CA2250087A1 - Device for highly sensitive magnetic detection of analytes - Google Patents

Device for highly sensitive magnetic detection of analytes

Info

Publication number
CA2250087A1
CA2250087A1 CA002250087A CA2250087A CA2250087A1 CA 2250087 A1 CA2250087 A1 CA 2250087A1 CA 002250087 A CA002250087 A CA 002250087A CA 2250087 A CA2250087 A CA 2250087A CA 2250087 A1 CA2250087 A1 CA 2250087A1
Authority
CA
Canada
Prior art keywords
analytes
sample
location
detection
measurement
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002250087A
Other languages
French (fr)
Other versions
CA2250087C (en
Inventor
Hans Koch
Hartmut Matz
Roman Kotitz
Dietmar Drung
Lutz Trahms
Werner Weitschies
Wolfhard Semmler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Institut Fur Diagnostikforschung Gmbh An Der Freien Universitat Berlin
Hans Koch
Hartmut Matz
Roman Kotitz
Dietmar Drung
Lutz Trahms
Werner Weitschies
Wolfhard Semmler
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut Fur Diagnostikforschung Gmbh An Der Freien Universitat Berlin, Hans Koch, Hartmut Matz, Roman Kotitz, Dietmar Drung, Lutz Trahms, Werner Weitschies, Wolfhard Semmler filed Critical Institut Fur Diagnostikforschung Gmbh An Der Freien Universitat Berlin
Publication of CA2250087A1 publication Critical patent/CA2250087A1/en
Application granted granted Critical
Publication of CA2250087C publication Critical patent/CA2250087C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S505/00—Superconductor technology: apparatus, material, process
    • Y10S505/825—Apparatus per se, device per se, or process of making or operating same
    • Y10S505/842—Measuring and testing
    • Y10S505/843—Electrical
    • Y10S505/845—Magnetometer
    • Y10S505/846—Magnetometer using superconductive quantum interference device, i.e. squid

Abstract

An apparatus for the qualitative and/or quantitative measurement of analytes, in particular in biological samples by means of receptor ligand binding and having a magnetizing device for the production of a magnetic field at the location of the sample and with a detection device for measurement of magnetic properties of the sample is characterized in that the magnetizing device (11'; 11'') is spatially disposed with respect to the detection device (71, 8, 9, 10; 16; 20) in such a fashion that the magnetic field produced by the magnetization device (11', 11'') at the location of the magnetization is attenuated by at least a factor of 10, and preferentially by a factor of 1000 or more, at the location occupied by the sample during the measurement, or in that a switching device is provided for which, throughout a predetermined time duration and in particular during the measurement phase of the detection device (71, 8, 9, 10; 16), can switch-off the magnetic field of the magnetizing device (11; 21) at the location of the sample (12). In this fashion new types of measurements for magnetorelaxometric detection of analytes or for the detection of analytes by means of remanence measurements can be carried out in a routine and economical fashion in vitro or in vivo. (Fig. 1)
CA002250087A 1996-04-18 1997-03-26 Device for highly sensitive magnetic detection of analytes Expired - Fee Related CA2250087C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19615254.2 1996-04-18
DE19615254A DE19615254C2 (en) 1996-04-18 1996-04-18 Device for the highly sensitive magnetic detection of analytes
PCT/DE1997/000611 WO1997040377A1 (en) 1996-04-18 1997-03-26 Device for highly sensitive magnetic detection of analytes

Publications (2)

Publication Number Publication Date
CA2250087A1 true CA2250087A1 (en) 1997-10-30
CA2250087C CA2250087C (en) 2003-12-02

Family

ID=7791594

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002250087A Expired - Fee Related CA2250087C (en) 1996-04-18 1997-03-26 Device for highly sensitive magnetic detection of analytes

Country Status (26)

Country Link
US (1) US6123902A (en)
EP (1) EP0898706B1 (en)
JP (1) JP2001515585A (en)
KR (1) KR100305102B1 (en)
CN (1) CN1105917C (en)
AT (1) ATE234465T1 (en)
AU (1) AU718523B2 (en)
BR (1) BR9708780A (en)
CA (1) CA2250087C (en)
CZ (1) CZ293853B6 (en)
DE (3) DE19615254C2 (en)
DK (1) DK0898706T3 (en)
ES (1) ES2192269T3 (en)
GE (1) GEP20012591B (en)
HK (1) HK1019249A1 (en)
HU (1) HUP9901377A3 (en)
IL (1) IL126067A (en)
NO (1) NO984856L (en)
NZ (1) NZ331772A (en)
PL (1) PL183725B1 (en)
PT (1) PT898706E (en)
RU (1) RU2217751C2 (en)
SK (1) SK283627B6 (en)
TW (1) TW356519B (en)
UA (1) UA41476C2 (en)
WO (1) WO1997040377A1 (en)

