CA2251816A1 - Sustained release heterodisperse hydrogel systems - amorphous drugs - Google Patents
Sustained release heterodisperse hydrogel systems - amorphous drugsInfo
- Publication number
- CA2251816A1 CA2251816A1 CA002251816A CA2251816A CA2251816A1 CA 2251816 A1 CA2251816 A1 CA 2251816A1 CA 002251816 A CA002251816 A CA 002251816A CA 2251816 A CA2251816 A CA 2251816A CA 2251816 A1 CA2251816 A1 CA 2251816A1
- Authority
- CA
- Canada
- Prior art keywords
- sustained release
- hydrogel systems
- amorphous drugs
- dosage forms
- solid dosage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
- C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
- C08J3/075—Macromolecular gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dispersion Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Sustained release oral solid dosage forms comprising agglomerated particles of a therapeutically active medicament in amorphous form, a gelling agent, an ionizable gel strength enhancing agent and an inert diluent, as well as processes for preparing and using the same are disclosed. The sustained release oral solid dosage forms are useful in the treatment of hypertension in human patients.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002461157A CA2461157C (en) | 1996-04-18 | 1997-04-18 | Sustained release heterodisperse hydrogel systems - amorphous drugs |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/634,295 | 1996-04-18 | ||
US08/634,295 US5773025A (en) | 1993-09-09 | 1996-04-18 | Sustained release heterodisperse hydrogel systems--amorphous drugs |
PCT/US1997/006816 WO1997039050A1 (en) | 1996-04-18 | 1997-04-18 | Sustained release heterodisperse hydrogel systems - amorphous drugs |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002461157A Division CA2461157C (en) | 1996-04-18 | 1997-04-18 | Sustained release heterodisperse hydrogel systems - amorphous drugs |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2251816A1 true CA2251816A1 (en) | 1997-10-23 |
CA2251816C CA2251816C (en) | 2004-07-06 |
Family
ID=24543216
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002251816A Expired - Fee Related CA2251816C (en) | 1996-04-18 | 1997-04-18 | Sustained release heterodisperse hydrogel systems - amorphous drugs |
Country Status (9)
Country | Link |
---|---|
US (5) | US5773025A (en) |
EP (1) | EP0912627A4 (en) |
JP (1) | JPH11507958A (en) |
KR (1) | KR100384215B1 (en) |
AU (1) | AU739114B2 (en) |
CA (1) | CA2251816C (en) |
IL (1) | IL126595A (en) |
NZ (1) | NZ332299A (en) |
WO (1) | WO1997039050A1 (en) |
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-
1996
- 1996-04-18 US US08/634,295 patent/US5773025A/en not_active Expired - Lifetime
-
1997
- 1997-04-18 CA CA002251816A patent/CA2251816C/en not_active Expired - Fee Related
- 1997-04-18 WO PCT/US1997/006816 patent/WO1997039050A1/en not_active Application Discontinuation
- 1997-04-18 JP JP9537444A patent/JPH11507958A/en active Pending
- 1997-04-18 KR KR10-1998-0708354A patent/KR100384215B1/en not_active IP Right Cessation
- 1997-04-18 AU AU26805/97A patent/AU739114B2/en not_active Ceased
- 1997-04-18 NZ NZ332299A patent/NZ332299A/en not_active IP Right Cessation
- 1997-04-18 EP EP97918790A patent/EP0912627A4/en not_active Ceased
- 1997-04-18 IL IL12659597A patent/IL126595A/en not_active IP Right Cessation
-
1998
- 1998-06-29 US US09/106,438 patent/US6048548A/en not_active Expired - Lifetime
-
2000
- 2000-02-04 US US09/498,448 patent/US6245356B1/en not_active Expired - Lifetime
-
2001
- 2001-06-12 US US09/879,296 patent/US6709677B2/en not_active Expired - Fee Related
-
2004
- 2004-01-27 US US10/766,688 patent/US20040241233A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JPH11507958A (en) | 1999-07-13 |
US6245356B1 (en) | 2001-06-12 |
US20010046516A1 (en) | 2001-11-29 |
CA2251816C (en) | 2004-07-06 |
US6709677B2 (en) | 2004-03-23 |
KR100384215B1 (en) | 2003-08-30 |
US20040241233A1 (en) | 2004-12-02 |
AU2680597A (en) | 1997-11-07 |
WO1997039050A1 (en) | 1997-10-23 |
US6048548A (en) | 2000-04-11 |
IL126595A0 (en) | 1999-08-17 |
EP0912627A1 (en) | 1999-05-06 |
IL126595A (en) | 2001-12-23 |
US5773025A (en) | 1998-06-30 |
AU739114B2 (en) | 2001-10-04 |
KR20000005554A (en) | 2000-01-25 |
NZ332299A (en) | 2001-01-26 |
EP0912627A4 (en) | 2006-04-12 |
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