CA2265508A1 - Bone morphogenetic protein-16 (bmp-16) compositions - Google Patents

Bone morphogenetic protein-16 (bmp-16) compositions

Info

Publication number
CA2265508A1
CA2265508A1 CA002265508A CA2265508A CA2265508A1 CA 2265508 A1 CA2265508 A1 CA 2265508A1 CA 002265508 A CA002265508 A CA 002265508A CA 2265508 A CA2265508 A CA 2265508A CA 2265508 A1 CA2265508 A1 CA 2265508A1
Authority
CA
Canada
Prior art keywords
proteins
bmp
compositions
disorders
tissues
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002265508A
Other languages
French (fr)
Other versions
CA2265508C (en
Inventor
Anthony J. Celeste
Beth L. Murray
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetics Institute LLC
Original Assignee
Genetics Institute, Inc.
Anthony J. Celeste
Beth L. Murray
Genetics Institute, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetics Institute, Inc., Anthony J. Celeste, Beth L. Murray, Genetics Institute, Llc filed Critical Genetics Institute, Inc.
Publication of CA2265508A1 publication Critical patent/CA2265508A1/en
Application granted granted Critical
Publication of CA2265508C publication Critical patent/CA2265508C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

Purified BMP-16 proteins and processes for producing them are disclosed. DNA
molecules encoding the BMP-16 proteins are also disclosed. The proteins may be used in the treatment of bone, cartilage, other connective tissue defects and disorders, including tendon, ligament and meniscus, in wound healing and related tissue repair, as well as for treatment of disorders and defects to tissues which include epidermis, nerve, muscle, including cardiac muscle, and other tissues and wounds, and organs such as liver, lung, cardiac, pancreas and kidney tissue. The proteins may also be useful for the induction of growth and/or differentiation of undifferentiated embryonic and stem cells.
CA002265508A 1996-09-18 1997-07-09 Bone morphogenetic protein-16 (bmp-16) compositions Expired - Fee Related CA2265508C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/715,202 US5965403A (en) 1996-09-18 1996-09-18 Nucleic acids encoding bone morphogenic protein-16 (BMP-16)
US08/715,202 1996-09-18
PCT/US1997/011954 WO1998012322A1 (en) 1996-09-18 1997-07-09 Bone morphogenetic protein-16 (bmp-16) compositions

Publications (2)

Publication Number Publication Date
CA2265508A1 true CA2265508A1 (en) 1998-03-26
CA2265508C CA2265508C (en) 2003-11-18

Family

ID=24873057

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002265508A Expired - Fee Related CA2265508C (en) 1996-09-18 1997-07-09 Bone morphogenetic protein-16 (bmp-16) compositions

Country Status (9)

Country Link
US (3) US5965403A (en)
EP (1) EP0941323A1 (en)
JP (1) JP2001500737A (en)
KR (1) KR20000036012A (en)
CA (1) CA2265508C (en)
FI (1) FI990596A (en)
NO (1) NO991271D0 (en)
OA (1) OA10997A (en)
WO (1) WO1998012322A1 (en)

