509669A/en not_active Ceased
- 1998-01-09 CA CA002278782A patent/CA2278782C/en not_active Expired - Fee Related
- 1998-01-09 AU AU58204/98A patent/AU742405B2/en not_active Ceased
- 1998-01-09 AT AT98901761T patent/ATE375389T1/en not_active IP Right Cessation
- 1998-01-09 DE DE69838553T patent/DE69838553T2/en not_active Expired - Fee Related
-
1999
- 1999-07-27 NO NO993653A patent/NO993653L/en unknown
Also Published As
Publication number | Publication date |
---|---|
NZ336860A (en) | 2001-06-29 |
US6171788B1 (en) | 2001-01-09 |
NO993653D0 (en) | 1999-07-27 |
WO1998032850A1 (en) | 1998-07-30 |
DE69838553T2 (en) | 2008-07-03 |
NO993653L (en) | 1999-09-28 |
ATE375389T1 (en) | 2007-10-15 |
DE69838553D1 (en) | 2007-11-22 |
AU5820498A (en) | 1998-08-18 |
EP1012271A1 (en) | 2000-06-28 |
JP2001509669A (en) | 2001-07-24 |
AU742405B2 (en) | 2002-01-03 |
EP1012271B1 (en) | 2007-10-10 |
CA2278782C (en) | 2004-05-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |