CA2240416A1 - Method for producing transdermal patches - Google Patents

Method for producing transdermal patches

Info

Publication number
CA2240416A1
CA2240416A1 CA002240416A CA2240416A CA2240416A1 CA 2240416 A1 CA2240416 A1 CA 2240416A1 CA 002240416 A CA002240416 A CA 002240416A CA 2240416 A CA2240416 A CA 2240416A CA 2240416 A1 CA2240416 A1 CA 2240416A1
Authority
CA
Canada
Prior art keywords
band
layer
sections
active ingredient
transdermal patches
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002240416A
Other languages
French (fr)
Other versions
CA2240416C (en
Inventor
Bodo Asmussen
Thomas Hille
Klaus Schumann
Peter Steinborn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LTS Lohmann Therapie Systeme AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2240416A1 publication Critical patent/CA2240416A1/en
Application granted granted Critical
Publication of CA2240416C publication Critical patent/CA2240416C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive plasters or dressings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive plasters or dressings
    • A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
    • A61F2013/0296—Apparatus or processes for manufacturing adhesive dressings or bandages for making transdermal patches (chemical processes excluded)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
    • Y10T156/19—Delaminating means
    • Y10T156/1961—Severing delaminating means [e.g., chisel, etc.]
    • Y10T156/1967—Cutting delaminating means

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

The invention relates to a method for continuous production of transdermal patches. In said method, a laminate comprising an auxiliary layer (3) which is siliconised on one side, a self-adhesive layer (4) containing the active ingredient, and a carrier layer (9) is provided in the form of a striplike band (1).
The sections (4') containing the active ingredient and obtained by punching out the layers (3) and (4) at right angles to the direction of the band are transferred in stages to a second band (2). There is punching out during the resting stage between the stages and transfer to the second band (2) is carried out at preferably equal distances using transfer means (11, 12). The invention is characterised in that during transfer the carrier layer (9) is initially removed from the sections (4') containing the active ingredient and subsequently the sections (3') of the auxiliary layer are removed using a self-adhesive process layer (5).
CA002240416A 1995-12-20 1996-12-04 Method for producing transdermal patches Expired - Fee Related CA2240416C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19547691.3 1995-12-20
DE19547691A DE19547691C1 (en) 1995-12-20 1995-12-20 Continuous prodn. of transdermal therapeutic plaster
PCT/EP1996/005410 WO1997022315A1 (en) 1995-12-20 1996-12-04 Method for producing transdermal patches (tts)

Publications (2)

Publication Number Publication Date
CA2240416A1 true CA2240416A1 (en) 1997-06-26
CA2240416C CA2240416C (en) 2005-03-29

Family

ID=7780735

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002240416A Expired - Fee Related CA2240416C (en) 1995-12-20 1996-12-04 Method for producing transdermal patches

Country Status (24)

Country Link
US (1) US6059913A (en)
EP (1) EP0959834B1 (en)
JP (1) JP3585128B2 (en)
KR (1) KR100439921B1 (en)
CN (1) CN1130172C (en)
AT (1) ATE213144T1 (en)
AU (1) AU709517B2 (en)
CA (1) CA2240416C (en)
CZ (1) CZ289083B6 (en)
DE (2) DE19547691C1 (en)
DK (1) DK0959834T3 (en)
ES (1) ES2172698T3 (en)
HK (1) HK1026356A1 (en)
HU (1) HU225104B1 (en)
IL (1) IL124618A (en)
MX (1) MX9804996A (en)
MY (1) MY113548A (en)
NO (1) NO311636B1 (en)
NZ (1) NZ324305A (en)
PL (1) PL183410B1 (en)
PT (1) PT959834E (en)
SK (1) SK282988B6 (en)
WO (1) WO1997022315A1 (en)
ZA (1) ZA9610666B (en)

Families Citing this family (40)

