CA2241322A1 - Sustained-release preparation and its production - Google Patents

Sustained-release preparation and its production

Info

Publication number
CA2241322A1
CA2241322A1 CA002241322A CA2241322A CA2241322A1 CA 2241322 A1 CA2241322 A1 CA 2241322A1 CA 002241322 A CA002241322 A CA 002241322A CA 2241322 A CA2241322 A CA 2241322A CA 2241322 A1 CA2241322 A1 CA 2241322A1
Authority
CA
Canada
Prior art keywords
sustained
production
release preparation
dispersing
surfactant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002241322A
Other languages
French (fr)
Other versions
CA2241322C (en
Inventor
Shigeyuki Takada
Tomofumi Kurokawa
Susumu Iwasa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries, Ltd.
Shigeyuki Takada
Tomofumi Kurokawa
Susumu Iwasa
Takeda Pharmaceutical Company Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries, Ltd., Shigeyuki Takada, Tomofumi Kurokawa, Susumu Iwasa, Takeda Pharmaceutical Company Limited filed Critical Takeda Chemical Industries, Ltd.
Publication of CA2241322A1 publication Critical patent/CA2241322A1/en
Application granted granted Critical
Publication of CA2241322C publication Critical patent/CA2241322C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Abstract

Disclosed is a sustained-release preparation characterized in that it is produced by dispersing in an oil phase a rapidly dried product containing a bioactive polypeptide and a surfactant, and subsequent shaping, and a method of its production.
CA002241322A 1996-03-28 1997-03-27 Sustained-release preparation and its production Expired - Fee Related CA2241322C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP7301696 1996-03-28
JP8/73016 1996-03-28
PCT/JP1997/001041 WO1997035563A2 (en) 1996-03-28 1997-03-27 Sustained-release preparation and its production

Publications (2)

Publication Number Publication Date
CA2241322A1 true CA2241322A1 (en) 1997-10-02
CA2241322C CA2241322C (en) 2009-01-13

Family

ID=13506129

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002241322A Expired - Fee Related CA2241322C (en) 1996-03-28 1997-03-27 Sustained-release preparation and its production

Country Status (8)

