CA2237578C - Copolymers of tyrosine-based polycarbonate and poly(alkylene oxide) - Google Patents
Copolymers of tyrosine-based polycarbonate and poly(alkylene oxide) Download PDFInfo
- Publication number
- CA2237578C CA2237578C CA002237578A CA2237578A CA2237578C CA 2237578 C CA2237578 C CA 2237578C CA 002237578 A CA002237578 A CA 002237578A CA 2237578 A CA2237578 A CA 2237578A CA 2237578 C CA2237578 C CA 2237578C
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- CA
- Canada
- Prior art keywords
- random block
- block copolymer
- copolymer
- biologically
- alkylene oxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L77/00—Compositions of polyamides obtained by reactions forming a carboxylic amide link in the main chain; Compositions of derivatives of such polymers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G64/00—Macromolecular compounds obtained by reactions forming a carbonic ester link in the main chain of the macromolecule
- C08G64/18—Block or graft polymers
- C08G64/183—Block or graft polymers containing polyether sequences
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/68—Polyesters containing atoms other than carbon, hydrogen and oxygen
- C08G63/685—Polyesters containing atoms other than carbon, hydrogen and oxygen containing nitrogen
- C08G63/6854—Polyesters containing atoms other than carbon, hydrogen and oxygen containing nitrogen derived from polycarboxylic acids and polyhydroxy compounds
- C08G63/6856—Dicarboxylic acids and dihydroxy compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G64/00—Macromolecular compounds obtained by reactions forming a carbonic ester link in the main chain of the macromolecule
- C08G64/16—Aliphatic-aromatic or araliphatic polycarbonates
- C08G64/1608—Aliphatic-aromatic or araliphatic polycarbonates saturated
- C08G64/1625—Aliphatic-aromatic or araliphatic polycarbonates saturated containing atoms other than carbon, hydrogen or oxygen
- C08G64/1641—Aliphatic-aromatic or araliphatic polycarbonates saturated containing atoms other than carbon, hydrogen or oxygen containing nitrogen
Abstract
Random block copolymers having formula (I), wherein R1 is -CH=CH- or (-CH2-)j, in which j is zero or an integer from one to eight; R2 is selected from hydrogen, straight and branched alkyl and alkylaryl groups containing up to 18 carbon atoms and derivatives or biologically and pharmaceutically active compounds covalently bonded to said copolymer; each R3 is independently an alkylene group containing up to 4 carbon atoms; y is an integer between about 5 and about 3000; and f is the percent molar fraction of alkylene oxide in the copolymer and ranges between about 1 and about 99 mole percent. Implantable medical devices and drug delivery implants containing the random block copolymers are also disclosed, along with methods for drug delivery and for preventing the formation of adhesions between injured tissues employing the random block copolymers. Polyarylate random block copolymers are also described.
Claims (16)
1. A random block copolymer characterized by the formula:
wherein R; is -CH=CH- or (-CH2-)j, in which j is zero or an integer from one to eight; R2 is selected from the group consisting of hydrogen, straight and branched alkyl and alkylaryl groups containing up to 18 carbon atoms, and derivatives of biologically and physiologically active compounds covalently bonded to said copolymer;
each R3 is independently an alkylene group containing up to 4 carbon atoms;
y is between about 5 and about 3000; and f is the percent molar fraction of alkylene oxide in said copolymer and ranges between about 1 and about 99 mole percent.
wherein R; is -CH=CH- or (-CH2-)j, in which j is zero or an integer from one to eight; R2 is selected from the group consisting of hydrogen, straight and branched alkyl and alkylaryl groups containing up to 18 carbon atoms, and derivatives of biologically and physiologically active compounds covalently bonded to said copolymer;
each R3 is independently an alkylene group containing up to 4 carbon atoms;
y is between about 5 and about 3000; and f is the percent molar fraction of alkylene oxide in said copolymer and ranges between about 1 and about 99 mole percent.
2. The random block copolymer of claim 1, characterized in that R1 is -CH2-CH2-.
3. The random block copolymer of claim 1, characterized in that R2 is a straight-chained alkyl group selected from the group consisting of ethyl, butyl, hexyl and octyl groups.
4. The random block copolymer of claim 3, characterized in that R2 is a hexyl group.
5. The random block copolymer of claim 1, characterized in that each R3 is ethylene.
6. The random block copolymer of claim 1, characterized in that y is between about 20 and about 200.
7. The random block copolymer of claim 1, characterized in that f is between about 5 and about 95 mole percent.
8. An implantable medical device comprising the random block copolymer of claim 1.
9. The implantable medical device of claim 8, characterized in that the surface of said device is coated with said random block copolymer.
10. The implantable medical device of claim 8, characterized by a biologically or physiologically active compound in combination with said random block copolymer, wherein said active compound is present in an amount sufficient for therapeutically effective site-specific or systemic drug delivery.
11. The Implantable medical device of claim 10, characterized in that said biologically or physiologically active compound is covalently bonded to said copolymer.
12. An implantable medical device in the form of a sheet consisting essentially of the random block copolymer of claim 1 for use as a barrier for surgical adhesion prevention.
13. The use of an implantable drug delivery device for site-specific or systemic drug delivery to the body of a patient to deliver a therapeutically effective amount of a biologically or physiologically active compound in combination with the random block copolymer of claim 1.
14. The use of the implantable drug delivery device of claim 13, characterized in that said biologically or physiologically active compound is covalently bonded to said copolymer.
15. The use of a barrier between injured tissues to prevent formation of adhesions between the injured tissues, said barrier comprising a sheet consisting essentially of the random block copolymer of claim 1.
16. A polyarylate, characterized by being polymerized as a random block copolymer of a dicarboxylic acid with both a tyrosine-derived diphenol and a poly(alkylene oxide) and characterized in that an equimolar combined quantity of said diphenol and said poly(alkylene oxide) is reacted with said dicarboxylic acid in a molar ratio of said diphenol to said poly(alkylene oxide) between about 1:99 and about 99:1;
wherein said dicarboxylic acid has the structure:
in which R is selected from the group consisting of saturated and unsaturated, substituted and unsubstituted alkyl, aryl and alkylaryl groups containing up to 18 carbon atoms;
said tyrosine-derived diphenol has the structure:
in which R1 is -CH =CH- or (-CH2-)j, wherein j is zero or an integer from one to eight, and R2 is selected from the group consisting of hydrogen, straight and branched alkyl and alkylaryl groups containing up to 18 carbon atoms and derivatives of biologically and pharmaceutically active compounds covalently bonded to said diphenol; and said poly(alkylene oxide) has the structure:
(OR3)y in which each R3 is independently an alkylene group containing up to 4 carbon atoms and y is an integer between about 5 and about 3000.
wherein said dicarboxylic acid has the structure:
in which R is selected from the group consisting of saturated and unsaturated, substituted and unsubstituted alkyl, aryl and alkylaryl groups containing up to 18 carbon atoms;
said tyrosine-derived diphenol has the structure:
in which R1 is -CH =CH- or (-CH2-)j, wherein j is zero or an integer from one to eight, and R2 is selected from the group consisting of hydrogen, straight and branched alkyl and alkylaryl groups containing up to 18 carbon atoms and derivatives of biologically and pharmaceutically active compounds covalently bonded to said diphenol; and said poly(alkylene oxide) has the structure:
(OR3)y in which each R3 is independently an alkylene group containing up to 4 carbon atoms and y is an integer between about 5 and about 3000.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/562,842 US5658995A (en) | 1995-11-27 | 1995-11-27 | Copolymers of tyrosine-based polycarbonate and poly(alkylene oxide) |
US08/562,842 | 1995-11-27 | ||
PCT/US1996/019098 WO1997019996A1 (en) | 1995-11-27 | 1996-11-27 | Copolymers of tyrosine-based polycarbonate and poly(alkylene oxide) |
Publications (3)
Publication Number | Publication Date |
---|---|
CA2237578A1 CA2237578A1 (en) | 1997-06-05 |
CA2237578C true CA2237578C (en) | 2003-09-30 |
CA2237578E CA2237578E (en) | 2011-10-11 |
Family
ID=24248016
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2237578A Expired - Lifetime CA2237578E (en) | 1995-11-27 | 1996-11-27 | Copolymers of tyrosine-based polycarbonate and poly(alkylene oxide) |
Country Status (11)
Country | Link |
---|---|
US (1) | US5658995A (en) |
EP (1) | EP0863946B1 (en) |
JP (2) | JP2000501139A (en) |
KR (1) | KR100479288B1 (en) |
AT (1) | ATE258565T1 (en) |
AU (1) | AU722764B2 (en) |
CA (1) | CA2237578E (en) |
DE (1) | DE69631431T2 (en) |
ES (1) | ES2215200T3 (en) |
MX (1) | MX9804174A (en) |
WO (1) | WO1997019996A1 (en) |
Families Citing this family (210)
Publication number | Priority date | Publication date | Assignee | Title |
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US6319492B1 (en) * | 1996-11-27 | 2001-11-20 | Rutgers, The State University | Copolymers of tyrosine-based polyarylates and poly(alkylene oxides) |
JP4465105B2 (en) * | 1997-11-07 | 2010-05-19 | ルトガーズ、ザ ステイト ユニバーシティ オブ ニュージャージー | Radiopaque polymer biocompatible material |
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- 1996-11-27 KR KR10-1998-0703886A patent/KR100479288B1/en not_active IP Right Cessation
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- 1996-11-27 ES ES96942102T patent/ES2215200T3/en not_active Expired - Lifetime
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KR19990071610A (en) | 1999-09-27 |
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WO1997019996A1 (en) | 1997-06-05 |
DE69631431D1 (en) | 2004-03-04 |
JP4996391B2 (en) | 2012-08-08 |
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