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DE19730497C2 (en) * 1997-07-16 2000-02-10 Heermann Klaus Hinrich Method for washing, separating and concentrating biomolecules using a magnetic pen
US6437563B1 (en) * 1997-11-21 2002-08-20 Quantum Design, Inc. Method and apparatus for making measurements of accumulations of magnetically susceptible particles combined with analytes
FI102906B1 (en) * 1998-02-23 1999-03-15 Bio Nobile Oy Process and means for transporting a substance
US8480580B2 (en) 1998-04-30 2013-07-09 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6175752B1 (en) 1998-04-30 2001-01-16 Therasense, Inc. Analyte monitoring device and methods of use
US9066695B2 (en) 1998-04-30 2015-06-30 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8688188B2 (en) 1998-04-30 2014-04-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8346337B2 (en) 1998-04-30 2013-01-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8974386B2 (en) 1998-04-30 2015-03-10 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8465425B2 (en) 1998-04-30 2013-06-18 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6949816B2 (en) * 2003-04-21 2005-09-27 Motorola, Inc. Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same
CA2370745A1 (en) * 1999-02-17 2000-08-24 Kilian Hennes Method for representing biologically activated inductance-altering particles and device for carrying out the method
JP4171139B2 (en) * 1999-07-21 2008-10-22 住友電気工業株式会社 Immunoassay method and apparatus using magnetic substance labeling
GB2362588A (en) * 2000-05-23 2001-11-28 Alistair Forrest Air freshening device
US6420868B1 (en) * 2000-06-16 2002-07-16 Honeywell International Inc. Read-out electronics for DC squid magnetic measurements
US6560471B1 (en) 2001-01-02 2003-05-06 Therasense, Inc. Analyte monitoring device and methods of use
FI113297B (en) * 2001-06-19 2004-03-31 Magnasense Oy Method and apparatus for qualitatively and quantitatively displaying analytes
DE10210072B4 (en) * 2002-03-08 2005-11-03 Bundesrepublik Deutschland, vertr. d. d. Bundesministerium für Wirtschaft und Arbeit, dieses vertr. d. d. Präsidenten der Physikalisch-Technischen Bundesanstalt magnetometer
US6724188B2 (en) * 2002-03-29 2004-04-20 Wavbank, Inc. Apparatus and method for measuring molecular electromagnetic signals with a squid device and stochastic resonance to measure low-threshold signals
EP1541083A3 (en) * 2003-12-09 2006-03-01 Olympus Corporation Magnetic fluid detection device
JP3962385B2 (en) * 2004-03-11 2007-08-22 株式会社日立製作所 Immunoassay device and immunoassay method
JP4758713B2 (en) * 2005-08-30 2011-08-31 旭化成株式会社 Measuring apparatus and measuring method using magnetic sensor
US8034634B2 (en) * 2005-11-16 2011-10-11 Rex Chih-Yih Hong Ultra-sensitive magnetoreduction measurement system and ultra-sensitive, wash-free assay using the same
JP4676361B2 (en) * 2006-03-09 2011-04-27 株式会社日立製作所 Magnetic immunoassay device
JP4823726B2 (en) 2006-03-17 2011-11-24 国立大学法人豊橋技術科学大学 Biopolymer detection method and detection apparatus thereof
JP4837410B2 (en) * 2006-03-22 2011-12-14 富士フイルム株式会社 Target compound detection method
DE102006061041B4 (en) * 2006-12-22 2010-05-12 Mesutronic Gerätebau GmbH Device for monitoring a product flow for interfering inclusions
JP5326138B2 (en) * 2009-03-31 2013-10-30 国立大学法人豊橋技術科学大学 Inspection apparatus and inspection method for magnetic foreign matter in powder material
WO2012011477A1 (en) * 2010-07-21 2012-01-26 株式会社日立製作所 Magnetic-field measurement device
KR101039912B1 (en) * 2010-08-16 2011-06-09 강학성 Fine steel ball detecting apparatus being able to sense x-y position of it
US8409807B2 (en) 2010-10-22 2013-04-02 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
ES2576927T3 (en) 2010-10-22 2016-07-12 T2 Biosystems, Inc. NMR systems and methods for rapid analyte detection
JP6414498B2 (en) * 2015-03-27 2018-10-31 愛知製鋼株式会社 Differential magnetic sensor
EP3405479A4 (en) 2016-01-21 2019-08-21 T2 Biosystems, Inc. Nmr methods and systems for the rapid detection of bacteria
CN108508390B (en) * 2018-05-28 2020-05-08 哈尔滨工业大学 Calibration method of vector magnetic sensor and simple calibration method thereof
SE1950159A1 (en) * 2019-02-11 2020-08-12 Alexei Kalaboukhov Measurement system for magnetic samples
CN111073948A (en) * 2019-07-04 2020-04-28 山东百多安医疗器械有限公司 Non-contact cell weak magnetic determination method
CN113390957A (en) * 2021-04-27 2021-09-14 杭州电子科技大学 Anti-crosstalk eddy current nondestructive flaw detection system based on magnetic sensing probe