Country Link
US (2) US6190702B1 (en)
EP (1) EP0889722B1 (en)
AT (1) ATE227980T1 (en)
AU (1) AU2043297A (en)
CA (1) CA2241322C (en)
DE (1) DE69717263T2 (en)
DK (1) DK0889722T3 (en)
WO (1) WO1997035563A2 (en)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000500744A (en) 1995-11-09 2000-01-25 マイクロバイオロジカル リサーチ オーソリティー Microencapsulated DNA for vaccination and gene therapy
US6270795B1 (en) 1995-11-09 2001-08-07 Microbiological Research Authority Method of making microencapsulated DNA for vaccination and gene therapy
US6287587B2 (en) 1997-07-15 2001-09-11 Takeda Chemical Industries, Ltd. Process for producing sustained-release preparation by in-water drying
HUP0100221A3 (en) 1998-01-16 2002-11-28 Takeda Pharmaceutical Sustained release compositions, process for producing the same and utilization thereof
CA2317039C (en) * 1998-01-21 2009-09-29 Takeda Chemical Industries, Ltd. Lyophilization method for sustained-release preparations
DK1061948T3 (en) 1998-03-20 2003-03-31 Takeda Chemical Industries Ltd Preparation for sustained release of a physiologically active polypeptide and its preparation
GB9810236D0 (en) 1998-05-13 1998-07-08 Microbiological Res Authority Improvements relating to encapsulation of bioactive agents
US7029700B2 (en) 2000-01-14 2006-04-18 Brown University Research Foundation Micronized freeze-dried particles
AU773735B2 (en) * 2000-01-14 2004-06-03 Brown University Research Foundation Micronized freeze-dried particles
WO2001072323A2 (en) 2000-03-24 2001-10-04 Genentech, Inc. Use of insulin for the treatment of cartilagenous disorders
US20080233165A1 (en) * 2000-08-07 2008-09-25 Biolok International, Inc. Time release calcium sulfate and growth factor matrix for bone augmentation
US7488761B2 (en) * 2000-08-07 2009-02-10 Orthogen Llc Polymer containing calcium sulfate particles for bone augmentation
US6824822B2 (en) * 2001-08-31 2004-11-30 Alkermes Controlled Therapeutics Inc. Ii Residual solvent extraction method and microparticles produced thereby
WO2002053136A1 (en) 2000-12-28 2002-07-11 Takeda Chemical Industries, Ltd. Sustained release preparations
JP2002265383A (en) * 2001-03-14 2002-09-18 Mitsubishi Pharma Corp LIQUID PREPARATION FOR INTERFERON-alpha INJECTION
WO2002078673A1 (en) * 2001-03-29 2002-10-10 Takeda Chemical Industries, Ltd. Process for producing fine granulate drug
US20040126900A1 (en) * 2001-04-13 2004-07-01 Barry Stephen E High affinity peptide- containing nanoparticles
US6887897B2 (en) 2001-07-31 2005-05-03 Mission Pharmacal Company Calcium glutarate supplement and phosphorus binder
CN101444476B (en) * 2001-12-26 2011-11-30 武田药品工业株式会社 New microsphere and method for producing the same
EP1551876B1 (en) 2002-10-16 2011-03-16 Purdue Pharma L.P. Antibodies that bind cell-associated ca 125/0722p and methods of use thereof
WO2004035762A2 (en) * 2002-10-17 2004-04-29 Alkermes Controlled Therapeutics, Inc. Ii Microencapsulation and sustained release of biologically active polypeptides
US20060110423A1 (en) * 2004-04-15 2006-05-25 Wright Steven G Polymer-based sustained release device
CN1968700A (en) * 2004-04-15 2007-05-23 阿尔克姆斯有限公司 Polymer-based sustained release device
US7456254B2 (en) * 2004-04-15 2008-11-25 Alkermes, Inc. Polymer-based sustained release device
US20070219131A1 (en) * 2004-04-15 2007-09-20 Ben-Sasson Shmuel A Compositions capable of facilitating penetration across a biological barrier
US8075910B2 (en) * 2004-05-20 2011-12-13 Pbm Pharmaceuticals, Inc. Oral compositions comprising edible oils and vitamins and/or minerals and methods for making oral compositions
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
DE102005017777A1 (en) * 2005-04-13 2006-10-19 Pharmasol Gmbh Preparation of high fine particle suspension comprises dissolving solid in a solvent, freezing, lyophilizing solid matrix, withdrawing solid matrix from solvent and dispersing in an external phase and applying high power on the dispersion
US9248101B2 (en) * 2005-04-13 2016-02-02 Abbvie Deutschland Gmbh & Co Kg Method for the gentle production of ultrafine particle suspensions and ultrafine particles and the use thereof
KR101200728B1 (en) 2006-08-09 2012-11-13 인타르시아 세라퓨틱스 인코포레이티드 Osmotic delivery system and piston assemblies
WO2008118712A1 (en) * 2007-03-22 2008-10-02 Alkermes, Inc. Coacervation process
AU2008244523B2 (en) 2007-04-23 2012-02-16 Intarcia Therapeutics, Inc. Suspension formulations of insulinotropic peptides and uses thereof
US20080317865A1 (en) * 2007-06-20 2008-12-25 Alkermes, Inc. Quench liquids and washing systems for production of microparticles
EP2044934A1 (en) * 2007-10-01 2009-04-08 Institut National De La Sante Et De La Recherche Medicale (Inserm) Dispersion of poloxamer-protein particles, methods of manufacturing and uses thereof
EP2240155B1 (en) 2008-02-13 2012-06-06 Intarcia Therapeutics, Inc Devices, formulations, and methods for delivery of multiple beneficial agents
FI2341905T4 (en) * 2008-09-04 2023-12-04 Amylin Pharmaceuticals Llc Sustained release formulations using non-aqueous carriers
CA2963659C (en) 2008-09-17 2020-06-23 Chiasma Inc. Use of oral octreotride compositions
SI2462246T1 (en) 2009-09-28 2018-01-31 Intarcia Therapeutics, Inc. Rapid establishment and/or termination of substantial steady-state drug delivery
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
EP3253401A4 (en) 2015-02-03 2018-11-21 Chiasma Inc. Method of treating diseases
KR20240042548A (en) 2015-06-03 2024-04-02 인타르시아 세라퓨틱스 인코포레이티드 Implant placement and removal systems
MA53353A (en) 2016-05-16 2021-06-09 Intarcia Therapeutics Inc GLUCAGON RECEPTOR SELECTIVE POLYPEPTIDES AND METHODS FOR THEIR USE
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
EP3565580B1 (en) 2017-01-03 2024-03-06 i2o Therapeutics, Inc. Continuous administration of exenatide and co-adminstration of acetaminophen, ethinylestradiol or levonorgestrel
EP4218738A1 (en) 2017-02-24 2023-08-02 The Regents of The University of California Particle-drop structures and methods for making and using the same
US11141457B1 (en) 2020-12-28 2021-10-12 Amryt Endo, Inc. Oral octreotide therapy and contraceptive methods

