CA2255657A1 - Solution and process for resuscitation and reparation of ischemically damaged tissue - Google Patents

Solution and process for resuscitation and reparation of ischemically damaged tissue

Info

Publication number
CA2255657A1
CA2255657A1 CA002255657A CA2255657A CA2255657A1 CA 2255657 A1 CA2255657 A1 CA 2255657A1 CA 002255657 A CA002255657 A CA 002255657A CA 2255657 A CA2255657 A CA 2255657A CA 2255657 A1 CA2255657 A1 CA 2255657A1
Authority
CA
Canada
Prior art keywords
organ
tissue
solution
function
ischemically damaged
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002255657A
Other languages
French (fr)
Other versions
CA2255657C (en
Inventor
Lauren Brasile
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Breonics Inc
Original Assignee
Breonics, Inc.
Lauren Brasile
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24603829&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2255657(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Breonics, Inc., Lauren Brasile filed Critical Breonics, Inc.
Publication of CA2255657A1 publication Critical patent/CA2255657A1/en
Application granted granted Critical
Publication of CA2255657C publication Critical patent/CA2255657C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0468—Liquids non-physiological
    • A61M2202/0476—Oxygenated solutions

Abstract

The invenetion discloses a process and resus-citation solution for inducing repair of ischemically damaged organs and tissues, to the degree that im-pairment of function can be reversed; and preventing further tissue damage during restoration of the circu-lation of the treated organ or tissue. The process comprises flushing the organ with the resuscitation solution according to the present invention at a warm temperature of about 28 °C to about 37 °C to remove accumulated blood and acidotic products from blood flow deprivation; and perfusing the flushed organ or tissue with the resuscitation solution, wherein the so-lution contains a novel combination of components to provide for (i) dilating of the blood vessels within the organ or tissue, (ii) reestablishing organ or tis-sue function by supplying trophic factors, (iii) restor-ing cellular integrity and function to the ischemically damaged organ or tissue, and (iv) reestablishing ox-idative metabolism by readapting the ischemically damaged organ or tissue, surviving by anaerobic res-piration, to an oxygenated resuscitation solution.
CA002255657A 1996-05-17 1997-05-16 Solution and process for resuscitation and reparation of ischemically damaged tissue Expired - Lifetime CA2255657C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/649,200 US5843024A (en) 1996-05-17 1996-05-17 Solution and process for resuscitation and preparation of ischemically damaged tissue
US649,200 1996-05-17
PCT/US1997/008205 WO1997043899A1 (en) 1996-05-17 1997-05-16 Solution and process for resuscitation and reparation of ischemically damaged tissue

Publications (2)

Publication Number Publication Date
CA2255657A1 true CA2255657A1 (en) 1997-11-27
CA2255657C CA2255657C (en) 2009-09-01

Family

ID=24603829

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002255657A Expired - Lifetime CA2255657C (en) 1996-05-17 1997-05-16 Solution and process for resuscitation and reparation of ischemically damaged tissue

Country Status (12)