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JPS6390765A (en) * 1986-10-03 1988-04-21 Nippon Telegr & Teleph Corp <Ntt> Squid immunoassay
US4913883A (en) * 1987-07-20 1990-04-03 Hitachi, Ltd. Particle agglutination immunoassay apparatus
JP2938918B2 (en) * 1990-01-25 1999-08-25 ティーディーケイ株式会社 Magnetic fine particle size measurement method
US5408178A (en) * 1991-05-17 1995-04-18 Vanderbilt University Apparatus and method for imaging the structure of diamagnetic and paramagnetic objects
JP3081902B2 (en) * 1991-11-07 2000-08-28 工業技術院長 Magnetic field detection circuit
US5329165A (en) * 1992-05-26 1994-07-12 Midwest Superconductivity, Inc. Selectively switchable superconducting electromagnetic shield
JP3204542B2 (en) * 1992-07-24 2001-09-04 株式会社東芝 Magnetic field source measurement device
US5532592A (en) * 1993-02-02 1996-07-02 Conductus, Inc. Squid control apparatus with non-cryogenic flux-locked loop disposed in close proximity to the squid
US5486457A (en) * 1993-08-25 1996-01-23 Children's Medical Center Corporation Method and system for measurement of mechanical properties of molecules and cells
DE19503664C2 (en) * 1995-01-27 1998-04-02 Schering Ag Magnetorelaxometric detection of analytes
DE19508772C2 (en) * 1995-03-01 1998-01-29 Schering Ag Methods and connections for the detection of analytes by means of remanence measurement and their use
JPH0984777A (en) * 1995-09-25 1997-03-31 Toshiba Corp Vital magnetic field measuring device

Also Published As

Publication number Publication date
PL328792A1 (en) 1999-02-15
KR100305102B1 (en) 2001-11-05
DE29780349U1 (en) 1999-04-01
DK0898706T3 (en) 2003-04-22
IL126067A0 (en) 1999-05-09
WO1997040377A1 (en) 1997-10-30
EP0898706A1 (en) 1999-03-03
BR9708780A (en) 2000-01-04
CZ333898A3 (en) 1999-04-14
PT898706E (en) 2003-07-31
CN1105917C (en) 2003-04-16
NZ331772A (en) 2000-04-28
SK143598A3 (en) 1999-05-07
DE19615254C2 (en) 1999-03-11
HUP9901377A2 (en) 1999-08-30
UA41476C2 (en) 2001-09-17
TW356519B (en) 1999-04-21
CN1216613A (en) 1999-05-12
US6123902A (en) 2000-09-26
NO984856L (en) 1998-12-04
DE59709508D1 (en) 2003-04-17
NO984856D0 (en) 1998-10-16
HUP9901377A3 (en) 2002-11-28
SK283627B6 (en) 2003-10-07
RU2217751C2 (en) 2003-11-27
ATE234465T1 (en) 2003-03-15
EP0898706B1 (en) 2003-03-12
HK1019249A1 (en) 2000-01-28
JP2001515585A (en) 2001-09-18
GEP20012591B (en) 2001-11-26
CZ293853B6 (en) 2004-08-18
KR20000005555A (en) 2000-01-25
AU2885497A (en) 1997-11-12
IL126067A (en) 2001-08-26
ES2192269T3 (en) 2003-10-01
DE19615254A1 (en) 1997-10-23
CA2250087C (en) 2003-12-02
AU718523B2 (en) 2000-04-13
PL183725B1 (en) 2002-07-31

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