CA2274581A1 - Oligonucleotide compositions and methods for the modulation of the expression of b7 protein - Google Patents
Oligonucleotide compositions and methods for the modulation of the expression of b7 protein Download PDFInfo
- Publication number
- CA2274581A1 CA2274581A1 CA002274581A CA2274581A CA2274581A1 CA 2274581 A1 CA2274581 A1 CA 2274581A1 CA 002274581 A CA002274581 A CA 002274581A CA 2274581 A CA2274581 A CA 2274581A CA 2274581 A1 CA2274581 A1 CA 2274581A1
- Authority
- CA
- Canada
- Prior art keywords
- modulation
- methods
- protein
- expression
- oligonucleotide compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
- C12N2310/3341—5-Methylcytosine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/341—Gapmers, i.e. of the type ===---===
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3515—Lipophilic moiety, e.g. cholesterol
Abstract
Compositions and methods for the diagnosis, prevention and treatment of immune states and disorders amenable to treatment through modulation of T cell activation are provided. In accordance with preferred embodiments, oligonucleotides are provided which are specifically hybridizable with nucleic acids encoding B7 proteins.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/777,266 US6077833A (en) | 1996-12-31 | 1996-12-31 | Oligonucleotide compositions and methods for the modulation of the expression of B7 protein |
US08/777,266 | 1996-12-31 | ||
PCT/US1997/023270 WO1998029124A1 (en) | 1996-12-31 | 1997-12-16 | Oligonucleotide compositions and methods for the modulation of the expression of b7 protein |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2274581A1 true CA2274581A1 (en) | 1998-07-09 |
CA2274581C CA2274581C (en) | 2004-02-10 |
Family
ID=25109768
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002274581A Expired - Fee Related CA2274581C (en) | 1996-12-31 | 1997-12-16 | Oligonucleotide compositions and methods for the modulation of the expression of b7 protein |
Country Status (10)
Country | Link |
---|---|
US (1) | US6077833A (en) |
EP (1) | EP0957926B1 (en) |
JP (1) | JP3471025B2 (en) |
KR (1) | KR100452105B1 (en) |
AT (1) | ATE289200T1 (en) |
AU (1) | AU720969B2 (en) |
CA (1) | CA2274581C (en) |
DE (1) | DE69732535T2 (en) |
ES (1) | ES2238083T3 (en) |
WO (1) | WO1998029124A1 (en) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040033977A1 (en) * | 1990-08-14 | 2004-02-19 | Bennett C. Frank | Oligonucleotide modulation of cell adhesion |
US6369209B1 (en) * | 1999-05-03 | 2002-04-09 | Isis Pharmaceuticals, Inc. | Oligonucleotides having A-DNA form and B-DNA form conformational geometry |
US7119184B2 (en) | 1991-08-12 | 2006-10-10 | Isis Pharmaceuticals, Inc. | Oligonucleotides having A-DNA form and B-DNA form conformational geometry |
CA2190304A1 (en) * | 1995-12-15 | 1997-06-16 | Elazar Rabbani | Property effecting and/or property exhibiting compositions for therapeutic and diagnostic uses |
US7115580B1 (en) * | 1996-12-31 | 2006-10-03 | Isis Pharmaceuticals, Inc. | Antisense modulation of B7 protein expression |
US6319906B1 (en) * | 1996-12-31 | 2001-11-20 | Isis Pharmaceuticals | Oligonucleotide compositions and methods for the modulation of the expression of B7 protein |
US7572582B2 (en) | 1997-09-12 | 2009-08-11 | Exiqon A/S | Oligonucleotide analogues |
US6518017B1 (en) * | 1997-10-02 | 2003-02-11 | Oasis Biosciences Incorporated | Combinatorial antisense library |
US20030165888A1 (en) | 2001-07-18 | 2003-09-04 | Brown Bob D. | Oligonucleotide probes and primers comprising universal bases for diagnostic purposes |
JP2003517283A (en) * | 1999-04-08 | 2003-05-27 | オアシス バイオサイエンシーズ インコーポレイティッド | Amplification and sequencing of primer pairs and their use |
ATE334193T1 (en) * | 1999-05-04 | 2006-08-15 | Genethor Gmbh | METHOD FOR REDUCING SPECIFIC IMMUNE REACTIONS |
EP1085085A1 (en) * | 1999-09-18 | 2001-03-21 | Ahmed Dr. Sheriff | Process for reducing specific immune reactions |
EP2267029B1 (en) | 1999-09-03 | 2016-06-15 | The Brigham And Women's Hospital, Inc. | Methods and compositions for treatment of inflammatory disease using Cadherin-11 modulating agents |
EP1296643A4 (en) * | 1999-09-17 | 2005-07-27 | Isis Pharmaceuticals Inc | Antisense modulation of transforming growth factor-beta expression |
