CA2262523A1 - Medical devices comprising ionically and non-ionically cross-linked polymer hydrogels having improved mechanical properties - Google Patents
Medical devices comprising ionically and non-ionically cross-linked polymer hydrogels having improved mechanical propertiesInfo
- Publication number
- CA2262523A1 CA2262523A1 CA002262523A CA2262523A CA2262523A1 CA 2262523 A1 CA2262523 A1 CA 2262523A1 CA 002262523 A CA002262523 A CA 002262523A CA 2262523 A CA2262523 A CA 2262523A CA 2262523 A1 CA2262523 A1 CA 2262523A1
- Authority
- CA
- Canada
- Prior art keywords
- ionically
- cross
- mechanical properties
- medical devices
- improved mechanical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M27/00—Drainage appliance for wounds or the like, i.e. wound drains, implanted drains
- A61M27/002—Implant devices for drainage of body fluids from one part of the body to another
- A61M27/008—Implant devices for drainage of body fluids from one part of the body to another pre-shaped, for use in the urethral or ureteral tract
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/145—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/145—Hydrogels or hydrocolloids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0084—Guluromannuronans, e.g. alginic acid, i.e. D-mannuronic acid and D-guluronic acid units linked with alternating alpha- and beta-1,4-glycosidic bonds; Derivatives thereof, e.g. alginates
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
- C08J3/243—Two or more independent types of crosslinking for one or more polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2300/00—Characterised by the use of unspecified polymers
- C08J2300/14—Water soluble or water swellable polymers, e.g. aqueous gels
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S524/00—Synthetic resins or natural rubbers -- part of the class 520 series
- Y10S524/916—Hydrogel compositions
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S525/00—Synthetic resins or natural rubbers -- part of the class 520 series
- Y10S525/903—Interpenetrating network
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
- Y10S623/901—Method of manufacturing prosthetic device
Abstract
Shaped medical devices, e.g. stents, having improved mechanical properties and structural integrity are disclosed. The devices commprise shaped polymeric hydrogels which are both ionically and non-ionically cross-linked and which exhibit improved structural integrity after selective removal of the crosslinking ions. Process for making such devices are also disclosed wherein an ionically cross-linkable polymer is both ionically and non-ionically crosslinked to form a shaped medical device. When implanted in the body, selective in-vivo stripping of the cross-linking ions produces a softer, more flexible implant having improved structural integrity.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/679,609 | 1996-07-11 | ||
US08/679,609 US6060534A (en) | 1996-07-11 | 1996-07-11 | Medical devices comprising ionically and non-ionically crosslinked polymer hydrogels having improved mechanical properties |
PCT/US1997/013119 WO1998002204A1 (en) | 1996-07-11 | 1997-06-30 | Medical devices comprising ionically and non-ionically cross-linked polymer hydrogels having improved mechanical properties |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2262523A1 true CA2262523A1 (en) | 1998-01-22 |
CA2262523C CA2262523C (en) | 2005-09-20 |
Family
ID=24727594
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002262523A Expired - Fee Related CA2262523C (en) | 1996-07-11 | 1997-06-30 | Medical devices comprising ionically and non-ionically cross-linked polymer hydrogels having improved mechanical properties |
Country Status (5)
Country | Link |
---|---|
US (3) | US6060534A (en) |
EP (1) | EP0912211B1 (en) |
CA (1) | CA2262523C (en) |
DE (1) | DE69725442T2 (en) |
WO (1) | WO1998002204A1 (en) |
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US5603955A (en) | 1994-07-18 | 1997-02-18 | University Of Cincinnati | Enhanced loading of solutes into polymer gels |
US5578662A (en) | 1994-07-22 | 1996-11-26 | United States Surgical Corporation | Bioabsorbable branched polymers containing units derived from dioxanone and medical/surgical devices manufactured therefrom |
US5527324A (en) | 1994-09-07 | 1996-06-18 | Krantz; Kermit E. | Surgical stent |
US5531735A (en) * | 1994-09-27 | 1996-07-02 | Hercules Incorporated | Medical devices containing triggerable disintegration agents |
US5690961A (en) | 1994-12-22 | 1997-11-25 | Hercules Incorporated | Acidic polysaccharides crosslinked with polycarboxylic acids and their uses |
EP0810845A2 (en) | 1995-02-22 | 1997-12-10 | Menlo Care Inc. | Covered expanding mesh stent |
US5713852A (en) * | 1995-06-07 | 1998-02-03 | Alza Corporation | Oral dosage and method for treating painful conditions of the oral cavity |
US5702682A (en) | 1995-12-01 | 1997-12-30 | Hercules Incorporated | Methods for preparing radiopaque medical devices |
US5684051A (en) * | 1996-04-24 | 1997-11-04 | Hercules Incorporated | Medical devices with improved elastic response |
US5670161A (en) | 1996-05-28 | 1997-09-23 | Healy; Kevin E. | Biodegradable stent |
US5820918A (en) | 1996-07-11 | 1998-10-13 | Hercules Incorporated | Medical devices containing in-situ generated medical compounds |
US5830217A (en) | 1996-08-09 | 1998-11-03 | Thomas J. Fogarty | Soluble fixation device and method for stent delivery catheters |
US5718916A (en) | 1997-02-03 | 1998-02-17 | Scherr; George H. | Alginate foam products |
-
1996
- 1996-07-11 US US08/679,609 patent/US6060534A/en not_active Expired - Lifetime
-
1997
- 1997-06-30 CA CA002262523A patent/CA2262523C/en not_active Expired - Fee Related
- 1997-06-30 EP EP97934303A patent/EP0912211B1/en not_active Expired - Lifetime
- 1997-06-30 WO PCT/US1997/013119 patent/WO1998002204A1/en active IP Right Grant
- 1997-06-30 DE DE69725442T patent/DE69725442T2/en not_active Expired - Lifetime
-
2000
- 2000-02-02 US US09/496,709 patent/US6184266B1/en not_active Expired - Lifetime
-
2001
- 2001-01-08 US US09/757,396 patent/US6387978B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0912211A1 (en) | 1999-05-06 |
EP0912211B1 (en) | 2003-10-08 |
US20010002411A1 (en) | 2001-05-31 |
WO1998002204A1 (en) | 1998-01-22 |
US6184266B1 (en) | 2001-02-06 |
EP0912211A4 (en) | 2000-08-16 |
CA2262523C (en) | 2005-09-20 |
US6387978B2 (en) | 2002-05-14 |
US6060534A (en) | 2000-05-09 |
DE69725442D1 (en) | 2003-11-13 |
DE69725442T2 (en) | 2004-07-29 |
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