CA2221712A1 - A method and apparatus for predicting the presence of congenital and acquired imbalances and therapeutic conditions - Google Patents

A method and apparatus for predicting the presence of congenital and acquired imbalances and therapeutic conditions

Info

Publication number
CA2221712A1
CA2221712A1 CA002221712A CA2221712A CA2221712A1 CA 2221712 A1 CA2221712 A1 CA 2221712A1 CA 002221712 A CA002221712 A CA 002221712A CA 2221712 A CA2221712 A CA 2221712A CA 2221712 A1 CA2221712 A1 CA 2221712A1
Authority
CA
Canada
Prior art keywords
congenital
time
predicting
dependent measurement
acquired
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002221712A
Other languages
French (fr)
Other versions
CA2221712C (en
Inventor
Thomas B. Givens
Paul Braun
Timothy J. Fischer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biomerieux Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2221712A1 publication Critical patent/CA2221712A1/en
Application granted granted Critical
Publication of CA2221712C publication Critical patent/CA2221712C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/4905—Determining clotting time of blood
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
    • G16H10/40—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/50—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/22—Haematology
    • G01N2800/226—Thrombotic disorders, i.e. thrombo-embolism irrespective of location/organ involved, e.g. renal vein thrombosis, venous thrombosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/38—Pediatrics
    • G01N2800/385—Congenital anomalies
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
    • G16H10/60—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

A method and apparatus are disclosed for predicting the presence of at least one congenital or acquired imbalance or therapeutic condition associated with thrombosis/hemostasis from at least one time-dependent measurement profile, (Figs. 3-6). At least one time-dependent measurement on an unknown sample is performed and a respective property of said sample is measured over time so as to derive a time-dependent measurement profile, (Figs. 3-6). A set of a plurality of predictor variables are defined which sufficiently define the data of the time-dependent measurement profile, (Fig. 13). A model is then derived that represents the relationship between the congenital or acquired imbalance or therapeutic condition and the set of predictor variables. Subsequently, the model is utilized to predict the existence of the congenital or acquired imbalance or therapeutic condition in the unknown sample.
CA002221712A 1995-06-07 1996-06-05 A method and apparatus for predicting the presence of congenital and acquired imbalances and therapeutic conditions Expired - Fee Related CA2221712C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/477,839 1995-06-07
US08/477,839 US5708591A (en) 1995-02-14 1995-06-07 Method and apparatus for predicting the presence of congenital and acquired imbalances and therapeutic conditions
PCT/US1996/008905 WO1996041291A1 (en) 1995-06-07 1996-06-05 A method and apparatus for predicting the presence of congenital and acquired imbalances and therapeutic conditions

Publications (2)

Publication Number Publication Date
CA2221712A1 true CA2221712A1 (en) 1996-12-19
CA2221712C CA2221712C (en) 2005-01-11

Family

ID=23897564

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002221712A Expired - Fee Related CA2221712C (en) 1995-06-07 1996-06-05 A method and apparatus for predicting the presence of congenital and acquired imbalances and therapeutic conditions

Country Status (12)

Country Link
US (4) US5708591A (en)
EP (1) EP0834145B1 (en)
JP (1) JP3534415B2 (en)
KR (1) KR100462688B1 (en)
AT (1) ATE206226T1 (en)
AU (1) AU711998B2 (en)
CA (1) CA2221712C (en)
DE (1) DE69615556T2 (en)
DK (1) DK0834145T3 (en)
ES (1) ES2164888T3 (en)
PT (1) PT834145E (en)
WO (1) WO1996041291A1 (en)

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Also Published As

Publication number Publication date
ATE206226T1 (en) 2001-10-15
AU5984796A (en) 1996-12-30
DK0834145T3 (en) 2002-01-21
DE69615556D1 (en) 2001-10-31
US5708591A (en) 1998-01-13
EP0834145B1 (en) 2001-09-26
CA2221712C (en) 2005-01-11
US6101449A (en) 2000-08-08
JPH11507131A (en) 1999-06-22
US6269313B1 (en) 2001-07-31
JP3534415B2 (en) 2004-06-07
EP0834145A4 (en) 2000-01-26
DE69615556T2 (en) 2002-06-06
PT834145E (en) 2002-03-28
EP0834145A1 (en) 1998-04-08
AU711998B2 (en) 1999-10-28
KR19990022407A (en) 1999-03-25
US20010053959A1 (en) 2001-12-20
ES2164888T3 (en) 2002-03-01
WO1996041291A1 (en) 1996-12-19
KR100462688B1 (en) 2005-06-13

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