CA2258239A1 - Detection of ligand interaction with polymeric material - Google Patents

Detection of ligand interaction with polymeric material

Info

Publication number
CA2258239A1
CA2258239A1 CA002258239A CA2258239A CA2258239A1 CA 2258239 A1 CA2258239 A1 CA 2258239A1 CA 002258239 A CA002258239 A CA 002258239A CA 2258239 A CA2258239 A CA 2258239A CA 2258239 A1 CA2258239 A1 CA 2258239A1
Authority
CA
Canada
Prior art keywords
protein
arms
strips
sample
dna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002258239A
Other languages
French (fr)
Other versions
CA2258239C (en
Inventor
Victor N. Morozov
Tamara Ya Morozova
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
New York University NYU
Original Assignee
New York University
Victor N. Morozov
Tamara Ya Morozova
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New York University, Victor N. Morozov, Tamara Ya Morozova filed Critical New York University
Publication of CA2258239A1 publication Critical patent/CA2258239A1/en
Application granted granted Critical
Publication of CA2258239C publication Critical patent/CA2258239C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N3/00—Investigating strength properties of solid materials by application of mechanical stress
    • G01N3/02—Details
    • G01N3/04—Chucks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N11/00—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties
    • G01N11/10—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by moving a body within the material
    • G01N11/16—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by moving a body within the material by measuring damping effect upon oscillatory body
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/701—Integrated with dissimilar structures on a common substrate
    • Y10S977/702—Integrated with dissimilar structures on a common substrate having biological material component
    • Y10S977/704—Nucleic acids, e.g. DNA or RNA

Abstract

A method and apparatus for measuring ligand binding to DNA or protein uses changes in the mechanical properties of strips of the DNA or protein to detect the formation of ligand complexes. Samples strips are prepared by pouring protein solution onto a glass surface, drying the solution, and causing the protein to be cross-linked; the cross-linked film is scraped off, cut into strips, and mounted in the stress/strain measuring apparatus, which includes force and strain transducers. The sample is held by arms and can be immersed into solutions. The arms are attached to transducers. The apparatus includes a sample holder. The sample films may include end reinforcements and may be pinned or glued to the arms.
CA002258239A 1996-06-20 1997-06-20 Detection of ligand interaction with polymeric material Expired - Fee Related CA2258239C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2814796P 1996-06-20 1996-06-20
US60/028,147 1996-06-20
PCT/US1997/011328 WO1997048977A2 (en) 1996-06-20 1997-06-20 Detection of ligand interaction with polymeric material

Publications (2)

Publication Number Publication Date
CA2258239A1 true CA2258239A1 (en) 1997-12-24
CA2258239C CA2258239C (en) 2005-09-06

Family

ID=21841841

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002258239A Expired - Fee Related CA2258239C (en) 1996-06-20 1997-06-20 Detection of ligand interaction with polymeric material

Country Status (9)

Country Link
US (1) US6033913A (en)
EP (1) EP0906562B1 (en)
JP (1) JP3784074B2 (en)
AT (1) ATE239905T1 (en)
AU (1) AU741069B2 (en)
CA (1) CA2258239C (en)
DE (1) DE69721765T2 (en)
NZ (1) NZ333413A (en)
WO (1) WO1997048977A2 (en)

