CA2220295A1 - Blood collection and separation system - Google Patents

Blood collection and separation system

Info

Publication number
CA2220295A1
CA2220295A1 CA002220295A CA2220295A CA2220295A1 CA 2220295 A1 CA2220295 A1 CA 2220295A1 CA 002220295 A CA002220295 A CA 002220295A CA 2220295 A CA2220295 A CA 2220295A CA 2220295 A1 CA2220295 A1 CA 2220295A1
Authority
CA
Canada
Prior art keywords
rotor
container
blood
needle
tubing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002220295A
Other languages
French (fr)
Other versions
CA2220295C (en
Inventor
Gordon F. Kingsley
Thomas D. Headley
Lise N. Halpern
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Haemonetics Corp
Original Assignee
Transfusion Technologies Corporation
Gordon F. Kingsley
Thomas D. Headley
Lise N. Halpern
Haemonetics Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transfusion Technologies Corporation, Gordon F. Kingsley, Thomas D. Headley, Lise N. Halpern, Haemonetics Corporation filed Critical Transfusion Technologies Corporation
Publication of CA2220295A1 publication Critical patent/CA2220295A1/en
Application granted granted Critical
Publication of CA2220295C publication Critical patent/CA2220295C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0407—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles
    • B04B5/0428—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles with flexible receptacles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3692—Washing or rinsing blood or blood constituents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A61M1/3696—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A61M1/3698—Expressing processed fluid out from the turning rotor using another fluid compressing the treatment chamber; Variable volume rotors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/60—Containers for suction drainage, adapted to be used with an external suction source
    • A61M1/62—Containers comprising a bag in a rigid low-pressure chamber, with suction applied to the outside surface of the bag
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/64—Containers with integrated suction means
    • A61M1/67—Containers incorporating a piston-type member to create suction, e.g. syringes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3306—Optical measuring means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3306—Optical measuring means
    • A61M2205/331—Optical measuring means used as turbidity change detectors, e.g. for priming-blood or plasma-hemoglubine-interface detection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3379—Masses, volumes, levels of fluids in reservoirs, flow rates
    • A61M2205/3393—Masses, volumes, levels of fluids in reservoirs, flow rates by weighing the reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/148—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags
    • A61M5/1483—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags using flexible bags externally pressurised by fluid pressure

Abstract

The system includes a needle (72) (or other cannula-like device) for insertion into a vein of the donor and drawing whole blood therethrough, a variable-volume rotor (2a) for holding the blood after it is drawn, and a motor (50) for spinning the rotor so as to cause the blood to seperate into components, for example, plasma and red blood cells. The system also provides for a container for collecting a separated component. In a preferred embodiment two containers are used: the first container (92) for containing an anticoagulant, which is preferably added to the whole blood as it is drawn from the donor, and then for storing the plasma after it has been separated from the red blood cells, and the second container (91) for storing the separated red blood cells. The system further includes tubing (73), which may have valving (81) built into it and which may be acted on externally, so as to direct the blood components in the desired manner. The tubing connects the needle (72), the rotor (2a), and the first and second containers (92, 91). With the valving, the tubing is able to permit (i) the flow of whole blood from the needle (72) to the rotor (2a), (ii) the flow of anticoagulant from the first container (92) to the whole blood flowing from the needle to the rotor, (iii) the flow of plasma from the rotor to the first container, and (iv) the flow of red blood cells from the rotor to the second container (91).
The motor (50) and the valving are preferably controlled by an electronic controller. Preferably, the system also includes a pump (61), which is also controlled by the controller, and which forces the blood components out of the rotor (2a) to the tubing. The pump is preferably able to draw the whole blood into the rotor.
CA002220295A 1995-06-07 1996-03-05 Blood collection and separation system Expired - Fee Related CA2220295C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/482,617 1995-06-07
US08/482,617 US5651766A (en) 1995-06-07 1995-06-07 Blood collection and separation system
PCT/US1996/003018 WO1996040319A1 (en) 1995-06-07 1996-03-05 Blood collection and separation system

Publications (2)

Publication Number Publication Date
CA2220295A1 true CA2220295A1 (en) 1996-12-19
CA2220295C CA2220295C (en) 2008-11-04

Family

ID=23916756

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002220295A Expired - Fee Related CA2220295C (en) 1995-06-07 1996-03-05 Blood collection and separation system

Country Status (8)

