CA2250118A1 - Method enabling use of extracellular rna extracted from plasma or serum to detect, monitor or evaluate cancer - Google Patents

Method enabling use of extracellular rna extracted from plasma or serum to detect, monitor or evaluate cancer

Info

Publication number
CA2250118A1
CA2250118A1 CA002250118A CA2250118A CA2250118A1 CA 2250118 A1 CA2250118 A1 CA 2250118A1 CA 002250118 A CA002250118 A CA 002250118A CA 2250118 A CA2250118 A CA 2250118A CA 2250118 A1 CA2250118 A1 CA 2250118A1
Authority
CA
Canada
Prior art keywords
rna
plasma
serum
complexes
circulating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002250118A
Other languages
French (fr)
Other versions
CA2250118C (en
Inventor
Michael S. Kopreski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21767359&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2250118(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of CA2250118A1 publication Critical patent/CA2250118A1/en
Application granted granted Critical
Publication of CA2250118C publication Critical patent/CA2250118C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Abstract

This invention relates to the use of tumor-derived or associated extracellular ribonucleic acid (RNA) found circulating in the plasma or serum fraction of blood for the detection, monitoring, or evaluation of cancer or premalignant conditions. Extracellular RNA may circulate as non-bound RNA, protein-bound RNA, lipid-RNA complexes, lipoprotein (proteolipid) - RNA complexes, protein-RNA complexes including within or in association with ribonucleoprotein complexes, nucleosomes, or within apoptotic bodies. Any intracellular RNA found in plasma or serum can additionally be detected by this invention. Specifically, this invention enables the extraction of circulating RNA from plasma or serum and utilizes nucleic acid amplification assays for the identification, detection, inference, monitoring, or evaluation of any neoplasm, benign, premalignant, or malignant, in humans or other animals, which might be associated with that RNA. Further, this invention allows the qualitative or quantitative detection of tumor-derived or associated extracellular RNA circulating in the plasma or serum of humans or animals with or without any prior knowledge of the presence of cancer or premalignant tissue.
CA002250118A 1996-03-26 1997-03-14 Method enabling use of extracellular rna extracted from plasma or serum to detect, monitor or evaluate cancer Expired - Lifetime CA2250118C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1473096P 1996-03-26 1996-03-26
US60/014,730 1996-03-26
PCT/US1997/003479 WO1997035589A1 (en) 1996-03-26 1997-03-14 Method enabling use of extracellular rna extracted from plasma or serum to detect, monitor or evaluate cancer

Publications (2)

Publication Number Publication Date
CA2250118A1 true CA2250118A1 (en) 1997-10-02
CA2250118C CA2250118C (en) 2009-09-29

Family

ID=21767359

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002250118A Expired - Lifetime CA2250118C (en) 1996-03-26 1997-03-14 Method enabling use of extracellular rna extracted from plasma or serum to detect, monitor or evaluate cancer

Country Status (9)

Country Link
US (8) US6329179B1 (en)
EP (1) EP0938320B2 (en)
AT (1) ATE471150T1 (en)
CA (1) CA2250118C (en)
DE (1) DE69739909D1 (en)
DK (1) DK0938320T3 (en)
ES (1) ES2347854T5 (en)
PT (1) PT938320E (en)
WO (1) WO1997035589A1 (en)

Families Citing this family (227)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6511805B1 (en) * 1996-03-15 2003-01-28 The Penn State Research Foundation Methods for detecting papillomavirus DNA in blood plasma and serum
CA2248981C (en) * 1996-03-15 2009-11-24 The Penn State Research Foundation Detection of extracellular tumor-associated nucleic acid in blood plasma or serum using nucleic acid amplification assays
US8048629B2 (en) 1996-03-15 2011-11-01 The Penn State Research Foundation Detection of extracellular tumor-associated nucleic acid in blood plasma or serum
US6794135B1 (en) * 1996-03-26 2004-09-21 Oncomedx, Inc. Method for detection of 5T4 RNA in plasma or serum
US6759217B2 (en) 1996-03-26 2004-07-06 Oncomedx, Inc. Method enabling use of extracellular RNA extracted from plasma or serum to detect, monitor or evaluate cancer
US8043835B1 (en) 1996-03-26 2011-10-25 Oncomedx, Inc. Methods for detecting and monitoring cancer using extracellular RNA
US6607898B1 (en) * 1996-03-26 2003-08-19 Oncomedx, Inc. Method for detection of hTR and hTERT telomerase-associated RNA in plasma or serum
ES2347854T5 (en) * 1996-03-26 2014-07-24 Michael S. Kopreski Method that allows the use of extracellular RNA extracted from plasma or serum to detect, monitor or evaluate a cancer
US7785842B2 (en) 1996-03-26 2010-08-31 Oncomedx, Inc. Comparative analysis of extracellular RNA species
AU4667297A (en) * 1996-10-04 1998-04-24 Chronix Biomedical, Inc. Diagnostic detection of nucleic acids
US8440396B2 (en) * 1997-03-14 2013-05-14 Oncomedx, Inc. Method enabling use of extracellular RNA extracted from plasma or serum to detect, monitor or evaluate cancer
US20070009934A1 (en) * 1997-03-14 2007-01-11 Kopreski Michael S Method enabling use of extracellular RNA extracted from plasma or serum to detect, monitor or evaluate cancer
WO1998046788A2 (en) * 1997-04-11 1998-10-22 Micromet Gesellschaft Für Biomedizinische Forschung Mbh Primers and methods for the detection of disseminated tumor cells
US7229772B1 (en) 1998-03-18 2007-06-12 Roche Diagnostics Gmbh Detection of apoptotic products
ATE329264T1 (en) 1998-03-18 2006-06-15 Roche Diagnostics Gmbh DETECTION OF APOPTOSIS PRODUCTS
DE19836559A1 (en) * 1998-08-12 2000-03-23 Antigen Gmbh Blood collection vessel
US20060204989A1 (en) * 1998-09-22 2006-09-14 Kopreski Michael S Comparative analysis of extracellular RNA species
US8163524B2 (en) 1998-09-22 2012-04-24 Oncomedx, Inc. Comparative analysis of extracellular RNA species
US7767422B2 (en) * 1998-09-22 2010-08-03 Oncomedx, Inc. Detection of 5T4 RNA in plasma and serum
US20090233276A1 (en) * 1998-09-22 2009-09-17 Oncomedx, Inc. Method Enabling the Use of Extracellular Ribonucleic Acid (RNA) Extracted from Plasma or Serum to Detect, Monitor or Evaluate Cancer or Premalignant Conditions
EP1158055A1 (en) * 2000-05-26 2001-11-28 Xu Qi University of Teaxs Laboratoire de Leucémie Chen Method for diagnosing cancers
DE60144027D1 (en) * 2000-08-28 2011-03-24 Oncomedx Inc 5T4 RNA IN PLASMA AND SERUM AS A MARKER FOR NEOPLASTIC ILLNESSES
US6664056B2 (en) 2000-10-17 2003-12-16 The Chinese University Of Hong Kong Non-invasive prenatal monitoring
CA2443170A1 (en) * 2001-03-30 2002-10-10 Chronix Biomedical, Inc. Diagnostic detection of nucleic acids
AU2002345854A1 (en) * 2001-06-25 2003-01-08 Oncomedx, Inc. Methods for detecting and monitoring cox-2 rna in plasma and serum
DK1421215T3 (en) * 2001-07-25 2011-06-27 Oncomedx Inc Methods for evaluating pathological conditions using extracellular RNA
DE10143775A1 (en) * 2001-09-06 2003-04-10 Adnagen Ag Selection and determination of specific cells, useful particularly for diagnosis and monitoring of tumors, by antibody-mediated selection then detecting specific mRNA
DE10143776A1 (en) * 2001-09-06 2003-04-03 Adnagen Ag Selection and determination of specific cells, useful particularly for diagnosis and monitoring of tumors, by antibody-mediated selection then detecting specific mRNA
ES2253533T3 (en) 2001-09-06 2006-06-01 Adnagen Ag PROCEDURE FOR QUALITATIVE AND / OR QUANTITATIVE DETECTION OF CELLS.
US8980568B2 (en) 2001-10-11 2015-03-17 Aviva Biosciences Corporation Methods and compositions for detecting non-hematopoietic cells from a blood sample
US8986944B2 (en) * 2001-10-11 2015-03-24 Aviva Biosciences Corporation Methods and compositions for separating rare cells from fluid samples
KR20040047971A (en) * 2001-10-26 2004-06-05 이뮤니베스트 코포레이션 Multiparameter analysis of comprehensive nucleic acids and morphological features on the same sample
US20100159464A1 (en) * 2001-11-05 2010-06-24 Oncomedx, Inc. Method for Detection of DNA Methyltransferase RNA in Plasma and Serum
US20030104454A1 (en) * 2001-11-05 2003-06-05 Kopreski Michael S. Method for detection of DNA methyltransferase RNA in plasma and serum
WO2003044215A2 (en) * 2001-11-20 2003-05-30 Oncomedx, Inc. Methods for evaluating drug-resistance gene expression in the cancer patient
AU2002362055A1 (en) * 2001-12-03 2003-06-17 Oncomedx, Inc. Detection of matrix metalloproteinase rna in plasma and serum
US20030170617A1 (en) * 2002-01-28 2003-09-11 Pasloske Brittan L. Crude biological derivatives competent for nucleic acid detection
US6977162B2 (en) 2002-03-01 2005-12-20 Ravgen, Inc. Rapid analysis of variations in a genome
US20050266405A1 (en) * 2002-03-08 2005-12-01 Kopreski Michael S Analysis of apoptotic bodies in bodily fluids
