CA2253948A1 - Carboline derivatives - Google Patents

Carboline derivatives

Info

Publication number
CA2253948A1
CA2253948A1 CA002253948A CA2253948A CA2253948A1 CA 2253948 A1 CA2253948 A1 CA 2253948A1 CA 002253948 A CA002253948 A CA 002253948A CA 2253948 A CA2253948 A CA 2253948A CA 2253948 A1 CA2253948 A1 CA 2253948A1
Authority
CA
Canada
Prior art keywords
carboline derivatives
potent
thought
inhibition
variety
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002253948A
Other languages
French (fr)
Other versions
CA2253948C (en
Inventor
Agnes Bombrun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Icos Corp
Original Assignee
Icos Corporation
Agnes Bombrun
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9609777.9A external-priority patent/GB9609777D0/en
Priority claimed from GBGB9609820.7A external-priority patent/GB9609820D0/en
Application filed by Icos Corporation, Agnes Bombrun filed Critical Icos Corporation
Publication of CA2253948A1 publication Critical patent/CA2253948A1/en
Application granted granted Critical
Publication of CA2253948C publication Critical patent/CA2253948C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

Carboline derivatives of formula (I), are potent and selective inhibitors of cyclic guanosine 3',5'-monophosphate specific phosphodiesterase (cGMP specific PDE) and have utility in a variety of therapeutic areas where such inhibition is thought to be beneficial, including the treatment of cardiovascular disorders.
CA002253948A 1996-05-10 1997-05-05 Carboline derivatives Expired - Fee Related CA2253948C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9609777.9A GB9609777D0 (en) 1996-05-10 1996-05-10 Chemical compounds
GBGB9609820.7A GB9609820D0 (en) 1996-05-10 1996-05-10 Chemical compounds
GB9609777.9 1996-05-10
GB9609820.7 1996-05-10
PCT/EP1997/002277 WO1997043287A1 (en) 1996-05-10 1997-05-05 Carboline derivatives

Publications (2)

Publication Number Publication Date
CA2253948A1 true CA2253948A1 (en) 1997-11-20
CA2253948C CA2253948C (en) 2005-07-26

Family

ID=26309303

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002253948A Expired - Fee Related CA2253948C (en) 1996-05-10 1997-05-05 Carboline derivatives

Country Status (26)

Country Link
US (2) US6117881A (en)
EP (1) EP0912567B1 (en)
JP (1) JP3418405B2 (en)
KR (1) KR20000010918A (en)
CN (1) CN1067071C (en)
AP (1) AP9801365A0 (en)
AT (1) ATE215950T1 (en)
AU (1) AU711885B2 (en)
BG (1) BG102879A (en)
BR (1) BR9709230A (en)
CA (1) CA2253948C (en)
CZ (1) CZ358598A3 (en)
DE (1) DE69711882T2 (en)
EA (1) EA199800907A1 (en)
EE (1) EE9800390A (en)
ES (1) ES2175404T3 (en)
HU (1) HUP9901478A3 (en)
IL (1) IL126951A0 (en)
IS (1) IS4864A (en)
NO (1) NO985222L (en)
OA (1) OA10920A (en)
PL (1) PL329875A1 (en)
SK (1) SK154498A3 (en)
TR (1) TR199802282T2 (en)
WO (1) WO1997043287A1 (en)
YU (1) YU49898A (en)

