CA2273140A1 - Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media - Google Patents

Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media Download PDF

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Publication number
CA2273140A1
CA2273140A1 CA002273140A CA2273140A CA2273140A1 CA 2273140 A1 CA2273140 A1 CA 2273140A1 CA 002273140 A CA002273140 A CA 002273140A CA 2273140 A CA2273140 A CA 2273140A CA 2273140 A1 CA2273140 A1 CA 2273140A1
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Prior art keywords
contrast media
ultrasound contrast
gases
microbubbles
agents
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Granted
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CA002273140A
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French (fr)
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CA2273140C (en
Inventor
Stephen C. Quay
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GE Healthcare AS
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Priority claimed from CA002119129A external-priority patent/CA2119129C/en
Publication of CA2273140A1 publication Critical patent/CA2273140A1/en
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Publication of CA2273140C publication Critical patent/CA2273140C/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

Abstract

Disclosed herein are agents for enhancing the contrast in an ultrasound image. These agents are extremely small bubbles, or "microbubbles," comprised of specially selected gases. The microbubbles described herein exhibit long life spans in solution and may be produced at a size small enough to traverse the lungs, thus enabling improved ultrasound imaging of the cardiovascular system and other vital organs. Also disclosed herein is a method for selecting gases from which contrast agents may be produced. The method is based on calculations using inherent physical properties of gases and describes a means to associate the properties of a gas with the time for dissolution of microbubbles comprised of the gas.
CA002273140A 1991-09-17 1992-09-02 Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media Expired - Lifetime CA2273140C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US76131191A 1991-09-17 1991-09-17
US07/761,311 1991-09-17
US07/893,657 1992-06-05
US07/893,657 US5409688A (en) 1991-09-17 1992-06-05 Gaseous ultrasound contrast media
CA002119129A CA2119129C (en) 1991-09-17 1992-09-02 Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media

Related Parent Applications (1)

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CA002119129A Division CA2119129C (en) 1991-09-17 1992-09-02 Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media

Publications (2)

Publication Number Publication Date
CA2273140A1 true CA2273140A1 (en) 1993-04-01
CA2273140C CA2273140C (en) 2003-05-20

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CA002273140A Expired - Lifetime CA2273140C (en) 1991-09-17 1992-09-02 Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media

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US (3) US5409688A (en)
CA (1) CA2273140C (en)
PL (1) PL173817B1 (en)
ZA (1) ZA927114B (en)

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US5409688A (en) 1995-04-25
US5573751A (en) 1996-11-12
PL173817B1 (en) 1998-05-29
US5393524A (en) 1995-02-28

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