Country Link
US (1) US5843024A (en)
EP (1) EP1021084B2 (en)
JP (1) JP4259614B2 (en)
CN (1) CN1163125C (en)
AT (1) ATE374526T1 (en)
AU (1) AU723424B2 (en)
CA (1) CA2255657C (en)
DE (1) DE69738184T2 (en)
ES (1) ES2296310T5 (en)
HK (1) HK1021925A1 (en)
RU (1) RU2199310C2 (en)
WO (1) WO1997043899A1 (en)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060003447A1 (en) * 2003-12-30 2006-01-05 Richard Fike Dry powder cells and cell culture reagents and methods of production thereof
US8409846B2 (en) 1997-09-23 2013-04-02 The United States Of America As Represented By The Department Of Veteran Affairs Compositions, methods and devices for maintaining an organ
US6736790B2 (en) * 1998-02-25 2004-05-18 Denise R. Barbut Method and system for selective or isolated integrate cerebral perfusion and cooling
US8518882B2 (en) * 1998-07-31 2013-08-27 Massachusetts Institute Of Technology Methods and compositions for ameliorating or inhibiting decline in memory or intelligence or improving same
US8314064B2 (en) * 1998-07-31 2012-11-20 Massachusetts Institute Of Technology Uridine administration stimulates membrane production
US20050203053A1 (en) * 1999-07-30 2005-09-15 Wurtman Richard J. Uridine administration improves phosphatide synthesis, synaptic transmission and cogntive function
DK2329829T3 (en) * 1998-07-31 2014-07-21 Massachusetts Inst Technology Utilization of uridine in combination with choline for the treatment of neurological disorders
US8143234B2 (en) 1998-07-31 2012-03-27 Massachusetts Institute Of Technology Uridine administration improves phosphatide synthesis, synaptic transmission and cognitive function
US6977140B1 (en) 1998-09-29 2005-12-20 Organ Recovery Systems, Inc. Method for maintaining and/or restoring viability of organs
US6673594B1 (en) 1998-09-29 2004-01-06 Organ Recovery Systems Apparatus and method for maintaining and/or restoring viability of organs
US7749693B2 (en) 1998-09-29 2010-07-06 Lifeline Scientific, Inc. Method of determining that an organ is not suitable for transplantation and using it for testing substances
EP2308296A3 (en) * 1998-09-29 2011-08-24 Organ Recovery Systems, Inc. System and method for holding an organ
US6485959B1 (en) * 1998-10-07 2002-11-26 Cedars Sinai Medical Center Cell preconditioning and cryopresevation medium
US20040038192A1 (en) * 1999-04-14 2004-02-26 Breonics, Inc. System for exsanguinous metabolic support of an organ or tissue
AU4345400A (en) * 1999-04-14 2000-11-14 Breonics, Inc. System for exsanguinous metabolic support of an organ or tissue
US20070166292A1 (en) * 1999-04-14 2007-07-19 Breonics, Inc. System for exsanguinous metabolic support of an organ or tissue
US6846842B2 (en) * 1999-10-07 2005-01-25 Beth Israel Deconess Medical Center, Inc. Pyruvate ester composition and method of use for resuscitation after events of ischemia and reperfusion
PT1252293E (en) 2000-01-19 2013-01-23 Univ North Carolina Liver tissue source
US6492103B1 (en) 2000-01-31 2002-12-10 Organ Recovery Systems, Inc. System for organ and tissue preservation and hypothermic blood substitution
EP1311154A2 (en) * 2000-08-25 2003-05-21 Organ Recovery Systems, Inc. Methods of thrombolytic organ treatment and repair
AU2002214443B2 (en) * 2000-11-03 2005-12-15 Vitrolife Ab Evaluation and preservation solution
JP2004521615A (en) * 2000-11-06 2004-07-22 インヴィトロジェン コーポレーション Dry powder cells and cell culture reagents and methods of production thereof
AU2002254525B2 (en) * 2001-04-04 2004-12-23 Critical Therapeutics, Inc. Method for preventing acute renal failure
EP2253699A1 (en) * 2001-11-30 2010-11-24 Life Technologies Corporation Dry powder cell culture products containing lipid and methods of production thereof
US20030232884A1 (en) * 2002-04-17 2003-12-18 Critical Therapeutics, Inc. New pharmaceutical formulation
AU2003287444A1 (en) * 2002-10-31 2004-05-25 The General Hospital Corporation Repairing or replacing tissues or organs
US7998725B2 (en) 2003-04-04 2011-08-16 Organ Recovery Systems Method and apparatus for holding a plurality of tubes connectible to an organ or tissue container
WO2004089085A2 (en) 2003-04-04 2004-10-21 Organ Recovery Systems, Inc. Device for separating gas from a liquid path
EP1475434A1 (en) 2003-05-09 2004-11-10 Oncoscience AG Method for storing tumor cells
WO2004103440A1 (en) 2003-05-21 2004-12-02 Jms Co., Ltd. Container for serum production and method of regenerative medicine using the same
US7504201B2 (en) * 2004-04-05 2009-03-17 Organ Recovery Systems Method for perfusing an organ and for isolating cells from the organ
US8304181B2 (en) 2004-10-07 2012-11-06 Transmedics, Inc. Method for ex-vivo organ care and for using lactate as an indication of donor organ status
US9301519B2 (en) 2004-10-07 2016-04-05 Transmedics, Inc. Systems and methods for ex-vivo organ care
CA3178010A1 (en) 2004-10-07 2006-04-20 Transmedics, Inc. Systems and methods for ex-vivo organ care
US20060079479A1 (en) * 2004-10-13 2006-04-13 Italo Biaggioni Methods of inducing vasodilation