Country Link
US (8) US5651766A (en)
EP (1) EP0830157B1 (en)
JP (2) JP3958364B2 (en)
AT (1) ATE269116T1 (en)
AU (1) AU710558B2 (en)
CA (1) CA2220295C (en)
DE (1) DE69632731T2 (en)
WO (1) WO1996040319A1 (en)

Families Citing this family (132)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5733253A (en) * 1994-10-13 1998-03-31 Transfusion Technologies Corporation Fluid separation system
US5651766A (en) 1995-06-07 1997-07-29 Transfusion Technologies Corporation Blood collection and separation system
US7332125B2 (en) * 1994-10-13 2008-02-19 Haemonetics Corporation System and method for processing blood
US6632191B1 (en) 1994-10-13 2003-10-14 Haemonetics Corporation System and method for separating blood components
SE9700495D0 (en) 1997-02-12 1997-02-12 Omega Medicinteknik Ab Method and round bag system and centrifuge for blood treatment
SE9701423D0 (en) * 1997-04-16 1997-04-16 Omega Medicinteknik Ab Container set and device for blood separation
EP1011752B1 (en) * 1997-05-20 2004-10-13 Zymequest, Inc. Cell processing system and method for controlling it
US6852074B1 (en) * 1997-05-20 2005-02-08 Zymequest, Inc. Biological processing apparatus for expressing fluid material
US5976388A (en) * 1997-05-20 1999-11-02 Cobe Cardiovascular Operating Co., Inc. Method and apparatus for autologous blood salvage
US6027441A (en) * 1997-07-01 2000-02-22 Baxter International Inc. Systems and methods providing a liquid-primed, single flow access chamber
US6200287B1 (en) * 1997-09-05 2001-03-13 Gambro, Inc. Extracorporeal blood processing methods and apparatus
WO1999062583A1 (en) * 1998-06-01 1999-12-09 Harvest Technologies Corporation System for withdrawal of blood
WO2000023140A1 (en) 1998-10-16 2000-04-27 Mission Medical, Inc. Blood processing system
JP5015379B2 (en) * 1999-03-17 2012-08-29 ヘモネティクス・コーポレーション Apparatus and method for processing blood
US6296602B1 (en) 1999-03-17 2001-10-02 Transfusion Technologies Corporation Method for collecting platelets and other blood components from whole blood
SE516321C2 (en) * 1999-05-31 2001-12-17 Gambro Inc Centrifuge for the treatment of blood and blood components
US6652475B1 (en) * 1999-07-07 2003-11-25 Mission Medical, Inc. Automated blood component separation system
US6261065B1 (en) 1999-09-03 2001-07-17 Baxter International Inc. System and methods for control of pumps employing electrical field sensing
US6296450B1 (en) 1999-09-03 2001-10-02 Baxter International Inc. Systems and methods for control of pumps employing gravimetric sensing
US20020077241A1 (en) * 1999-09-03 2002-06-20 Baxter International Inc. Blood processing systems and methods with quick attachment of a blood separation chamber to a centrifuge rotor
US6759007B1 (en) 1999-09-03 2004-07-06 Baxter International Inc. Blood processing systems and methods employing fluid pressure actuated pumps and valves
US6325775B1 (en) 1999-09-03 2001-12-04 Baxter International Inc. Self-contained, transportable blood processsing device
US6709412B2 (en) 1999-09-03 2004-03-23 Baxter International Inc. Blood processing systems and methods that employ an in-line leukofilter mounted in a restraining fixture
US20060178612A9 (en) * 1999-09-03 2006-08-10 Baxter International Inc. Blood processing systems with fluid flow cassette with a pressure actuated pump chamber and in-line air trap
CN1321100A (en) * 1999-09-03 2001-11-07 巴克斯特国际公司 Blood processing systems and methods with on-line mixing of replacement fluids
US6723062B1 (en) * 1999-09-03 2004-04-20 Baxter International Inc. Fluid pressure actuated blood pumping systems and methods with continuous inflow and pulsatile outflow conditions
US6348156B1 (en) * 1999-09-03 2002-02-19 Baxter International Inc. Blood processing systems and methods with sensors to detect contamination due to presence of cellular components or dilution due to presence of plasma
US6270673B1 (en) 1999-09-03 2001-08-07 Baxter International Inc. Door latching assembly for holding a fluid pressure actuated cassette during use
US6315707B1 (en) 1999-09-03 2001-11-13 Baxter International Inc. Systems and methods for seperating blood in a rotating field