WO2002026757A2 (en) * | 2000-09-26 | 2002-04-04 | Hybridon, Inc. | Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes |
CA2790034A1 (en) * | 2001-06-21 | 2003-01-03 | Isis Pharmaceuticals, Inc. | Antisense modulation of superoxide dismutase 1, soluble expression |
US20050019915A1 (en) * | 2001-06-21 | 2005-01-27 | Bennett C. Frank | Antisense modulation of superoxide dismutase 1, soluble expression |
US20030054354A1 (en) * | 2001-08-23 | 2003-03-20 | Bennett C. Frank | Use of antisense oligonucleotide libraries for identifying gene function |
US20040044404A1 (en) * | 2002-08-30 | 2004-03-04 | Stucke Sean M. | Retention coatings for delivery systems |
US7960355B2 (en) * | 2003-05-23 | 2011-06-14 | Isis Pharmaceuticals, Inc. | Compositions and methods for the modulation of the expression of B7 protein |
US7897582B2 (en) * | 2003-05-23 | 2011-03-01 | Isis Pharmaceuticals, Inc. | Oligonucleotide compositions and methods for the modulation of the expression of B7 protein |
WO2005017163A2 (en) * | 2003-08-15 | 2005-02-24 | Imperial College Innovations Limited | Phenotypic knockout of cell-surface proteins |
WO2005112885A2 (en) * | 2004-05-12 | 2005-12-01 | Baxter International Inc. | Oligonucleotide-containing microspheres, their use for the manufacture of a medicament for treating diabetes type 1 |
EP1765294B1 (en) * | 2004-05-12 | 2008-09-24 | Baxter International Inc. | Nucleic acid microspheres, production and delivery thereof |
KR100721928B1 (en) | 2004-11-05 | 2007-05-28 | 주식회사 바이오씨에스 | Pharmaceutical composition for treating or preventing dermatitis comprising CpG oligodeoxynucleotide |
MX2009001226A (en) | 2006-08-04 | 2009-03-20 | Baxter Int | Microsphere-based composition for preventing and/or reversing new-onset autoimmune diabetes. |
CN101686939B (en) * | 2007-04-17 | 2013-03-27 | 巴克斯特国际公司 | Nucleic acid microparticles for pulmonary delivery |
US8841429B2 (en) | 2009-11-03 | 2014-09-23 | Vivonics, Inc. | Nucleic acid ligands against infectious prions |
US8236570B2 (en) | 2009-11-03 | 2012-08-07 | Infoscitex | Methods for identifying nucleic acid ligands |
WO2011088148A1 (en) * | 2010-01-12 | 2011-07-21 | Isis Pharmaceuticals, Inc. | Modulation of transforming growth factor-beta 1 expression |
EP3757214B1 (en) | 2014-04-01 | 2022-06-15 | Biogen MA Inc. | Compositions for modulating sod-1 expression |
US10294454B2 (en) | 2016-08-24 | 2019-05-21 | General Electric Company | Methods and kits for cell activation |
Family Cites Families (33)
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NZ209840A (en) * | 1983-10-17 | 1988-11-29 | Kaji Akira | A method of inhibiting viral propagation by hybridising dna with the viral rna thus blocking its action |
US5034506A (en) * | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
US4806463A (en) * | 1986-05-23 | 1989-02-21 | Worcester Foundation For Experimental Biology | Inhibition of HTLV-III by exogenous oligonucleotides |
US5194428A (en) * | 1986-05-23 | 1993-03-16 | Worcester Foundation For Experimental Biology | Inhibition of influenza virus replication by oligonucleotide phosphorothioates |
US5264423A (en) * | 1987-03-25 | 1993-11-23 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibitors for replication of retroviruses and for the expression of oncogene products |
US5276019A (en) * | 1987-03-25 | 1994-01-04 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibitors for replication of retroviruses and for the expression of oncogene products |
US5004810A (en) * | 1988-09-30 | 1991-04-02 | Schering Corporation | Antiviral oligomers |
US5098890A (en) * | 1988-11-07 | 1992-03-24 | Temple University-Of The Commonwealth System Of Higher Education | Antisence oligonucleotides to c-myb proto-oncogene and uses thereof |
US5087617A (en) * | 1989-02-15 | 1992-02-11 | Board Of Regents, The University Of Texas System | Methods and compositions for treatment of cancer using oligonucleotides |
US5514788A (en) * | 1993-05-17 | 1996-05-07 | Isis Pharmaceuticals, Inc. | Oligonucleotide modulation of cell adhesion |
US5459255A (en) * | 1990-01-11 | 1995-10-17 | Isis Pharmaceuticals, Inc. | N-2 substituted purines |
US6641809B1 (en) * | 1990-03-26 | 2003-11-04 | Bristol-Myers Squibb Company | Method of regulating cellular processes mediated by B7 and CD28 |
