CA2261804A1 - Improved products and methods for the remineralization and prevention of demineralization of teeth - Google Patents

Improved products and methods for the remineralization and prevention of demineralization of teeth

Info

Publication number
CA2261804A1
CA2261804A1 CA002261804A CA2261804A CA2261804A1 CA 2261804 A1 CA2261804 A1 CA 2261804A1 CA 002261804 A CA002261804 A CA 002261804A CA 2261804 A CA2261804 A CA 2261804A CA 2261804 A1 CA2261804 A1 CA 2261804A1
Authority
CA
Canada
Prior art keywords
water
cationic
soluble
aqueous composition
anionic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002261804A
Other languages
French (fr)
Other versions
CA2261804C (en
Inventor
Anthony E. Winston
Norman Usen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Enamelon Inc
Original Assignee
Enamelon, Inc.
Anthony E. Winston
Norman Usen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enamelon, Inc., Anthony E. Winston, Norman Usen filed Critical Enamelon, Inc.
Publication of CA2261804A1 publication Critical patent/CA2261804A1/en
Application granted granted Critical
Publication of CA2261804C publication Critical patent/CA2261804C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A61K8/21—Fluorides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24—Phosphorous; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/88—Two- or multipart kits

Abstract

Improved one-part and two-part liquid products such as, e.g., mouthwashes, mouthrinses, toothpastes, gels and the like, for remineralizing subsurface lesions and/or mineralizing exposed dentin tubules in teeth contain a cationic component, an anionic component and a separating means for separating the cationic and anionic components. The anionic component contains water-soluble phosphate and fluoride salts, while the cationic component contains at least one partially water-soluble calcium salt and preferably at least one water-soluble salt of a divalent metal other than calcium. The tooth is treated with a mixed aqueous composition formed by mixing the cationic and anionic components with water and/or saliva. The mixed aqueous composition has a pH of from about 4.0 to about 10.0 and, in addition to dissolved calcium cations and dissolved phosphate and fluoride anions, contains a quantity of undissolved calcium salt. The use of the partially water-soluble calcium salt delays precipitation of the cations and anions in the aqueous composition until after the ions have diffused through the tooth surface to the subsurface and/or dentin so as to effect remineralization and/or mineralization, respectively.
CA002261804A 1996-09-27 1997-08-26 Improved products and methods for the remineralization and prevention of demineralization of teeth Expired - Lifetime CA2261804C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/722,457 US6159448A (en) 1996-09-27 1996-09-27 Products and methods for the remineralization and prevention of demineralization of teeth
US08/722,457 1996-09-27
PCT/US1997/014818 WO1998013012A1 (en) 1996-09-27 1997-08-26 Improved products and methods for the remineralization and prevention of demineralization of teeth

Publications (2)

Publication Number Publication Date
CA2261804A1 true CA2261804A1 (en) 1998-04-02
CA2261804C CA2261804C (en) 2003-12-16

Family

ID=24901930

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002261804A Expired - Lifetime CA2261804C (en) 1996-09-27 1997-08-26 Improved products and methods for the remineralization and prevention of demineralization of teeth

Country Status (11)

Country Link
US (1) US6159448A (en)
EP (1) EP0930867B1 (en)
JP (1) JP2000504037A (en)
KR (1) KR100362638B1 (en)
CN (1) CN1150881C (en)
AU (1) AU713177B2 (en)
BR (1) BR9711416A (en)
CA (1) CA2261804C (en)
DE (1) DE69730336T2 (en)
IL (1) IL129000A0 (en)
WO (1) WO1998013012A1 (en)

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Also Published As

Publication number Publication date
BR9711416A (en) 1999-08-17
CN1231596A (en) 1999-10-13
JP2000504037A (en) 2000-04-04
EP0930867A4 (en) 2001-08-22
KR100362638B1 (en) 2002-11-30
CA2261804C (en) 2003-12-16
EP0930867A1 (en) 1999-07-28
WO1998013012A1 (en) 1998-04-02
DE69730336T2 (en) 2005-09-01
CN1150881C (en) 2004-05-26
IL129000A0 (en) 2000-02-17
KR20000036009A (en) 2000-06-26
AU4158297A (en) 1998-04-17
DE69730336D1 (en) 2004-09-23
AU713177B2 (en) 1999-11-25
EP0930867B1 (en) 2004-08-18
US6159448A (en) 2000-12-12

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Effective date: 20170828