US7041076B1 (en) * 1999-09-03 2006-05-09 Baxter International Inc. Blood separation systems and methods using a multiple function pump station to perform different on-line processing tasks
US6322488B1 (en) 1999-09-03 2001-11-27 Baxter International Inc. Blood separation chamber with preformed blood flow passages and centralized connection to external tubing
US6949079B1 (en) 1999-09-03 2005-09-27 Baxter International Inc. Programmable, fluid pressure actuated blood processing systems and methods
US6860846B2 (en) * 1999-09-03 2005-03-01 Baxter International Inc. Blood processing systems and methods with umbilicus-driven blood processing chambers
US6524231B1 (en) * 1999-09-03 2003-02-25 Baxter International Inc. Blood separation chamber with constricted interior channel and recessed passage
US6875191B2 (en) 1999-09-03 2005-04-05 Baxter International Inc. Blood processing systems and methods that alternate flow of blood component and additive solution through an in-line leukofilter
US6481980B1 (en) 1999-09-03 2002-11-19 Baxter International Inc. Fluid flow cassette with pressure actuated pump and valve stations
US6730054B2 (en) * 1999-10-16 2004-05-04 Baxter International Inc. Blood collection systems and methods that derive estimated effects upon the donor's blood volume and hematocrit
SE517032C2 (en) 1999-10-26 2002-04-02 Gambro Inc Method and apparatus for treating blood and blood components
US6406919B1 (en) * 1999-12-16 2002-06-18 Biosafe Laboratories, Inc. Whole blood collection device and method
ATE523217T1 (en) * 2000-03-09 2011-09-15 Caridianbct Inc EXTRACORPORAL DEVICE FOR BLOOD PROCESSING
JP3847053B2 (en) * 2000-03-15 2006-11-15 純 菊地 Blood analyzer
FR2808693B1 (en) * 2000-05-12 2002-10-25 Maco Pharma Sa TAKING DEVICE WITH TUBES OF DIFFERENT SECTION
AU2002253801A1 (en) 2000-11-02 2002-08-19 Gambro, Inc. Fluid separation devices, systems and methods
US6612975B2 (en) 2001-04-09 2003-09-02 Medtronic, Inc. Blood centrifuge with an enhanced internal drive assembly
US6835316B2 (en) 2001-04-09 2004-12-28 Medtronic, Inc. Clam shell blood reservoir holder with index line
US6790371B2 (en) * 2001-04-09 2004-09-14 Medtronic, Inc. System and method for automated separation of blood components
US6605028B2 (en) 2001-04-09 2003-08-12 Medtronic, Inc. Blood centrifuge having integral heating to control cellular component temperature
US6589155B2 (en) 2001-04-09 2003-07-08 Medtronic, Inc. Miniaturized blood centrifuge having side mounted motor with belt drive
US20020144939A1 (en) * 2001-04-09 2002-10-10 Dolecek Victor D. Miniaturized blood centrifuge having side mounted motor with belt drive
WO2002087662A1 (en) * 2001-04-27 2002-11-07 Nexell Therapeutics Inc. Cell processing and fluid transfer apparatus and method of use
US6890291B2 (en) 2001-06-25 2005-05-10 Mission Medical, Inc. Integrated automatic blood collection and processing unit
US6589153B2 (en) 2001-09-24 2003-07-08 Medtronic, Inc. Blood centrifuge with exterior mounted, self-balancing collection chambers
US20050215975A1 (en) * 2002-01-31 2005-09-29 Jean-Marie Mathias Irreversibly closable flow control clamp
US8262639B2 (en) * 2002-01-31 2012-09-11 Fenwal, Inc. Irreversible flow control clamp
ATE527004T1 (en) * 2002-02-01 2011-10-15 Caridianbct Inc SYSTEM FOR COLLECTION AND PROCESSING OF WHOLE BLOOD
US20030173274A1 (en) * 2002-02-01 2003-09-18 Frank Corbin Blood component separation device, system, and method including filtration
US7479123B2 (en) 2002-03-04 2009-01-20 Therakos, Inc. Method for collecting a desired blood component and performing a photopheresis treatment
US7211037B2 (en) * 2002-03-04 2007-05-01 Therakos, Inc. Apparatus for the continuous separation of biological fluids into components and method of using same
DE60331794D1 (en) 2002-04-16 2010-04-29 Caridianbct Inc Process for processing blood components
US7037428B1 (en) 2002-04-19 2006-05-02 Mission Medical, Inc. Integrated automatic blood processing unit
US6982038B2 (en) * 2002-06-14 2006-01-03 Medtronic, Inc. Centrifuge system utilizing disposable components and automated processing of blood to collect platelet rich plasma
US7297272B2 (en) 2002-10-24 2007-11-20 Fenwal, Inc. Separation apparatus and method