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US8106001B2 (en) * 1996-08-27 2012-01-31 University Of South Florida Diagnostic markers of human female infertility
US5965403A (en) * 1996-09-18 1999-10-12 Genetics Institute, Inc. Nucleic acids encoding bone morphogenic protein-16 (BMP-16)
CA2279575A1 (en) * 1997-02-06 1998-08-13 Genetics Institute, Inc. Human sdf-5 protein and compositions
JP2001512003A (en) * 1997-08-04 2001-08-21 ミレニアム ファーマシューティカルズ インク． Tango-78, Tango-79 and Tango-81 polypeptides, nucleic acid molecules encoding Tango-78, Tango-79 and Tango-81 and uses thereof
US6211157B1 (en) 1998-05-01 2001-04-03 Sulzer Biologics, Inc. Protein mixtures to induce therapeutic angiogenesis
US7087577B2 (en) * 1998-10-16 2006-08-08 Zimmer Orthobiologies, Inc. Method of promoting natural bypass
US6992066B2 (en) 1998-10-16 2006-01-31 Zimmer Orthobiologics, Inc. Povidone-containing carriers for polypeptide growth factors
CA2371695A1 (en) * 1999-04-30 2000-11-09 Curis, Inc. Morphogen-induced enhancement of fertility
MXPA02000877A (en) * 1999-07-28 2002-08-06 Regeneration Tech Inc Cartilage or bone matrix as a nucleic acid delivery vehicle.
CN1331248A (en) * 2000-06-30 2002-01-16 上海博德基因开发有限公司 Polypeptide-human chondral connexin 10.67 and polynucleotide for coding it
US6482936B1 (en) * 2001-04-17 2002-11-19 Pe Corporation (Ny) Isolated human secreted proteins, nucleic acid molecules encoding human secreted proteins, and uses thereof
DK1399023T3 (en) * 2001-06-01 2008-08-18 Wyeth Corp Compositions for systemic administration of sequences encoding bone morphogenesis proteins
TWI267378B (en) 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
US7232802B2 (en) * 2001-12-21 2007-06-19 Zimmer Orthobiologics, Inc. Compositions and methods for promoting myocardial and peripheral angiogenesis
ES2309485T3 (en) * 2003-01-06 2008-12-16 Wyeth COMPOSITIONS AND PROCEDURES TO DIAGNOSE AND TREAT COLON CANCER.
WO2004070062A2 (en) * 2003-02-04 2004-08-19 Wyeth Compositions and methods for diagnosing and treating cancers
US20050119210A1 (en) * 2003-05-20 2005-06-02 Xiaobing Be Compositions and methods for diagnosing and treating cancers
ES2282904T3 (en) 2003-09-12 2007-10-16 Wyeth SOLID BARS OF INJECTABLE CALCIUM PHOSPHATE FOR THE SUPPLY OF OSTEOGENIC PROTEINS.
DE10361075A1 (en) * 2003-12-22 2005-07-28 Pac Tech - Packaging Technologies Gmbh Method and apparatus for drying circuit substrates
EP1571159A1 (en) * 2004-03-04 2005-09-07 Bayerische Julius-Maximilians-Universität Würzburg Mutein of a bone morphogenetic protein and use thereof
WO2005116052A2 (en) * 2004-04-27 2005-12-08 Research Development Foundation ANTAGONISM OF TGF-β SUPERFAMILY RECEPTOR SIGNALING
WO2005113585A2 (en) * 2004-05-20 2005-12-01 Acceleron Pharma Inc. Modified tgf-beta superfamily polypeptides
JP2008509087A (en) * 2004-05-27 2008-03-27 アクセルロン ファーマ インコーポレーテッド TGF derepression factor and related methods of use
US7799754B2 (en) 2004-10-14 2010-09-21 Biomimetic Therapeutics, Inc. Compositions and methods for treating bone
US7473678B2 (en) 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
US20060166251A1 (en) * 2005-01-26 2006-07-27 Archambault Joanne M Use of sFRPs as markers of BMP activity
EP1863518A2 (en) * 2005-03-30 2007-12-12 Wyeth Methods for stimulating hair growth by administering bmps
US20060247790A1 (en) * 2005-04-30 2006-11-02 Mckay William F Shaped osteochondral grafts and methods of using same
NZ571113A (en) 2005-11-17 2012-02-24 Biomimetic Therapeutics Inc Maxillofacial bone augmentation using rhpdgf-bb and a biocompatible matrix
US8147860B2 (en) 2005-12-06 2012-04-03 Etex Corporation Porous calcium phosphate bone material
US7659999B2 (en) * 2005-12-23 2010-02-09 Xerox Corporation UIdesign: N-up calculator user interface
US9161967B2 (en) 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
AU2007269712B2 (en) 2006-06-30 2013-02-07 Biomimetic Therapeutics, Llc PDGF-biomatrix compositions and methods for treating rotator cuff injuries
US8524265B2 (en) 2006-08-17 2013-09-03 Warsaw Orthopedic, Inc. Medical implant sheets useful for tissue regeneration
AU2007333425B2 (en) 2006-11-03 2014-03-27 Biomimetic Therapeutics, Llc Compositions and methods for arthrodetic procedures
US20080195476A1 (en) * 2007-02-09 2008-08-14 Marchese Michael A Abandonment remarketing system
CN102014977B (en) 2008-02-07 2015-09-02 生物模拟治疗有限责任公司 For compositions and the method for Distraction Osteogenesis
US20100004175A1 (en) * 2008-06-09 2010-01-07 Tanya Shang Novel bmp-12-related proteins and methods of their manufacture
EP2341951A2 (en) 2008-09-09 2011-07-13 BioMimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods for the treatment of tendon and ligament injuries
US8609127B2 (en) 2009-04-03 2013-12-17 Warsaw Orthopedic, Inc. Medical implant with bioactive material and method of making the medical implant
US20110002897A1 (en) 2009-06-11 2011-01-06 Burnham Institute For Medical Research Directed differentiation of stem cells
JP6144049B2 (en) 2010-02-22 2017-06-07 バイオミメティック セラピューティクス，リミテッド ライアビリティ カンパニー Platelet-derived growth factor compositions and methods for treating tendon disorders
US9688735B2 (en) 2010-08-20 2017-06-27 Wyeth Llc Designer osteogenic proteins
KR101630501B1 (en) 2010-08-20 2016-06-15 와이어쓰 엘엘씨 Designer osteogenic proteins
WO2014012101A1 (en) 2012-07-13 2014-01-16 Trustees Of Tufts College Silk powder compaction for production of constructs with high mechanical strength and stiffness
US10780171B2 (en) 2015-10-26 2020-09-22 President And Fellows Of Harvard College Reduced and oxidized polysaccharides and methods of use thereof

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US5187076A (en) * 1986-07-01 1993-02-16 Genetics Institute, Inc. DNA sequences encoding BMP-6 proteins
US5106748A (en) * 1986-07-01 1992-04-21 Genetics Institute, Inc. Dna sequences encoding 5 proteins
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Also Published As

Publication number Publication date
CA2265508C (en) 2003-11-18
NO991271L (en) 1999-03-16
FI990596A (en) 1999-05-03
US6331612B1 (en) 2001-12-18
NO991271D0 (en) 1999-03-16
US5965403A (en) 1999-10-12
EP0941323A1 (en) 1999-09-15
KR20000036012A (en) 2000-06-26
OA10997A (en) 2003-03-04
US20030158379A1 (en) 2003-08-21
FI990596A0 (en) 1999-03-17
US6623934B2 (en) 2003-09-23
JP2001500737A (en) 2001-01-23
WO1998012322A1 (en) 1998-03-26

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