CA2221712A1 - A method and apparatus for predicting the presence of congenital and acquired imbalances and therapeutic conditions - Google Patents
A method and apparatus for predicting the presence of congenital and acquired imbalances and therapeutic conditionsInfo
- Publication number
- CA2221712A1 CA2221712A1 CA002221712A CA2221712A CA2221712A1 CA 2221712 A1 CA2221712 A1 CA 2221712A1 CA 002221712 A CA002221712 A CA 002221712A CA 2221712 A CA2221712 A CA 2221712A CA 2221712 A1 CA2221712 A1 CA 2221712A1
- Authority
- CA
- Canada
- Prior art keywords
- congenital
- time
- predicting
- dependent measurement
- acquired
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/4905—Determining clotting time of blood
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
- G16H10/40—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/50—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/22—Haematology
- G01N2800/226—Thrombotic disorders, i.e. thrombo-embolism irrespective of location/organ involved, e.g. renal vein thrombosis, venous thrombosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/38—Pediatrics
- G01N2800/385—Congenital anomalies
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
- G16H10/60—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
Abstract
A method and apparatus are disclosed for predicting the presence of at least one congenital or acquired imbalance or therapeutic condition associated with thrombosis/hemostasis from at least one time-dependent measurement profile, (Figs. 3-6). At least one time-dependent measurement on an unknown sample is performed and a respective property of said sample is measured over time so as to derive a time-dependent measurement profile, (Figs. 3-6). A set of a plurality of predictor variables are defined which sufficiently define the data of the time-dependent measurement profile, (Fig. 13). A model is then derived that represents the relationship between the congenital or acquired imbalance or therapeutic condition and the set of predictor variables. Subsequently, the model is utilized to predict the existence of the congenital or acquired imbalance or therapeutic condition in the unknown sample.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/477,839 US5708591A (en) | 1995-02-14 | 1995-06-07 | Method and apparatus for predicting the presence of congenital and acquired imbalances and therapeutic conditions |
US08/477,839 | 1995-06-07 | ||
PCT/US1996/008905 WO1996041291A1 (en) | 1995-06-07 | 1996-06-05 | A method and apparatus for predicting the presence of congenital and acquired imbalances and therapeutic conditions |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2221712A1 true CA2221712A1 (en) | 1996-12-19 |
CA2221712C CA2221712C (en) | 2005-01-11 |
Family
ID=23897564
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002221712A Expired - Fee Related CA2221712C (en) | 1995-06-07 | 1996-06-05 | A method and apparatus for predicting the presence of congenital and acquired imbalances and therapeutic conditions |
Country Status (12)
Country | Link |
---|---|
US (4) | US5708591A (en) |
EP (1) | EP0834145B1 (en) |
JP (1) | JP3534415B2 (en) |
KR (1) | KR100462688B1 (en) |
AT (1) | ATE206226T1 (en) |
AU (1) | AU711998B2 (en) |
CA (1) | CA2221712C (en) |
DE (1) | DE69615556T2 (en) |
DK (1) | DK0834145T3 (en) |
ES (1) | ES2164888T3 (en) |
PT (1) | PT834145E (en) |
WO (1) | WO1996041291A1 (en) |
Families Citing this family (41)
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US5708591A (en) * | 1995-02-14 | 1998-01-13 | Akzo Nobel N.V. | Method and apparatus for predicting the presence of congenital and acquired imbalances and therapeutic conditions |
US6321164B1 (en) * | 1995-06-07 | 2001-11-20 | Akzo Nobel N.V. | Method and apparatus for predicting the presence of an abnormal level of one or more proteins in the clotting cascade |
US6429017B1 (en) * | 1999-02-04 | 2002-08-06 | Biomerieux | Method for predicting the presence of haemostatic dysfunction in a patient sample |
US6898532B1 (en) | 1995-06-07 | 2005-05-24 | Biomerieux, Inc. | Method and apparatus for predicting the presence of haemostatic dysfunction in a patient sample |
US6016475A (en) * | 1996-10-08 | 2000-01-18 | The Regents Of The University Of Minnesota | System, method, and article of manufacture for generating implicit ratings based on receiver operating curves |
US6108493A (en) * | 1996-10-08 | 2000-08-22 | Regents Of The University Of Minnesota | System, method, and article of manufacture for utilizing implicit ratings in collaborative filters |
US5842199A (en) * | 1996-10-18 | 1998-11-24 | Regents Of The University Of Minnesota | System, method and article of manufacture for using receiver operating curves to evaluate predictive utility |
US6063028A (en) | 1997-03-20 | 2000-05-16 | Luciano; Joanne Sylvia | Automated treatment selection method |
US6502040B2 (en) | 1997-12-31 | 2002-12-31 | Biomerieux, Inc. | Method for presenting thrombosis and hemostasis assay data |
DE19858278A1 (en) * | 1998-12-17 | 2000-06-21 | Dade Behring Marburg Gmbh | Method for locating defects in the coagulation system |
