CA2253963A1 - Targeted hysteresis hyperthermia as a method for treating diseased tissue - Google Patents

Targeted hysteresis hyperthermia as a method for treating diseased tissue Download PDF

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Publication number
CA2253963A1
CA2253963A1 CA002253963A CA2253963A CA2253963A1 CA 2253963 A1 CA2253963 A1 CA 2253963A1 CA 002253963 A CA002253963 A CA 002253963A CA 2253963 A CA2253963 A CA 2253963A CA 2253963 A1 CA2253963 A1 CA 2253963A1
Authority
CA
Canada
Prior art keywords
diseased tissue
microcapsules
magnetic material
magnetic
magnetic field
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002253963A
Other languages
French (fr)
Inventor
Bruce Nathaniel Gray
Stephen Keith Jones
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sirtex Medical Pty Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=3794095&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2253963(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of CA2253963A1 publication Critical patent/CA2253963A1/en
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/02—Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5094—Microcapsules containing magnetic carrier material, e.g. ferrite for drug targeting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0052—Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
    • A61N1/403—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals for thermotherapy, e.g. hyperthermia
    • A61N1/406—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals for thermotherapy, e.g. hyperthermia using implantable thermoseeds or injected particles for localized hyperthermia

Abstract

A method for site specific treatment of diseased tissue in a patient, comprising the steps of: (i) selecting at least a magnetic material which has a magnetic heating efficiency of at least about 4.5 x 10-8 J.m./A.g, when magnetic field conditions are equal to or less than about 7.5 x 107 A/s; (ii) delivering the magnetic material to diseased tissue in a patient; and (iii) exposing the magnetic material in the patient to a linear alternating magnetic field with a frequency of greater than about 10 kHz and a field strength such that the product of field strength, frequency and the radius of the exposed region is less than about 7.5 x 107 A/s to generate hysteresis heat in the diseased tissue.

Description

CA 022~3963 1998-11-09 TARGETED HYSTERESIS HYPERTHER

Claims (35)

