CA2258483A1 - Biocompatible devices with foam scaffolds - Google Patents
Biocompatible devices with foam scaffoldsInfo
- Publication number
- CA2258483A1 CA2258483A1 CA002258483A CA2258483A CA2258483A1 CA 2258483 A1 CA2258483 A1 CA 2258483A1 CA 002258483 A CA002258483 A CA 002258483A CA 2258483 A CA2258483 A CA 2258483A CA 2258483 A1 CA2258483 A1 CA 2258483A1
- Authority
- CA
- Canada
- Prior art keywords
- jacket
- core
- foam
- foam scaffold
- scaffold
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0619—Neurons
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0623—Stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0658—Skeletal muscle cells, e.g. myocytes, myotubes, myoblasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/126—Immunoprotecting barriers, e.g. jackets, diffusion chambers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/30—Synthetic polymers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/70—Polysaccharides
- C12N2533/72—Chitin, chitosan
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- General Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Molecular Biology (AREA)
- Psychology (AREA)
- Botany (AREA)
- Developmental Biology & Embryology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Materials For Medical Uses (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Biological Depolymerization Polymers (AREA)
Abstract
A biocompatible cell device is provided having an internal foam scaffold to provide a growth surface for encapsulated cells which produce a biologically active molecule (DA) or provide a biological function.
Claims (22)
1. A biocompatible device for implantation in a recipient comprising:
(a) a core comprising a reticulate foam scaffold having interconnected pores, the pore density of the foam varying between 20% - 90%, the core further comprising a population of living cells dispersed in the pores;
(b) a jacket surrounding the core, the jacket comprising at least one permeable membrane surface which permits passage of biologically active substances across said membrane while preventing passage of cells thereacross.
(a) a core comprising a reticulate foam scaffold having interconnected pores, the pore density of the foam varying between 20% - 90%, the core further comprising a population of living cells dispersed in the pores;
(b) a jacket surrounding the core, the jacket comprising at least one permeable membrane surface which permits passage of biologically active substances across said membrane while preventing passage of cells thereacross.
2. The device of claim 1 wherein the foam scaffold is a thermoplastic or a thermoplastic elastomer.
3. The device of claim 1 wherein the foam scaffold is formed from a material from the group consisting of polysulfone, polyethersulfone, polyurethane, and polyvinyl alcohol.
4. The device of claim 1 wherein the void volume of the foam scaffold is between 20 to 90 %.
5. The device of claim 1 wherein the foam scaffold has been coated with an extracellular matrix adhesion molecule or adhesion peptide fragment thereof.
6. The device of claim 5 wherein the foam scaffold is coated with one or more extracellular matrix molecules from the group consisting of collagen, laminin, vitronectin, polyornithine, fibronectin, elastin, glycosaminoglycans and proteoglycans.
7. The device of claim 1 wherein at least a portion of the foam scaffold has been exposed to a non-permissive material that inhibits cell proliferation or migration.
8. The device of claim 1 wherein the core of the device further comprises a second population of living cells.
9. The device of claim 1 wherein the device comprises a hollow fiber jacket.
10. The device of claim 1 wherein the jacket is formed from a thermoplastic or a hydrogel.
11. A method of manufacturing an implantable, biocompatible cell encapsulation device comprising:
(a) forming a core comprising a reticulate foam scaffold having interconnected pores the pore density of the foam varying between 20% - 90%, the core further comprising a population of living cells dispersed in the pores;
(b) forming a jacket around the core, the jacket comprising at least one permeable membrane surface which permits passage of biologically active substances across said membrane while preventing passage of cells thereacross;
(c) sealing the jacket.
(a) forming a core comprising a reticulate foam scaffold having interconnected pores the pore density of the foam varying between 20% - 90%, the core further comprising a population of living cells dispersed in the pores;
(b) forming a jacket around the core, the jacket comprising at least one permeable membrane surface which permits passage of biologically active substances across said membrane while preventing passage of cells thereacross;
(c) sealing the jacket.
12. A method of manufacturing an implantable, biocompatible cell encapsulation device comprising:
(a) forming a jacket comprising a permeable biocompatible material;
(b) loading the jacket with a core comprising a reticulate foam scaffold having interconnected pores, the pore density of the foam varying between 20% - 90%, the core further comprising a population of living cells dispersed in the pores;
(c) sealing the jacket;
wherein the jacket provides at least one permeable membrane surface which permits passage of biologically active substances across said membrane while preventing passage of cells thereacross.