WO2000046603A1 (en) * | 1999-02-04 | 2000-08-10 | Akzo Nobel N.V. | A method and apparatus for predicting the presence of haemostatic dysfunction in a patient sample |
EP1522860A1 (en) * | 1999-02-04 | 2005-04-13 | bioMérieux, Inc. | A method and apparatus for predicting the presence of haemostatic dysfunction in a patient sample |
AU2004201011B2 (en) * | 1999-06-30 | 2005-12-22 | Biomerieux, Inc | Method and apparatus for presenting thrombosis and hemostasis assay data |
US6484122B1 (en) * | 2000-05-16 | 2002-11-19 | Siemens Aktiengesellschaft | System and method for evaluating characteristics for suitability in classification |
JP5051960B2 (en) * | 2000-06-09 | 2012-10-17 | ビオメリュー・インコーポレイテッド | Methods for detecting complexes of lipoproteins and acute phase proteins to predict increased risk of system failure or lethality |
US7179612B2 (en) | 2000-06-09 | 2007-02-20 | Biomerieux, Inc. | Method for detecting a lipoprotein-acute phase protein complex and predicting an increased risk of system failure or mortality |
US7003403B1 (en) | 2000-06-15 | 2006-02-21 | The United States Of America As Represented By The Department Of Health And Human Services | Quantifying gene relatedness via nonlinear prediction of gene |
US7107287B2 (en) * | 2000-07-27 | 2006-09-12 | Canberra Industries | Method, system and storage medium for automated independent technical review |
US6743596B1 (en) | 2000-10-27 | 2004-06-01 | Biomerieux, Inc. | Method of determining global coagulability hemostatic potential |
US20030104493A1 (en) * | 2001-06-29 | 2003-06-05 | Ortel Thomas L. | Method for predicting an increased likelihood of antiphospholipid syndrome in a patient |
EP1476752A4 (en) | 2002-02-27 | 2008-02-13 | Bio Merieux Inc | Method for diagnosing and monitoring hemostatic dysfunction, severe infection and systematic inflammatory response syndrome |
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JP2008539438A (en) * | 2005-04-25 | 2008-11-13 | プラコア・インコーポレーテッド | Method and device for monitoring platelet function |
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US8046175B2 (en) * | 2008-10-13 | 2011-10-25 | Actherm Inc | Analytical strip reading apparatus and the analyical strip used therein |
JP2012510621A (en) * | 2008-12-05 | 2012-05-10 | 紅電醫學科技股▲分▼有限公司 | Test strip reader with removable firmware |
US8645306B2 (en) * | 2010-07-02 | 2014-02-04 | Idexx Laboratories, Inc. | Automated calibration method and system for a diagnostic analyzer |
CN103282873B (en) * | 2010-11-12 | 2016-08-24 | 生命科技公司 | Confirm for experimental determination or the system and method for checking |
JP6211806B2 (en) * | 2013-05-31 | 2017-10-11 | 株式会社日立ハイテクノロジーズ | Automatic analyzer |
EP3519828A4 (en) | 2016-09-29 | 2020-06-03 | Animantis, LLC | Methods and apparatus for assessing immune system activity and therapeutic efficacy |
JP6873833B2 (en) * | 2017-06-09 | 2021-05-19 | シスメックス株式会社 | Blood sample judgment method, blood sample analyzer and computer program |
GB202004047D0 (en) | 2020-03-20 | 2020-05-06 | Ainger Phill | Point of care sepsis assay device and method |
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-
1995
- 1995-06-07 US US08/477,839 patent/US5708591A/en not_active Expired - Lifetime
-
1996
- 1996-06-05 JP JP50136597A patent/JP3534415B2/en not_active Expired - Fee Related
- 1996-06-05 AU AU59847/96A patent/AU711998B2/en not_active Ceased
- 1996-06-05 PT PT96917181T patent/PT834145E/en unknown
- 1996-06-05 WO PCT/US1996/008905 patent/WO1996041291A1/en active IP Right Grant
- 1996-06-05 AT AT96917181T patent/ATE206226T1/en not_active IP Right Cessation
- 1996-06-05 ES ES96917181T patent/ES2164888T3/en not_active Expired - Lifetime
- 1996-06-05 CA CA002221712A patent/CA2221712C/en not_active Expired - Fee Related
- 1996-06-05 EP EP96917181A patent/EP0834145B1/en not_active Expired - Lifetime
- 1996-06-05 KR KR1019970708887A patent/KR100462688B1/en not_active IP Right Cessation
- 1996-06-05 DE DE69615556T patent/DE69615556T2/en not_active Expired - Fee Related
- 1996-06-05 DK DK96917181T patent/DK0834145T3/en active
-
1997
- 1997-05-21 US US08/859,773 patent/US6101449A/en not_active Expired - Fee Related
-
2000
- 2000-03-02 US US09/517,496 patent/US6269313B1/en not_active Expired - Fee Related
-
2001
- 2001-07-30 US US09/918,214 patent/US20010053959A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JPH11507131A (en) | 1999-06-22 |
PT834145E (en) | 2002-03-28 |
US6269313B1 (en) | 2001-07-31 |
JP3534415B2 (en) | 2004-06-07 |
EP0834145A1 (en) | 1998-04-08 |
ES2164888T3 (en) | 2002-03-01 |
AU711998B2 (en) | 1999-10-28 |
CA2221712C (en) | 2005-01-11 |
US6101449A (en) | 2000-08-08 |
US20010053959A1 (en) | 2001-12-20 |
US5708591A (en) | 1998-01-13 |
ATE206226T1 (en) | 2001-10-15 |
EP0834145A4 (en) | 2000-01-26 |
KR100462688B1 (en) | 2005-06-13 |
AU5984796A (en) | 1996-12-30 |
EP0834145B1 (en) | 2001-09-26 |
WO1996041291A1 (en) | 1996-12-19 |
DE69615556T2 (en) | 2002-06-06 |
KR19990022407A (en) | 1999-03-25 |
DK0834145T3 (en) | 2002-01-21 |
DE69615556D1 (en) | 2001-10-31 |
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