US6846161B2 (en) 2002-10-24 2005-01-25 Baxter International Inc. Blood component processing systems and methods using fluid-actuated pumping elements that are integrity tested prior to use
FR2850581B1 (en) * 2003-02-03 2005-09-09 Maco Pharma Sa PRECAUTIONED LOOP PICKUP SYSTEM
US20050049539A1 (en) * 2003-09-03 2005-03-03 O'hara Gerald P. Control system for driving fluids through an extracorporeal blood circuit
ITMI20031715A1 (en) * 2003-09-05 2005-03-06 Dideco Spa CONTROL DEVICE IN THE DIFFERENTIATED COLLECTION OF THE
US7060018B2 (en) 2003-09-11 2006-06-13 Cobe Cardiovascular, Inc. Centrifuge apparatus for processing blood
US7708710B2 (en) * 2003-12-23 2010-05-04 Fenwal, Inc. Method and apparatus for collecting and processing blood
US8157792B2 (en) * 2004-02-26 2012-04-17 Haemonetics Corporation Wound drainage suction relief
US7799754B2 (en) 2004-10-14 2010-09-21 Biomimetic Therapeutics, Inc. Compositions and methods for treating bone
US7473678B2 (en) 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
US7476209B2 (en) * 2004-12-21 2009-01-13 Therakos, Inc. Method and apparatus for collecting a blood component and performing a photopheresis treatment
DE602005018443D1 (en) * 2004-12-28 2010-02-04 Caridianbct Inc Apparatus and method for separating a lot of blood into four components
US20060226086A1 (en) * 2005-04-08 2006-10-12 Robinson Thomas C Centrifuge for blood processing systems
US7473216B2 (en) * 2005-04-21 2009-01-06 Fresenius Hemocare Deutschland Gmbh Apparatus for separation of a fluid with a separation channel having a mixer component
US20100210441A1 (en) * 2005-06-22 2010-08-19 Caridianbct, Inc. Apparatus And Method For Separating Discrete Volumes Of A Composite Liquid
CA2612891A1 (en) * 2005-06-22 2007-01-04 Gambro Bct, Inc. Apparatus and method for separating discrete volumes of a composite liquid
NZ571113A (en) 2005-11-17 2012-02-24 Biomimetic Therapeutics Inc Maxillofacial bone augmentation using rhpdgf-bb and a biocompatible matrix
US7998052B2 (en) * 2006-03-07 2011-08-16 Jacques Chammas Rotor defining a fluid separation chamber of varying volume
US7819793B2 (en) * 2006-06-07 2010-10-26 Caridianbct, Inc. Apparatus for separating a composite liquid into at least two components
AU2007269712B2 (en) 2006-06-30 2013-02-07 Biomimetic Therapeutics, Llc PDGF-biomatrix compositions and methods for treating rotator cuff injuries
US9161967B2 (en) 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
WO2008051847A2 (en) * 2006-10-20 2008-05-02 Caridianbct Biotechnologies, Llc Methods for washing a red blood cell component and for removing prions therefrom
AU2007333425B2 (en) 2006-11-03 2014-03-27 Biomimetic Therapeutics, Llc Compositions and methods for arthrodetic procedures
CN101534877B (en) * 2006-11-08 2013-01-16 美国血液技术公司 Adaptable perioperative cell-salvage system and methods and disposable units for same
JP5405313B2 (en) * 2006-12-20 2014-02-05 テルモ ビーシーティー、インコーポレーテッド Apparatus and method for separating a composite liquid into at least two components
US20080195476A1 (en) * 2007-02-09 2008-08-14 Marchese Michael A Abandonment remarketing system
US7905853B2 (en) * 2007-10-30 2011-03-15 Baxter International Inc. Dialysis system having integrated pneumatic manifold
CN102014977B (en) 2008-02-07 2015-09-02 生物模拟治疗有限责任公司 For compositions and the method for Distraction Osteogenesis
US8685258B2 (en) 2008-02-27 2014-04-01 Fenwal, Inc. Systems and methods for conveying multiple blood components to a recipient
US8075468B2 (en) 2008-02-27 2011-12-13 Fenwal, Inc. Systems and methods for mid-processing calculation of blood composition
US8628489B2 (en) 2008-04-14 2014-01-14 Haemonetics Corporation Three-line apheresis system and method
US8702637B2 (en) * 2008-04-14 2014-04-22 Haemonetics Corporation System and method for optimized apheresis draw and return
US8454548B2 (en) * 2008-04-14 2013-06-04 Haemonetics Corporation System and method for plasma reduced platelet collection
EP2341951A2 (en) 2008-09-09 2011-07-13 BioMimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods for the treatment of tendon and ligament injuries
US8834402B2 (en) 2009-03-12 2014-09-16 Haemonetics Corporation System and method for the re-anticoagulation of platelet rich plasma