US5166195A (en) * | 1990-05-11 | 1992-11-24 | Isis Pharmaceuticals, Inc. | Antisense inhibitors of the human immunodeficiency virus phosphorothioate oligonucleotides |
US5135917A (en) * | 1990-07-12 | 1992-08-04 | Nova Pharmaceutical Corporation | Interleukin receptor expression inhibiting antisense oligonucleotides |
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US5378825A (en) * | 1990-07-27 | 1995-01-03 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogs |
US5138045A (en) * | 1990-07-27 | 1992-08-11 | Isis Pharmaceuticals | Polyamine conjugated oligonucleotides |
US5242906A (en) * | 1991-04-22 | 1993-09-07 | University Of North Carolina At Chapel Hill | Antisense oligonucleotides against Epstein-Barr virus |
US5539082A (en) * | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
AU661854B2 (en) * | 1991-06-27 | 1995-08-10 | Bristol-Myers Squibb Company | CTL4A receptor, fusion proteins containing it and uses thereof |
US5747034A (en) * | 1992-07-09 | 1998-05-05 | Chiron Corporation | Methods and materials for the induction of T cell anergy |
DE69333698T2 (en) * | 1992-07-20 | 2005-12-01 | Isis Pharmaceutical, Inc., Carlsbad | PSEUDO HALF NODES FORMING RNA BY HYBRIDIZING ANTISSESEOLIGON NUCLEOTIDES TO TARGETED RNA SECONDARY STRUCTURES |
US5585479A (en) * | 1992-07-24 | 1996-12-17 | The United States Of America As Represented By The Secretary Of The Navy | Antisense oligonucleotides directed against human ELAM-I RNA |
MX9306147A (en) * | 1992-10-02 | 1994-06-30 | Bristol Myers Squibb Co | PHARMACEUTICAL COMPOSITION TO INHIBIT THE GROWTH OF TUMOR CELLS. |
EP0711345A1 (en) * | 1993-07-26 | 1996-05-15 | Dana Farber Cancer Institute | B7-2: ctl a4/cd 28 counter receptor |
CA2168202A1 (en) * | 1993-07-30 | 1995-03-16 | Joseph Dougherty | Efficient gene transfer into primary lymphocytes |
AU7526894A (en) * | 1993-08-16 | 1995-03-14 | Arch Development Corporation | B7-2: ctla4/cd28 counter receptor |
AU7638894A (en) * | 1993-09-03 | 1995-03-22 | Miyuki Azuma | B70(b7-2):ctla-4 bonding protein |
JPH0779793A (en) * | 1993-09-14 | 1995-03-28 | Sumitomo Electric Ind Ltd | Monoclonal antibody against b70 molecule |
CA2188812A1 (en) * | 1994-05-26 | 1995-12-07 | Mark De Boer | New methods and compounds for the selective modulation of antigen-specific t-cell responsiveness |
EP0784482A2 (en) * | 1994-06-07 | 1997-07-23 | The Regents Of The University Of Minnesota | Methods for inhibiting antigen specific t cell responses |
CA2201592A1 (en) * | 1994-10-03 | 1996-04-18 | The Government Of The United States Of America, Represented By The Secre Tary, Department Of Health And Human Services | Enhanced immune response by introduction of cytokine gene and/or costimulatory molecule b7 gene in a recombinant virus expressing system |
WO1996015780A1 (en) * | 1994-11-23 | 1996-05-30 | Isis Pharmaceuticals, Inc. | Compositions and methods for preventing and treating allograft rejection |
-
1996
- 1996-12-31 US US08/777,266 patent/US6077833A/en not_active Expired - Fee Related
-
1997
- 1997-12-16 CA CA002274581A patent/CA2274581C/en not_active Expired - Fee Related
- 1997-12-16 KR KR10-1999-7005654A patent/KR100452105B1/en not_active IP Right Cessation
- 1997-12-16 WO PCT/US1997/023270 patent/WO1998029124A1/en active IP Right Grant
- 1997-12-16 AT AT97953268T patent/ATE289200T1/en not_active IP Right Cessation
- 1997-12-16 EP EP97953268A patent/EP0957926B1/en not_active Expired - Lifetime
- 1997-12-16 JP JP53008598A patent/JP3471025B2/en not_active Expired - Fee Related
- 1997-12-16 AU AU57051/98A patent/AU720969B2/en not_active Ceased
- 1997-12-16 ES ES97953268T patent/ES2238083T3/en not_active Expired - Lifetime
- 1997-12-16 DE DE69732535T patent/DE69732535T2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0957926A4 (en) | 2002-01-23 |
AU720969B2 (en) | 2000-06-22 |
AU5705198A (en) | 1998-07-31 |
US6077833A (en) | 2000-06-20 |
DE69732535D1 (en) | 2005-03-24 |
CA2274581C (en) | 2004-02-10 |
ATE289200T1 (en) | 2005-03-15 |
ES2238083T3 (en) | 2005-08-16 |
JP2000507833A (en) | 2000-06-27 |
JP3471025B2 (en) | 2003-11-25 |
DE69732535T2 (en) | 2006-03-30 |
EP0957926A1 (en) | 1999-11-24 |
KR100452105B1 (en) | 2004-10-08 |
EP0957926B1 (en) | 2005-02-16 |
KR20000062274A (en) | 2000-10-25 |
WO1998029124A1 (en) | 1998-07-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20121217 |