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US7022856B2 (en) 2001-02-12 2006-04-04 Lilly Icos Llc. Carboline derivatives
ES2272695T3 (en) * 2001-02-12 2007-05-01 Lilly Icos Llc CARBOLINE DERIVATIVES.
DE60216745T2 (en) * 2001-04-25 2007-05-16 Lilly Icos Llc, Wilmington Chemical compounds
WO2002098875A1 (en) * 2001-06-05 2002-12-12 Lilly Icos Llc Carboline derivatives as pde-5 inhibitors
MXPA03011167A (en) * 2001-06-21 2004-02-26 Lilly Icos Llc Carboline derivatives as pdev inhibitors.
EP1442042A1 (en) 2001-11-09 2004-08-04 Schering Corporation Polycyclic guanine derivative phosphodiesterase v inhibitors
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US7595311B2 (en) 2002-05-24 2009-09-29 Exelixis, Inc. Azepinoindole derivatives as pharmaceutical agents
TWI329111B (en) 2002-05-24 2010-08-21 X Ceptor Therapeutics Inc Azepinoindole and pyridoindole derivatives as pharmaceutical agents
PT1644021E (en) * 2003-06-13 2013-01-30 Ironwood Pharmaceuticals Inc Methods and compositions for the treatment of gastrointestinal disorders
ES2427166T3 (en) * 2003-06-23 2013-10-29 Ono Pharmaceutical Co., Ltd. Novel tricyclic heterocyclic compound
US8076353B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Inhibition of VEGF translation
US8076352B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Administration of carboline derivatives useful in the treatment of cancer and other diseases
US7767689B2 (en) 2004-03-15 2010-08-03 Ptc Therapeutics, Inc. Carboline derivatives useful in the treatment of cancer
DK1737461T3 (en) 2004-03-15 2013-03-18 Ptc Therapeutics Inc CARBOLIN DERIVATIVES FOR INHIBITING ANGIOGENESES
ZA200609845B (en) * 2004-05-26 2010-02-24 Eisai R&D Man Co Ltd Cinnamide compound
AU2005247746B2 (en) 2004-05-26 2010-11-11 Eisai R&D Management Co., Ltd. Cinnamide compound
CA2580119A1 (en) 2004-10-26 2006-05-04 Eisai R & D Management Co., Ltd. Amorphous object of cinnamide compound
US7964726B2 (en) 2004-12-22 2011-06-21 Ono Pharmaceutical Co., Ltd. Tricyclic compound and use thereof
US8506934B2 (en) 2005-04-29 2013-08-13 Robert I. Henkin Methods for detection of biological substances
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
US7678363B2 (en) 2005-08-26 2010-03-16 Braincells Inc Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs
JP2009512711A (en) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Regulation of neurogenesis by PDE inhibition
AU2006308889A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. GABA receptor mediated modulation of neurogenesis
NZ568694A (en) 2005-11-09 2011-09-30 Zalicus Inc Method, compositions, and kits for the treatment of medical conditions
KR20080076907A (en) * 2005-11-18 2008-08-20 에자이 알앤드디 매니지먼트 가부시키가이샤 Process for production of cinnamamide derivative
US20090048448A1 (en) * 2005-11-18 2009-02-19 Ikuo Kushida Salts of cynnamide compound or solvates thereof
US20070117839A1 (en) * 2005-11-24 2007-05-24 Eisai R&D Management Co., Ltd. Two cyclic cinnamide compound
TWI370130B (en) 2005-11-24 2012-08-11 Eisai R&D Man Co Ltd Two cyclic cinnamide compound
WO2007060810A1 (en) 2005-11-24 2007-05-31 Eisai R & D Management Co., Ltd. Morpholine type cinnamide compound
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
TWI378091B (en) 2006-03-09 2012-12-01 Eisai R&D Man Co Ltd Multi-cyclic cinnamide derivatives
EP2026813A2 (en) 2006-05-09 2009-02-25 Braincells, Inc. 5 ht receptor mediated neurogenesis
EP2377531A2 (en) 2006-05-09 2011-10-19 Braincells, Inc. Neurogenesis by modulating angiotensin
AR062095A1 (en) 2006-07-28 2008-10-15 Eisai R&D Man Co Ltd CINAMIDE COMPOUND PROFARMACO
AU2007292848A1 (en) 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
US8293489B2 (en) 2007-01-31 2012-10-23 Henkin Robert I Methods for detection of biological substances
CL2008000582A1 (en) 2007-02-28 2008-06-27 Eisai R&D Man Co Ltd CYCLE COMPOUNDS DERIVED FROM CONDENSED OXIMORPHOLINE; PHARMACES THAT INCLUDE SUCH COMPOUNDS; AND ITS USE TO TREAT ALZHEIMER'S DISEASE, SENILE DEMENTIA, DOWN SYNDROME OR AMYLOIDOSIS.
US20080306272A1 (en) * 2007-05-16 2008-12-11 Eisai R&D Management Co., Ltd. One-pot methods for preparing cinnamide derivatives
US7935815B2 (en) * 2007-08-31 2011-05-03 Eisai R&D Management Co., Ltd. Imidazoyl pyridine compounds and salts thereof
KR20100055456A (en) 2007-08-31 2010-05-26 에자이 알앤드디 매니지먼트 가부시키가이샤 Polycyclic compound
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US20150119399A1 (en) 2012-01-10 2015-04-30 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
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EP3352566A4 (en) 2015-09-23 2019-07-31 Minerva Biotechnologies Corporation Method of screening for agents for differentiating stem cells

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Also Published As

Publication number Publication date
CA2253948C (en) 2005-07-26
AU2891097A (en) 1997-12-05
DE69711882T2 (en) 2002-10-31
SK154498A3 (en) 2000-01-18
CZ358598A3 (en) 1999-03-17
JP2000513717A (en) 2000-10-17
WO1997043287A1 (en) 1997-11-20
CN1218471A (en) 1999-06-02
IL126951A0 (en) 1999-09-22
KR20000010918A (en) 2000-02-25
DE69711882D1 (en) 2002-05-16
NO985222D0 (en) 1998-11-09
JP3418405B2 (en) 2003-06-23
IS4864A (en) 1998-10-13
AU711885B2 (en) 1999-10-21
EP0912567B1 (en) 2002-04-10
CN1067071C (en) 2001-06-13
HUP9901478A2 (en) 1999-08-30
ES2175404T3 (en) 2002-11-16
EA199800907A1 (en) 1999-04-29
PL329875A1 (en) 1999-04-12
US6306870B1 (en) 2001-10-23
AP9801365A0 (en) 1998-12-31
YU49898A (en) 2000-03-21
BG102879A (en) 1999-09-30
NO985222L (en) 1999-01-11
US6117881A (en) 2000-09-12
OA10920A (en) 2003-02-21
EE9800390A (en) 1999-06-15
TR199802282T2 (en) 1999-03-22
BR9709230A (en) 1999-08-10
EP0912567A1 (en) 1999-05-06
ATE215950T1 (en) 2002-04-15
HUP9901478A3 (en) 1999-11-29

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