EP1809101B1 (en) * 2004-11-12 2016-11-02 Organoflush B.V. Composition for cold preservation and perfusion of organs
US20060160062A1 (en) * 2005-01-14 2006-07-20 Young Lindon H Perfusion and/or preservation solution for organs
US20060204482A1 (en) * 2005-03-14 2006-09-14 Deolden James Methods of islet isolation and transplantation
US9078428B2 (en) 2005-06-28 2015-07-14 Transmedics, Inc. Systems, methods, compositions and solutions for perfusing an organ
US20070169779A1 (en) 2006-01-24 2007-07-26 Freeman Gary A Reperfusion protection in resuscitation
US10071218B2 (en) 2006-01-24 2018-09-11 Zoll Medical Corporation Reperfusion protection in resuscitation
CA2881613C (en) 2006-04-19 2017-11-14 Stanley Kyi Systems and methods for ex vivo organ care
US9457179B2 (en) 2007-03-20 2016-10-04 Transmedics, Inc. Systems for monitoring and applying electrical currents in an organ perfusion system
DE102007038121A1 (en) * 2007-07-31 2009-02-05 Novalung Gmbh Conditioning of a patient's blood by gases
WO2009059306A1 (en) 2007-11-02 2009-05-07 Massachusetts Institute Of Technology Uridine dietary supplementation compliance methods and use thereof
US8420380B2 (en) 2008-01-31 2013-04-16 Transmedics, Inc. Systems and methods for ex vivo lung care
JP5562939B2 (en) * 2008-04-09 2014-07-30 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル Actin cytoskeletal rearrangement and method of regulation of intercellular gap formation
CA2770565A1 (en) * 2009-08-10 2011-02-17 P2-Science Aps Utp for the diagnosis of stenoses and other conditions of restricted blood flow
US9320269B2 (en) 2009-09-25 2016-04-26 John Brassil Organ preservation system
DE102009045589A1 (en) 2009-10-12 2011-04-14 Universitätsklinikum Freiburg Apparatus for treating an individual with cardiac output, cardiac arrest or stroke
CA2805717C (en) 2010-07-16 2019-04-16 Michael J. Taylor Methods for increasing isolation yields of cellular products
CN103429733B (en) 2010-10-22 2015-11-25 细胞与组织系统股份有限公司 The pancreas islet cultivated
WO2012078968A2 (en) 2010-12-10 2012-06-14 Lifeline Scientific, Inc. Machine perfusion with complement inhibitors
US8835158B2 (en) 2011-03-15 2014-09-16 Paragonix Technologics, Inc. Apparatus for oxygenation and perfusion of tissue for organ preservation
US11178866B2 (en) 2011-03-15 2021-11-23 Paragonix Technologies, Inc. System for hypothermic transport of samples
US9426979B2 (en) 2011-03-15 2016-08-30 Paragonix Technologies, Inc. Apparatus for oxygenation and perfusion of tissue for organ preservation
US9253976B2 (en) 2011-03-15 2016-02-09 Paragonix Technologies, Inc. Methods and devices for preserving tissues
US8828710B2 (en) 2011-03-15 2014-09-09 Paragonix Technologies, Inc. System for hypothermic transport of samples
US9867368B2 (en) 2011-03-15 2018-01-16 Paragonix Technologies, Inc. System for hypothermic transport of samples
EP2704560B1 (en) 2011-04-14 2022-04-06 Transmedics, Inc. Organ care solution for ex-vivo machine perfusion of donor lungs
WO2012170633A1 (en) 2011-06-09 2012-12-13 Lifeline Scientific, Inc. Data record for organ transport and/or storage, comprising biomarker and events information
US20120330438A1 (en) 2011-06-22 2012-12-27 Shaf Keshavjee Repaired organ and method for making the same
US9560846B2 (en) 2012-08-10 2017-02-07 Paragonix Technologies, Inc. System for hypothermic transport of biological samples
US8785116B2 (en) 2012-08-10 2014-07-22 Paragonix Technologies, Inc. Methods for evaluating the suitability of an organ for transplant
JP6336392B2 (en) * 2012-09-08 2018-06-06 株式会社オーガンテクノロジーズ Long-term maintenance method of organ or tissue for transplantation
US10420337B2 (en) 2013-03-15 2019-09-24 Lifeline Scientific, Inc. Transporter with a glucose sensor for determining viability of an organ or tissue
US20140278468A1 (en) 2013-03-15 2014-09-18 I.D. Therapeutics Llc Apparatus and method for optimizing treatment using medication compliance patterns and glucose sensor
DK3151663T3 (en) 2014-06-02 2020-11-30 Transmedics Inc EX VIVO ORGAN CARE SYSTEM
US9994811B2 (en) 2014-10-09 2018-06-12 Lauren Brasile Reducing the immunogenicity of allografts
GB201511207D0 (en) * 2015-06-25 2015-08-12 Xvivo Perfusion Ab Isolated organ evaluation and treatment
CN107949419B (en) 2015-09-09 2021-03-05 特兰斯迈迪茨公司 Aorta cannula for isolated organ care system
CN105918308A (en) * 2016-04-28 2016-09-07 上海市胸科医院 Lung perfusion fluid for perfusing transplant donor lung and preparation method for lung perfusion fluid
US10091986B2 (en) 2016-05-09 2018-10-09 Xor-Labs Toronto Inc. Organ perfusion device and method
WO2018226993A1 (en) 2017-06-07 2018-12-13 Paragonix Technologies, Inc. Apparatus for tissue transport and preservation
JP2020002062A (en) * 2018-06-28 2020-01-09 株式会社Ｓｃｒｅｅｎホールディングス Perfusion device and perfusion method
US11632951B2 (en) 2020-01-31 2023-04-25 Paragonix Technologies, Inc. Apparatus for tissue transport and preservation
WO2022233642A1 (en) * 2021-05-06 2022-11-10 Xvivo Perfusion Ab Methods for removing leucocytes from isolated organs