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JP4433100B2 (en) * 1997-06-20 2010-03-17 ニューヨーク ユニヴァーシティ Electrostatic spraying of substance solutions in mass production of chips and libraries
EP0919811A1 (en) * 1997-12-01 1999-06-02 Universiteit Maastricht Immunoassay method and kit
US6821738B2 (en) * 1999-01-20 2004-11-23 The Board Of Regents For Oklahoma State University Broad spectrum bio-detection of nerve agents, organophosphates, and other chemical warfare agents
JP4362559B2 (en) * 1999-03-04 2009-11-11 独立行政法人理化学研究所 Capacitive force measuring device
US6393898B1 (en) 2000-05-25 2002-05-28 Symyx Technologies, Inc. High throughput viscometer and method of using same
US6664067B1 (en) 2000-05-26 2003-12-16 Symyx Technologies, Inc. Instrument for high throughput measurement of material physical properties and method of using same
US20020092340A1 (en) * 2000-10-30 2002-07-18 Veeco Instruments Inc. Cantilever array sensor system
US6862398B2 (en) * 2001-03-30 2005-03-01 Texas Instruments Incorporated System for directed molecular interaction in surface plasmon resonance analysis
US6650102B2 (en) 2001-08-24 2003-11-18 Symyx Technologies, Inc. High throughput mechanical property testing of materials libraries using a piezoelectric
US6860148B2 (en) 2001-08-24 2005-03-01 Symyx Technologies, Inc. High throughput fabric handle screening
US6772642B2 (en) 2001-08-24 2004-08-10 Damian A. Hajduk High throughput mechanical property and bulge testing of materials libraries
US6837115B2 (en) 2001-08-24 2005-01-04 Symyx Technologies, Inc. High throughput mechanical rapid serial property testing of materials libraries
US6857309B2 (en) 2001-08-24 2005-02-22 Symyx Technologies, Inc. High throughput mechanical rapid serial property testing of materials libraries
US6769292B2 (en) 2001-08-24 2004-08-03 Symyx Technologies, Inc High throughput rheological testing of materials
US6736017B2 (en) 2001-08-24 2004-05-18 Symyx Technologies, Inc. High throughput mechanical rapid serial property testing of materials libraries
US6690179B2 (en) * 2001-08-24 2004-02-10 Symyx Technologies, Inc. High throughput mechanical property testing of materials libraries using capacitance
US20030055587A1 (en) * 2001-09-17 2003-03-20 Symyx Technologies, Inc. Rapid throughput surface topographical analysis
NL1019121C2 (en) * 2001-10-05 2003-04-08 Datascan Group B V Flat, homogeneous light source.
KR100442822B1 (en) * 2001-10-23 2004-08-02 삼성전자주식회사 Methods for detecting binding of biomolecules using shear stress measurements
US7013709B2 (en) * 2002-01-31 2006-03-21 Symyx Technologies, Inc. High throughput preparation and analysis of plastically shaped material samples
US6881950B2 (en) * 2002-04-12 2005-04-19 University Of South Florida Method for producing a three-dimensional macro-molecular structure
US20030203500A1 (en) * 2002-04-26 2003-10-30 Symyx Technologies, Inc. High throughput testing of fluid samples using an electric field
US20040123650A1 (en) * 2002-09-17 2004-07-01 Symyx Technologies, Inc. High throughput rheological testing of materials
US7112443B2 (en) * 2002-10-18 2006-09-26 Symyx Technologies, Inc. High throughput permeability testing of materials libraries
JP4247554B2 (en) * 2003-07-30 2009-04-02 独立行政法人理化学研究所 Mechanochemical sensor
US7094622B1 (en) 2003-08-27 2006-08-22 Louisiana Tech University Foundation, Inc. Polymer based tunneling sensor
JPWO2005093430A1 (en) * 2004-03-25 2008-02-14 株式会社 フューエンス Method for detecting amyloid structural change of protein, method for searching for substance having activity affecting amyloid structural change, method for searching for therapeutic agent or diagnostic agent for amyloid-related disease
JP2006133164A (en) * 2004-11-09 2006-05-25 Fyuuensu:Kk Method for detecting structural change in calmodulin and method for searching material having activity affecting structural change in calmodulin
US20060246467A1 (en) * 2004-11-15 2006-11-02 California Institute Of Technology Biomarker sensors and method for multi-color imaging and processing of single-molecule life signatures
JP4200147B2 (en) * 2005-06-09 2008-12-24 Ｔｄｋ株式会社 Fine structure, cantilever, scanning probe microscope, and method for measuring deformation of fine structure
WO2007061943A2 (en) * 2005-11-21 2007-05-31 Applera Corporation Portable preparation, analysis, and detection apparatus for nucleic acid processing
US9562921B2 (en) * 2008-03-25 2017-02-07 Ortho-Clinical Diagnostics, Inc. Immunodiagnostic test element having weakened foil layer
RU2485482C2 (en) * 2011-09-13 2013-06-20 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Северо-Кавказский федеральный университет" Method to determine porosity of ceramic and silicate materials using magnetic fluid
KR101611178B1 (en) * 2014-09-17 2016-04-11 한국생산기술연구원 Lens Mounted Tissue Pressure Device
US20200176248A1 (en) * 2018-11-29 2020-06-04 Zyvex Labs, Llc Surface contaminant reduction in controlled environments
DE102020007279B4 (en) 2020-11-28 2022-10-06 Netzsch - Gerätebau Gesellschaft mit beschränkter Haftung Gauge with vibration dampener and method of isolating a gauge from vibration
CN116294958B (en) * 2023-03-10 2023-12-15 香港中文大学（深圳） Flexible strain sensor with fold structure and anisotropy and preparation method thereof
CN116593356B (en) * 2023-06-05 2023-11-17 南京工业大学 Method for detecting viscosity of micro-solution by stirring magnetic nano brush

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Also Published As

Publication number Publication date
AU3584797A (en) 1998-01-07
WO1997048977A3 (en) 1998-05-22
NZ333413A (en) 2000-01-28
ATE239905T1 (en) 2003-05-15
DE69721765D1 (en) 2003-06-12
JP2002503332A (en) 2002-01-29
DE69721765T2 (en) 2004-02-26
US6033913A (en) 2000-03-07
CA2258239C (en) 2005-09-06
EP0906562A2 (en) 1999-04-07
JP3784074B2 (en) 2006-06-07
AU741069B2 (en) 2001-11-22
WO1997048977A2 (en) 1997-12-24
EP0906562B1 (en) 2003-05-07

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