CA2239070A1 - Systems and methods for removing viral agents from blood - Google Patents

Systems and methods for removing viral agents from blood

Info

Publication number
CA2239070A1
CA2239070A1 CA002239070A CA2239070A CA2239070A1 CA 2239070 A1 CA2239070 A1 CA 2239070A1 CA 002239070 A CA002239070 A CA 002239070A CA 2239070 A CA2239070 A CA 2239070A CA 2239070 A1 CA2239070 A1 CA 2239070A1
Authority
CA
Canada
Prior art keywords
methods
systems
plasma
cellular matter
blood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002239070A
Other languages
French (fr)
Other versions
CA2239070C (en
Inventor
Robert E. Herman
John Chapman
Sun Chong-Son
Jean M. Mathias
Veronique Mayaudon
Serge De Gheldere
Daniel F. Bischof
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fenwal Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2239070A1 publication Critical patent/CA2239070A1/en
Application granted granted Critical
Publication of CA2239070C publication Critical patent/CA2239070C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04Inactivation or attenuation; Producing viral sub-units
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/16Blood plasma; Blood serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/022Filtration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/08Radiation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04Inactivation or attenuation; Producing viral sub-units
    • C12N7/06Inactivation or attenuation by chemical treatment
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/975Kit

Abstract

Systems and methods treat plasma carrying contaminants and cellular matter that are capable of entraining contaminants. The systems and methods separate cellular matter from the plasma by filtration, thereby removing contaminants entrained within the cellular matter. The system and methods add to the plasma a photoactive material. The systems and methods emit radiation at a selected wavelength into the plasma to activate the photoactive material and thereby eradicate the contaminant that is free of entrainment by cellular matter.
CA002239070A 1996-10-28 1997-10-03 Systems and methods for removing viral agents from blood Expired - Lifetime CA2239070C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/742,572 US6190855B1 (en) 1996-10-28 1996-10-28 Systems and methods for removing viral agents from blood
US08/742,572 1996-10-28
PCT/US1997/017984 WO1998018908A1 (en) 1996-10-28 1997-10-03 Systems and methods for removing viral agents from blood

Publications (2)

Publication Number Publication Date
CA2239070A1 true CA2239070A1 (en) 1998-05-07
CA2239070C CA2239070C (en) 2005-06-21

Family

ID=24985365

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002239070A Expired - Lifetime CA2239070C (en) 1996-10-28 1997-10-03 Systems and methods for removing viral agents from blood

Country Status (11)