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5331209B2 (en) 1973-10-05 1978-09-01
US4110474A (en) 1977-08-26 1978-08-29 Suntech, Inc. Tetramethylpentane blood substitutes
US4187252A (en) 1977-08-26 1980-02-05 Suntech, Inc. Tetramethylpentane blood substitutes
US4186253A (en) 1978-10-10 1980-01-29 The Green Cross Corporation Perfusate for preserving organ to be transplanted and preserving method
US4252827A (en) 1979-05-23 1981-02-24 The Green Cross Corporation Oxygen-transferable fluorocarbon emulsion
US4686085A (en) * 1980-04-14 1987-08-11 Thomas Jefferson University Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US5085630A (en) * 1980-04-14 1992-02-04 Thomas Jefferson University Oxygenated fluorocarbon nutrient solution
US4443480A (en) 1982-04-12 1984-04-17 Children's Hospital Medical Center Artificial blood and other gas transport agents
US4423077A (en) 1982-07-27 1983-12-27 The University Of Pennsylvania Perfluorochemical emulsion artificial blood
US4534978A (en) 1982-12-28 1985-08-13 The Green Cross Corporation Perfluorocycloamines
US4686024A (en) 1985-02-01 1987-08-11 The Green Cross Corporation Novel perfluoro chemicals and polyfluorinated compounds and process for production of the same
US4868318A (en) 1985-02-01 1989-09-19 The Green Cross Corporation Perfluoro chemicals and polyfluorinated compounds
US4865836A (en) 1986-01-14 1989-09-12 Fluoromed Pharmaceutical, Inc. Brominated perfluorocarbon emulsions for internal animal use for contrast enhancement and oxygen transport
US4866096A (en) 1987-03-20 1989-09-12 Air Products And Chemicals, Inc. Stable fluorochemical aqueous emulsions
US5130230A (en) * 1988-05-02 1992-07-14 Cryomedical Sciences, Inc. Blood substitute
US5011469A (en) * 1988-08-29 1991-04-30 Shiley, Inc. Peripheral cardiopulmonary bypass and coronary reperfusion system
US5395314A (en) * 1990-10-10 1995-03-07 Life Resuscitation Technologies, Inc. Brain resuscitation and organ preservation device and method for performing the same
US5584804A (en) * 1990-10-10 1996-12-17 Life Resuscitation Technologies, Inc. Brain resuscitation and organ preservation device and method for performing the same
US5137510A (en) * 1990-12-14 1992-08-11 Mallinckrodt Medical, Inc. System and method for oxygenation of the heart using subpericardial fluids
US5290766A (en) * 1991-02-18 1994-03-01 The National Heart Foundation Of New Zealand Cardioplegic compositions
CA2066374C (en) * 1991-04-19 2002-01-29 Paul E. Segall Solution for perfusing primates
US5409688A (en) 1991-09-17 1995-04-25 Sonus Pharmaceuticals, Inc. Gaseous ultrasound contrast media
US5403575A (en) 1991-12-12 1995-04-04 Hemagen/Pfc Highly fluorinated, chloro-substituted organic compound-containing emulsions and methods of using them
US5552267A (en) * 1992-04-03 1996-09-03 The Trustees Of Columbia University In The City Of New York Solution for prolonged organ preservation
US5370989A (en) * 1992-04-03 1994-12-06 The Trustees Of Columbia University In The City Of New York Solution for prolonged organ preservation
US5362622A (en) * 1993-03-11 1994-11-08 Board Of Regents, The University Of Texas System Combined perfusion and oxygenation apparatus
WO1994021116A1 (en) * 1993-03-16 1994-09-29 Alliance Pharmaceutical Corp. Preservation solution and method for warm organ preservation
US5405742A (en) * 1993-07-16 1995-04-11 Cyromedical Sciences, Inc. Solutions for tissue preservation and bloodless surgery and methods using same
AU2595195A (en) * 1994-05-20 1995-12-18 Vec Tec, Inc. Method and apparatus monitoring viability of transplantable organs