US20110003675A1 (en) * 2009-07-06 2011-01-06 Caridianbct, Inc. Apparatus and Method for Automatically Loading Washing Solution In A Multi-Unit Blood Processor
JP5695574B2 (en) 2009-11-10 2015-04-08 テルモ株式会社 Blood bag system and blood processing method
JP6144049B2 (en) 2010-02-22 2017-06-07 バイオミメティック セラピューティクス，リミテッド ライアビリティ カンパニー Platelet-derived growth factor compositions and methods for treating tendon disorders
ES2523125T3 (en) 2010-05-27 2014-11-21 Terumo Bct, Inc. Multi-unit blood processor with temperature detection
US9028388B2 (en) 2010-06-07 2015-05-12 Terumo Bct, Inc. Multi-unit blood processor with volume prediction
JP5876047B2 (en) 2010-07-19 2016-03-02 テルモ ビーシーティー、インコーポレーテッド Centrifuge for processing blood and blood components
CN103221078B (en) 2010-11-05 2015-09-16 赫摩耐提克斯公司 For the system and method for automatization's platelet washing
US9302042B2 (en) 2010-12-30 2016-04-05 Haemonetics Corporation System and method for collecting platelets and anticipating plasma return
AU2012242802B2 (en) 2011-04-12 2017-04-20 Applied Science, Inc. Systems and methods for managing blood donations
WO2012154572A1 (en) 2011-05-06 2012-11-15 Haemonetics Corporation System and method for automated separation of whole blood
US11386993B2 (en) 2011-05-18 2022-07-12 Fenwal, Inc. Plasma collection with remote programming
WO2019226654A1 (en) 2018-05-21 2019-11-28 Fenwal, Inc. Systems and methods for optimization of plasma collection volumes
EP3135324B1 (en) 2011-09-26 2019-11-06 Fenwal, Inc. Optical monitoring system for blood processing system
US9733805B2 (en) 2012-06-26 2017-08-15 Terumo Bct, Inc. Generating procedures for entering data prior to separating a liquid into components
WO2014011416A2 (en) 2012-07-11 2014-01-16 Biomimetic Therapeutics, Llc Cell-based assay for neutralizing antibodies
CN104812421B (en) 2012-08-15 2017-06-06 旋风医疗科技股份有限公司 For the system and method for the Blood calldack from absorbable surgical material
US9833606B2 (en) 2012-09-07 2017-12-05 Fenwal, Inc. Non-reopenable flow control clamp
AU2013323621B2 (en) 2012-09-25 2016-04-14 Stem Cell Partners Llc Method and apparatus for preparing single donor thrombin serum
EP3560534B1 (en) 2012-11-05 2021-03-10 Haemonetics Corporation Continuous flow separation chamber
US9302041B2 (en) * 2013-03-15 2016-04-05 Haemonetics Corporation Blood-donation system
US10159778B2 (en) 2014-03-24 2018-12-25 Fenwal, Inc. Biological fluid filters having flexible walls and methods for making such filters
US9796166B2 (en) 2014-03-24 2017-10-24 Fenwal, Inc. Flexible biological fluid filters
US10376627B2 (en) 2014-03-24 2019-08-13 Fenwal, Inc. Flexible biological fluid filters
US9782707B2 (en) 2014-03-24 2017-10-10 Fenwal, Inc. Biological fluid filters having flexible walls and methods for making such filters
US9968738B2 (en) 2014-03-24 2018-05-15 Fenwal, Inc. Biological fluid filters with molded frame and methods for making such filters
SI3148438T1 (en) 2014-05-30 2019-11-29 Applied Science Inc Methods for managing blood donations
WO2016057664A1 (en) 2014-10-07 2016-04-14 Haemonetics Corporation System and method for washing shed blood
US11541161B2 (en) 2016-06-24 2023-01-03 Haemonetics Corporation System and method for continuous flow red blood cell washing
US10758652B2 (en) 2017-05-30 2020-09-01 Haemonetics Corporation System and method for collecting plasma
US10792416B2 (en) 2017-05-30 2020-10-06 Haemonetics Corporation System and method for collecting plasma
US10561784B2 (en) 2017-05-31 2020-02-18 Fenwal, Inc. Stationary optical monitoring system for blood processing system
US11065376B2 (en) 2018-03-26 2021-07-20 Haemonetics Corporation Plasmapheresis centrifuge bowl
US11412967B2 (en) 2018-05-21 2022-08-16 Fenwal, Inc. Systems and methods for plasma collection
KR20210050534A (en) * 2018-08-26 2021-05-07 해모네틱스 코포레이션 Separate take-out device controller
US11898967B2 (en) 2021-02-02 2024-02-13 Fenwal, Inc. Predicting malfunction and failure of centrifuge umbilicus
WO2023014584A2 (en) * 2021-08-02 2023-02-09 Shlomo Gabbay Implantable or para-corporeal blood filtration and oxygenation device for maintaining homeostasis and methods thereof