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US6464818B1 (en) * 1996-10-04 2002-10-15 Tesa Ag Method of wasteless punching of adhesive punched items
DE19820366C2 (en) * 1998-05-07 2000-08-17 Lohmann Gmbh & Co Kg Method and device for producing segmented PSA layers and attaching them to a substrate
DE19837764C1 (en) 1998-08-20 2000-03-16 Lohmann Therapie Syst Lts Process for producing adhesive die-cuts from an endless web and die-cut produced according to the method
US6220437B1 (en) * 1998-08-24 2001-04-24 Gemtron Corporation Stack of spaced sheets
DE19853737C2 (en) * 1998-11-21 2003-03-06 Lohmann Therapie Syst Lts Method for dispensing flat structures
DE19946384A1 (en) 1999-09-28 2001-04-05 Lohmann Therapie Syst Lts Method and device for dispensing pressure-sensitive adhesive laminate sections from a movable primary to a movable secondary carrier web
US7013340B1 (en) 2000-05-18 2006-03-14 Microsoft Corporation Postback input handling by server-side control objects
US7380250B2 (en) * 2001-03-16 2008-05-27 Microsoft Corporation Method and system for interacting with devices having different capabilities
DE10114382A1 (en) * 2001-03-23 2002-09-26 Beiersdorf Ag Moisture-absorbing material used for plasters, medical fixings, wound coverings and bandages comprises adhesive matrix of silicon, gel former and optionally silicone resin
US7493397B1 (en) 2001-06-06 2009-02-17 Microsoft Corporation Providing remote processing services over a distributed communications network
US6915454B1 (en) 2001-06-12 2005-07-05 Microsoft Corporation Web controls validation
TW564471B (en) * 2001-07-16 2003-12-01 Semiconductor Energy Lab Semiconductor device and peeling off method and method of manufacturing semiconductor device
JP2003109773A (en) * 2001-07-27 2003-04-11 Semiconductor Energy Lab Co Ltd Light-emitting device, semiconductor device and its manufacturing method
JP5057619B2 (en) * 2001-08-01 2012-10-24 株式会社半導体エネルギー研究所 Method for manufacturing semiconductor device
TW554398B (en) * 2001-08-10 2003-09-21 Semiconductor Energy Lab Method of peeling off and method of manufacturing semiconductor device
TW558743B (en) 2001-08-22 2003-10-21 Semiconductor Energy Lab Peeling method and method of manufacturing semiconductor device
KR100944886B1 (en) * 2001-10-30 2010-03-03 가부시키가이샤 한도오따이 에네루기 켄큐쇼 A method of manufacturing a semiconductor device
TWI264121B (en) 2001-11-30 2006-10-11 Semiconductor Energy Lab A display device, a method of manufacturing a semiconductor device, and a method of manufacturing a display device
US6953735B2 (en) 2001-12-28 2005-10-11 Semiconductor Energy Laboratory Co., Ltd. Method for fabricating a semiconductor device by transferring a layer to a support with curvature
DE10207776A1 (en) * 2002-02-23 2003-09-04 Tesa Ag Process for the production of a partially coated plaster
US7396493B2 (en) * 2002-05-21 2008-07-08 3M Innovative Properties Company Multilayer optical film with melt zone to control delamination
US6991695B2 (en) * 2002-05-21 2006-01-31 3M Innovative Properties Company Method for subdividing multilayer optical film cleanly and rapidly
US7574653B2 (en) 2002-10-11 2009-08-11 Microsoft Corporation Adaptive image formatting control
CN100391004C (en) 2002-10-30 2008-05-28 株式会社半导体能源研究所 Semiconductor device and manufacturing method thereof
CN100425216C (en) * 2003-02-13 2008-10-15 上海东月医疗保健用品有限公司 Filling type fortified scar plaster and method for making same
US7890604B2 (en) 2004-05-07 2011-02-15 Microsoft Corproation Client-side callbacks to server events
US9026578B2 (en) 2004-05-14 2015-05-05 Microsoft Corporation Systems and methods for persisting data between web pages
US7464386B2 (en) 2004-05-17 2008-12-09 Microsoft Corporation Data controls architecture
CN101232875B (en) * 2005-06-10 2014-06-25 3M创新有限公司 Method for handling adhesive laminate sections
TWI289059B (en) * 2006-01-24 2007-11-01 Tsung-Ching Shiu Prototype machine for in time manufacturing of functional adhesive patch in germ-free room
KR100796676B1 (en) 2006-08-25 2008-01-21 김승자 A manufacturing apparatus for patch containing tourmaline
ATE485797T1 (en) * 2007-08-21 2010-11-15 Lohmann Therapie Syst Lts METHOD FOR MULTI-LINE ASSEMBLING TRANSDERMAL THERAPEUTIC PLASTERS
RU2497679C2 (en) 2008-10-02 2013-11-10 Милан Инк. Method of making multilayer adhesive laminated material
CA2815568C (en) * 2010-09-23 2018-10-09 Monosolrx Llc Method and system for forming a pharmaceutical product directly onto a packaging surface
JP5240348B2 (en) * 2011-11-07 2013-07-17 トヨタ自動車株式会社 Manufacturing method of membrane electrode assembly
KR20150120376A (en) 2013-02-20 2015-10-27 가부시키가이샤 한도오따이 에네루기 켄큐쇼 Peeling method, semiconductor device, and peeling apparatus
CN105793957B (en) 2013-12-12 2019-05-03 株式会社半导体能源研究所 Stripping means and stripping off device
US20160144528A1 (en) * 2014-11-25 2016-05-26 Biodelivery Sciences International, Inc. Patch devices, methods and apparatus for forming, and testing pharmaceutical agent delivery patch devices
EP3233492B1 (en) 2014-12-18 2021-11-10 Kindeva Drug Delivery L.P. Methods of handling adhesive laminate patches
EP3744491A1 (en) * 2019-05-27 2020-12-02 LTS Lohmann Therapie-Systeme AG Tool set for manufacturing adhesive patches, method of manufacturing an adhesive patch and adhesive layering