Also Published As

Publication number Publication date
DE69738184T2 (en) 2008-07-24
EP1021084A4 (en) 2004-10-13
AU723424B2 (en) 2000-08-24
AU3067197A (en) 1997-12-09
DE69738184D1 (en) 2007-11-15
EP1021084B2 (en) 2016-03-09
RU2199310C2 (en) 2003-02-27
EP1021084B9 (en) 2008-02-27
JP2000511531A (en) 2000-09-05
HK1021925A1 (en) 2000-07-21
ES2296310T3 (en) 2008-04-16
ES2296310T5 (en) 2016-06-24
WO1997043899A1 (en) 1997-11-27
EP1021084B1 (en) 2007-10-03
CN1226132A (en) 1999-08-18
ATE374526T1 (en) 2007-10-15
JP4259614B2 (en) 2009-04-30
US5843024A (en) 1998-12-01
EP1021084A1 (en) 2000-07-26
CA2255657C (en) 2009-09-01
CN1163125C (en) 2004-08-25

Similar Documents

Publication Publication Date Title
CA2255657A1 (en) Solution and process for resuscitation and reparation of ischemically damaged tissue
AU669833B2 (en) Inhibition of restenosis by ultraviolet radiation
ATE235813T1 (en) METHOD FOR PREPARING ORGANS FOR CRYOPRESERVATION
WO2002039906A3 (en) Method and device for the treatment of vulnerable tissue site
ATE188622T1 (en) A BLADDER CATHETER SET WITH A READY-TO-USE CATHETER
BRPI0418326A (en) tissue regeneration method
EP1637037A3 (en) Method for processing and preserving collagen-based tissues for transplantation
WO2003085092A3 (en) Cellular transplantation for heart regeneration
CA2044143A1 (en) Method of preventing or limiting reperfusion damage
Schimert et al. Free internal mammary artery graft: an improved surgical technique
Menasche et al. Cardioplegia by way of the coronary sinus for valvular and coronary surgery
AU2002222913A1 (en) Cardiac support device and method
AU4124089A (en) Use of ACE-inhibitor for suppressing the formation of neointima and the reduction of the vascular lumen by vascular wall thickening after vascular damage
Zund et al. Improved exposure of the pulmonary arteries for thromboendarterectomy
Piwnica et al. Rupture of the right ventricular free wall
Goldberg et al. Does transjugular intrahepatic portosystemic shunting facilitate or complicate liver transplantation?
CA2089336A1 (en) Method for processing and preserving collagen-based tissues for transplantation
Skinner et al. Preservation and transplantation of dog organs maintained in vivo for 24 hours by mechanical ventricular assistance
WO2002007785A3 (en) Implantable biocompatible animal tissue
Misumi et al. Acute aortic dissection involving an aberrant right subclavian artery
RU2231378C1 (en) Method for treating hydrocele
Dresdale et al. Technical considerations in aortocoronary bypass grafting
Heiner et al. The effect of inadequate venous or arterial blood supply on the survival of abdominal islands flaps in rats
SU1147364A1 (en) Method of transplantation of pancreas
Macfarlane Peripheral arterial reconstruction

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20170516