CA2274174A1 - Glucose sensor - Google Patents

Glucose sensor Download PDF

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Publication number
CA2274174A1
CA2274174A1 CA002274174A CA2274174A CA2274174A1 CA 2274174 A1 CA2274174 A1 CA 2274174A1 CA 002274174 A CA002274174 A CA 002274174A CA 2274174 A CA2274174 A CA 2274174A CA 2274174 A1 CA2274174 A1 CA 2274174A1
Authority
CA
Canada
Prior art keywords
enzyme
glucose sensor
sensor
oxygen
containing membrane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002274174A
Other languages
French (fr)
Other versions
CA2274174C (en
Inventor
Elmo A. Blubaugh, Jr.
Alan R. Brunsman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tenax Therapeutics Inc
Original Assignee
Elmo A. Blubaugh, Jr.
Alan R. Brunsman
Implanted Biosystems, Inc.
Oxygen Biotherapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elmo A. Blubaugh, Jr., Alan R. Brunsman, Implanted Biosystems, Inc., Oxygen Biotherapeutics, Inc. filed Critical Elmo A. Blubaugh, Jr.
Publication of CA2274174A1 publication Critical patent/CA2274174A1/en
Application granted granted Critical
Publication of CA2274174C publication Critical patent/CA2274174C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/002—Electrode membranes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/082—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
    • C12Q1/006—Enzyme electrodes involving specific analytes or enzymes for glucose
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/817—Enzyme or microbe electrode

Abstract

A sensor (10) that is capable of accurately measuring glucose and other analytes in low oxygen environments is provided. The sensor employs and enzyme-containing membrane (14) comprising a semi-interpenetrating polymer network which is infiltrated by an enzyme. The enzyme-containing membrane increases oxygen transport to the enzyme such that oxygen is not a limiting factor in the oxidation taking place at the enzyme.
CA002274174A 1996-12-19 1997-12-17 Glucose sensor Expired - Fee Related CA2274174C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/769,863 US5964993A (en) 1996-12-19 1996-12-19 Glucose sensor
US08/769,863 1996-12-19
PCT/US1997/023426 WO1998027419A1 (en) 1996-12-19 1997-12-17 Glucose sensor

Publications (2)

Publication Number Publication Date
CA2274174A1 true CA2274174A1 (en) 1998-06-25
CA2274174C CA2274174C (en) 2006-02-21

Family

ID=25086741

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002274174A Expired - Fee Related CA2274174C (en) 1996-12-19 1997-12-17 Glucose sensor

Country Status (9)

Country Link
US (1) US5964993A (en)
EP (1) EP0948743B1 (en)
JP (1) JP4055912B2 (en)
AT (1) ATE426799T1 (en)
AU (1) AU720712B2 (en)
CA (1) CA2274174C (en)
DE (1) DE69739325D1 (en)
ES (1) ES2324804T3 (en)
WO (1) WO1998027419A1 (en)

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