(a) forming a jacket comprising a permeable biocompatible material;
(b) loading the jacket with a core comprising a reticulate foam scaffold having interconnected pores, the pore density of the foam varying between 20% - 90%, the core further comprising a population of living cells dispersed in the pores;
(c) sealing the jacket;
wherein the jacket provides at least one permeable membrane surface which permits passage of biologically active substances across said membrane while preventing passage of cells thereacross.
13. A method of manufacturing an implantable, biocompatible cell encapsulation comprising:
(a) forming a jacket comprising a permeable biocompatible material;
(b) forming a core within the jacket, the core comprising a reticulate foam scaffold having interconnected pores, the pore density of the foam varying between 20% - 90%;
(c) loading the core with a population of living cells;
(d) sealing the jacket;
wherein the jacket provides at least one permeable membrane surface which permits passage of biologically active substances across said membrane while preventing passage of cells thereacross.
(a) forming a jacket comprising a permeable biocompatible material;
(b) forming a core within the jacket, the core comprising a reticulate foam scaffold having interconnected pores, the pore density of the foam varying between 20% - 90%;
(c) loading the core with a population of living cells;
(d) sealing the jacket;
wherein the jacket provides at least one permeable membrane surface which permits passage of biologically active substances across said membrane while preventing passage of cells thereacross.
14. A method for delivering a biologically active molecule or providing a biological function to a recipient comprising implanting a biocompatible device in the recipient, the device comprising:
(a) a core comprising a reticulate foam scaffold having interconnected pores, the pore density of the foam varying between 20% - 90%, the core further comprising a population of living cells dispersed in the pores;
(b) a jacket surrounding the core, the jacket comprising at least one permeable membrane surface which permits passage of biologically active substances across said membrane while preventing passage of cells thereacross.
(a) a core comprising a reticulate foam scaffold having interconnected pores, the pore density of the foam varying between 20% - 90%, the core further comprising a population of living cells dispersed in the pores;
(b) a jacket surrounding the core, the jacket comprising at least one permeable membrane surface which permits passage of biologically active substances across said membrane while preventing passage of cells thereacross.
15. The method of any one of claims 11-14 wherein the foam scaffold is a thermoplastic or a thermoplastic elastomer.
16. The method of any one of claims 11-14 wherein the foam scaffold is formed from a material selected from the group consisting of polysulfone, polyethersulfone, polyurethane, and polyvinyl alcohol.
17. The method of any one of claims 11-14 wherein the void volume of the foam scaffold is between 20 to 90 %.
18. The method of any one of claims 11-14 wherein the foam scaffold has been coated with an extracellular matrix adhesion molecule or adhesion peptide fragment thereof.
19. The method of any one of claims 11-14 wherein the foam scaffold is coated with one or more extracellular matrix molecules from the group consisting of collagen, laminin, vitronectin, polyornithine, fibronectin, elastin, glycosaminoglycans and proteoglycans.
20. The method of any one of claims 11-14 wherein at least a portion of the foam scaffold is exposed to a non-permissive material that inhibits cell proliferation or migration.
21. The method of any one of claims 11-14 wherein the device comprises a hollow fiber jacket.
22. The method of any one of claims 11-14 wherein the jacket is formed from a thermoplastic or a hydrogel.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/690,969 US6054142A (en) | 1996-08-01 | 1996-08-01 | Biocompatible devices with foam scaffolds |
US08/690,969 | 1996-08-01 | ||
PCT/US1997/013541 WO1998005304A1 (en) | 1996-08-01 | 1997-07-31 | Biocompatible devices with foam scaffolds |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2258483A1 true CA2258483A1 (en) | 1998-02-12 |
CA2258483C CA2258483C (en) | 2009-11-17 |
Family
ID=24774674
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002258483A Expired - Fee Related CA2258483C (en) | 1996-08-01 | 1997-07-31 | Biocompatible devices with foam scaffolds |
Country Status (10)
Country | Link |
---|---|
US (2) | US6054142A (en) |
EP (1) | EP0918509B1 (en) |
JP (1) | JP4212116B2 (en) |
AT (1) | ATE250435T1 (en) |
AU (1) | AU723826B2 (en) |
CA (1) | CA2258483C (en) |
DE (1) | DE69725149T2 (en) |
DK (1) | DK0918509T3 (en) |
ES (1) | ES2208938T3 (en) |
WO (1) | WO1998005304A1 (en) |
Families Citing this family (532)
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