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5385738A (en) 1983-10-14 1995-01-31 Sumitomo Pharmaceuticals Company, Ltd. Sustained-release injection
US4774091A (en) 1983-10-14 1988-09-27 Sumitomo Pharmaceuticals Company, Ltd. Long-term sustained-release preparation
US4963367A (en) 1984-04-27 1990-10-16 Medaphore, Inc. Drug delivery compositions and methods
US4962091A (en) 1986-05-23 1990-10-09 Syntex (U.S.A.) Inc. Controlled release of macromolecular polypeptides
JP3116311B2 (en) 1990-06-13 2000-12-11 エーザイ株式会社 Manufacturing method of microsphere
NO302481B1 (en) 1990-10-16 1998-03-09 Takeda Chemical Industries Ltd Polymer for an extended release preparation, as well as an extended release preparation
US5288502A (en) 1991-10-16 1994-02-22 The University Of Texas System Preparation and uses of multi-phase microspheres
DK0674506T3 (en) 1992-12-02 2001-01-08 Alkermes Inc Controlled release growth hormone-containing microspheres
JP3698721B2 (en) 1993-02-23 2005-09-21 ジェネンテク・インコーポレイテッド Excipient stabilization of polypeptides treated with organic solvents
NZ260909A (en) 1993-07-05 1995-04-27 Takeda Chemical Industries Ltd Production of sustained release preparation by allowing a water-soluble polypeptide to permeate into a biodegradable matrix in an aqueous solution
DK0724433T3 (en) 1993-10-22 1999-08-30 Genentech Inc Process for preparing microspheres with a fluidized bed drying step
US6117455A (en) * 1994-09-30 2000-09-12 Takeda Chemical Industries, Ltd. Sustained-release microcapsule of amorphous water-soluble pharmaceutical active agent
TW448055B (en) * 1995-09-04 2001-08-01 Takeda Chemical Industries Ltd Method of production of sustained-release preparation
EP0765660A3 (en) * 1995-09-28 1998-09-23 Takeda Chemical Industries, Ltd. Microcapsules comprising 2-piperazinone-1-acetic acid compounds

Also Published As

Publication number Publication date
CA2241322C (en) 2009-01-13
DK0889722T3 (en) 2003-02-10
DE69717263T2 (en) 2003-07-24
ATE227980T1 (en) 2002-12-15
WO1997035563A3 (en) 1997-11-20
AU2043297A (en) 1997-10-17
US20010006678A1 (en) 2001-07-05
WO1997035563A2 (en) 1997-10-02
EP0889722B1 (en) 2002-11-20
US6190702B1 (en) 2001-02-20
DE69717263D1 (en) 2003-01-02
EP0889722A2 (en) 1999-01-13

Similar Documents

Publication Publication Date Title
CA2241322A1 (en) Sustained-release preparation and its production
CA2276328A1 (en) Comestible coated with a poorly water-soluble salt and process for making
CA2165781A1 (en) Process for producing relaxin
CA2272537A1 (en) Coated detergent tablet
CA2047256A1 (en) Process for decabromodiphenylalkane predominant product
CA2032278A1 (en) Multistep synthesis of hexafluoropropylene
CA2272642A1 (en) Coated detergent tablet
AU2503788A (en) Process for the production of biodegradable microcapsules of water-soluble peptides and proteins, and microcapsules obtained by this process
CA2267790A1 (en) Rapid fabric forming
AU8144994A (en) Copolymers of unsaturated carboxylic acids, process for producing them and their use
AU5579494A (en) Method of producing collagen-containing semi-finished product
AU5823596A (en) Method of producing a yeast extract useable in foodstuffs, w here undesirable flavouring agents in the extract have been removed
CA2240201A1 (en) Process for the preparation of felodipine
AU4201393A (en) Starch intermediate product, process for producing it and process for its further processing
CA2283572A1 (en) Bifurcated method to process aloe whole leaf
EP0376730A3 (en) Method of fabricating titanium-aluminum shapes
PH30914A (en) A process for the production of hydrolyzed vegetable proteins and the product therefrom.
CA2025678A1 (en) Natural delta-lactones and process of the production thereof
AU7273794A (en) Process for production of ice cream for domestic and small-scale purposes
AU6255190A (en) Chlorella-containing fatty oil foodstuff and process for producing the same
CA2157387A1 (en) Method and compositions for recombinant osteogenic protein production
AU6255090A (en) Chlorella-containing fatty oil foodstuff and process for producing the same
PL325398A1 (en) Novel derivatives of carboxylic acids, their production and application
AU3369289A (en) Process for producing shaped food
ZA976888B (en) A process for the preparation of 2-aryl-propionic and 2-aryl-acetic acids starting from aryl-olefins.

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20150327