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2661150A (en) * 1947-12-17 1953-12-01 Jr William G Abbott Centrifuge
US3096283A (en) * 1959-06-24 1963-07-02 Becton Dickinson Co Container for blood and machine for separating precipitates from liquid blood constituents
UST955355I4 (en) * 1959-06-24 1900-01-01
US3239136A (en) * 1962-05-07 1966-03-08 George N Hein Centrifuge and centrifuge head for separating constituents of a liquid and a liner therefor
US3373096A (en) * 1964-09-24 1968-03-12 North American Rockwell Electrolytic preparation of chlorine pentafluoride
US3456875A (en) * 1966-08-18 1969-07-22 George N Hein Air driven centrifuge
US3737096A (en) * 1971-12-23 1973-06-05 Ibm Blood processing control apparatus
US4934995A (en) * 1977-08-12 1990-06-19 Baxter International Inc. Blood component centrifuge having collapsible inner liner
DE2502122A1 (en) * 1973-08-27 1975-07-31 Separex Sa CENTRIFUGE
JPS50107565A (en) * 1974-01-29 1975-08-25
US4056224A (en) * 1975-03-27 1977-11-01 Baxter Travenol Laboratories, Inc. Flow system for centrifugal liquid processing apparatus
US4007871A (en) * 1975-11-13 1977-02-15 International Business Machines Corporation Centrifuge fluid container
US4010894A (en) * 1975-11-21 1977-03-08 International Business Machines Corporation Centrifuge fluid container
US4734089A (en) * 1976-05-14 1988-03-29 Baxter Travenol Laboratories, Inc. Centrifugal blood processing system
US4086924A (en) * 1976-10-06 1978-05-02 Haemonetics Corporation Plasmapheresis apparatus
US4430072A (en) * 1977-06-03 1984-02-07 International Business Machines Corporation Centrifuge assembly
US5217427A (en) * 1977-08-12 1993-06-08 Baxter International Inc. Centrifuge assembly
US5217426A (en) * 1977-08-12 1993-06-08 Baxter International Inc. Combination disposable plastic blood receiving container and blood component centrifuge
US4387848A (en) * 1977-10-03 1983-06-14 International Business Machines Corporation Centrifuge assembly
US4151844A (en) * 1977-11-11 1979-05-01 Baxter Travenol Laboratories, Inc. Method and apparatus for separating whole blood into its components and for automatically collecting one component
US4142670A (en) * 1978-01-27 1979-03-06 Beckman Instruments, Inc. Chylomicron rotor
CH632413A5 (en) * 1978-08-17 1982-10-15 Laszczower Max DEVICE FOR SUCTIONING BLOOD FROM BODY CAVIES.
US4285464A (en) * 1979-01-22 1981-08-25 Haemonetics Corporation Apparatus for separation of blood into components thereof
US4303193A (en) * 1979-01-22 1981-12-01 Haemonetics Corporation Apparatus for separating blood into components thereof
SE416378B (en) * 1979-03-28 1980-12-22 Johansson A S SET ON SEPARATION OF BLOOD COMPONENTS FROM WHOLE BLOOD APPLICABLE BLOOD PASS SYSTEM FOR EXECUTIVE DEVICE SET
US4300717A (en) * 1979-04-02 1981-11-17 Haemonetics Corporation Rotary centrifuge seal
US4457747A (en) * 1980-05-30 1984-07-03 Tu Ho C Exchange transfusion machine
US4387846A (en) * 1981-03-30 1983-06-14 Ducorday Gerard M Bag handle
JPS59500340A (en) * 1982-03-08 1984-03-01 モトロ−ラ・インコ−ポレ−テツド integrated circuit lead frame
US4447221A (en) * 1982-06-15 1984-05-08 International Business Machines Corporation Continuous flow centrifuge assembly
US4482342A (en) * 1982-06-17 1984-11-13 Haemonetics Corporation Blood processing system for cell washing
US4680025A (en) * 1982-08-24 1987-07-14 Baxter Travenol Laboratories, Inc. Blood component collection systems and methods
US4530691A (en) * 1983-12-13 1985-07-23 Baxter Travenol Laboratories, Inc. Centrifuge with movable mandrel
EP0165254A1 (en) * 1983-12-13 1985-12-27 Baxter Travenol Laboratories, Inc. Flexible disposable centrifuge system
US4776964A (en) * 1984-08-24 1988-10-11 William F. McLaughlin Closed hemapheresis system and method
US4643714A (en) * 1985-08-05 1987-02-17 Cobe Laboratories, Inc. Single needle apparatus