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3204582A1 (en) * 1982-02-10 1983-08-25 Hassia Verpackung Gmbh, 6479 Ranstadt Method of continuously producing plaster packs for transdermal administration of medicaments
AU6467090A (en) * 1989-10-25 1991-05-02 Osaka Sealing Printing Co., Ltd. Method for manufacturing label-continued sheet
DE4110027C2 (en) * 1991-03-27 1996-08-29 Lohmann Therapie Syst Lts Process for packaging transdermal therapeutic patches
DE4232279C1 (en) * 1992-09-25 1993-10-21 Lohmann Therapie Syst Lts Transfer process for the production of transdermal therapeutic systems
JP3156419B2 (en) * 1993-02-15 2001-04-16 松下電器産業株式会社 Method of removing separator for protecting anisotropic conductive film
DE4406976C1 (en) * 1994-03-03 1995-06-22 Lohmann Therapie Syst Lts Transfer of adhesive material sections

Also Published As

Publication number Publication date
JP2000502090A (en) 2000-02-22
AU1176397A (en) 1997-07-14
WO1997022315A1 (en) 1997-06-26
EP0959834A1 (en) 1999-12-01
PL183410B1 (en) 2002-06-28
HU225104B1 (en) 2006-06-28
SK282988B6 (en) 2003-01-09
CN1205623A (en) 1999-01-20
IL124618A0 (en) 1998-12-06
MX9804996A (en) 1998-09-30
EP0959834B1 (en) 2002-02-13
IL124618A (en) 2001-12-23
NZ324305A (en) 2000-01-28
CZ171098A3 (en) 1998-10-14
HK1026356A1 (en) 2000-12-15
DK0959834T3 (en) 2002-05-27
KR20000064426A (en) 2000-11-06
JP3585128B2 (en) 2004-11-04
CZ289083B6 (en) 2001-10-17
ZA9610666B (en) 1997-06-27
DE19547691C1 (en) 1997-04-24
PL327602A1 (en) 1998-12-21
AU709517B2 (en) 1999-09-02
DE59608749D1 (en) 2002-03-21
MY113548A (en) 2002-03-30
NO982844D0 (en) 1998-06-19
CA2240416C (en) 2005-03-29
KR100439921B1 (en) 2005-01-15
HUP0000209A2 (en) 2000-10-28
NO311636B1 (en) 2001-12-27
PT959834E (en) 2002-07-31
US6059913A (en) 2000-05-09
NO982844L (en) 1998-06-19
ES2172698T3 (en) 2002-10-01
ATE213144T1 (en) 2002-02-15
HUP0000209A3 (en) 2001-03-28
CN1130172C (en) 2003-12-10
SK67598A3 (en) 1998-10-07

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Effective date: 20131204