CA2239970A1 - Process for preparing optically active compounds - Google Patents

Process for preparing optically active compounds

Info

Publication number
CA2239970A1
CA2239970A1 CA002239970A CA2239970A CA2239970A1 CA 2239970 A1 CA2239970 A1 CA 2239970A1 CA 002239970 A CA002239970 A CA 002239970A CA 2239970 A CA2239970 A CA 2239970A CA 2239970 A1 CA2239970 A1 CA 2239970A1
Authority
CA
Canada
Prior art keywords
optically active
active compounds
transition metal
metal complex
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002239970A
Other languages
French (fr)
Other versions
CA2239970C (en
Inventor
Takao Ikariya
Shohei Hashiguchi
Jun Takehara
Nobuyuki Uematsu
Kazuhiko Matsumura
Ryoji Noyori
Akio Fujii
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takasago International Corp
Japan Science and Technology Agency
JFE Engineering Corp
Asahi Kasei Pharma Corp
Takeda Pharmaceutical Co Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP7318303A external-priority patent/JP2962668B2/en
Priority claimed from JP7318304A external-priority patent/JP2912572B2/en
Priority claimed from JP8284233A external-priority patent/JP3040353B2/en
Application filed by Individual filed Critical Individual
Priority claimed from PCT/JP1996/003573 external-priority patent/WO1997020789A1/en
Publication of CA2239970A1 publication Critical patent/CA2239970A1/en
Application granted granted Critical
Publication of CA2239970C publication Critical patent/CA2239970C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A novel and practically excellent process for preparing optically active compounds, such as optically active alcohols or amines, useful for various applications of, for example, synthetic intermediates of pharmaceuticals liquid crystalline materials, and reagents for optical resolution, wherein a hydrogen transfer type asymmetric reduction is carried out in the presence of both a transition metal complex and an optically active nitrogen compound or a transition metal complex having an optically active nitrogen compound as an asymmetric ligand, and a hydrogen-donating organic or inorganic compound. Further, optically active secondary alcohols are prepared from racemic secondary alcohols or meso-diols by a hydrogen transfer oxidation.
CA002239970A 1995-12-06 1996-12-06 Process for preparing optically active compounds Expired - Lifetime CA2239970C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP318304/1995 1995-12-06
JP318303/1995 1995-12-06
JP7318303A JP2962668B2 (en) 1995-12-06 1995-12-06 Method for producing optically active alcohols
JP7318304A JP2912572B2 (en) 1995-12-06 1995-12-06 Method for producing optically active amines
JP284233/1996 1996-10-25
JP8284233A JP3040353B2 (en) 1996-10-25 1996-10-25 Ruthenium-diamine complex and method for producing optically active alcohols using the same as a catalyst
PCT/JP1996/003573 WO1997020789A1 (en) 1995-12-06 1996-12-06 Process for preparating optically active compounds

Publications (2)

Publication Number Publication Date
CA2239970A1 true CA2239970A1 (en) 1997-06-12
CA2239970C CA2239970C (en) 2006-02-21

Family

ID=35929952

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002239970A Expired - Lifetime CA2239970C (en) 1995-12-06 1996-12-06 Process for preparing optically active compounds

Country Status (1)

Country Link
CA (1) CA2239970C (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999054337A1 (en) * 1998-04-17 1999-10-28 Symyx Technologies Ancillary ligands and metal complexes thereof
NL1009346C2 (en) * 1998-06-09 1999-12-10 Dsm Nv Catalyst for preparing optically active compounds asymmetric transfer hydrogenation comprises transition metal compound and optically active amino acid amide, peptide or protein ligand
US6124476A (en) * 1998-04-17 2000-09-26 Symyx Technologies, Inc. Catalyst ligands, catalyst compositions, catalyst metal complexes and processes for cross-coupling aromatic boron compounds with aromatic halogens or perfluoroalkylsulfonates
US6265601B1 (en) 1998-08-06 2001-07-24 Symyx Technologies, Inc. Methods for using phosphine ligands in compositions for suzuki cross-coupling reactions
US6268513B1 (en) 1998-08-06 2001-07-31 Symyx Technologies, Inc. Phosphine ligands metal complexes and compositions thereof for cross-coupling reactions
US6534653B2 (en) 2000-04-13 2003-03-18 Solvias Ag 3,5-Dioxa-8-aza-tricyclo[5.2.1.00,0]decane-9-methanols, their metal complexes and enantio-selective hydrogenation processes
US6635783B2 (en) 2000-03-06 2003-10-21 Solvias Ag Bicyclic 1,3-aminoalcohols, d8-metal complexes and hydrogenation processes

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999054337A1 (en) * 1998-04-17 1999-10-28 Symyx Technologies Ancillary ligands and metal complexes thereof
US6124476A (en) * 1998-04-17 2000-09-26 Symyx Technologies, Inc. Catalyst ligands, catalyst compositions, catalyst metal complexes and processes for cross-coupling aromatic boron compounds with aromatic halogens or perfluoroalkylsulfonates
US6225487B1 (en) 1998-04-17 2001-05-01 Symyx Technologies, Inc. Ancillary ligands and metal complexes, catalysts and compositions using same and methods of testing
NL1009346C2 (en) * 1998-06-09 1999-12-10 Dsm Nv Catalyst for preparing optically active compounds asymmetric transfer hydrogenation comprises transition metal compound and optically active amino acid amide, peptide or protein ligand
US6265601B1 (en) 1998-08-06 2001-07-24 Symyx Technologies, Inc. Methods for using phosphine ligands in compositions for suzuki cross-coupling reactions
US6268513B1 (en) 1998-08-06 2001-07-31 Symyx Technologies, Inc. Phosphine ligands metal complexes and compositions thereof for cross-coupling reactions
US6635783B2 (en) 2000-03-06 2003-10-21 Solvias Ag Bicyclic 1,3-aminoalcohols, d8-metal complexes and hydrogenation processes
US6534653B2 (en) 2000-04-13 2003-03-18 Solvias Ag 3,5-Dioxa-8-aza-tricyclo[5.2.1.00,0]decane-9-methanols, their metal complexes and enantio-selective hydrogenation processes

Also Published As

Publication number Publication date
CA2239970C (en) 2006-02-21

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