US4647279A (en) * 1985-10-18 1987-03-03 Cobe Laboratories, Inc. Centrifugal separator
US4708712A (en) * 1986-03-28 1987-11-24 Cobe Laboratories, Inc. Continuous-loop centrifugal separator
US4983158A (en) * 1986-07-22 1991-01-08 Haemonetics Corporation Plasmapheresis centrifuge bowl
DE3632176A1 (en) * 1986-09-22 1988-04-07 Fresenius Ag CONTROL OF A SYSTEM FOR SEPARATING THE COMPONENTS OF BLOOD TAKEN FROM A DONOR "IN VIVO"
US4940543A (en) * 1987-01-30 1990-07-10 Baxter International Inc. Plasma collection set
US4806252A (en) * 1987-01-30 1989-02-21 Baxter International Inc. Plasma collection set and method
JPH01124467A (en) * 1987-06-25 1989-05-17 Terumo Corp Blood component separator
US4850995A (en) * 1987-08-19 1989-07-25 Cobe Laboratories, Inc. Centrifugal separation of blood
US4889524A (en) * 1987-09-04 1989-12-26 Haemonetics Corporation Portable centrifuge apparatus
SE462015B (en) * 1987-09-15 1990-04-30 Omega Medicinteknik Ab SETTING AND DEVICE CLEANING BLOOD CELLS
AU617265B2 (en) * 1988-06-23 1991-11-21 Asahi Medical Co. Ltd. Method for separating blood into blood components, and blood components separator unit
US5484396A (en) * 1988-11-17 1996-01-16 Naficy; Sadeque S. Method and device for treatment of HIV infections and AIDS
US5300060A (en) * 1989-06-12 1994-04-05 Miles Inc. Blood bag system for separation and isolation of neocytes and gerocytes
US5039401A (en) * 1990-05-16 1991-08-13 Eastman Kodak Company Blood collection and centrifugal separation device including a valve
US5045048A (en) * 1990-03-29 1991-09-03 Haemonetics Corporation Rotary centrifuge bowl and seal for blood processing
US5234403A (en) * 1990-05-25 1993-08-10 Sumitomo Bakelite Co., Ltd. Blood collecting apparatus
US5112298A (en) * 1990-06-25 1992-05-12 Baxter International Inc. Apheresis method and device
US5141486B1 (en) * 1990-11-05 1996-01-30 Cobe Lab Washing cells
US5154716A (en) * 1990-11-06 1992-10-13 Miles Inc. Bottom blood bag separation system
US5273517A (en) * 1991-07-09 1993-12-28 Haemonetics Corporation Blood processing method and apparatus with disposable cassette
DE4129639C1 (en) * 1991-09-06 1993-02-11 Fresenius Ag, 6380 Bad Homburg, De
US5277701A (en) * 1991-11-15 1994-01-11 Regents Of The University Of Minnesota Treatment of aluimmunization and refractoriness to platelet transfusion by protein A column therapy
US5298016A (en) * 1992-03-02 1994-03-29 Advanced Haemotechnologies Apparatus for separating plasma and other wastes from blood
JP3231086B2 (en) * 1992-06-30 2001-11-19 テルモ株式会社 Liquid separation device
DE4227695C1 (en) * 1992-08-21 1993-10-07 Fresenius Ag Centrifuge to separate blood into its components
EP0591980B1 (en) * 1992-10-07 1999-05-06 Asahi Medical Co., Ltd. Leukocyte-removing filter device and system
WO1994012223A1 (en) * 1992-12-01 1994-06-09 Haemonetics Corporation Red blood cell apheresis apparatus and method
CH687505A5 (en) * 1993-01-29 1996-12-31 Elp Rochat Centrifugal separator for fluids.
FR2702962B1 (en) * 1993-03-22 1995-04-28 Hospal Ind Device and method for controlling the balance of fluids on an extracorporeal blood circuit.
US5437598A (en) * 1994-01-21 1995-08-01 Cobe Laboratories, Inc. Automation of plasma sequestration
US5514716A (en) * 1994-02-25 1996-05-07 Sterling Winthrop, Inc. Hydroxamic acid and carboxylic acid derivatives, process for their preparation and use thereof
US5733253A (en) * 1994-10-13 1998-03-31 Transfusion Technologies Corporation Fluid separation system
US5651766A (en) * 1995-06-07 1997-07-29 Transfusion Technologies Corporation Blood collection and separation system
US5958250A (en) * 1995-06-07 1999-09-28 Baxter International Inc. Blood processing systems and methods which optically derive the volume of platelets contained in a plasma constituent