The CLAIMS defining the invention are as follows:
1. A method for site specific treatment of diseased tissue in a patient, comprising the steps of:
(i) selecting at least a magnetic material which has a magnetic heating efficiency of at least about 4.5 x 10-8 J.m./A.g, when magnetic field conditions are equal to or less than about 7.5 x 10 7 A/s;
(ii) delivering the magnetic material to diseased tissue in a patient; and (iii) exposing the magnetic material in the patient to a linear alternating magnetic field with a frequency of greater than about 10kHz and a field strength such that the product of field strength, frequency and the radius of the exposed region is less than about 7.5 x 10 7 A/s to generate hysteresis heat in the diseased tissue.
2. A method according to claim 1 wherein steps (i) to (iii) are repeated until the diseased tissue has at least been treated sufficiently to ameliorate the disease.
3. A method according to claim 2 wherein the diseased tissue contains at least a cancerous growth or contains one or more tumours.
4. A method according to claim 1 wherein the selected magnetic material has a MHE of greater than about 7 x 10-6 J.m./A.g, when magnetic field conditions are equal to or less than about 7.5 x 10 7 A/s.
5. A method according to claim 1 wherein the selected magnetic material has a MHE of greater than about 1 x 10-7 J.m./A.g, when magnetic field conditions are equal to or less than about 7.5 x 10 7 A/s.
6. A method according to claim 1 wherein the magnetic material is a ferromagnetic material which contains at least an element selected from the group consisting of iron, manganese, arsenic, antimony and bismith.
7. A method according to claim 1 wherein the magnetic material is selected from compounds within the group of CrO2, metallic iron, cobalt, nickel, gamma-ferric oxide, cobalt treated gamma-ferric oxide, ferrites of general form MO.Fe2O3 where M is a bivalent metal, cobalt treated ferrites, or magnetoplumbite type oxides (M type) with general form MO.6Fe2O3 where M is a large divalent ion.
8. A method according to claim 7 wherein the magnetic material is a compound within the group of cobalt treated gamma-ferric oxide compounds.
9. A method according to claim 7 wherein the magnetic material is a compound within the group of un-modified gamma-ferric oxide compounds.
10. A method according to claim 7 wherein the magnetic material is a compound within the group of chromium dioxide compounds.
11. A method according to claim 1 wherein the magnetic material used is mixed in a biocompatible liquid emulsion prior to delivery into a patient.
12. A method according to claim 1 wherein the magnetic material used is bound in a matrix to form microcapsules.
13. A method according to claim 12 wherein the microcapsules range in size betweeen about 10 to 100 microns.
14. A method according to claim 13 wherein the microcapsules range in size between about 20 to 50 microns.
15. A method according to claim 14 wherein the microcapsules range in size between about 30 to 40 microns.
16. A method according to claim 12 wherein the microcapsules are adapted to bind, absorb or contain a cytotoxic material which is released upon heating of the microcapsule.
17. A method according to claim 12 wherein an ionizing radiation is applied to the locus of the diseased tissue in conjunction with the magnetic field.
18. A method according to claim 17 wherein the radiation is delivered by microcapsules which contain a radioactive compound.
19. A method according to claim 1 wherein the rate of tumour tissue heating is greater than 60 mW/cm3.
20. A method according to claim 19 wherein the rate of tumour tissue heating is is greater than 80 mW/cm3
21. A method according to claim 19 wherein the rate of tumour tissue heating is is greater than 100 mW/cm3.
22. A method according to claim 1 wherein the linear alternating magnetic field has an operational frequency of between about 10 kHz to 100 MHz.
23. A method according to claim 1 wherein the linear alternating magnetic field has an operational frequency of between about 10 kHz to 500 kHz.
24. A method according to claim 1 wherein the linear alternating magnetic field has an operational frequency of between about 10 kHz to 100 kHz
25. A method according to claim 1 wherein the magnetic field has an operational frequency of 20 kHz.
26. A method according to claim 12 wherein the microcapsules are of a suitable size to pass through a patient's vasculature network and become dispersed and embolised within diseased tissue
27. A method according to claim 12 wherein the microcapsules range in density between 1 to 5 g/cm3.
28. A method according to claim 12 wherein the microcapsules range in density between 1.8 to 3 g/cm3.
29. A method according to claim 12 wherein the microcapsules range in density between 1.8 to 2.2 g/cm3.
30. A method according to claim 12 wherein the microcapsules have a density of about 2 g/cm3.
31. A method according to claim 1 wherein the magnetic materials are bound together using a copolymer of (R)-3-hydroxybutyric acid and (R)-3-hydroxyvaleric acid.
32. A method according to claim 1 wherein the microcapsules are bound together using a copolymer of (R)-3-hydroxybutyric acid and (R)-3-hydroxyvaleric acid, have a density range of 1.8-2.2g/cm3 and range in size between 20-50 microns.
33. A method according to claim 1 wherein the magnetic materials are delivered to the diseased tissue by anyone of the administration methods selected from the group consisting of: intratumoral, peritumoral or intravascular administrations.
34. A method according to claim 1 wherein the magnetic materials are delivered to the diseased tissue by the arterial or venous blood supply.
35. A method according to claim 1 wherein the magnetic materials are delivered to the diseased tissue in combinantion with at least a vasoactive agent.
CA002253963A 1996-05-10 1997-05-09 Targeted hysteresis hyperthermia as a method for treating diseased tissue Abandoned CA2253963A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AUPN9782 1996-05-10
AUPN9782A AUPN978296A0 (en) 1996-05-10 1996-05-10 Targeted hysteresis hyperthermia as a method for treating cancer
PCT/AU1997/000287 WO1997043005A1 (en) 1996-05-10 1997-05-09 Targeted hysteresis hyperthermia as a method for treating diseased tissue

Publications (1)

Publication Number Publication Date
CA2253963A1 true CA2253963A1 (en) 1997-11-20

Family

ID=3794095

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002253963A Abandoned CA2253963A1 (en) 1996-05-10 1997-05-09 Targeted hysteresis hyperthermia as a method for treating diseased tissue

Country Status (11)

Country Link
US (2) US6167313A (en)
EP (1) EP0952873B1 (en)
JP (1) JP2000503879A (en)
KR (1) KR20000034772A (en)
CN (1) CN1218415A (en)
AT (1) ATE320283T1 (en)
AU (1) AUPN978296A0 (en)
CA (1) CA2253963A1 (en)
DE (1) DE69735481T2 (en)
ES (1) ES2260789T3 (en)
WO (1) WO1997043005A1 (en)

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Also Published As

Publication number Publication date
KR20000034772A (en) 2000-06-26
AUPN978296A0 (en) 1996-05-30
ATE320283T1 (en) 2006-04-15
US6167313A (en) 2000-12-26
EP0952873B1 (en) 2006-03-15
EP0952873A1 (en) 1999-11-03
EP0952873A4 (en) 2000-11-02
DE69735481T2 (en) 2006-10-12
CN1218415A (en) 1999-06-02
JP2000503879A (en) 2000-04-04
DE69735481D1 (en) 2006-05-11
WO1997043005A1 (en) 1997-11-20
ES2260789T3 (en) 2006-11-01
US6565887B1 (en) 2003-05-20

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