CA2249320A1 - Glycosylated humanized b-cell specific antibodies - Google Patents

Glycosylated humanized b-cell specific antibodies

Info

Publication number
CA2249320A1
CA2249320A1 CA002249320A CA2249320A CA2249320A1 CA 2249320 A1 CA2249320 A1 CA 2249320A1 CA 002249320 A CA002249320 A CA 002249320A CA 2249320 A CA2249320 A CA 2249320A CA 2249320 A1 CA2249320 A1 CA 2249320A1
Authority
CA
Canada
Prior art keywords
antibody
cell specific
fragment
specific antibodies
glycosylated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002249320A
Other languages
French (fr)
Other versions
CA2249320C (en
Inventor
Shui-On Leung
Hans Hansen
Zhengxing Qu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immunomedics Inc
Original Assignee
Immunomedics, Inc.
Shui-On Leung
Hans Hansen
Zhengxing Qu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunomedics, Inc., Shui-On Leung, Hans Hansen, Zhengxing Qu filed Critical Immunomedics, Inc.
Publication of CA2249320A1 publication Critical patent/CA2249320A1/en
Application granted granted Critical
Publication of CA2249320C publication Critical patent/CA2249320C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54—F(ab')2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A humanized specific monoclonal antibody or antibody fragment, especially a B-cell specific antibody or antibody fragment, is engineered to contain a glyxosylation site in the non-Fc constant region. The glycosylated antibody is useful for diagnosis and/or therapy whenever a targeting antibody or fragment is used, especially for B-cell malignancies. The carbohydrate moiety allows conjugation of labeling or therapeutic agents of increased size, without affecting the binding affinity or specificity of the antibody.
CA002249320A 1996-03-20 1997-03-19 Glycosylated humanized b-cell specific antibodies Expired - Fee Related CA2249320C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US1370996P 1996-03-20 1996-03-20
US60/013,709 1996-03-20
US60/013,709(CON) 1996-03-20
PCT/US1997/004196 WO1997034632A1 (en) 1996-03-20 1997-03-19 Glycosylated humanized b-cell specific antibodies

Publications (2)

Publication Number Publication Date
CA2249320A1 true CA2249320A1 (en) 1997-09-25
CA2249320C CA2249320C (en) 2008-12-23

Family

ID=21761323

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002249320A Expired - Fee Related CA2249320C (en) 1996-03-20 1997-03-19 Glycosylated humanized b-cell specific antibodies

Country Status (8)

Country Link
US (3) US6254868B1 (en)
EP (1) EP0888125B1 (en)
JP (1) JP3904238B2 (en)
AT (1) ATE267610T1 (en)
AU (1) AU705063B2 (en)
CA (1) CA2249320C (en)
DE (1) DE69729283T2 (en)
WO (1) WO1997034632A1 (en)

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Also Published As

Publication number Publication date
CA2249320C (en) 2008-12-23
US20030035800A1 (en) 2003-02-20
AU705063B2 (en) 1999-05-13
JP3904238B2 (en) 2007-04-11
WO1997034632A1 (en) 1997-09-25
DE69729283D1 (en) 2004-07-01
US6254868B1 (en) 2001-07-03
EP0888125B1 (en) 2004-05-26
EP0888125A1 (en) 1999-01-07
EP0888125A4 (en) 2001-04-25
JP2000507818A (en) 2000-06-27
US20040258682A1 (en) 2004-12-23
DE69729283T2 (en) 2005-05-25
AU2531897A (en) 1997-10-10
ATE267610T1 (en) 2004-06-15

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