US7727720B2 (en) * 2002-05-08 2010-06-01 Ravgen, Inc. Methods for detection of genetic disorders
US7022478B2 (en) * 2002-05-14 2006-04-04 The Chinese University Of Hong Kong Methods for evaluating stroke or cardiac ischemia by nucleic acid detection
US20040009518A1 (en) * 2002-05-14 2004-01-15 The Chinese University Of Hong Kong Methods for evaluating a disease condition by nucleic acid detection and fractionation
US7252976B2 (en) * 2002-08-28 2007-08-07 Board Of Regents The University Of Texas System Quantitative RT-PCR to AC133 to diagnose cancer and monitor angiogenic activity in a cell sample
US10966421B2 (en) 2002-10-16 2021-04-06 Streck, Inc. Method and device for collecting and preserving cells for analysis
US7074561B2 (en) * 2002-10-22 2006-07-11 Biomerieux, Inc. Isothermal amplification based assay for the detection and quantitation of alpha-fetoprotein mRNA
JP4583180B2 (en) * 2002-12-31 2010-11-17 ザ ハムナー リサーチ インスティテューツ RNA bioassay
US20040137539A1 (en) * 2003-01-10 2004-07-15 Bradford Sherry A. Cancer comprehensive method for identifying cancer protein patterns and determination of cancer treatment strategies
US20040178208A1 (en) * 2003-03-12 2004-09-16 Minh Leba Ice chest
ES2335344T3 (en) * 2003-03-19 2010-03-25 Hamamatsu Foundation For Science And Technology Promotion PROCEDURE FOR DETECTING A COLON CANCER MARKER.
TWI340168B (en) * 2003-05-07 2011-04-11 Tosoh Corp Method of detecting micrometastasis
WO2005014795A2 (en) 2003-08-08 2005-02-17 Genenews Inc. Osteoarthritis biomarkers and uses thereof
DE60309879D1 (en) * 2003-10-29 2007-01-04 Maurice Stroun Procedure for the diagnosis of cancer
CN101426930A (en) * 2004-05-25 2009-05-06 日立化成工业株式会社 Method of measuring cancer susceptibility
US20080268429A1 (en) * 2004-06-02 2008-10-30 Sourcepharm, Inc. Rna - Containing Microvesicles and Methods Therefor
US8021847B2 (en) 2004-06-02 2011-09-20 Proxy Life Science Holdings, Inc. Microvesicle-based compositions and methods
US20060003345A1 (en) * 2004-06-30 2006-01-05 Pfizer Inc RNA bioassay
WO2006042136A2 (en) * 2004-10-07 2006-04-20 Chronix Biomedical Detection of nucleic acids to assess risk for creutzfeldt-jakob disease
EP1802776B1 (en) * 2004-10-20 2013-01-02 Hitachi Chemical Company, Ltd. Method for tailoring administration of drugs by quantitation of mrna
US11105808B2 (en) 2004-11-12 2021-08-31 Health Discovery Corporation Methods for screening, predicting and monitoring prostate cancer
ATE477497T1 (en) * 2004-12-08 2010-08-15 Cedars Sinai Medical Center METHOD FOR DIAGNOSIS OF CROHN'S DISEASE
CN103497993A (en) 2005-02-07 2014-01-08 基因信息公司 Mild osteoarthritis biomarkers and uses thereof
DE602005009324D1 (en) 2005-04-06 2008-10-09 Maurice Stroun Method for cancer diagnosis by detection of DNA and RNA in the circulation
EP1888089B9 (en) * 2005-04-28 2012-08-08 Hitachi Chemical Research Center, Inc. Ex vivo gene expression in whole blood as a model of assessment of individual variation to dietary supplements
ATE510929T1 (en) * 2005-06-08 2011-06-15 Hitachi Chemical Res Ct Inc METHOD FOR PREDICTING AN IMMUNE RESPONSE TO TUMOR DISEASE BASED ON AN MRNA EXPRESSION PROFILE IN TUMOR CELLS AND STIMULATED LEUKOCYTES
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
WO2007018257A1 (en) * 2005-08-10 2007-02-15 Hamamatsu Foundation For Science And Technology Promotion Method of detecting large bowel cancer marker
EP1945816B1 (en) 2005-10-21 2011-07-27 GeneNews Inc. Method and apparatus for correlating levels of biomarker products with disease
CN101410714A (en) * 2006-04-07 2009-04-15 日立化成工业株式会社 Enhanced T cell receptor-mediated tumor necrosis factor superfamily and chemokine mRNA expression in peripheral blood leukocytes in patients with crohn's disease
US20090311684A1 (en) * 2006-04-07 2009-12-17 Hitachi Chemical Co., Ltd Enhanced fc receptor-mediated tumor necrosis factor superfamily and chemokine mrna expression in peripheral blood leukocytes in patients with rheumatoid arthritis
US20070248961A1 (en) * 2006-04-20 2007-10-25 Maher Albitar Methods for detecting mutations in JAK2 nucleic acid
WO2007133551A2 (en) * 2006-05-08 2007-11-22 Hitachi Chemical Co., Ltd. Method for testing drug sensitivity in solid tumors by quantifying mrna expression in thinly-sliced tumor tissue
US7798645B2 (en) * 2006-05-16 2010-09-21 Mark Costin Roser Visual and memory stimulating retina self-monitoring system
CA2657621A1 (en) * 2006-07-14 2008-01-17 Aviva Biosciences Corporation Methods and compositions for detecting rare cells from a biological sample
US20100021917A1 (en) * 2007-02-14 2010-01-28 Cedars-Sinai Medical Center Methods of using genes and genetic variants to predict or diagnose inflammatory bowel disease
US20100190162A1 (en) * 2007-02-26 2010-07-29 Cedars-Sinai Medical Center Methods of using single nucleotide polymorphisms in the tl1a gene to predict or diagnose inflammatory bowel disease
WO2010039931A2 (en) * 2008-10-01 2010-04-08 Cedars-Sinai Medical Center Methods of using il17rd and il23-il17 pathway genes to diagnose crohn's disease
US20100015156A1 (en) * 2007-03-06 2010-01-21 Cedars-Sinai Medical Center Diagnosis of inflammatory bowel disease in children
WO2008116150A2 (en) 2007-03-21 2008-09-25 Cedars-Sinai Medical Center Ileal pouch-anal anastomosis (ipaa) factors in the treatment of inflammatory bowel disease
AU2008230813B2 (en) 2007-03-26 2014-01-30 Sequenom, Inc. Restriction endonuclease enhanced polymorphic sequence detection