Also Published As

Publication number Publication date
JP2006212439A (en) 2006-08-17
US6379322B1 (en) 2002-04-30
AU5302696A (en) 1996-12-30
DE69632731T2 (en) 2005-07-14
ATE269116T1 (en) 2004-07-15
DE69632731D1 (en) 2004-07-22
US5853382A (en) 1998-12-29
JPH11506030A (en) 1999-06-02
US5728060A (en) 1998-03-17
JP3958364B2 (en) 2007-08-15
CA2220295C (en) 2008-11-04
EP0830157A1 (en) 1998-03-25
WO1996040319A1 (en) 1996-12-19
US6102883A (en) 2000-08-15
US6007509A (en) 1999-12-28
US5651766A (en) 1997-07-29
JP4031805B2 (en) 2008-01-09
US6641552B1 (en) 2003-11-04
US5779660A (en) 1998-07-14
AU710558B2 (en) 1999-09-23
EP0830157B1 (en) 2004-06-16

Similar Documents

Publication Publication Date Title
CA2220295A1 (en) Blood collection and separation system
EP0348475B1 (en) Apparatus and methods for generating platelet concentrate
CA2452055A1 (en) Integrated automatic blood collection and processing unit
DE3785348D1 (en) CENTRIFUGAL TREATMENT METHOD AND DEVICE FOR CYTOPHORESIS, E.g. THROMBOCYTE SEPARATION AND FOR PLASMA EXCHANGE TREATMENT.
US20060011545A1 (en) Method and device for separating whole blood under gravitational force
CA2101452A1 (en) Biological/Pharmaceutical Method and Apparatus for Collecting and Mixing Fluids
DE69117750T2 (en) DEVICE FOR PRODUCING COAGULATION FACTOR CONCENTRATES, LIKE FIBRINOGEN, FROM BLOOD SAMPLES
EP1627651A3 (en) Method and apparatus for blood component separation
CA2397959A1 (en) Cassette with integral separation device
GB1490166A (en) Process and pheresis procedure and disposable pheresis bowl therefor
CA2109837A1 (en) Apheresis Method and Device
GR3006417T3 (en)
EP0879608A3 (en) Means and Method for separating blood in its components
EP0487096B1 (en) Single-needle extracorporeal plasmapheresis circuit
EP1075844A3 (en) Device and method for autologous blood transfusion
US4474568A (en) Multipurpose component container and anticoagulant bag
CN2339156Y (en) Consumption apparatus for collecting and separating blood cells and blood plasma
JPS61501249A (en) Priming system for ultrafiltration units
JPS6337769B2 (en)
JPS62137060A (en) Double filtering type blood treatment apparatus
JPH04193177A (en) Blood component fractional collection device
JPH0775621B2 (en) Sampler
CN2325029Y (en) Blood sampling separating device
JPS6415060A (en) Plasma collecting apparatus
CN2177488Y (en) Closed ascites concentration recoverer

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed