CA2222676A1 - New pharmaceutical composition with anaesthetic effect - Google Patents

New pharmaceutical composition with anaesthetic effect

Info

Publication number
CA2222676A1
CA2222676A1 CA002222676A CA2222676A CA2222676A1 CA 2222676 A1 CA2222676 A1 CA 2222676A1 CA 002222676 A CA002222676 A CA 002222676A CA 2222676 A CA2222676 A CA 2222676A CA 2222676 A1 CA2222676 A1 CA 2222676A1
Authority
CA
Canada
Prior art keywords
pharmaceutical composition
new pharmaceutical
anaesthetic effect
anaesthetic
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002222676A
Other languages
French (fr)
Other versions
CA2222676C (en
Inventor
Arne Brodin
Lars Heijl
Adela Nyqvist-Mayer
Marie Scherlund
Raymond Fynes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Maillefer Instruments Trading SARL
Original Assignee
Astra Aktiebolag
Arne Brodin
Lars Heijl
Adela Nyqvist-Mayer
Marie Scherlund
Raymond Fynes
Astrazeneca Aktiebolag
Dentsply Anesthetics S.A.R.L.
Maillefer Instruments Trading S.A.R.L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Aktiebolag, Arne Brodin, Lars Heijl, Adela Nyqvist-Mayer, Marie Scherlund, Raymond Fynes, Astrazeneca Aktiebolag, Dentsply Anesthetics S.A.R.L., Maillefer Instruments Trading S.A.R.L filed Critical Astra Aktiebolag
Publication of CA2222676A1 publication Critical patent/CA2222676A1/en
Application granted granted Critical
Publication of CA2222676C publication Critical patent/CA2222676C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays

Abstract

The invention is directed to a novel pharmaceutical composition comprising one or more local anaesthetics in oil form, one or more surfactants, water and optionally a taste masking agent. The novel composition is advantageously used as a local anaesthetic for pain relief within the oral cavity.
CA002222676A 1996-04-12 1997-04-01 New pharmaceutical composition with anaesthetic effect Expired - Lifetime CA2222676C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9601421A SE9601421D0 (en) 1996-04-12 1996-04-12 New composition
SE9601421-2 1996-04-12
PCT/SE1997/000566 WO1997038675A1 (en) 1996-04-12 1997-04-01 New pharmaceutical composition with anaesthetic effect

Publications (2)

Publication Number Publication Date
CA2222676A1 true CA2222676A1 (en) 1997-10-23
CA2222676C CA2222676C (en) 2008-01-22

Family

ID=20402194

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002222676A Expired - Lifetime CA2222676C (en) 1996-04-12 1997-04-01 New pharmaceutical composition with anaesthetic effect

Country Status (30)

Country Link
US (1) US6031007A (en)
EP (1) EP0833612B1 (en)
JP (2) JPH11501678A (en)
KR (1) KR100508601B1 (en)
CN (1) CN1149072C (en)
AR (1) AR006484A1 (en)
AT (1) ATE248584T1 (en)
AU (1) AU716540B2 (en)
BR (1) BR9702147A (en)
CA (1) CA2222676C (en)
CZ (1) CZ371197A3 (en)
DE (1) DE69724545T2 (en)
DK (1) DK0833612T3 (en)
EE (1) EE9700363A (en)
ES (1) ES2203799T3 (en)
HK (1) HK1010144A1 (en)
HU (1) HUP9903544A3 (en)
ID (1) ID16420A (en)
IL (1) IL122447A (en)
IS (1) IS4618A (en)
NO (1) NO318239B1 (en)
NZ (1) NZ329246A (en)
PL (1) PL324170A1 (en)
RU (1) RU2185153C2 (en)
SE (1) SE9601421D0 (en)
SK (1) SK169897A3 (en)
TR (1) TR199701584T1 (en)
TW (1) TW473386B (en)
WO (1) WO1997038675A1 (en)
ZA (1) ZA973022B (en)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2764800B1 (en) * 1997-06-23 1999-09-10 Sanofi Sa SOLID PHARMACEUTICAL COMPOSITION CONTAINING BENZOFURAN DERIVATIVES
US7799337B2 (en) 1997-07-21 2010-09-21 Levin Bruce H Method for directed intranasal administration of a composition
WO2000010531A1 (en) * 1998-08-19 2000-03-02 Rtp Pharma Inc. Injectable aqueous dispersions of propofol
US6528086B2 (en) * 1999-09-28 2003-03-04 Zars, Inc. Methods and apparatus for drug delivery involving phase changing formulations
US20020013331A1 (en) * 2000-06-26 2002-01-31 Williams Robert O. Methods and compositions for treating pain of the mucous membrane
KR100416646B1 (en) * 2000-08-14 2004-02-05 구주제약주식회사 Hydrogel Preparation of Lidocaine Microemulsion for the Treatment of Premature Ejaculation
GB0120701D0 (en) 2001-08-24 2001-10-17 Maelor Pharmaceuticals Ltd Pharmaceutical formulations
US20040087520A1 (en) * 2002-10-25 2004-05-06 Chowdhury Dipak K. Compositions and methods for delivery of therapeutic agents
TW200410717A (en) * 2002-12-31 2004-07-01 Ind Tech Res Inst Delivery system for control release of temperature sensitive bioactive material
US8802116B2 (en) 2003-02-27 2014-08-12 Novasel Australia Pty. Ltd. Poloxamer emulsion preparations
AU2003900887A0 (en) * 2003-02-27 2003-03-13 Novasel Australia Pty Ltd Poloxamer emulsion preparations
BR0301968A (en) * 2003-05-22 2005-06-28 Cristalia Prod Quimicos Farm Ternary and quaternary eutectic mixtures composed of local anesthetic substances, their use in the preparation of pharmaceutical compositions and their use in anesthesia and topical analgesia
JP4669960B2 (en) * 2003-06-03 2011-04-13 株式会社 メドレックス Oral or pharyngeal preparations containing local anesthetics
US7943179B2 (en) * 2003-09-23 2011-05-17 Massachusetts Institute Of Technology pH triggerable polymeric particles
US20050123596A1 (en) * 2003-09-23 2005-06-09 Kohane Daniel S. pH-triggered microparticles
US20070232695A1 (en) * 2004-01-28 2007-10-04 Collegium Pharmaceutical, Inc. Gelled Periodontal Anesthetic Preparation
US8907153B2 (en) 2004-06-07 2014-12-09 Nuvo Research Inc. Adhesive peel-forming formulations for dermal delivery of drugs and methods of using the same
US8741333B2 (en) 2004-06-07 2014-06-03 Nuvo Research Inc. Compositions and methods for treating dermatitis or psoriasis
US8741332B2 (en) 2004-06-07 2014-06-03 Nuvo Research Inc. Compositions and methods for dermally treating neuropathic pain
WO2006036936A2 (en) * 2004-09-27 2006-04-06 Bridge Pharma, Inc. The s-isomer of 2-{2-[n-(2-indanyl)-n-phenylamino]ethyl}piperidine and other dermal anesthetic agents
WO2006037047A2 (en) * 2004-09-27 2006-04-06 Bridge Pharma, Inc. The r-isomer of 2-{2-[n-(2-indanyl)-n-phenylamino]ethyl}piperidine and other dermal anesthetic agents
WO2008011161A2 (en) * 2006-07-21 2008-01-24 Bridge Pharma, Inc. Dermal anesthetic compounds
US20080021068A1 (en) 2006-07-24 2008-01-24 Akorn, Inc. Aqueous gel formulation and method for inducing topical anesthesia
US20090123527A1 (en) * 2006-07-24 2009-05-14 Akorn, Inc. Method of inducing topical anesthesia and transdermal patch