CA2683559C (en) 2007-04-13 2019-09-24 Dana Farber Cancer Institute, Inc. Methods for treating cancer resistant to erbb therapeutics
WO2008134569A2 (en) * 2007-04-26 2008-11-06 Cedars-Sinai Medical Center Diagnosis and treatment of inflammatory bowel disease in the puerto rican population
US20100144903A1 (en) * 2007-05-04 2010-06-10 Cedars-Sinai Medical Center Methods of diagnosis and treatment of crohn's disease
US7964350B1 (en) 2007-05-18 2011-06-21 Applied Biosystems, Llc Sample preparation for in situ nucleic acid analysis
US20090136942A1 (en) * 2007-09-18 2009-05-28 Oncomedx, Inc. Analysis of Extracellular RNA
US20090123920A1 (en) * 2007-11-08 2009-05-14 Maher Albitar Jak2 mutations
EP2209919A4 (en) * 2007-11-14 2011-04-13 Hitachi Chemical Co Ltd Fc receptor-mediated tumor necrosis factor superfamily mrna expression in peripheral blood leukocytes
DK2245199T3 (en) * 2008-02-01 2014-02-03 Gen Hospital Corp APPLICATION OF MICROVESCIES IN DIAGNOSTICATION, PROGRAMMING AND TREATMENT OF MEDICAL DISEASES AND CONDITIONS
US20090215064A1 (en) * 2008-02-27 2009-08-27 Hitachi Chemical Co., Ltd. Quantitative assessment of individual cancer susceptibility by measuring dna damage-induced mrna in whole blood
WO2009114543A2 (en) * 2008-03-11 2009-09-17 Sequenom, Inc. Nucleic acid-based tests for prenatal gender determination
AU2009228312B2 (en) 2008-03-26 2015-05-21 Sequenom, Inc. Restriction endonuclease enhanced polymorphic sequence detection
US8614057B2 (en) * 2008-06-12 2013-12-24 The Invention Science Fund I, Llc Methods for collecting and detecting oligonucleotides
US8252528B2 (en) * 2008-06-12 2012-08-28 The Invention Science Fund I, Llc Methods, compositions, and kits for collecting and detecting oligonucleotides
US8252529B2 (en) * 2008-06-12 2012-08-28 The Invention Science Fund I, Llc Methods for collecting and detecting oligonucleotides
CA2728736A1 (en) * 2008-06-20 2009-12-23 Proxy Life Science Holdings, Inc. Microvesicle-based compositions and methods
US8476013B2 (en) 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
US8962247B2 (en) 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
US20110189685A1 (en) * 2008-10-22 2011-08-04 Cedars-Sinai Medical Center Methods of using jak3 genetic variants to diagnose and predict crohn's disease
JP2012507300A (en) * 2008-10-30 2012-03-29 カリス ライフ サイエンシズ ルクセンブルク ホールディングス Method for evaluating RNA patterns
US9702877B2 (en) * 2008-10-31 2017-07-11 Quest Diagnostics Investments Incorporated BCR-ABL variants
WO2010056337A2 (en) * 2008-11-12 2010-05-20 Caris Mpi, Inc. Methods and systems of using exosomes for determining phenotypes
WO2010062960A2 (en) 2008-11-26 2010-06-03 Cedars-Sinai Medical Center METHODS OF DETERMINING RESPONSIVENESS TO ANTI-TNFα THERAPY IN INFLAMMATORY BOWEL DISEASE
EP2367954B1 (en) * 2008-12-19 2015-02-18 Life Technologies Corporation Proteinase k inhibitors, methods and compositions therefor
US9580752B2 (en) 2008-12-24 2017-02-28 Cedars-Sinai Medical Center Methods of predicting medically refractive ulcerative colitis (MR-UC) requiring colectomy
WO2010078194A1 (en) * 2008-12-30 2010-07-08 Streck, Inc. Method for screening blood using a preservative that may be in a substantially solid state form
WO2010079118A1 (en) 2009-01-07 2010-07-15 Michael Roth-Chiarello Use of rna obtained from proteolipid complexes circulating in blood for diagnosis and treatment of tumors
US11634747B2 (en) * 2009-01-21 2023-04-25 Streck Llc Preservation of fetal nucleic acids in maternal plasma
NO2398912T3 (en) 2009-02-18 2018-02-10
US20110105585A1 (en) * 2009-04-23 2011-05-05 Northwestern University METHODS FOR DIAGNOSING AND TREATING SQUAMOUS CELL CARCINOMA UTILIZING miRNA-205 AND INHIBITORS THEREOF
AU2010249421A1 (en) 2009-05-22 2011-12-08 Asuragen, Inc. miRNA biomarkers of prostate disease
EP2454588B1 (en) * 2009-07-16 2015-07-15 The General Hospital Corporation Nucleic acid analysis
CN102725632A (en) 2009-08-28 2012-10-10 奥斯瑞根公司 MiRNA biomarkers of lung disease
EP3461912B1 (en) 2009-09-09 2022-07-13 The General Hospital Corporation Use of microvesicles in analyzing nucleic acid profiles
US20130029339A1 (en) 2009-09-09 2013-01-31 The General Hospital Corporation Use of microvesicles in analyzing kras mutations
US9488656B2 (en) 2009-09-30 2016-11-08 Quest Diagnostics Investments Incorporated BCR-ABL truncation mutations
EP3103883A1 (en) * 2009-11-09 2016-12-14 Streck, Inc. Stabilization of rna in and extracting from intact cells within a blood sample
US9926593B2 (en) 2009-12-22 2018-03-27 Sequenom, Inc. Processes and kits for identifying aneuploidy
JP5808349B2 (en) 2010-03-01 2015-11-10 カリス ライフ サイエンシズ スウィッツァーランド ホールディングスゲーエムベーハー Biomarkers for theranosis
KR20130043104A (en) 2010-04-06 2013-04-29 카리스 라이프 사이언스 룩셈부르크 홀딩스 Circulating biomarkers for disease
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
AU2011255641A1 (en) 2010-05-18 2012-12-06 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
KR20130123357A (en) * 2010-06-07 2013-11-12 오스나트 에슈어-파비안 Methods and kits for diagnosing conditions related to hypoxia
WO2011156763A1 (en) 2010-06-11 2011-12-15 Hitachi Chemical Co., Ltd. Methods for characterizing kidney function
WO2011156734A2 (en) * 2010-06-11 2011-12-15 Hitachi Chemical Co., Ltd. Method of characterizing vascular diseases
US10167508B2 (en) 2010-08-06 2019-01-01 Ariosa Diagnostics, Inc. Detection of genetic abnormalities
US11031095B2 (en) 2010-08-06 2021-06-08 Ariosa Diagnostics, Inc. Assay systems for determination of fetal copy number variation