Country Link
US (3) US6190855B1 (en)
EP (1) EP0870013B1 (en)
JP (1) JP2000507485A (en)
KR (1) KR100490072B1 (en)
CN (1) CN1160453C (en)
AU (1) AU735878B2 (en)
CA (1) CA2239070C (en)
DE (1) DE69739503D1 (en)
NO (1) NO982981D0 (en)
TW (1) TW346398B (en)
WO (1) WO1998018908A1 (en)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5935092A (en) * 1990-12-20 1999-08-10 Baxter International Inc. Systems and methods for removing free and entrained contaminants in plasma
US20040067157A1 (en) * 1993-07-22 2004-04-08 Clearant, Inc. Methods for sterilizing biological materials
US5362442A (en) 1993-07-22 1994-11-08 2920913 Canada Inc. Method for sterilizing products with gamma radiation
US6168718B1 (en) 1996-11-08 2001-01-02 Pall Corporation Method for purifying blood plasma and apparatus suitable therefor
US6197207B1 (en) * 1997-05-21 2001-03-06 Baxter International Inc. Method of reducing the possibility of transmission of spongiform encephalopathy diseases by blood products
US20040055965A1 (en) * 1997-06-13 2004-03-25 Hubig Stephan M. Recreational water treatment employing singlet oxygen
US20030194433A1 (en) * 2002-03-12 2003-10-16 Ecolab Antimicrobial compositions, methods and articles employing singlet oxygen- generating agent
US6669905B1 (en) * 1998-05-21 2003-12-30 Baxter International Inc. Systems and methods for collecting plasma that is free or virtually free of cellular blood species
US6267745B1 (en) 1998-05-21 2001-07-31 Baxter International Inc. Confined air tube and methods for handling air in closed blood processing systems
FR2782730B1 (en) * 1998-08-25 2002-05-17 Biocom Sa CELL SEPARATION PROCESS FOR THE ISOLATION OF PATHOGENIC CELLS, PARTICULARLY RARE CANCERES, EQUIPMENT AND REAGENT FOR IMPLEMENTING THE PROCESS AND APPLICATION OF THE PROCESS
US7025877B1 (en) * 1999-06-03 2006-04-11 Baxter International Inc. Processing set for processing and treating a biological fluid
US7445756B2 (en) * 1999-06-03 2008-11-04 Fenwal, Inc. Fluid processing sets and organizers for the same
FR2799986B1 (en) * 1999-10-20 2001-11-23 Maco Pharma Sa FILTER UNIT OF A VIRUCID SUBSTANCE
AU4998401A (en) * 2000-02-11 2001-08-20 Gen Hospital Corp Photochemical tissue bonding
US20040086420A1 (en) * 2000-03-23 2004-05-06 Macphee Martin J. Methods for sterilizing serum or plasma
US6843961B2 (en) * 2000-06-15 2005-01-18 Gambro, Inc. Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light
US9044523B2 (en) 2000-06-15 2015-06-02 Terumo Bct, Inc. Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light
EP1300168B1 (en) * 2000-07-10 2010-03-10 Asahi Kasei Medical Co., Ltd. Blood processing filter
US6682695B2 (en) * 2001-03-23 2004-01-27 Clearant, Inc. Methods for sterilizing biological materials by multiple rates
US6696060B2 (en) 2001-06-14 2004-02-24 Clearant, Inc. Methods for sterilizing preparations of monoclonal immunoglobulins
US20030031584A1 (en) * 2001-08-10 2003-02-13 Wilson Burgess Methods for sterilizing biological materials using dipeptide stabilizers
US6946098B2 (en) 2001-08-10 2005-09-20 Clearant, Inc. Methods for sterilizing biological materials
US6749851B2 (en) 2001-08-31 2004-06-15 Clearant, Inc. Methods for sterilizing preparations of digestive enzymes
US7252799B2 (en) * 2001-08-31 2007-08-07 Clearant, Inc. Methods for sterilizing preparations containing albumin
US20030185702A1 (en) * 2002-02-01 2003-10-02 Wilson Burgess Methods for sterilizing tissue
US20030095890A1 (en) * 2001-09-24 2003-05-22 Shirley Miekka Methods for sterilizing biological materials containing non-aqueous solvents
US6783968B2 (en) 2001-09-24 2004-08-31 Clearant, Inc. Methods for sterilizing preparations of glycosidases
US20110091353A1 (en) * 2001-09-24 2011-04-21 Wilson Burgess Methods for Sterilizing Tissue
US7264608B2 (en) * 2001-12-05 2007-09-04 Fenwal, Inc. Manual processing systems and methods for providing blood components conditioned for pathogen inactivation
US20030124023A1 (en) * 2001-12-21 2003-07-03 Wilson Burgess Method of sterilizing heart valves
US20030180181A1 (en) * 2002-02-01 2003-09-25 Teri Greib Methods for sterilizing tissue
US20070020300A1 (en) * 2002-03-12 2007-01-25 Ecolab Inc. Recreational water treatment employing singlet oxygen
US20040013562A1 (en) * 2002-07-18 2004-01-22 Wilson Burgess Methods for sterilizing milk.
US6908591B2 (en) * 2002-07-18 2005-06-21 Clearant, Inc. Methods for sterilizing biological materials by irradiation over a temperature gradient