US8473062B2 (en) 2008-05-01 2013-06-25 Autonomic Technologies, Inc. Method and device for the treatment of headache
US8412336B2 (en) 2008-12-29 2013-04-02 Autonomic Technologies, Inc. Integrated delivery and visualization tool for a neuromodulation system
US9012477B2 (en) 2009-01-06 2015-04-21 Nuvo Research Inc. Method of treating neuropathic pain
US9320908B2 (en) 2009-01-15 2016-04-26 Autonomic Technologies, Inc. Approval per use implanted neurostimulator
US8494641B2 (en) 2009-04-22 2013-07-23 Autonomic Technologies, Inc. Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism
US20130045238A1 (en) * 2009-04-22 2013-02-21 Agency For Science, Technology And Research Emulsions for transdermal delivery
WO2011074015A2 (en) 2009-12-17 2011-06-23 Themis Medicare Limited Novel composition of pharmaceutical product to treat sexual dysfunction
AU2011205730C1 (en) 2010-01-14 2014-10-09 Nuvo Research Inc. Solid-forming local anesthetic formulations for pain control
WO2011121034A2 (en) 2010-04-01 2011-10-06 Pharmanest Ab Water-free pharmaceutical compositions suitable for local anaesthetics
CN102869344A (en) 2010-04-01 2013-01-09 帕玛内斯特公司 Bioadhesive compositions of local anaesthetics
NZ602538A (en) * 2010-04-01 2014-03-28 Pharmanest Ab Thermogelling anaesthetic compositions
WO2011133177A1 (en) * 2010-04-21 2011-10-27 Teikoku Pharma Usa, Inc. Local anesthetic emulsion compositions and methods of making and using the same
GB201222455D0 (en) * 2012-12-13 2013-01-30 Perioc Ltd Novel pharmaceutical formulations and their use in the treatment of periodontaldisease
EP2968247A4 (en) * 2013-03-14 2017-04-26 Jsn I Llc Taste masking of anesthetics and analgesics
EP3344230B1 (en) 2015-09-02 2022-04-06 T.C. Istanbul Medipol Universitesi Formulations of benzocaine loaded microemulsion based hydrogels for therapeutic purposes and their production method
WO2020182535A1 (en) 2019-03-08 2020-09-17 Bayer Oy Uterine sound tube with anaesthetic applicator
CN113244167B (en) * 2021-05-20 2022-11-29 河北科技大学 Lidocaine hydrochloride gel and preparation method thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4188373A (en) * 1976-02-26 1980-02-12 Cooper Laboratories, Inc. Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes
US4478822A (en) * 1983-05-16 1984-10-23 Merck & Co., Inc. Drug delivery system utilizing thermosetting gels
US5288498A (en) * 1985-05-01 1994-02-22 University Of Utah Research Foundation Compositions of oral nondissolvable matrixes for transmucosal administration of medicaments
US5288497A (en) * 1985-05-01 1994-02-22 The University Of Utah Compositions of oral dissolvable medicaments
JPS62223112A (en) * 1986-03-25 1987-10-01 Rooto Seiyaku Kk Remedy for periodontosis
US4780320A (en) * 1986-04-29 1988-10-25 Pharmetrix Corp. Controlled release drug delivery system for the periodontal pocket
US5114719A (en) * 1987-04-29 1992-05-19 Sabel Bernhard A Extended drug delivery of small, water-soluble molecules
US5411738A (en) * 1989-03-17 1995-05-02 Hind Health Care, Inc. Method for treating nerve injury pain associated with shingles (herpes-zoster and post-herpetic neuralgia) by topical application of lidocaine
CA2040460C (en) * 1990-05-01 1997-06-10 Tacey X. Viegas Drug delivery with thermoreversible gels
US5292516A (en) * 1990-05-01 1994-03-08 Mediventures, Inc. Body cavity drug delivery with thermoreversible gels containing polyoxyalkylene copolymers
FR2704429B3 (en) * 1993-04-30 1995-07-13 Algovital Sarl Formulation combining an alkaline reaction and essential oil components to perform local anesthesia, externally, transcutaneously, without injection.
US5635540A (en) * 1994-12-09 1997-06-03 The University Of Virginia Patent Foundation Stabilized topical pharmaceutical preparations
US5612052A (en) * 1995-04-13 1997-03-18 Poly-Med, Inc. Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof

Also Published As

Publication number Publication date
WO1997038675A1 (en) 1997-10-23
CA2222676C (en) 2008-01-22
JPH11501678A (en) 1999-02-09
AU2416897A (en) 1997-11-07
US6031007A (en) 2000-02-29
NZ329246A (en) 2000-06-23
PL324170A1 (en) 1998-05-11
HUP9903544A2 (en) 2000-06-28
IS4618A (en) 1997-11-21
JP2004149544A (en) 2004-05-27
EE9700363A (en) 1998-06-15
EP0833612B1 (en) 2003-09-03
CZ371197A3 (en) 1998-06-17
MX9709941A (en) 1998-03-29
NO318239B1 (en) 2005-02-21
IL122447A0 (en) 1998-06-15
CN1188407A (en) 1998-07-22
IL122447A (en) 2001-04-30
DK0833612T3 (en) 2003-12-01
TR199701584T1 (en) 1999-03-22
HUP9903544A3 (en) 2000-07-28
KR100508601B1 (en) 2006-03-23
KR19990022833A (en) 1999-03-25
EP0833612A1 (en) 1998-04-08
SK169897A3 (en) 1998-07-08
DE69724545D1 (en) 2003-10-09
AR006484A1 (en) 1999-08-25
NO975831L (en) 1997-12-11
NO975831D0 (en) 1997-12-11
ATE248584T1 (en) 2003-09-15
ZA973022B (en) 1997-10-13
ID16420A (en) 1997-09-25
RU2185153C2 (en) 2002-07-20
CN1149072C (en) 2004-05-12
ES2203799T3 (en) 2004-04-16
BR9702147A (en) 1999-07-20
DE69724545T2 (en) 2004-06-03
SE9601421D0 (en) 1996-04-12
AU716540B2 (en) 2000-02-24
HK1010144A1 (en) 1999-06-17
TW473386B (en) 2002-01-21

Similar Documents

Publication Publication Date Title
CA2222676A1 (en) New pharmaceutical composition with anaesthetic effect
CA2181172A1 (en) Storage-stable prostaglandin compositions
CA2239174A1 (en) Novel compounds with analgesic effect
DE69600065T2 (en) Dermatological and / or pharmaceutical preparation, its manufacture and use
HK1059215A1 (en) Pharmaceutical compositions for the treatment of mucositis, stomatitis and behcet's syndrome
MY132705A (en) Novel compounds with analgesic effect
MY119403A (en) Novel compounds with analgesic effect.
HK1015269A1 (en) Use of r-enantiomer of n-propargyl-1-aminoindan, salts, and compositions thereof
FR2718639B1 (en) Cosmetic and / or dermatological composition containing a tri (alpha-hydroxyacylate) of glycerol as the only precursor of glycerol.
ZA9811445B (en) Aminobiguanides and the use thereof to disinfect contact lenses and preserve pharmaceutical compositions.
CA2095721A1 (en) Gel type compositions having improved oil control
BR9702603A (en) Hygienic and / or pharmaceutical dermatological cosmetic composition Hygienic and / or pharmaceutical dermatological cosmetic composition without transfer using the association between a volatile compound and a silicone oil and process to limit decrease and / or eliminate transfer
BR9702608A (en) Hygienic and / or pharmaceutical dermatological cosmetic composition without transfer using the association between a volatile compound and a polymer process to limit decrease and / or hinder transfer
HUP9802897A3 (en) Optically active pyridyl-4h-1,2,4-oxadiazine derivatives, the use thereof in the treatment of vascular diseases and pharmaceutical composition containing the compound as active ingredient
UA37278C2 (en) Antitussive pharmaceutical oral composition
AU2002226060A1 (en) Compositions containing gangliosides for use in the treatment of skin disorders
CA2077693A1 (en) Use of ketorolac for treatment of periodontal disease
WO2001022917A3 (en) Effervescent compositions comprising nimesulide
MD980129A (en) Antiherpetic remedy
CA2221592A1 (en) Use of forskolin or extracts containing it in the manufacture of a medicament for the treatment of alcohol addiction
EP0786248A3 (en) Use of S,S'-ehtylidene diacetate as perfuming and flavouring ingredient
RU96115480A (en) MEDICINAL PREPARED WITH CHOLOLYTOLITIC ACTION
IT1243593B (en) Natural anti-wrinkle tonic
HUP0104267A3 (en) 1,4-diaryl-2-fluoro-1-buten-3-ol compounds and their use in the preparation of 1,4-diaryl-2-fluoro-1,3-butadiane and 1,4-diaryl-2-fluoro-2-butene compounds
ITBO960501A0 (en) BALSAMIC VINEGAR CANDY

Legal Events

Date Code Title Description
EEER Examination request