US11203786B2 (en) * 2010-08-06 2021-12-21 Ariosa Diagnostics, Inc. Detection of target nucleic acids using hybridization
US20130261003A1 (en) 2010-08-06 2013-10-03 Ariosa Diagnostics, In. Ligation-based detection of genetic variants
US8700338B2 (en) 2011-01-25 2014-04-15 Ariosa Diagnosis, Inc. Risk calculation for evaluation of fetal aneuploidy
US20130040375A1 (en) 2011-08-08 2013-02-14 Tandem Diagnotics, Inc. Assay systems for genetic analysis
US20140342940A1 (en) 2011-01-25 2014-11-20 Ariosa Diagnostics, Inc. Detection of Target Nucleic Acids using Hybridization
US20120034603A1 (en) 2010-08-06 2012-02-09 Tandem Diagnostics, Inc. Ligation-based detection of genetic variants
US10533223B2 (en) 2010-08-06 2020-01-14 Ariosa Diagnostics, Inc. Detection of target nucleic acids using hybridization
WO2012031008A2 (en) 2010-08-31 2012-03-08 The General Hospital Corporation Cancer-related biological materials in microvesicles
WO2012064993A1 (en) 2010-11-10 2012-05-18 Exosome Diagnosties, Inc. Method for isolation of nucleic acid containing particles and extraction of nucleic acids therefrom
US8603740B2 (en) 2010-12-29 2013-12-10 Quest Diagnostics Investments Incorporated BCR-ABL1 splice variants and uses thereof
US9994897B2 (en) 2013-03-08 2018-06-12 Ariosa Diagnostics, Inc. Non-invasive fetal sex determination
US10131947B2 (en) 2011-01-25 2018-11-20 Ariosa Diagnostics, Inc. Noninvasive detection of fetal aneuploidy in egg donor pregnancies
US11270781B2 (en) 2011-01-25 2022-03-08 Ariosa Diagnostics, Inc. Statistical analysis for non-invasive sex chromosome aneuploidy determination
US8756020B2 (en) 2011-01-25 2014-06-17 Ariosa Diagnostics, Inc. Enhanced risk probabilities using biomolecule estimations
GB201105295D0 (en) * 2011-03-29 2011-05-11 Univ Liverpool Cancer detection
WO2012149339A2 (en) 2011-04-29 2012-11-01 Sequenom, Inc. Quantification of a minority nucleic acid species
WO2012151391A2 (en) 2011-05-04 2012-11-08 Streck, Inc. Inactivated virus compositions and methods of preparing such compositions
EP2717989B1 (en) 2011-06-10 2018-05-30 Hitachi Chemical Co., Ltd. Vesicle capturing devices and methods for using same
GB201115095D0 (en) * 2011-09-01 2011-10-19 Singapore Volition Pte Ltd Method for detecting nucleosomes containing nucleotides
US8712697B2 (en) 2011-09-07 2014-04-29 Ariosa Diagnostics, Inc. Determination of copy number variations using binomial probability calculations
ES2937410T3 (en) 2011-09-26 2023-03-28 Qiagen Gmbh Rapid method to isolate extracellular nucleic acids
AU2012314515B2 (en) 2011-09-26 2018-03-15 Preanalytix Gmbh Stabilisation and isolation of extracellular nucleic acids
US11021733B2 (en) 2011-09-26 2021-06-01 Qiagen Gmbh Stabilization and isolation of extracellular nucleic acids
AU2012314514B2 (en) 2011-09-26 2018-03-15 Qiagen Gmbh Stabilisation and isolation of extracellular nucleic acids
WO2013064163A1 (en) 2011-11-01 2013-05-10 Academisch Medisch Centrum Methylation markers for colorectal cancer
PL2809810T3 (en) 2012-01-06 2020-07-27 Viomics Inc. System and method of detecting rnas altered by lung cancer in peripheral blood
US8838394B2 (en) 2012-02-03 2014-09-16 California Institute Of Technology Signal encoding and decoding in multiplexed biochemical assays
ES2930180T3 (en) 2012-03-02 2022-12-07 Sequenom Inc Methods for enriching for cancer nucleic acid from a biological sample
US10289800B2 (en) 2012-05-21 2019-05-14 Ariosa Diagnostics, Inc. Processes for calculating phased fetal genomic sequences
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
CA2877721A1 (en) 2012-06-27 2014-01-03 Berg Llc Use of markers in the diagnosis and treatment of prostate cancer
CA2878979C (en) 2012-07-13 2021-09-14 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
CA2878280A1 (en) 2012-07-19 2014-01-23 Ariosa Diagnostics, Inc. Multiplexed sequential ligation-based detection of genetic variants
KR102210852B1 (en) 2012-09-04 2021-02-01 가던트 헬쓰, 인크. Systems and methods to detect rare mutations and copy number variation
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US10876152B2 (en) 2012-09-04 2020-12-29 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US11913065B2 (en) 2012-09-04 2024-02-27 Guardent Health, Inc. Systems and methods to detect rare mutations and copy number variation
AU2013322643C1 (en) 2012-09-25 2018-11-08 Qiagen Gmbh Stabilisation of biological samples
EP3597774A1 (en) 2013-03-13 2020-01-22 Sequenom, Inc. Primers for dna methylation analysis
WO2014145296A2 (en) 2013-03-15 2014-09-18 Theranos, Inc. Nuclei acid amplification
US10450595B2 (en) 2013-03-15 2019-10-22 Theranos Ip Company, Llc Nucleic acid amplification
EP2970961B1 (en) 2013-03-15 2019-04-24 Theranos IP Company, LLC Nucleic acid amplification
EP3564370B1 (en) 2013-03-15 2022-01-12 Labrador Diagnostics LLC Nucleic acid amplification
US11525155B2 (en) 2013-03-18 2022-12-13 Qiagen Gmbh Stabilisation of biological samples
JP6407248B2 (en) 2013-03-18 2018-10-17 キアゲン ゲーエムベーハー Stabilization and isolation of extracellular nucleic acids
JP6671276B2 (en) 2013-03-27 2020-03-25 セダーズ−シナイ メディカル センター Alleviation and recovery of fibrosis and inflammation by suppression of TL1A function and related signaling pathways
JP6297676B2 (en) 2013-05-06 2018-03-20 日立化成株式会社 Devices and methods for capturing target molecules
EP3022295A4 (en) 2013-07-19 2017-03-01 Cedars-Sinai Medical Center Signature of tl1a (tnfsf15) signaling pathway