CA2502221A1 (en) * 2002-10-16 2004-04-29 Asahi Kasei Pharma Corporation Plasma preparation or serum preparation and process for producing the same
US7534348B2 (en) * 2003-09-12 2009-05-19 Fenwal, Inc. Flow-through removal device and system using such device
US20050137517A1 (en) * 2003-12-19 2005-06-23 Baxter International Inc. Processing systems and methods for providing leukocyte-reduced blood components conditioned for pathogen inactivation
DE102004035352B4 (en) * 2004-07-21 2007-05-10 Gerätezentrale für Bluttransfusion des Österreichischen Roten Kreuzes GmbH Closed sterile system for filtering biological or medical fluids, especially whole blood
US8631683B2 (en) 2007-02-06 2014-01-21 Fresenius Medical Care Holdings, Inc. Dialysis systems including non-invasive multi-function sensor systems
US8889004B2 (en) 2007-11-16 2014-11-18 Fresenius Medical Care Holdings, Inc. Dialysis systems and methods
NZ584767A (en) * 2007-11-16 2012-06-29 Fresenius Med Care Hldg Inc Dialysis system with module having sodium control function
JP5662444B2 (en) 2009-08-04 2015-01-28 フレセニウス メディカル ケア ホールディングス インコーポレーテッド Dialysis system
US8449686B2 (en) 2010-04-26 2013-05-28 Fresenius Medical Care Holdings, Inc. Methods for cleaning a drain line of a dialysis machine
US8784668B2 (en) 2010-10-12 2014-07-22 Fresenius Medical Care Holdings, Inc. Systems and methods for compensation of compliant behavior in regenerative dialysis systems
EP2497506B1 (en) * 2011-03-11 2015-04-08 Fenwal, Inc. Plasma filter with laminated prefilter
US8836519B2 (en) 2011-05-12 2014-09-16 Fresenius Medical Care Holdings, Inc. Determining the absence or presence of fluid in a dialysis system
US9333286B2 (en) 2011-05-12 2016-05-10 Fresenius Medical Care Holdings, Inc. Medical tubing installation detection
US8906240B2 (en) 2011-08-29 2014-12-09 Fresenius Medical Care Holdings, Inc. Early detection of low bicarbonate level
CN102397538A (en) * 2011-10-27 2012-04-04 上海市血液中心 Application of viral vaccine prepared by using methylene blue photochemical virus inactivating method
US8992777B2 (en) 2011-11-18 2015-03-31 Fresenius Medical Care Holdings, Inc. Systems and methods for providing notifications in dialysis systems
US9165112B2 (en) 2012-02-03 2015-10-20 Fresenius Medical Care Holdings, Inc. Systems and methods for displaying objects at a medical treatment apparatus display screen
DE102012022826B4 (en) * 2012-11-22 2022-10-13 Hubert Wöllenstein Process for preparing a pooled platelet concentrate
WO2014110149A2 (en) * 2013-01-08 2014-07-17 Stoneburner Jon F Method of testing or treating the presence of live viruses
US9103842B2 (en) 2013-01-31 2015-08-11 Biomet Biologics, Llc Methods for rejuvenating red blood cells
US9011408B2 (en) * 2013-01-31 2015-04-21 Biomet Biologics, Llc Functionally-closed, sterile blood processing solution system and method
US9102918B2 (en) 2013-01-31 2015-08-11 Biomet Biologics, Llc Methods for rejuvenating red blood cells
US9796166B2 (en) 2014-03-24 2017-10-24 Fenwal, Inc. Flexible biological fluid filters
US9968738B2 (en) 2014-03-24 2018-05-15 Fenwal, Inc. Biological fluid filters with molded frame and methods for making such filters
US9782707B2 (en) 2014-03-24 2017-10-10 Fenwal, Inc. Biological fluid filters having flexible walls and methods for making such filters
US10376627B2 (en) 2014-03-24 2019-08-13 Fenwal, Inc. Flexible biological fluid filters
US10159778B2 (en) 2014-03-24 2018-12-25 Fenwal, Inc. Biological fluid filters having flexible walls and methods for making such filters
EP3194576B1 (en) 2014-07-23 2020-11-18 Cerus Corporation Methods for preparing platelet products
EP3204426B1 (en) 2014-10-10 2020-11-25 Cerus Corporation Compositions for use in treating viral hemorrhagic fever
WO2016210374A1 (en) 2015-06-26 2016-12-29 Cerus Corporation Cryoprecipitate compositions and methods of preparation thereof
WO2017070619A1 (en) 2015-10-23 2017-04-27 Cerus Corporation Plasma compositions and methods of use thereof
WO2017120545A2 (en) 2016-01-07 2017-07-13 Cerus Corporation Systems and methods for preparation of platelets
AU2018227586B2 (en) 2017-03-03 2023-12-21 Cerus Corporation Kits and methods for preparing pathogen-inactivated platelet compositions
EP3684774A1 (en) 2017-09-20 2020-07-29 Cerus Corporation Compositions and methods for pathogen inactivation of platelets
CN111770789B (en) 2017-12-29 2023-05-05 塞鲁斯公司 System and method for processing biological fluids
CN114269394A (en) 2019-06-28 2022-04-01 塞鲁斯公司 System and method for implementing a biological fluid treatment device

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3876738A (en) 1973-07-18 1975-04-08 Amf Inc Process for producing microporous films and products
US4025618A (en) 1974-09-03 1977-05-24 Baxter Travenol Laboratories, Inc. Method for separation of cryoprecipitate from blook plasma
US4150744A (en) 1976-02-27 1979-04-24 Smith & Nephew Pharmaceuticals Ltd. Packaging
US4246107A (en) 1978-03-06 1981-01-20 Asahi Kasei Kogyo Kabushiki Kaisha Separation of lymphocytes from lymphocyte-containing suspension by filtration
DK170416B1 (en) 1978-05-15 1995-08-28 Pall Corp Microporous, hydrophilic, membrane-free, alcohol-insoluble polyamide resin membrane, process for its preparation, use of the membrane in filter elements, and resin molding solution for use in the process
US4711793A (en) 1980-10-27 1987-12-08 Cuno Incorporated Process for charge modifying a microphorous membrane
US4708803A (en) 1980-10-27 1987-11-24 Cuno Incorporated Liquid filtration using hydrophilic cationic isotropic microporous nylon membrane
US4473474A (en) 1980-10-27 1984-09-25 Amf Inc. Charge modified microporous membrane, process for charge modifying said membrane and process for filtration of fluid
US4673504A (en) 1980-10-27 1987-06-16 Cuno Inc. Charge modified microporous membrane
US4396382A (en) * 1981-12-07 1983-08-02 Travenol European Research And Development Centre Multiple chamber system for peritoneal dialysis
US4439179A (en) * 1982-02-16 1984-03-27 Baxter Travenol Laboratories, Inc. Dual tubing clamp
US4767541A (en) * 1982-06-04 1988-08-30 Miles Laboratories, Inc. Method of removing platelets and white cells from a red cell concentrate
JPS5984719A (en) 1982-10-30 1984-05-16 テルモ株式会社 Manufacture of plastic vessel containing chemical which do not deteriorate for prolonged term
US4701267B1 (en) 1984-03-15 1996-03-12 Asahi Medical Co Method for removing leukocytes
US4915683A (en) 1986-11-21 1990-04-10 The Medical College Of Wisconsin, Inc. Antiviral method, agents and apparatus
US4900449A (en) 1987-05-20 1990-02-13 Gelman Sciences Filtration membranes and method of making the same
US5108607A (en) 1987-05-20 1992-04-28 Gelman Sciences, Inc. Filtration membranes and method of making the same
US4964990A (en) 1987-05-20 1990-10-23 Gelman Sciences, Inc. Filtration membranes and method of making the same
US4925572A (en) 1987-10-20 1990-05-15 Pall Corporation Device and method for depletion of the leukocyte content of blood and blood components
JPH0726959B2 (en) 1988-01-20 1995-03-29 富士写真フイルム株式会社 Whole blood analysis element
US5423989A (en) 1988-05-19 1995-06-13 Chemtrack, Inc. Plasma forming device
AU617265B2 (en) 1988-06-23 1991-11-21 Asahi Medical Co. Ltd. Method for separating blood into blood components, and blood components separator unit
US5229012A (en) 1989-05-09 1993-07-20 Pall Corporation Method for depletion of the leucocyte content of blood and blood components
US5344561A (en) 1989-05-09 1994-09-06 Pall Corporation Device for depletion of the leucocyte content of blood and blood components
US5152905A (en) 1989-09-12 1992-10-06 Pall Corporation Method for processing blood for human transfusion
US5100564A (en) 1990-11-06 1992-03-31 Pall Corporation Blood collection and processing system
US4997577A (en) * 1989-12-20 1991-03-05 Baxter International Inc. Systems and methods for removing undesired matter from blood cells
US5089146A (en) 1990-02-12 1992-02-18 Miles Inc. Pre-storage filtration of platelets
US5102407A (en) 1990-03-13 1992-04-07 Miles Inc. Blood separation system
US5545516A (en) * 1990-05-01 1996-08-13 The American National Red Cross Inactivation of extracellular enveloped viruses in blood and blood components by phenthiazin-5-ium dyes plus light
US5126054A (en) 1990-05-24 1992-06-30 Pall Corporation Venting means
US5076935A (en) 1990-05-31 1991-12-31 Gelman Sciences, Inc. Filtration membranes made from polyethersulfone/phenoxy resin blend
DE69133218T2 (en) 1990-09-25 2004-02-12 Asahi Medical Co. Ltd. METHOD AND FILTER SYSTEM FOR REMOVING LEUKOCYTES
US5217627A (en) 1990-11-06 1993-06-08 Pall Corporation System and method for processing biological fluid
US5252222A (en) 1990-12-03 1993-10-12 Pall Corporation Filter for parenteral systems and method of using thereof
US5536413A (en) 1990-12-03 1996-07-16 Pall Corporation Method for treating a parenteral emulsion-containing medicament fluid
CA2075704A1 (en) 1990-12-20 1992-06-21 Daniel F. Bischof Systems and methods eradicating contaminants in fluids
ZA919934B (en) * 1990-12-20 1992-09-30 Baxter Int Systems and methods for eradicating contaminants using photoactive materials in fluids like blood using discrete sources of radiation
EP0516839B1 (en) 1990-12-20 1999-11-24 Baxter International Inc. Systems and methods for simultaneously removing free and entrained contaminants in fluids like blood using photoactive therapy and cellular separation techniques
DE69130218T2 (en) * 1990-12-20 1999-05-12 Baxter Int DEVICE FOR REMOVING IMPURITIES FROM LIQUIDS
US5092996A (en) * 1991-02-19 1992-03-03 Miles Inc. Blood filtering system
US5498336A (en) 1991-02-22 1996-03-12 Terumo Kabushiki Kaisha Leukocyte-removing filter and leukocyte-removing apparatus furnished therewith
DE69203828T2 (en) 1991-05-08 1996-05-02 Baxter Int METHOD FOR TREATING PRODUCTS OF RED BLOOD CELLS FOR LONG-TERM STORAGE FREE OF MICRO-ORGANISMS.
US5128048A (en) 1991-05-22 1992-07-07 Baxter International Inc. Systems and methods for removing undesired matter from blood cells
US5180504A (en) 1991-05-22 1993-01-19 Baxter International Inc. Systems and methods for removing undesired matter from blood cells
US5269946A (en) 1991-05-22 1993-12-14 Baxter Healthcare Corporation Systems and methods for removing undesired matter from blood cells
CA2074671A1 (en) 1991-11-04 1993-05-05 Thomas Bormann Device and method for separating plasma from a biological fluid
US5549834A (en) * 1991-12-23 1996-08-27 Baxter International Inc. Systems and methods for reducing the number of leukocytes in cellular products like platelets harvested for therapeutic purposes
JP3383962B2 (en) 1992-02-28 2003-03-10 ニプロ株式会社 Leukocyte removal filter
US5403272A (en) 1992-05-29 1995-04-04 Baxter International Inc. Apparatus and methods for generating leukocyte free platelet concentrate
GB9218239D0 (en) 1992-08-27 1992-10-14 Pall Corp Processing of protein-containing body fluids
DE69328738T2 (en) 1992-12-01 2000-12-07 Haemonetics Corp DEVICE FOR APHERESIS OF RED BLOOD CELLS
JP2776988B2 (en) 1993-04-27 1998-07-16 ヘモネティクス・コーポレイション Apheresis device
US5527472A (en) * 1993-06-14 1996-06-18 Baxter International Inc. Closed systems and methods for removing undesired matter from blood cells
JP3311091B2 (en) 1993-06-27 2002-08-05 テルモ株式会社 Filter for separating white blood cells and filter for separating white blood cells and platelets
US5536283A (en) * 1993-07-30 1996-07-16 Norton Company Alumina abrasive wheel with improved corner holding
US5591337A (en) * 1993-09-14 1997-01-07 Baxter International Inc. Apparatus for filtering leukocytes from blood cells
US6319662B1 (en) * 1993-12-17 2001-11-20 Baxter International Inc. Method and apparatus for removing viral contaminants from a body fluid
US5639376A (en) 1994-01-10 1997-06-17 Hemasure, Inc. Process for simultaneously removing leukocytes and methylene blue from plasma
ITMI940055A1 (en) 1994-01-18 1995-07-18 Bracco Spa CONTAINER FOR DIAGNOSTIC COUNTERTOGRAPHIC SOLUTIONS
US5545339A (en) 1994-02-25 1996-08-13 Pall Corporation Method for processing biological fluid and treating separated component
US5660731A (en) 1994-11-08 1997-08-26 Pall Corporation Filter for separating photoactive agent
JP3541245B2 (en) * 1997-07-15 2004-07-07 株式会社日立グローバルストレージテクノロジーズ Magnetic head and magnetic storage device having the same

