CA2226784A1 - Use of cgmp-phosphodiesterase inhibitors to treat impotence - Google Patents

Use of cgmp-phosphodiesterase inhibitors to treat impotence

Info

Publication number
CA2226784A1
CA2226784A1 CA002226784A CA2226784A CA2226784A1 CA 2226784 A1 CA2226784 A1 CA 2226784A1 CA 002226784 A CA002226784 A CA 002226784A CA 2226784 A CA2226784 A CA 2226784A CA 2226784 A1 CA2226784 A1 CA 2226784A1
Authority
CA
Canada
Prior art keywords
cgmp
phosphodiesterase inhibitors
treat impotence
impotence
pyrazino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002226784A
Other languages
French (fr)
Other versions
CA2226784C (en
Inventor
Alain Claude-Marie Daugan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Icos Corp
Original Assignee
Icos Corporation
Alain Claude-Marie Daugan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10777695&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2226784(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Icos Corporation, Alain Claude-Marie Daugan filed Critical Icos Corporation
Publication of CA2226784A1 publication Critical patent/CA2226784A1/en
Application granted granted Critical
Publication of CA2226784C publication Critical patent/CA2226784C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The use of compounds of formula (I) (6R, 12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':
6,1]pyrido[3,4-b]indole-1,4-dione, (3S, 6R, 12aR)-2,3,6,7,12,12a-hexahydro-2,3-dimethyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':
6,1]pyrido[3,4-b]indole-1,4-dione, and physiologically acceptable salts and solvates thereof, in the treatment of impotence.
CA002226784A 1995-07-14 1996-07-11 Use of cgmp-phosphodiesterase inhibitors to treat impotence Expired - Lifetime CA2226784C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9514464.8 1995-07-14
GBGB9514464.8A GB9514464D0 (en) 1995-07-14 1995-07-14 Medicaments
PCT/EP1996/003024 WO1997003675A1 (en) 1995-07-14 1996-07-11 Use of cgmp-phosphodiesterase inhibitors to treat impotence

Publications (2)

Publication Number Publication Date
CA2226784A1 true CA2226784A1 (en) 1997-02-06
CA2226784C CA2226784C (en) 2003-07-08

Family

ID=10777695

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002226784A Expired - Lifetime CA2226784C (en) 1995-07-14 1996-07-11 Use of cgmp-phosphodiesterase inhibitors to treat impotence

Country Status (25)

Country Link
US (2) US6140329A (en)
EP (1) EP0839040B1 (en)
JP (1) JP4169365B2 (en)
CN (2) CN1311828C (en)
AT (1) ATE327756T1 (en)
AU (1) AU704955B2 (en)
BR (1) BR9609758A (en)
CA (1) CA2226784C (en)
CY (2) CY2563B1 (en)
CZ (1) CZ289686B6 (en)
DE (1) DE69636193T2 (en)
DK (1) DK0839040T3 (en)
ES (1) ES2267111T3 (en)
GB (1) GB9514464D0 (en)
HK (1) HK1005363A1 (en)
HU (1) HU228369B1 (en)
IL (1) IL122870A (en)
MX (2) MXPA02009987A (en)
NO (1) NO314685B1 (en)
PL (2) PL185737B1 (en)
PT (1) PT839040E (en)
RU (1) RU2181288C2 (en)
SI (1) SI0839040T1 (en)
SK (2) SK284494B6 (en)
WO (1) WO1997003675A1 (en)

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Also Published As

Publication number Publication date
CY2006007I2 (en) 2009-11-04
CN1311828C (en) 2007-04-25
ATE327756T1 (en) 2006-06-15
AU6419196A (en) 1997-02-18
AU704955B2 (en) 1999-05-13
CA2226784C (en) 2003-07-08
SK284494B6 (en) 2005-05-05
CN1112928C (en) 2003-07-02
PL185999B1 (en) 2003-09-30
SK3998A3 (en) 1998-07-08
US6608065B1 (en) 2003-08-19
MX9800414A (en) 1998-06-30
JPH11509221A (en) 1999-08-17
EP0839040A1 (en) 1998-05-06
CY2563B1 (en) 2008-07-02
US6140329A (en) 2000-10-31
GB9514464D0 (en) 1995-09-13
SK284141B6 (en) 2004-10-05
JP4169365B2 (en) 2008-10-22
CZ3398A3 (en) 1998-05-13
CN1513452A (en) 2004-07-21
RU2181288C2 (en) 2002-04-20
EP0839040B1 (en) 2006-05-31
NO980153L (en) 1998-03-10
PL185737B1 (en) 2003-07-31
CN1195290A (en) 1998-10-07
MXPA02009987A (en) 2003-02-28
DE69636193T2 (en) 2007-04-26
HUP9900065A2 (en) 1999-05-28
CZ289686B6 (en) 2002-03-13
PL324495A1 (en) 1998-05-25
CY2006007I1 (en) 2009-11-04
BR9609758A (en) 1999-01-26
PT839040E (en) 2006-09-29
DE69636193D1 (en) 2006-07-06
SI0839040T1 (en) 2006-10-31
ES2267111T3 (en) 2007-03-01
WO1997003675A1 (en) 1997-02-06
IL122870A (en) 2002-03-10
IL122870A0 (en) 1998-08-16
HUP9900065A3 (en) 1999-11-29
HK1005363A1 (en) 1999-01-08
DK0839040T3 (en) 2006-09-25
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HU228369B1 (en) 2013-03-28
NO314685B1 (en) 2003-05-05

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