US10091984B2 (en) 2013-07-24 2018-10-09 Streck, Inc. Compositions and methods for stabilizing circulating tumor cells
US9644232B2 (en) 2013-07-26 2017-05-09 General Electric Company Method and device for collection and amplification of circulating nucleic acids
CN111378568A (en) 2013-09-06 2020-07-07 赛拉诺斯知识产权有限责任公司 Systems and methods for detecting infectious diseases
FR3010530B1 (en) * 2013-09-11 2015-10-09 Univ Rouen METHOD OF DIAGNOSING MALIGNANT HEMOPATHIES AND KIT THEREFOR
WO2015042708A1 (en) 2013-09-25 2015-04-02 Bio-Id Diagnostic Inc. Methods for detecting nucleic acid fragments
EP3495506B1 (en) 2013-12-11 2023-07-12 AccuraGen Holdings Limited Methods for detecting rare sequence variants
US11859246B2 (en) 2013-12-11 2024-01-02 Accuragen Holdings Limited Methods and compositions for enrichment of amplification products
US11286519B2 (en) 2013-12-11 2022-03-29 Accuragen Holdings Limited Methods and compositions for enrichment of amplification products
SG11201604923XA (en) 2013-12-28 2016-07-28 Guardant Health Inc Methods and systems for detecting genetic variants
EP3736344A1 (en) 2014-03-13 2020-11-11 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
AU2015233500B2 (en) 2014-03-18 2018-11-01 Qiagen Gmbh Stabilization and isolation of extracellular nucleic acids
CN109971852A (en) 2014-04-21 2019-07-05 纳特拉公司 Detect the mutation and ploidy in chromosome segment
TW201617368A (en) 2014-09-05 2016-05-16 史坦森特瑞斯公司 Novel anti-MFI2 antibodies and methods of use
US10266895B2 (en) 2014-11-05 2019-04-23 Hitachi Chemical Company Ltd. Exosomes and microvesicles in intestinal luminal fluids and stool and use of same for the assessment of inflammatory bowel disease
JP6631852B2 (en) 2014-11-12 2020-01-15 日立化成株式会社 Method and apparatus for diagnosing organ damage
AU2015346185A1 (en) * 2014-11-14 2017-05-04 Liquid Genomics, Inc. Use of circulating cell-free RNA for diagnosis and/or monitoring cancer
WO2016094330A2 (en) 2014-12-08 2016-06-16 20/20 Genesystems, Inc Methods and machine learning systems for predicting the liklihood or risk of having cancer
EP4242329A3 (en) 2014-12-08 2023-10-25 Berg LLC Use of markers including filamin a in the diagnosis and treatment of prostate cancer
US11168351B2 (en) 2015-03-05 2021-11-09 Streck, Inc. Stabilization of nucleic acids in urine
WO2016161107A1 (en) 2015-03-31 2016-10-06 Syros Pharmaceuticals, Inc. METHODS OF STRATIFYING PATIENTS FOR TREATMENT WITH RETINOIC ACID RECEPTOR-α AGONISTS
US11479812B2 (en) 2015-05-11 2022-10-25 Natera, Inc. Methods and compositions for determining ploidy
EP3307886B1 (en) 2015-06-10 2021-03-24 Qiagen GmbH Method for isolating extracellular nucleic acids using anion exchange particles
US11028443B2 (en) 2015-08-31 2021-06-08 Showa Denko Materials Co., Ltd. Molecular methods for assessing urothelial disease
CN108368545B (en) 2015-10-09 2022-05-17 安可济控股有限公司 Methods and compositions for enriching amplification products
US20170145475A1 (en) 2015-11-20 2017-05-25 Streck, Inc. Single spin process for blood plasma separation and plasma composition including preservative
JP7166169B2 (en) 2015-11-20 2022-11-07 キアゲン ゲーエムベーハー Method for preparing a sterile composition for sterilization of extracellular nucleic acids
CN108603228B (en) 2015-12-17 2023-09-01 夸登特健康公司 Method for determining tumor gene copy number by analyzing cell-free DNA
KR102464372B1 (en) 2016-03-17 2022-11-04 세다르스-신나이 메디칼 센터 Methods of diagnosing inflammatory bowel disease through rnaset2
US9868994B2 (en) 2016-04-08 2018-01-16 Syros Pharmaceuticals, Inc. Methods of stratifying patients for treatment with retinoic acid receptor-α agonists
US11427866B2 (en) 2016-05-16 2022-08-30 Accuragen Holdings Limited Method of improved sequencing by strand identification
US10066263B2 (en) 2016-06-17 2018-09-04 California Institute Of Technology Nucleic acid reactions and related methods and compositions
EP3491381A1 (en) 2016-07-29 2019-06-05 Streck, Inc. Suspension composition for hematology analysis control
SG11201901296TA (en) 2016-08-15 2019-03-28 Accuragen Holdings Ltd Compositions and methods for detecting rare sequence variants
US9850523B1 (en) 2016-09-30 2017-12-26 Guardant Health, Inc. Methods for multi-resolution analysis of cell-free nucleic acids
CA3027919C (en) 2016-09-30 2023-02-28 Guardant Health, Inc. Methods for multi-resolution analysis of cell-free nucleic acids
US11485996B2 (en) 2016-10-04 2022-11-01 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
WO2018146162A1 (en) 2017-02-07 2018-08-16 Academisch Medisch Centrum Molecular biomarker for prognosis of sepsis patients
US10907211B1 (en) 2017-02-16 2021-02-02 Quantgene Inc. Methods and compositions for detecting cancer biomarkers in bodily fluids
WO2019045803A1 (en) * 2017-09-01 2019-03-07 Genemo Inc. Methods for rna sequencing
US11203782B2 (en) 2018-03-29 2021-12-21 Accuragen Holdings Limited Compositions and methods comprising asymmetric barcoding
CN108949906B (en) * 2018-06-22 2020-12-18 中南大学 dsDNA-AgNCs fluorescent probe for HER2 detection and construction method and application thereof
US11525159B2 (en) 2018-07-03 2022-12-13 Natera, Inc. Methods for detection of donor-derived cell-free DNA
WO2020160414A1 (en) 2019-01-31 2020-08-06 Guardant Health, Inc. Compositions and methods for isolating cell-free dna
WO2020260620A1 (en) 2019-06-28 2020-12-30 Qiagen Gmbh Method for enriching nucleic acids by size

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1473096A (en) † 1921-06-10 1923-11-06 Lawrence Paper Mfg Company Machine for making cellular board
US4383555A (en) * 1976-04-20 1983-05-17 Plastiflex Company International Helically wound hose from co-extruded profile with reinforcing ribs interlocked at adjacent convolutions
US4350156A (en) * 1980-05-29 1982-09-21 Japan Foundation For Artificial Organs Method and apparatus for on-line filtration removal of macromolecules from a physiological fluid
DE3171592D1 (en) * 1980-09-25 1985-09-05 Terumo Corp Plasma separator
EP0091539B2 (en) * 1982-03-31 1996-11-27 Ajinomoto Co., Inc. Gene coding for interleukin-2 polypeptide, recombinant DNA carrying said gene, cell lines possessing the recombinant DNA,and method for producing interleukin-2 using said cells
US4699877A (en) 1982-11-04 1987-10-13 The Regents Of The University Of California Methods and compositions for detecting human tumors
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
JPS61276561A (en) * 1985-05-31 1986-12-06 株式会社クラレ Blood treatment apparatus
EP0246709A1 (en) * 1986-05-20 1987-11-25 Stichting Katholieke Universiteit Recombinant DNA and cDNA, mRNA, protein, antibodies, and a method of detecting tumor cells
US5274087A (en) * 1986-08-13 1993-12-28 Molecular Diagnostics, Inc. cDNA coding for carcinoembryonic antigen (CEA)
EP0272098A3 (en) * 1986-12-15 1990-06-06 City Of Hope National Medical Center Method for amplification and detection of rna sequences
US5019243A (en) * 1987-04-03 1991-05-28 Mcewen James A Apparatus for collecting blood
US5085983A (en) * 1988-08-19 1992-02-04 City Of Hope Detection of human tumor progression and drug resistance
DE3717212A1 (en) 1987-05-22 1988-12-08 Viktor Dr Dr Med Balazs METHOD FOR THE EXAMINATION OF A CELLULAR BIOLOGICAL LIQUID FOR CELLULAR ONCOGEN TRANScripts or THEIR FRAGMENTS
US5532220A (en) * 1987-08-31 1996-07-02 The Regents Of The University Of California Genetic mechanisms of tumor suppression
US5124246A (en) 1987-10-15 1992-06-23 Chiron Corporation Nucleic acid multimers and amplified nucleic acid hybridization assays using same
US5350671A (en) * 1987-11-18 1994-09-27 Chiron Corporation HCV immunoassays employing C domain antigens
CA1340807C (en) * 1988-02-24 1999-11-02 Lawrence T. Malek Nucleic acid amplification process
US4874858A (en) 1988-03-28 1989-10-17 The B. F. Goodrich Company Triazine-containing multisilane coupling agents for coating glass fibers, for adhesives, and for protective coatings
US4999290A (en) * 1988-03-31 1991-03-12 The Board Of Regents, The University Of Texas System Detection of genomic abnormalities with unique aberrant gene transcripts
US4874853A (en) * 1988-04-18 1989-10-17 City Of Hope Synthetic oligonucleotides useful in diagnosis of chronic myelogenous leukemia
US5098890A (en) * 1988-11-07 1992-03-24 Temple University-Of The Commonwealth System Of Higher Education Antisence oligonucleotides to c-myb proto-oncogene and uses thereof
US5087617A (en) * 1989-02-15 1992-02-11 Board Of Regents, The University Of Texas System Methods and compositions for treatment of cancer using oligonucleotides
WO1990009456A1 (en) 1989-02-16 1990-08-23 Viktor Balazs Malignancy test (cancer test) using the polymerase chain reaction
ES2152922T3 (en) * 1990-04-06 2001-02-16 Genelabs Tech Inc HEPATITIS VIRUS VIRUS EPITHOPES.
US5217889A (en) * 1990-10-19 1993-06-08 Roninson Igor B Methods and applications for efficient genetic suppressor elements
US5155018A (en) * 1991-07-10 1992-10-13 Hahnemann University Process and kit for isolating and purifying RNA from biological sources
WO1993007293A1 (en) * 1991-10-04 1993-04-15 The Children's Hospital Of Philadelphia Detecting digeorge syndrome mutations
WO1993017127A1 (en) * 1992-02-20 1993-09-02 The State Of Oregon Acting By And Through The Oregon State Board Of Higher Education On Behalf Of Oregon State University Boomerand dna amplification
JPH08502889A (en) * 1992-10-29 1996-04-02 トーマス・ジェファーソン・ユニバーシティ Method of detecting micrometastases of prostate cancer
US5429923A (en) * 1992-12-11 1995-07-04 President And Fellows Of Harvard College Method for detecting hypertrophic cardiomyophathy associated mutations
US5300635A (en) 1993-02-01 1994-04-05 University Of Iowa Research Foundation Quaternary amine surfactants and methods of using same in isolation of nucleic acids
US6051374A (en) * 1994-02-14 2000-04-18 Abbott Laboratories Non-A, non-B, non-C, non-D, non-E hepatitis reagents and methods for their use
US5660979A (en) † 1994-11-04 1997-08-26 Akzo Nobel N.V. Detection of human retrovirus infection
DE69637552D1 (en) * 1995-03-17 2008-07-10 Wayne John Cancer Inst Detection of breast metastases using a multi-marker test
FR2737500B1 (en) * 1995-08-03 1997-08-29 Bio Merieux VIRAL MATERIAL AND NUCLEOTIDE FRAGMENTS ASSOCIATED WITH MULTIPLE SCLEROSIS, FOR DIAGNOSIS, PROPHYLACTICS AND THERAPEUTICS
US6156535A (en) * 1995-08-04 2000-12-05 University Of Ottawa Mammalian IAP gene family, primers, probes, and detection methods
CA2157416A1 (en) † 1995-09-01 1997-03-02 Kalyx Biosciences Inc. Method for enhancing detection ability of nucleic acid assays employing nucleic acid sequence based amplification
US5994062A (en) * 1995-10-02 1999-11-30 The United States Of America As Represented By The Department Of Health And Human Services Epithelial protein and DNA thereof for use in early cancer detection
CA2248981C (en) † 1996-03-15 2009-11-24 The Penn State Research Foundation Detection of extracellular tumor-associated nucleic acid in blood plasma or serum using nucleic acid amplification assays
ES2347854T5 (en) * 1996-03-26 2014-07-24 Michael S. Kopreski Method that allows the use of extracellular RNA extracted from plasma or serum to detect, monitor or evaluate a cancer
US6607898B1 (en) * 1996-03-26 2003-08-19 Oncomedx, Inc. Method for detection of hTR and hTERT telomerase-associated RNA in plasma or serum
US6794135B1 (en) * 1996-03-26 2004-09-21 Oncomedx, Inc. Method for detection of 5T4 RNA in plasma or serum
US6759217B2 (en) * 1996-03-26 2004-07-06 Oncomedx, Inc. Method enabling use of extracellular RNA extracted from plasma or serum to detect, monitor or evaluate cancer
AU4667297A (en) * 1996-10-04 1998-04-24 Chronix Biomedical, Inc. Diagnostic detection of nucleic acids
CA2331781C (en) 1998-06-25 2008-01-08 The General Hospital Corporation De novo dna cytosine methyltransferase genes, polypeptides and uses thereof
US7767422B2 (en) * 1998-09-22 2010-08-03 Oncomedx, Inc. Detection of 5T4 RNA in plasma and serum
JP2002372533A (en) * 2001-06-13 2002-12-26 Kiwamu Akagi Examination method of blood, examination chip, and examination device
AU2002345854A1 (en) * 2001-06-25 2003-01-08 Oncomedx, Inc. Methods for detecting and monitoring cox-2 rna in plasma and serum
DK1421215T3 (en) * 2001-07-25 2011-06-27 Oncomedx Inc Methods for evaluating pathological conditions using extracellular RNA
AU2007324128B2 (en) * 2006-10-10 2013-10-10 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Prostate cancer-specific alterations in ERG gene expression and detection and treatment methods based on those alterations

Also Published As

Publication number Publication date
ES2347854T5 (en) 2014-07-24
DK0938320T3 (en) 2010-10-18
US20080057502A1 (en) 2008-03-06
AU722476B2 (en) 2000-08-03
US7767423B2 (en) 2010-08-03
US8809020B2 (en) 2014-08-19
ES2347854T3 (en) 2010-11-04
US6329179B1 (en) 2001-12-11
US7972817B2 (en) 2011-07-05
US20020155469A1 (en) 2002-10-24
CA2250118C (en) 2009-09-29
ES2347854T9 (en) 2011-02-25
US20060228732A1 (en) 2006-10-12
US20020106684A1 (en) 2002-08-08
EP0938320B2 (en) 2014-06-18
DE69739909D1 (en) 2010-07-29
US6916634B2 (en) 2005-07-12
US20050003440A1 (en) 2005-01-06
US8030031B2 (en) 2011-10-04
US7932061B2 (en) 2011-04-26
EP0938320B9 (en) 2010-11-03
EP0938320A1 (en) 1999-09-01
PT938320E (en) 2010-09-22
US20070026427A1 (en) 2007-02-01
ATE471150T1 (en) 2010-07-15
US20060166229A1 (en) 2006-07-27
EP0938320B1 (en) 2010-06-16
EP0938320A4 (en) 2006-09-06
US6939671B2 (en) 2005-09-06
WO1997035589A1 (en) 1997-10-02
AU2318697A (en) 1997-10-17

Similar Documents

Publication Publication Date Title
CA2250118A1 (en) Method enabling use of extracellular rna extracted from plasma or serum to detect, monitor or evaluate cancer
EP1776471B9 (en) Method of measuring cancer susceptibility
WO2005067692A3 (en) Detection and quantification of analytes in solution using polymers
WO2005010494A3 (en) Multiplexed analyte detection
ATE502119T1 (en) METHOD FOR EVALUATION OF PATHOLOGICAL DISEASE CONDITIONS USING EXTRACELLULAR RNA
WO2001042504A3 (en) Detection of extracellular tumor-associated nucleic acid in blood plasma or serum
CA2421007A1 (en) Method for detection of htr and htert telomerase-associated rna in plasma or serum
NO955119L (en) Salmonella identification by polymerase chain reaction
WO2021113394A3 (en) Methods of detection and analysis of nucleic acid in neural-derived exosomes
WO1998014611A3 (en) Detection and identification of non-polio enteroviruses
Townsend et al. Methods for detecting processing temperatures of previously cooked meat and poultry products-a review
WO2003001183A3 (en) Methods for detecting and monitoring cox-2 rna in plasma and serum
Amjadi et al. Development of rapid PCR-RFLP technique for identification of sheep, cattle and goat’s species and fraud detection in Iranian commercial meat products
Kuhnell et al. Correlation of vibration, wear debris analysis and oil analysis in rolling element bearing condition monitoring
FR2800874B1 (en) METHOD FOR RAPIDLY HIGHLIGHTING MALONDIALDEHYDE (MDA) IN URINE, IN FOOD AND COSMETIC PRODUCTS
Raharjo et al. Analysis of pork contamination in Abon using mitochondrial D-Loop22 primers using real time polymerase chain reaction method
Zhang et al. B1 Sequence–Based Real-Time Quantitative PCR: A Sensitive Method for Direct Measurement of Mouse Plasma DNA Levels After Gamma Irradiation
Muralidharan Spectrophotometric analysis of catechins and condensed tannins using Ehrlich's reagent
PT729518E (en) INITIATORS AND PROBES FOR AMPLIFICATION AND DETECTION OF CMV NUCLEIC ACID
Reno et al. Formability of Cold Rolled Aluminum Killed Steel: Critical Analysis.(Retroactive Coverage)
Mašlej et al. Determining the presence of chicken and turkey meat in selected meat products using Real-Time PCR method.
Ferrari et al. Corrigendum to" Validation of PCR methods for confirmation and species identification of thermotolerant Campylobacter as part of EN ISO 10272-Microbiology of the food chain-Horizontal method for detection and enumeration of Campylobacter spp."[Int. J. Food Microbiol. 388 (2023) 110064]
Muller et al. Practical strategies for SARS-CoV-2 RT-PCR testing in resource-constrained settings (preprint)
Williger THE RELATIONSHIP OF GENDER IDENTITY IN MARRIED COUPLES TO CONFLICT, CONFLICT RESOLUTION, INTIMACY, AND ADJUSTMENT.
Kreger Counseling and reemployment: An investigation of reliable predictors.

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20170314