Also Published As

Publication number Publication date
US6190855B1 (en) 2001-02-20
AU735878B2 (en) 2001-07-19
NO982981L (en) 1998-06-26
US6855489B1 (en) 2005-02-15
DE69739503D1 (en) 2009-09-03
TW346398B (en) 1998-12-01
EP0870013A1 (en) 1998-10-14
AU4894897A (en) 1998-05-22
EP0870013B1 (en) 2009-07-22
KR19990076873A (en) 1999-10-25
US20050186553A1 (en) 2005-08-25
WO1998018908A1 (en) 1998-05-07
NO982981D0 (en) 1998-06-26
EP0870013A4 (en) 2003-02-05
CN1160453C (en) 2004-08-04
KR100490072B1 (en) 2006-03-23
JP2000507485A (en) 2000-06-20
CA2239070C (en) 2005-06-21
CN1211277A (en) 1999-03-17
US7374870B2 (en) 2008-05-20

Similar Documents

Publication Publication Date Title
CA2239070A1 (en) Systems and methods for removing viral agents from blood
CA2208051A1 (en) Systems and method for removing free and entrained contaminants in plasma
FI99192B (en) Procedure for inactivation of viruses in blood and blood products
AU5370598A (en) Methods for purifying viruses
CA2392034A1 (en) Process and system for treatment of waste streams containing water-soluble polymers
CA2304766A1 (en) System and method for photocatalytic treatment of contaminated media
AU6272198A (en) Process for recovering organic hydroxides from waste solutions
AU2634297A (en) Procedure and filter device for removal and/or destruction of organic substances in contaminated air
EP0565176A3 (en) Process for the treatment of organic waste
EP0589818A3 (en) Process for the biological removal of nitrated derivatives.
CA2044324A1 (en) Multi-stage infectious waste treatment system
ITMI940211A0 (en) PROCEDURE FOR THE RECOVERY AND REUSE OF COBALT AND TUNGSTEN FROM REACTION WATERS
FI99007B (en) Procedure for the treatment of waste, waste treatment systems and waste containers
IT1272973B (en) SYSTEM FOR THE REMOVAL OF DEBRIS FROM PRINTING MACHINE.
WO1996008211A3 (en) Plasma grafting methods and compounds
ZA963521B (en) Process of removing NOx from nitrosyl hydrogensulfate.
ZA993773B (en) Process for the recovery of highly purified alpha olefins.
FR2685317B1 (en) WATER TREATMENT PROCESS FOR REMOVING VIRUSES AND PESTICIDES.
AU3766197A (en) Device for treatment of possibly contaminated sludge occurring in sanitary facilities
ZA978139B (en) Process for the biological-thermal treatment of waste.
EP0934780A3 (en) Process for removing contaminants from moist soil
DK0892707T3 (en) Improved decontamination of RPET via particle size reduction
MX9603017A (en) Metropolitan area air decontaminating and purifying plant.
WO2001050942A3 (en) Energy filtering system
ZA9971B (en) Process for the recovery of medicinal substances from preparations, their initial products or waste.

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20171003